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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbp

Z-value: 2.76

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Transcription factors associated with tbp

Gene Symbol Gene ID Gene Info
ENSDARG00000014994 TATA box binding protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbpdr11_v1_chr13_-_24396199_24396199-0.801.0e-21Click!

Activity profile of tbp motif

Sorted Z-values of tbp motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_32818607 46.64 ENSDART00000075465
myosin light chain, phosphorylatable, fast skeletal muscle a
chr21_+_20383837 42.96 ENSDART00000026430
heat shock protein, alpha-crystallin-related, b11
chr5_-_36837846 42.10 ENSDART00000032481
creatine kinase, muscle a
chr1_+_55137943 40.40 ENSDART00000138070
ENSDART00000150510
ENSDART00000133472
ENSDART00000136378
myoglobin
chr23_+_45456490 37.20 ENSDART00000036631
cysteine-rich, angiogenic inducer, 61
chr5_-_32274383 34.72 ENSDART00000122889
myosin, heavy polypeptide 1.3, skeletal muscle
chr25_+_35020529 34.29 ENSDART00000158016
filamin C, gamma a (actin binding protein 280)
chr12_-_17712393 33.94 ENSDART00000143534
ENSDART00000010144
parvalbumin 2
chr9_+_23900703 29.65 ENSDART00000127859
tripartite motif containing 63b
chr22_-_263117 29.15 ENSDART00000158134
zgc:66156
chr22_-_282498 28.24 ENSDART00000182766

chr5_-_71722257 26.92 ENSDART00000013404
adenylate kinase 1
chr15_-_5815006 26.54 ENSDART00000102459
retinol binding protein 2a, cellular
chr16_+_1471 26.31 ENSDART00000181972

chr8_+_48613040 25.83 ENSDART00000121432
natriuretic peptide A
chr23_-_35082494 25.15 ENSDART00000189809

chr7_-_16562200 23.97 ENSDART00000169093
ENSDART00000173491
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr20_-_9980318 23.61 ENSDART00000080664
zgc:86709
chr5_-_64168415 21.88 ENSDART00000048395
cardiac myosin light chain-1
chr24_-_25691020 21.54 ENSDART00000015391
cholinergic receptor, nicotinic, delta (muscle)
chr13_-_12660318 20.95 ENSDART00000008498
alcohol dehydrogenase 8a
chr23_+_27675581 20.57 ENSDART00000127198
ribosomal protein S26
chr8_-_24970790 20.24 ENSDART00000141267
si:ch211-199o1.2
chr2_+_24507597 19.69 ENSDART00000133109
ribosomal protein S28
chr1_-_49225890 19.27 ENSDART00000111598
chemokine (C-X-C motif) ligand 18b
chr22_-_294700 19.11 ENSDART00000189179

chr23_+_25305431 18.54 ENSDART00000143291
si:dkey-151g10.6
chr8_+_48609521 17.87 ENSDART00000060765
natriuretic peptide B
chr2_+_16780643 17.76 ENSDART00000125647
ENSDART00000108611
ENSDART00000181245
ENSDART00000163194
transferrin-a
chr11_+_6456146 17.69 ENSDART00000036939
growth arrest and DNA-damage-inducible, beta a
chr2_+_24507770 17.59 ENSDART00000154802
ENSDART00000052063
ribosomal protein S28
chr13_-_2215213 17.59 ENSDART00000129773
muscular LMNA-interacting protein
chr6_-_54180699 17.53 ENSDART00000045901
ribosomal protein S10
chr18_-_46010 17.49 ENSDART00000052641
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr2_+_15100742 16.38 ENSDART00000027171
coagulation factor IIIb
chr2_+_16781015 15.60 ENSDART00000155147
ENSDART00000003845
transferrin-a
chr6_+_269204 15.56 ENSDART00000191678
activating transcription factor 4a
chr7_-_31441420 15.49 ENSDART00000075398
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr7_+_29951997 14.55 ENSDART00000173453
alpha-tropomyosin
chr5_-_25583125 14.52 ENSDART00000031665
ENSDART00000145353
annexin A1a
chr5_-_33259079 14.30 ENSDART00000132223
interferon induced transmembrane protein 1
chr8_-_31369161 13.22 ENSDART00000019937
growth arrest and DNA-damage-inducible, gamma a
chr18_-_5527050 12.93 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
chr2_-_30182353 12.92 ENSDART00000019149
ribosomal protein L7
chr20_-_26846028 12.81 ENSDART00000136687
myosin light chain kinase family, member 4b
chr13_-_15702672 12.81 ENSDART00000144445
ENSDART00000168950
creatine kinase, brain a
chr14_-_33334065 12.40 ENSDART00000052761
ribosomal protein L39
chr16_+_53455638 12.05 ENSDART00000045792
ENSDART00000154189
RNA binding motif protein 24b
chr8_+_26818446 12.04 ENSDART00000134987
ENSDART00000138835
si:ch211-156j16.1
chr21_-_11646878 11.96 ENSDART00000162426
ENSDART00000135937
ENSDART00000131448
ENSDART00000148097
ENSDART00000133443
calpastatin
chr16_-_45917322 11.87 ENSDART00000060822
antifreeze protein type IV
chr9_-_22232902 11.76 ENSDART00000101845
crystallin, gamma M2d5
chr25_+_30298377 11.59 ENSDART00000153622
chromosome 11 open reading frame 96
chr3_+_5575313 11.56 ENSDART00000134693
ENSDART00000101807
si:ch211-106h11.3
chr16_+_32736588 11.56 ENSDART00000075191
ENSDART00000168358
zgc:172323
chr5_-_7834582 11.52 ENSDART00000162626
ENSDART00000157661
PDZ and LIM domain 5a
chr21_-_28523548 11.47 ENSDART00000077910
ependymin-like 2
chr5_+_37978501 11.46 ENSDART00000012050
apolipoprotein A-Ia
chr2_+_55365727 11.24 ENSDART00000162943

chr4_+_842010 11.04 ENSDART00000067461
si:ch211-152c2.3
chr4_+_7817996 10.90 ENSDART00000166809
si:ch1073-67j19.1
chr24_-_10021341 10.85 ENSDART00000137250
zgc:173856
chr23_+_18103080 10.79 ENSDART00000010270
major facilitator superfamily domain containing 4Ab
chr9_-_33081978 10.66 ENSDART00000100918
zgc:172053
chr3_-_57425961 10.58 ENSDART00000033716
suppressor of cytokine signaling 3a
chr9_-_22240052 10.50 ENSDART00000111109
crystallin, gamma M2d9
chr11_+_13207898 10.46 ENSDART00000060310
ATP synthase F1 subunit beta
chr7_-_73851280 10.30 ENSDART00000190053

chr21_+_30043054 10.15 ENSDART00000065448
fatty acid binding protein 6, ileal (gastrotropin)
chr3_+_26135502 10.12 ENSDART00000146979
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr15_+_28368823 10.08 ENSDART00000142298
solute carrier family 43 (amino acid system L transporter), member 2a
chr5_-_15851953 10.04 ENSDART00000173101
si:dkey-1k23.3
chr17_+_27456804 10.00 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
cathepsin L.1
chr12_-_20665164 9.93 ENSDART00000105352
gastric inhibitory polypeptide
chr23_+_43950674 9.85 ENSDART00000167813
corin, serine peptidase
chr5_-_30615901 9.75 ENSDART00000147769
si:ch211-117m20.5
chr24_-_9991153 9.60 ENSDART00000137794
ENSDART00000106252
ENSDART00000188309
ENSDART00000188266
ENSDART00000188660
ENSDART00000185713
ENSDART00000179773
zgc:152652
chr22_-_817479 9.56 ENSDART00000123487
zgc:153675
chr24_+_3307857 9.54 ENSDART00000106527
glycogenin 1b
chr1_-_43920371 9.52 ENSDART00000109283
secretory calcium-binding phosphoprotein 7
chr12_+_20641102 9.43 ENSDART00000152964
calcium binding and coiled-coil domain 2
chr21_+_25221940 9.42 ENSDART00000108972
syncollin, tandem duplicate 1
chr2_+_24536762 9.42 ENSDART00000144149
angiopoietin-like 4
chr14_+_22132388 9.36 ENSDART00000109065
cyclin G1
chr24_-_9979342 9.34 ENSDART00000138576
ENSDART00000191206
zgc:171977
chr24_+_21621654 9.26 ENSDART00000002595
ribosomal protein L21
chr3_-_24456451 9.26 ENSDART00000024480
ENSDART00000156814
BAI1-associated protein 2-like 2a
chr10_-_40557210 9.23 ENSDART00000135297
trace amine associated receptor 18b
chr16_-_31598771 9.05 ENSDART00000016386
thyroglobulin
chr2_+_55665322 9.02 ENSDART00000183636
ENSDART00000183814
Kruppel-like factor 2b
chr24_-_27419198 8.95 ENSDART00000141124
chemokine (C-C motif) ligand 34b, duplicate 4
chr1_+_23408622 8.95 ENSDART00000140706
cholinergic receptor, nicotinic, alpha 9
chr7_-_73717082 8.69 ENSDART00000164301
ENSDART00000082625

chr18_-_50799510 8.61 ENSDART00000174373
transaldolase 1
chr9_-_33063083 8.60 ENSDART00000048550
si:ch211-125e6.5
chr9_+_23770666 8.58 ENSDART00000182493
si:ch211-219a4.3
chr6_+_52918537 8.55 ENSDART00000174229
odorant receptor, family H, subfamily 137, member 1
chr11_+_25477643 8.48 ENSDART00000065941
opsin 1 (cone pigments), long-wave-sensitive, 1
chr12_+_48340133 8.48 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
DNA-damage-inducible transcript 4
chr2_-_127945 8.42 ENSDART00000056453
insulin-like growth factor binding protein 1b
chr22_+_16497670 8.40 ENSDART00000014330
immediate early response 5
chr13_-_12645584 8.31 ENSDART00000176216
alcohol dehydrogenase 8b
chr16_-_25085327 8.24 ENSDART00000077661
protease, serine 1
chr22_+_5752257 8.24 ENSDART00000143052
COX14 cytochrome c oxidase assembly factor
chr21_+_5531138 8.12 ENSDART00000163825
lymphocyte antigen 6 family member M6
chr1_-_43920576 8.12 ENSDART00000191914
secretory calcium-binding phosphoprotein 7
chr10_+_17026870 8.11 ENSDART00000184529
ENSDART00000157480

chr4_+_25706037 8.08 ENSDART00000141133
laminin, beta 1b
chr20_-_52928541 8.07 ENSDART00000162812
farnesyl-diphosphate farnesyltransferase 1
chr7_+_35068036 7.69 ENSDART00000022139
zgc:136461
chr7_-_73845736 7.67 ENSDART00000193414
zgc:173552
chr17_-_20118145 7.65 ENSDART00000149737
ENSDART00000165606
ryanodine receptor 2b (cardiac)
chr10_+_38593645 7.63 ENSDART00000011573
matrix metallopeptidase 13a
chr24_-_9985019 7.62 ENSDART00000193536
ENSDART00000189595
zgc:171977
chr22_+_635813 7.47 ENSDART00000179067

chr3_+_15505275 7.43 ENSDART00000141714
nuclear protein 1
chr7_-_66137065 7.21 ENSDART00000145843
parathyroid hormone 1b
chr13_-_20381485 7.17 ENSDART00000131351
si:ch211-270n8.1
chr23_+_19655301 7.16 ENSDART00000104441
ENSDART00000135269
abhydrolase domain containing 6b
chr3_-_23643751 7.15 ENSDART00000078425
ENSDART00000140264
even-skipped-like1
chr11_+_3575963 7.13 ENSDART00000077305
si:dkey-33m11.8
chr6_-_49173891 6.98 ENSDART00000132867
nerve growth factor b (beta polypeptide)
chr7_-_73846995 6.97 ENSDART00000188079

chr9_-_22355391 6.97 ENSDART00000009115
crystallin, gamma M3
chr6_-_40755909 6.91 ENSDART00000026257
myosin, heavy chain b
chr21_+_25777425 6.85 ENSDART00000021620
claudin d
chr25_+_35132090 6.82 ENSDART00000154377
si:dkey-261m9.6
chr9_-_33081781 6.82 ENSDART00000165748
zgc:172053
chr8_-_22965214 6.75 ENSDART00000148178
elastin microfibril interfacer 3a
chr2_+_17181777 6.74 ENSDART00000112063
prostaglandin E receptor 4 (subtype EP4) c
chr11_+_42478184 6.71 ENSDART00000089963
zgc:110286
chr7_+_5960491 6.70 ENSDART00000145370
zgc:112234
chr23_-_35195908 6.66 ENSDART00000122429
Kruppel-like factor 15
chr21_-_280769 6.65 ENSDART00000157753
plasminogen receptor, C-terminal lysine transmembrane protein
chr3_-_40276057 6.59 ENSDART00000132225
ENSDART00000074737
serine hydroxymethyltransferase 1 (soluble)
chr1_-_59169815 6.58 ENSDART00000100163
wu:fk65c09
chr10_-_7785930 6.58 ENSDART00000043961
ENSDART00000111058
myeloid-specific peroxidase
chr19_+_10845953 6.48 ENSDART00000157589
apolipoprotein A-IV a
chr9_+_1139378 6.47 ENSDART00000170033
solute carrier family 15 (oligopeptide transporter), member 1a
chr19_-_42557416 6.45 ENSDART00000163217
ENSDART00000128278
ENSDART00000162304
ENSDART00000166556
si:dkey-267n13.1
chr15_-_18232712 6.34 ENSDART00000081199
wu:fj20b03
chr10_+_36334502 6.32 ENSDART00000099400
odorant receptor, family G, subfamily 106, member 1
chr5_+_4366431 6.26 ENSDART00000168560
ENSDART00000149185
spermidine/spermine N1-acetyltransferase 1a, duplicate 2
chr4_-_19033805 6.24 ENSDART00000133203
leptin b
chr9_-_45602978 6.21 ENSDART00000139019
ENSDART00000085763
anterior gradient 1
chr3_+_1037946 6.20 ENSDART00000167590
ENSDART00000011111
zgc:153921
zgc:153921
chr11_-_45152702 6.19 ENSDART00000168066
arylformamidase
chr6_-_40756138 6.19 ENSDART00000156295
myosin, heavy chain b
chr22_+_25774750 6.15 ENSDART00000174421

chr11_-_40030139 6.13 ENSDART00000021916
urotensin 2, beta
chr9_-_22272181 6.11 ENSDART00000113174
crystallin, gamma M2d7
chr4_+_306036 6.10 ENSDART00000103659
mesogenin 1
chr6_+_41181869 6.08 ENSDART00000002046
opsin 1 (cone pigments), medium-wave-sensitive, 1
chr15_+_714203 6.07 ENSDART00000153847
si:dkey-7i4.24
chr17_+_37227936 6.05 ENSDART00000076009
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b
chr5_+_68807170 5.98 ENSDART00000017849
hairy and enhancer of split related-7
chr25_-_12982193 5.97 ENSDART00000159617
chemokine (C-C motif) ligand 39, duplicate 5
chr13_+_40501455 5.95 ENSDART00000114985
heparanase 2
chr15_+_15390882 5.93 ENSDART00000062024
carbonic anhydrase IV b
chr9_-_33062891 5.89 ENSDART00000161182
si:ch211-125e6.5
chr9_-_22245572 5.89 ENSDART00000114943
crystallin, gamma M2d4
chr20_+_46255057 5.86 ENSDART00000100536
trace amine associated receptor 14i
chr3_+_52145511 5.85 ENSDART00000078485
adhesion G protein-coupled receptor E14
chr12_-_36268723 5.85 ENSDART00000113740
potassium inwardly-rectifying channel, subfamily J, member 16
chr11_-_24016761 5.85 ENSDART00000153601
ENSDART00000067817
ENSDART00000170531
chitinase, acidic.3
chr25_+_8407892 5.83 ENSDART00000153536
mucin 5.2
chr3_-_6709938 5.82 ENSDART00000172196
autophagy related 4D, cysteine peptidase b
chr15_-_5222924 5.82 ENSDART00000128924
odorant receptor, family E, subfamily 128, member 4
chr5_+_21181047 5.81 ENSDART00000088506
Rho GTPase activating protein 25
chr7_-_7810348 5.80 ENSDART00000171984
chemokine (C-X-C motif) ligand 19
chr25_-_375882 5.78 ENSDART00000165705
sizzled
chr9_-_22281854 5.71 ENSDART00000146319
crystallin, gamma M2d3
chr7_+_5906327 5.71 ENSDART00000173160
zgc:112234
chr3_-_55121125 5.64 ENSDART00000125092
hemoglobin, alpha embryonic 1
chr16_-_28091597 5.63 ENSDART00000166595

chr16_+_31542645 5.59 ENSDART00000163724
Src like adaptor
chr7_+_5976613 5.57 ENSDART00000173105
si:dkey-23a13.21
chr18_+_14342326 5.57 ENSDART00000181013
ENSDART00000138372
si:dkey-246g23.2
chr19_-_2707048 5.55 ENSDART00000166112
interleukin 6 (interferon, beta 2)
chr6_+_49052741 5.55 ENSDART00000011876
synaptonemal complex protein 1
chr22_-_8499778 5.55 ENSDART00000142219
si:ch73-27e22.4
chr13_+_14976108 5.48 ENSDART00000011520
notochord homeobox
chr12_-_20665865 5.47 ENSDART00000183922
gastric inhibitory polypeptide
chr21_+_25226558 5.40 ENSDART00000168480
syncollin, tandem duplicate 2
chr20_-_22464250 5.37 ENSDART00000165904
platelet-derived growth factor receptor, alpha polypeptide
chr9_+_33207574 5.30 ENSDART00000055897
ENSDART00000166030
si:ch211-125e6.11
chr24_-_26854032 5.27 ENSDART00000087991
fibronectin type III domain containing 3Bb
chr8_+_999421 5.27 ENSDART00000149528
fatty acid binding protein 1b, tandem duplicate 1
chr20_+_46268906 5.25 ENSDART00000113372
trace amine associated receptor 14e
chr3_-_36606884 5.25 ENSDART00000172003
si:dkeyp-72e1.6
chr9_+_22080122 5.22 ENSDART00000065956
ENSDART00000136014
crystallin, gamma M2e
chr14_-_11507211 5.18 ENSDART00000186873
ENSDART00000109181
ENSDART00000186166
ENSDART00000186986
zgc:174917
chr21_+_21673516 5.17 ENSDART00000147601
odorant receptor, family E, subfamily 125, member 6
chr21_-_42876565 5.14 ENSDART00000126480
zmp:0000001268
chr20_-_33976937 5.13 ENSDART00000136834
selectin E
chr5_-_22027357 5.10 ENSDART00000023306
ankyrin repeat and SOCS box-containing 12a
chr19_-_3193912 5.10 ENSDART00000133159
si:ch211-133n4.6
chr19_-_3193443 5.08 ENSDART00000179855
si:ch211-133n4.6
chr8_+_37111643 5.08 ENSDART00000061336
renin
chr21_+_25354106 5.06 ENSDART00000133406
odorant receptor, family H, subfamily 132, member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of tbp

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.6 43.7 GO:1905072 cardiac jelly development(GO:1905072)
6.0 24.0 GO:0035994 response to muscle stretch(GO:0035994)
5.8 17.5 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
4.5 13.5 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
4.2 54.9 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
4.2 29.3 GO:0046294 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
3.8 26.9 GO:0009180 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
3.8 34.3 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
3.6 21.9 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
3.4 30.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
3.0 33.4 GO:0019731 antibacterial humoral response(GO:0019731)
3.0 12.1 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
3.0 29.9 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
2.6 10.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
2.5 2.5 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
2.5 10.1 GO:0045988 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
2.4 54.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.3 11.5 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
2.3 9.1 GO:0006590 thyroid hormone generation(GO:0006590)
2.2 6.6 GO:0006565 L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264)
2.0 6.1 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
2.0 40.4 GO:0014823 response to activity(GO:0014823)
1.9 40.2 GO:0031033 myosin filament organization(GO:0031033)
1.8 5.5 GO:0000711 meiotic DNA repair synthesis(GO:0000711) chiasma assembly(GO:0051026)
1.8 5.5 GO:0048321 axial mesoderm formation(GO:0048320) axial mesodermal cell differentiation(GO:0048321) axial mesodermal cell fate commitment(GO:0048322) axial mesodermal cell fate specification(GO:0048327)
1.7 8.6 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
1.7 12.0 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
1.7 5.0 GO:2000009 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
1.7 6.7 GO:0010755 regulation of plasminogen activation(GO:0010755)
1.6 6.3 GO:0006598 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
1.6 4.7 GO:0065001 specification of axis polarity(GO:0065001)
1.4 6.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.3 6.7 GO:0071380 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
1.3 10.6 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
1.3 15.6 GO:0045667 regulation of osteoblast differentiation(GO:0045667) intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059) lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
1.2 3.7 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
1.2 9.4 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
1.2 9.4 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
1.2 9.4 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
1.1 3.4 GO:0015695 organic cation transport(GO:0015695)
1.1 5.5 GO:0006953 acute-phase response(GO:0006953)
1.1 11.8 GO:0006032 chitin catabolic process(GO:0006032)
1.1 5.4 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
1.0 1.0 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
1.0 9.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.9 1.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.9 7.0 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.8 4.1 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.8 45.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.8 86.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.8 8.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.7 5.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.7 6.5 GO:0006857 oligopeptide transport(GO:0006857)
0.7 11.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.7 2.0 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.6 4.8 GO:0090594 inflammatory response to wounding(GO:0090594)
0.6 6.6 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
0.6 2.3 GO:0042148 strand invasion(GO:0042148)
0.6 4.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.6 7.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.6 2.9 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.6 5.0 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.5 2.7 GO:0010693 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.5 4.5 GO:0030719 P granule organization(GO:0030719)
0.5 3.4 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.4 2.6 GO:0070874 negative regulation of peptidyl-serine phosphorylation(GO:0033137) negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 20.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.4 3.7 GO:0060004 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.4 4.9 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.4 2.0 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.3 5.1 GO:0016486 peptide hormone processing(GO:0016486)
0.3 1.3 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.3 1.3 GO:0010459 cardiac conduction system development(GO:0003161) negative regulation of heart rate(GO:0010459)
0.3 4.1 GO:0042572 retinol metabolic process(GO:0042572)
0.3 2.2 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.3 1.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.3 8.1 GO:0070831 basement membrane assembly(GO:0070831)
0.3 9.1 GO:0051058 negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.3 10.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.3 5.9 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.3 3.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 8.3 GO:0060030 dorsal convergence(GO:0060030)
0.3 10.1 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 7.6 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.2 16.4 GO:0007596 blood coagulation(GO:0007596)
0.2 5.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.2 4.3 GO:0048570 notochord morphogenesis(GO:0048570)
0.2 4.4 GO:0048246 macrophage chemotaxis(GO:0048246)
0.2 21.3 GO:0030239 myofibril assembly(GO:0030239)
0.2 14.6 GO:0061515 myeloid cell development(GO:0061515)
0.2 5.0 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.2 8.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 4.1 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 3.6 GO:0051923 sulfation(GO:0051923)
0.1 3.6 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 2.3 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 3.9 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 3.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 5.0 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 5.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 4.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 4.4 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 0.4 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 2.4 GO:0001757 somite specification(GO:0001757)
0.1 2.0 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 7.3 GO:0042594 response to starvation(GO:0042594)
0.1 1.6 GO:0051604 protein maturation(GO:0051604)
0.1 4.4 GO:0097530 granulocyte migration(GO:0097530)
0.1 2.9 GO:0003094 glomerular filtration(GO:0003094)
0.1 3.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 8.0 GO:0050768 negative regulation of neurogenesis(GO:0050768)
0.1 6.8 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.3 GO:0090299 regulation of neural crest formation(GO:0090299)
0.1 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 5.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 7.6 GO:0017038 protein import(GO:0017038)
0.1 16.3 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.1 26.3 GO:0016567 protein ubiquitination(GO:0016567)
0.1 4.4 GO:0007098 centrosome cycle(GO:0007098)
0.1 0.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 1.6 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 1.9 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 20.4 GO:0006412 translation(GO:0006412)
0.0 2.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.9 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 8.5 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.2 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.9 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 3.8 GO:0030111 regulation of Wnt signaling pathway(GO:0030111)
0.0 24.9 GO:0006508 proteolysis(GO:0006508)
0.0 1.5 GO:0006364 rRNA processing(GO:0006364)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.4 37.3 GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556)
2.5 10.1 GO:0031673 H zone(GO:0031673)
1.5 10.5 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.5 4.5 GO:0033391 chromatoid body(GO:0033391)
1.4 5.5 GO:0043073 germ cell nucleus(GO:0043073)
1.2 14.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.2 15.6 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
1.2 16.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.1 7.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
1.0 14.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.9 11.5 GO:0042627 chylomicron(GO:0042627)
0.8 5.8 GO:0001891 phagocytic cup(GO:0001891)
0.8 17.5 GO:0030667 secretory granule membrane(GO:0030667)
0.7 35.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 7.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.6 71.7 GO:0016459 myosin complex(GO:0016459)
0.6 34.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.5 2.0 GO:1904423 dehydrodolichyl diphosphate synthase complex(GO:1904423)
0.5 4.4 GO:0070652 HAUS complex(GO:0070652)
0.5 2.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.5 17.6 GO:0016605 PML body(GO:0016605)
0.4 4.8 GO:0045095 keratin filament(GO:0045095)
0.4 8.1 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.4 35.5 GO:0030018 Z disc(GO:0030018)
0.3 15.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 2.9 GO:0071797 LUBAC complex(GO:0071797)
0.2 24.3 GO:0000786 nucleosome(GO:0000786)
0.2 1.9 GO:0034451 centriolar satellite(GO:0034451)
0.2 8.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 6.0 GO:0098798 mitochondrial protein complex(GO:0098798)
0.2 27.4 GO:0005769 early endosome(GO:0005769)
0.2 23.8 GO:0031012 extracellular matrix(GO:0031012)
0.1 7.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 152.5 GO:0005615 extracellular space(GO:0005615)
0.1 11.1 GO:0005884 actin filament(GO:0005884)
0.1 2.2 GO:0005921 gap junction(GO:0005921)
0.1 3.8 GO:0035869 ciliary transition zone(GO:0035869)
0.1 5.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.1 GO:0005811 lipid particle(GO:0005811)
0.1 1.3 GO:0030008 TRAPP complex(GO:0030008)
0.1 4.3 GO:0005643 nuclear pore(GO:0005643)
0.1 20.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 80.8 GO:0005829 cytosol(GO:0005829)
0.1 8.2 GO:0031966 mitochondrial membrane(GO:0031966)
0.1 1.3 GO:0000784 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 6.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 3.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 29.3 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903)
5.7 22.9 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
4.4 17.6 GO:0005521 lamin binding(GO:0005521)
4.2 54.9 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
3.8 19.0 GO:0031769 glucagon receptor binding(GO:0031769)
3.1 9.4 GO:0004061 arylformamidase activity(GO:0004061)
2.7 8.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
2.4 14.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
2.3 11.5 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
2.2 15.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
2.2 6.6 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) serine binding(GO:0070905)
2.1 8.5 GO:0071889 14-3-3 protein binding(GO:0071889)
2.1 26.9 GO:0004017 adenylate kinase activity(GO:0004017)
2.0 6.0 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
1.9 40.4 GO:0019825 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
1.7 12.0 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.7 10.1 GO:0032052 bile acid binding(GO:0032052)
1.5 7.6 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
1.4 8.6 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.4 4.1 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
1.3 5.4 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
1.3 30.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
1.2 86.4 GO:0005212 structural constituent of eye lens(GO:0005212)
1.1 3.4 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
1.1 7.8 GO:0034632 retinol transporter activity(GO:0034632)
1.1 29.6 GO:0042805 actinin binding(GO:0042805)
1.1 11.8 GO:0004568 chitinase activity(GO:0004568)
1.0 12.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.0 10.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 6.5 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.9 6.3 GO:0019809 spermidine binding(GO:0019809)
0.8 3.4 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.8 2.5 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.8 5.7 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.8 8.4 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.8 12.9 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.7 51.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.7 4.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.7 6.7 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.7 2.0 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.6 11.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.6 10.8 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.6 10.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.6 16.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.6 110.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 43.9 GO:0051427 hormone receptor binding(GO:0051427)
0.5 4.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.5 7.0 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.5 17.5 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.5 2.1 GO:0070513 death domain binding(GO:0070513)
0.4 2.6 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.4 12.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.4 1.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.4 20.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.4 4.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 3.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.4 1.5 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.4 5.3 GO:0005504 fatty acid binding(GO:0005504)
0.3 10.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 7.0 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.3 3.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 4.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 3.4 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.3 5.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 5.9 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.3 2.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 10.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 2.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 59.5 GO:0003774 motor activity(GO:0003774)
0.2 1.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 5.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 4.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 5.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 33.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 35.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 20.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 5.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 6.6 GO:0004601 peroxidase activity(GO:0004601)
0.1 8.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 12.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 1.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.7 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 3.7 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 3.0 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1 3.5 GO:0051020 GTPase binding(GO:0051020)
0.1 0.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 3.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 6.0 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 2.2 GO:0022829 wide pore channel activity(GO:0022829)
0.1 32.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 1.2 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 2.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 2.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 8.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 2.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 6.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.9 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 3.6 GO:0045296 cadherin binding(GO:0045296)
0.0 9.5 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 6.0 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 19.5 GO:0003779 actin binding(GO:0003779)
0.0 31.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 3.7 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 2.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.3 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 1.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.0 GO:0005179 hormone activity(GO:0005179)
0.0 16.3 GO:0038023 signaling receptor activity(GO:0038023)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 37.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.6 5.5 ST STAT3 PATHWAY STAT3 Pathway
0.4 22.1 PID AP1 PATHWAY AP-1 transcription factor network
0.3 10.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.2 3.7 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 9.4 PID P53 REGULATION PATHWAY p53 pathway
0.2 8.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 1.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 4.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 12.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 7.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 21.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
2.2 9.0 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
1.7 10.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
1.4 75.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.4 25.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.3 15.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.3 26.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.2 8.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
1.1 3.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.9 14.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 53.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.7 3.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.7 9.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.6 5.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.5 10.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.4 2.3 REACTOME OPSINS Genes involved in Opsins
0.3 2.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.3 6.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.3 5.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 7.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 3.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 3.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 6.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 12.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 1.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.2 7.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 23.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 4.3 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 8.6 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction