ISMARA results: tbx15_tbx1_mgaa

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbx15_tbx1_mgaa_tbx4

Z-value: 1.47

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Transcription factors associated with tbx15_tbx1_mgaa_tbx4

Gene Symbol	Gene ID	Gene Info
tbx15 NCBI UniProt	ENSDARG00000002582	T-box transcription factor 15
tbx1 NCBI UniProt	ENSDARG00000031891	T-box transcription factor 1
mgaa NCBI UniProt	ENSDARG00000078784	MAX dimerization protein MGA a
tbx4 NCBI UniProt	ENSDARG00000030058	T-box transcription factor 4
tbx4 NCBI UniProt	ENSDARG00000113067	T-box transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tbx15	dr11_v1_chr9_-_21067673_21067673	0.53	4.9e-08	Click!
mgaa	dr11_v1_chr17_+_10578823_10578823	0.32	1.6e-03	Click!
tbx4	dr11_v1_chr15_+_27384798_27384798	0.20	4.8e-02	Click!
tbx1	dr11_v1_chr5_+_15202495_15202495	0.04	7.2e-01	Click!

Activity profile of tbx15_tbx1_mgaa_tbx4 motif

Sorted Z-values of tbx15_tbx1_mgaa_tbx4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_37837245 Show fit	37.93	ENSDART00000171617	epd NCBI UniProt Show fit	ependymin
chr3_-_61205711 Show fit	26.75	ENSDART00000055062	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr7_+_6969909 Show fit	24.40	ENSDART00000189886	actn3b NCBI UniProt Show fit	actinin alpha 3b
chr7_+_7048245 Show fit	23.72	ENSDART00000001649	actn3b NCBI UniProt Show fit	actinin alpha 3b
chr5_-_33215261 Show fit	21.24	ENSDART00000097935 ENSDART00000134777	si:dkey-226m8.10 NCBI UniProt Show fit	si:dkey-226m8.10
chr24_-_6158933 Show fit	19.82	ENSDART00000021609	gad2 NCBI UniProt Show fit	glutamate decarboxylase 2
chr10_-_31782616 Show fit	18.92	ENSDART00000128839	fez1 NCBI UniProt Show fit	fasciculation and elongation protein zeta 1 (zygin I)
chr7_-_38612230 Show fit	16.58	ENSDART00000173678	c1qtnf4 NCBI UniProt Show fit	C1q and TNF related 4
chr23_-_4855122 Show fit	16.50	ENSDART00000133701	slc6a1a NCBI UniProt Show fit	solute carrier family 6 (neurotransmitter transporter), member 1a
chr25_+_37397031 Show fit	16.25	ENSDART00000193643 ENSDART00000169132	slc1a2b NCBI UniProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx15_tbx1_mgaa_tbx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	34.6	GO:0007160	cell-matrix adhesion(GO:0007160)
2.6	23.3	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.2	22.6	GO:0035725	sodium ion transmembrane transport(GO:0035725)
0.3	20.9	GO:0043044	ATP-dependent chromatin remodeling(GO:0043044)
0.8	20.7	GO:0008345	larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
6.6	19.8	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1	19.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	18.1	GO:0007626	locomotory behavior(GO:0007626)
0.8	17.0	GO:0045773	positive regulation of axon extension(GO:0045773)
0.7	16.4	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)

Showing 1 to 10 of 250 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	61.7	GO:0030424	axon(GO:0030424)
0.1	52.3	GO:0043005	neuron projection(GO:0043005)
0.2	27.6	GO:0045211	postsynaptic membrane(GO:0045211)
2.7	21.2	GO:0016586	RSC complex(GO:0016586)
0.3	20.1	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1	19.5	GO:0005764	lysosome(GO:0005764)
0.1	16.5	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	14.1	GO:0005887	integral component of plasma membrane(GO:0005887)
1.1	11.1	GO:0098982	GABA-ergic synapse(GO:0098982)
0.2	11.0	GO:0005891	voltage-gated calcium channel complex(GO:0005891)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	192.6	GO:0005509	calcium ion binding(GO:0005509)
0.1	28.7	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.1	22.5	GO:0003682	chromatin binding(GO:0003682)
0.1	21.0	GO:0015293	symporter activity(GO:0015293)
0.1	20.6	GO:0008017	microtubule binding(GO:0008017)
6.6	19.8	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.4	18.7	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
1.3	16.4	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.7	16.4	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	15.3	GO:0051015	actin filament binding(GO:0051015)

Showing 1 to 10 of 161 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	12.5	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.7	11.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	10.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	8.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.2	8.3	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	7.0	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	6.4	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.6	5.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	4.7	NABA COLLAGENS	Genes encoding collagen proteins

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	19.8	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.8	10.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.6	9.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3	8.5	REACTOME FRS2 MEDIATED CASCADE	Genes involved in FRS2-mediated cascade
0.2	8.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
2.8	8.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.2	8.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.8	7.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.9	5.5	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.3	4.9	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation

Showing 1 to 10 of 53 entries

Results for tbx15_tbx1_mgaa_tbx4

Z-value: 1.47

Motif logo

Transcription factors associated with tbx15_tbx1_mgaa_tbx4

Activity-expression correlation:

Activity profile of tbx15_tbx1_mgaa_tbx4 motif

Sorted Z-values of tbx15_tbx1_mgaa_tbx4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx15_tbx1_mgaa_tbx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: