ISMARA results: tcf12

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tcf12

Z-value: 2.32

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Transcription factors associated with tcf12

Gene Symbol	Gene ID	Gene Info
tcf12 NCBI UniProt	ENSDARG00000004714	transcription factor 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tcf12	dr11_v1_chr7_-_52709759_52709935	0.60	1.1e-10	Click!

Activity profile of tcf12 motif

Sorted Z-values of tcf12 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_36911118 Show fit	38.27	ENSDART00000048739	trim9 NCBI UniProt Show fit	tripartite motif containing 9
chr15_-_15357178 Show fit	37.59	ENSDART00000106120	ywhag2 NCBI UniProt Show fit	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr4_-_14328997 Show fit	35.41	ENSDART00000091151	nell2b NCBI UniProt Show fit	neural EGFL like 2b
chr19_+_30633453 Show fit	35.30	ENSDART00000052124	fam49al NCBI UniProt Show fit	family with sequence similarity 49, member A-like
chr10_+_15777258 Show fit	32.85	ENSDART00000140511	apba1b NCBI UniProt Show fit	amyloid beta (A4) precursor protein-binding, family A, member 1b
chr2_-_16565690 Show fit	32.55	ENSDART00000022549	atp1b3a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 3a
chr16_-_17207754 Show fit	30.27	ENSDART00000063804	wu:fj39g12 NCBI UniProt Show fit	wu:fj39g12
chr10_+_15777064 Show fit	29.97	ENSDART00000114483	apba1b NCBI UniProt Show fit	amyloid beta (A4) precursor protein-binding, family A, member 1b
chr20_+_27020201 Show fit	28.91	ENSDART00000126919 ENSDART00000016014	chga NCBI UniProt Show fit	chromogranin A
chr11_+_7324704 Show fit	26.79	ENSDART00000031937	diras1a NCBI UniProt Show fit	DIRAS family, GTP-binding RAS-like 1a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	71.7	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
6.2	67.8	GO:0006797	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.2	62.2	GO:0007268	chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
2.4	54.9	GO:0045773	positive regulation of axon extension(GO:0045773)
2.6	46.8	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.4	45.5	GO:0017157	regulation of exocytosis(GO:0017157)
14.0	42.1	GO:0090278	negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
2.2	41.3	GO:0071436	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
2.2	40.2	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.4	38.6	GO:0002088	lens development in camera-type eye(GO:0002088)

Showing 1 to 10 of 385 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	100.6	GO:0043005	neuron projection(GO:0043005)
0.6	96.5	GO:0030424	axon(GO:0030424)
1.8	80.7	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	75.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	63.1	GO:0015630	microtubule cytoskeleton(GO:0015630)
0.6	53.8	GO:0043025	neuronal cell body(GO:0043025)
0.7	52.2	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.4	45.2	GO:0030425	dendrite(GO:0030425)
4.2	42.3	GO:0042583	chromaffin granule(GO:0042583)
2.8	42.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)

Showing 1 to 10 of 136 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	144.4	GO:0008017	microtubule binding(GO:0008017)
0.3	117.0	GO:0003924	GTPase activity(GO:0003924)
0.2	84.1	GO:0005096	GTPase activator activity(GO:0005096)
6.2	67.8	GO:0004309	exopolyphosphatase activity(GO:0004309)
2.6	62.8	GO:0001540	beta-amyloid binding(GO:0001540)
3.7	56.2	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.2	47.6	GO:0015293	symporter activity(GO:0015293)
1.2	45.9	GO:0019003	GDP binding(GO:0019003)
0.9	44.1	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
2.1	42.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)

Showing 1 to 10 of 252 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	32.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.6	19.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.6	18.6	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.8	16.5	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3	14.2	PID LKB1 PATHWAY	LKB1 signaling events
0.4	11.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.8	10.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	10.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	9.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.5	8.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling

Showing 1 to 10 of 35 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	37.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	26.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	21.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.9	17.1	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
1.2	16.5	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.2	16.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.6	13.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	13.3	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.8	11.9	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.5	11.3	REACTOME AMYLOIDS	Genes involved in Amyloids

Showing 1 to 10 of 65 entries

Results for tcf12

Z-value: 2.32

Motif logo

Transcription factors associated with tcf12

Activity-expression correlation:

Activity profile of tcf12 motif

Sorted Z-values of tcf12 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: