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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for stat1a+stat2-1_stat1b

Z-value: 1.55

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Transcription factors associated with stat1a+stat2-1_stat1b

Gene Symbol Gene ID Gene Info
ENSDARG00000006266 signal transducer and activator of transcription 1a
ENSDARG00000031647 signal transducer and activator of transcription 2
ENSDARG00000076182 signal transducer and activator of transcription 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
stat1bdr11_v1_chr9_+_41224100_412241000.593.0e-10Click!
stat2dr11_v1_chr6_-_39158953_391589530.312.4e-03Click!
stat1adr11_v1_chr22_+_12798569_127985690.065.9e-01Click!

Activity profile of stat1a+stat2-1_stat1b motif

Sorted Z-values of stat1a+stat2-1_stat1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_36834505 23.63 ENSDART00000141275
ENSDART00000139588
ENSDART00000041993
purine nucleoside phosphorylase 4b
chr21_+_45626136 22.46 ENSDART00000158742
interferon regulatory factor 1b
chr16_+_38394371 18.11 ENSDART00000137954
CD83 molecule
chr15_+_20239141 17.93 ENSDART00000101152
ENSDART00000152473
serine peptidase inhibitor, Kunitz type, 2
chr14_+_29975268 17.91 ENSDART00000172985
cytochrome P450, family 4, subfamily V, polypeptide 7
chr3_-_44059902 16.88 ENSDART00000158485
ENSDART00000159088
ENSDART00000165628
interleukin 4 receptor, tandem duplicate 1
chr6_+_22068589 16.73 ENSDART00000151205
aldehyde dehydrogenase 1 family, member L1
chr20_+_23440632 16.27 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr6_+_41503854 16.01 ENSDART00000136538
ENSDART00000140108
ENSDART00000084861
cytokine inducible SH2-containing protein
chr17_-_10838434 15.86 ENSDART00000064597
lectin, galactoside binding soluble 3b
chr9_-_32813177 15.69 ENSDART00000012694
myxovirus (influenza virus) resistance C
chr6_-_8498908 15.00 ENSDART00000149222
peptidoglycan recognition protein 2
chr6_+_28294113 14.40 ENSDART00000136898
LIM domain containing preferred translocation partner in lipoma
chr5_-_42878178 14.05 ENSDART00000162981
C-X-C motif chemokine ligand 11
chr15_-_29598679 12.97 ENSDART00000155153
si:ch211-207n23.2
chr23_-_31763753 12.90 ENSDART00000053399
aldehyde dehydrogenase 8 family, member A1
chr11_-_17964525 12.77 ENSDART00000018948
cytokine inducible SH2-containing protein b
chr10_+_17776981 12.76 ENSDART00000141693
chemokine (C-C motif) ligand 19b
chr16_+_42772678 12.72 ENSDART00000155575
si:ch211-135n15.2
chr11_+_14286160 12.68 ENSDART00000166236
si:ch211-262i1.3
chr15_-_32383340 12.50 ENSDART00000185632
complement component 4
chr6_-_8498676 12.50 ENSDART00000148627
peptidoglycan recognition protein 2
chr10_-_25823258 12.49 ENSDART00000064327
finTRIM family, member 54
chr14_+_11457500 12.34 ENSDART00000169202
si:ch211-153b23.5
chr18_-_14860435 12.16 ENSDART00000018502
mitogen-activated protein kinase 12a
chr2_+_42005217 11.78 ENSDART00000143562
guanylate binding protein 2
chr1_-_10071422 11.42 ENSDART00000135522
ENSDART00000033118
fibrinogen alpha chain
chr14_-_30747686 11.23 ENSDART00000008373
FOS-like antigen 1a
chr14_+_33329420 11.09 ENSDART00000171090
ENSDART00000164062
sosondowah ankyrin repeat domain family d
chr23_+_44611864 11.00 ENSDART00000145905
ENSDART00000132361
enolase 3, (beta, muscle)
chr2_+_26288301 10.84 ENSDART00000017668
polypyrimidine tract binding protein 1a
chr9_+_41218967 10.76 ENSDART00000000280
ENSDART00000145674
signal transducer and activator of transcription 1b
chr8_+_47099033 10.70 ENSDART00000142979
Rho guanine nucleotide exchange factor (GEF) 16
chr21_+_20771082 10.69 ENSDART00000079732
3-oxoacid CoA transferase 1b
chr16_-_36099492 10.67 ENSDART00000180905

chr23_-_5101847 10.09 ENSDART00000122240
ets variant 7
chr11_-_8167799 9.66 ENSDART00000133574
ENSDART00000024046
ENSDART00000146940
urate oxidase
chr6_+_21202639 9.51 ENSDART00000083126
cell death-inducing DFFA-like effector c
chr21_-_27338639 9.41 ENSDART00000130632
hypoxia-inducible factor 1, alpha subunit, like 2
chr11_+_13224281 9.15 ENSDART00000102557
ENSDART00000178706
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr16_-_31675669 8.94 ENSDART00000168848
ENSDART00000158331
complement component 1, r subcomponent
chr24_-_38113208 8.89 ENSDART00000079003
c-reactive protein, pentraxin-related
chr12_-_46228023 8.83 ENSDART00000153455
si:ch211-226h7.6
chr19_-_5699703 8.82 ENSDART00000082050
zgc:174904
chr20_-_25551676 8.78 ENSDART00000063081
cytochrome P450, family 2, subfamily AD, polypeptide 3
chr1_-_9195629 8.62 ENSDART00000143587
ENSDART00000192174
endoplasmic reticulum to nucleus signaling 2
chr14_-_32631519 8.49 ENSDART00000167282
ENSDART00000052938
ATPase phospholipid transporting 11C
chr16_-_27749172 8.48 ENSDART00000145198
STEAP family member 4
chr1_-_49225890 8.42 ENSDART00000111598
chemokine (C-X-C motif) ligand 18b
chr14_-_21123551 8.26 ENSDART00000171679
ENSDART00000165882
si:dkey-74k8.4
chr15_-_3282220 8.25 ENSDART00000092942
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15a
chr11_-_22303678 8.25 ENSDART00000159527
ENSDART00000159681
transcription factor EB
chr2_-_10098191 8.18 ENSDART00000138081
B-cell CLL/lymphoma 6a, genome duplicate b
chr3_+_36646054 8.16 ENSDART00000170013
ENSDART00000159948
G1 to S phase transition 1, like
chr14_+_16345003 8.05 ENSDART00000003040
ENSDART00000165193
intelectin 3
chr25_-_17395315 7.99 ENSDART00000064596
cytochrome P450, family 2, subfamily X, polypeptide 8
chr5_-_57624425 7.99 ENSDART00000167892
zgc:193711
chr7_+_73295890 7.74 ENSDART00000174331
ENSDART00000174250

chr18_+_30567945 7.73 ENSDART00000078894
interferon regulatory factor 8
chr19_+_17385561 7.70 ENSDART00000141397
ENSDART00000143913
ENSDART00000133626
ribosomal protein L15
chr15_+_6661343 7.70 ENSDART00000160136
NOP53 ribosome biogenesis factor
chr6_+_39923052 7.58 ENSDART00000149019
inositol 1,4,5-trisphosphate receptor, type 1a
chr22_+_22004082 7.52 ENSDART00000148375
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2
chr11_-_287670 7.49 ENSDART00000035737
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr2_+_42005475 7.46 ENSDART00000056461
guanylate binding protein 2
chr15_-_29598444 7.46 ENSDART00000154847
si:ch211-207n23.2
chr7_-_28658143 7.45 ENSDART00000173556
adhesion G protein-coupled receptor G1
chr23_-_5783421 7.43 ENSDART00000131521
ENSDART00000019455
cysteine and glycine-rich protein 1a
chr8_-_38406831 7.36 ENSDART00000112991
ENSDART00000191445
sorbin and SH3 domain containing 3
chr16_+_40954481 7.32 ENSDART00000058587
glycogen synthase kinase binding protein
chr7_+_26029672 7.32 ENSDART00000101126
arachidonate 12-lipoxygenase
chr5_-_42071505 7.30 ENSDART00000137224
ENSDART00000193721
chemokine (C-X-C motif) ligand 11, duplicate 7
centromere protein V
chr15_-_32383529 7.23 ENSDART00000028349
complement component 4
chr1_-_8020589 7.19 ENSDART00000143881
si:dkeyp-9d4.2
chr3_+_26813058 7.13 ENSDART00000055537
suppressor of cytokine signaling 1a
chr10_+_13209580 7.00 ENSDART00000000887
ENSDART00000136932
Ras association (RalGDS/AF-6) domain family 6
chr7_+_12950507 7.00 ENSDART00000067629
ENSDART00000158004
serum amyloid A
chr20_-_37813863 6.96 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr9_+_40825065 6.84 ENSDART00000137673
si:dkey-95p16.2
chr5_-_42883761 6.77 ENSDART00000167374

chr19_-_24757231 6.69 ENSDART00000128177
si:dkey-154b15.1
chr24_-_38197040 6.68 ENSDART00000137949
ENSDART00000105639
immunoglobulin light iota constant 1, s1
chr20_+_52458765 6.57 ENSDART00000057980
tissue specific transplantation antigen P35B
chr5_+_57658898 6.53 ENSDART00000074268
ENSDART00000124568
zgc:153929
chr16_+_40560622 6.53 ENSDART00000038294
tumor protein p53 inducible nuclear protein 1
chr14_+_33329761 6.51 ENSDART00000161138
sosondowah ankyrin repeat domain family d
chr9_-_12443726 6.43 ENSDART00000102434
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr5_-_25583125 6.24 ENSDART00000031665
ENSDART00000145353
annexin A1a
chr2_-_42035250 6.20 ENSDART00000056460
ENSDART00000140788
guanylate binding protein 1
chr7_-_28696556 6.19 ENSDART00000148822
adhesion G protein-coupled receptor G1
chr15_+_37412883 6.16 ENSDART00000156474
zinc finger and BTB domain containing 32
chr5_+_1911814 6.10 ENSDART00000172233
si:ch73-55i23.1
chr3_-_24337814 6.02 ENSDART00000153553
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr23_-_33558161 6.01 ENSDART00000018301
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr3_-_49110710 5.97 ENSDART00000160404
tripartite motif containing 35-12
chr8_+_19548985 5.88 ENSDART00000123104
notch 2
chr13_+_30696286 5.87 ENSDART00000192411
chemokine (C-X-C motif) ligand 18a, duplicate 1
chr8_+_8936912 5.84 ENSDART00000135958
si:dkey-83k24.5
chr5_-_30620625 5.78 ENSDART00000098273
transcobalamin like
chr14_-_36799280 5.76 ENSDART00000168615
ring finger protein 130
chr2_+_4402765 5.69 ENSDART00000159525
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b
chr2_+_4207209 5.64 ENSDART00000157903
ENSDART00000166476
GATA binding protein 6
chr13_+_13681681 5.57 ENSDART00000057825
complement factor D (adipsin)
chr21_-_22676323 5.44 ENSDART00000167392
grass carp reovirus (GCRV)-induced gene 2h
chr7_+_39706004 5.40 ENSDART00000161856
chemokine (C-C motif) ligand 36, duplicate 1
chr3_-_24338163 5.39 ENSDART00000115283
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr5_-_25582721 5.39 ENSDART00000123986
annexin A1a
chr17_+_16046132 5.35 ENSDART00000155005
si:ch73-204p21.2
chr9_-_23922011 5.34 ENSDART00000145734
collagen, type VI, alpha 3
chr20_-_3238110 5.26 ENSDART00000008077
serine peptidase inhibitor, Kunitz type 1 b
chr20_+_25552057 5.24 ENSDART00000102913
cytochrome P450, family 2, subfamily V, polypeptide 1
chr9_-_23922778 5.20 ENSDART00000135769
collagen, type VI, alpha 3
chr18_-_16801033 5.20 ENSDART00000100100
adrenomedullin b
chr11_-_27962757 5.16 ENSDART00000147386
endothelin converting enzyme 1
chr3_-_32275975 5.13 ENSDART00000178448
carnitine palmitoyltransferase 1Cb
chr23_+_10469955 5.11 ENSDART00000140557
tensin 2a
chr18_-_40773413 5.10 ENSDART00000133797
vasodilator stimulated phosphoprotein b
chr16_+_54513267 5.04 ENSDART00000161923

chr12_-_23365737 4.95 ENSDART00000170376
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr1_-_6085750 4.92 ENSDART00000138891
si:ch1073-345a8.1
chr23_+_1216215 4.91 ENSDART00000165957
utrophin
chr17_+_16046314 4.89 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
chr13_-_37631092 4.89 ENSDART00000108855
si:dkey-188i13.7
chr21_-_10886709 4.83 ENSDART00000134408
si:dkey-277m11.2
chr22_-_16180467 4.72 ENSDART00000171331
ENSDART00000185607
vascular cell adhesion molecule 1b
chr8_-_31701157 4.72 ENSDART00000141799
F-box protein 4
chr24_-_19719240 4.69 ENSDART00000135405
cysteine-serine-rich nuclear protein 1b
chr11_+_13223625 4.65 ENSDART00000161275
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr7_+_41313568 4.62 ENSDART00000016660
zgc:165532
chr10_+_24692076 4.60 ENSDART00000181600
transmembrane phosphatase with tensin homology
chr7_-_20241346 4.50 ENSDART00000173619
ENSDART00000127699
si:ch73-335l21.4
chr6_+_102506 4.46 ENSDART00000172678
low density lipoprotein receptor b
chr13_-_40238813 4.46 ENSDART00000044963
lysyl oxidase-like 4
chr24_-_25256670 4.44 ENSDART00000126270
HERV-H LTR-associating 2b, tandem duplicate 1
chr2_+_22659787 4.44 ENSDART00000043956
zgc:161973
chr5_+_29820266 4.41 ENSDART00000146331
ENSDART00000098315
F11 receptor, tandem duplicate 2
chr7_+_26545502 4.39 ENSDART00000140528
tyrosine kinase, non-receptor, 1
chr4_+_76735113 4.39 ENSDART00000075602
membrane-spanning 4-domains, subfamily A, member 17A.6
chr9_-_43644261 4.39 ENSDART00000023684
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr11_+_16040517 4.37 ENSDART00000111284
angiotensin II receptor-associated protein
chr10_-_41352502 4.34 ENSDART00000052971
ENSDART00000128156
RAB11 family interacting protein 1 (class I) b
chr3_+_32571929 4.31 ENSDART00000151025
si:ch73-248e21.1
chr18_+_13315739 4.30 ENSDART00000143404
si:ch211-260p9.3
chr7_+_26167420 4.19 ENSDART00000173941
si:ch211-196f2.6
chr20_+_36812368 4.13 ENSDART00000062931
ABRA C-terminal like
chr19_+_43359075 4.10 ENSDART00000148287
ENSDART00000149856
ENSDART00000188236
ENSDART00000136695
ENSDART00000193859
Yes-related kinase
chr19_-_35596207 4.09 ENSDART00000136811
collagen, type VIII, alpha 2
chr22_+_7480465 4.03 ENSDART00000034545
zgc:92745
chr17_+_24821627 4.01 ENSDART00000112389
WD repeat domain 43
chr17_+_24064014 4.01 ENSDART00000182782
ENSDART00000139063
ENSDART00000132755
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2b
chr9_-_54304684 3.99 ENSDART00000109512
interleukin 13
chr19_+_48176745 3.98 ENSDART00000164963
PR domain containing 1b, with ZNF domain
chr21_-_34844059 3.96 ENSDART00000136402
zgc:56585
chr23_+_33413804 3.96 ENSDART00000142328
Rap guanine nucleotide exchange factor (GEF) 3
chr21_-_20932603 3.95 ENSDART00000138155
ENSDART00000079709
complement component 6
chr17_-_2834764 3.86 ENSDART00000024027
bradykinin receptor B1
chr11_-_11882982 3.84 ENSDART00000190853
WAS/WASL interacting protein family, member 2a
chr3_+_22381955 3.82 ENSDART00000185315
Rho GTPase activating protein 27, like
chr17_-_12498096 3.81 ENSDART00000149551
ENSDART00000105215
ENSDART00000191207
elastin microfibril interfacer 1b
chr25_-_21822426 3.79 ENSDART00000151993
zgc:158222
chr11_+_30321116 3.79 ENSDART00000187921
ENSDART00000127075
UDP glucuronosyltransferase 1 family, polypeptide B1
chr6_+_19948043 3.79 ENSDART00000182636
phosphoinositide-3-kinase, regulatory subunit 5
chr21_-_34844316 3.78 ENSDART00000029708
zgc:56585
chr14_+_30774894 3.66 ENSDART00000023054
atlastin 3
chr17_+_6563307 3.65 ENSDART00000156454
adhesion G protein-coupled receptor F3a
chr4_-_18436899 3.64 ENSDART00000141671
suppressor of cytokine signaling 2
chr5_+_25317061 3.56 ENSDART00000170097
transient receptor potential cation channel, subfamily M, member 6
chr17_+_10318071 3.53 ENSDART00000161844
forkhead box A1
chr12_-_22379421 3.48 ENSDART00000187875
si:dkey-38p12.3
chr24_-_11905911 3.47 ENSDART00000033621
transmembrane 9 superfamily member 1
chr6_+_18321627 3.45 ENSDART00000183107
ENSDART00000189715
caspase recruitment domain family, member 14
chr9_-_9282519 3.42 ENSDART00000146821
si:ch211-214p13.3
chr7_+_32369463 3.38 ENSDART00000180544
leucine-rich repeat containing G protein-coupled receptor 4
chr12_-_3133483 3.37 ENSDART00000015092
collagen, type I, alpha 1b
chr5_+_29160324 3.34 ENSDART00000137324
dipeptidyl-peptidase 7
chr19_+_43780970 3.34 ENSDART00000063870
ribosomal protein L11
chr10_+_20608676 3.27 ENSDART00000140141
si:dkey-81j8.6
chr7_+_41314862 3.25 ENSDART00000185198
zgc:165532
chr16_-_45398408 3.24 ENSDART00000004052
ral guanine nucleotide dissociation stimulator-like 2
chr7_+_32369026 3.23 ENSDART00000169588
leucine-rich repeat containing G protein-coupled receptor 4
chr10_-_11385155 3.21 ENSDART00000064214
placenta-specific 8, tandem duplicate 1
chr21_-_22715297 3.20 ENSDART00000065548
complement component 1, q subcomponent, B chain
chr10_-_4375190 3.19 ENSDART00000016102

chr21_-_20840714 3.17 ENSDART00000144861
ENSDART00000139430
complement component 6
chr6_+_13046720 3.17 ENSDART00000165896
caspase 8, apoptosis-related cysteine peptidase
chr21_-_8085635 3.13 ENSDART00000082790
si:dkey-163m14.2
chr20_-_23440955 3.09 ENSDART00000153386
solute carrier family 10, member 4
chr14_-_52433292 3.09 ENSDART00000164272
RE1-silencing transcription factor
chr22_+_20427170 3.08 ENSDART00000136744
forkhead box Q2
chr3_-_57779801 3.07 ENSDART00000074285
synaptogyrin 2a
chr20_+_21595244 3.06 ENSDART00000010643
estrogen receptor 2a
chr22_-_13165186 3.06 ENSDART00000105762
aryl hydrocarbon receptor 2
chr20_-_33704753 3.05 ENSDART00000157427
rho-associated, coiled-coil containing protein kinase 2b
chr12_-_16990896 3.04 ENSDART00000152402
interferon-induced protein with tetratricopeptide repeats 12
chr12_-_46252062 3.03 ENSDART00000153223
si:ch211-226h7.5
chr13_-_36798204 3.01 ENSDART00000012357
salvador family WW domain containing protein 1
chr8_-_38159805 3.00 ENSDART00000112331
ENSDART00000180006
adhesion G protein-coupled receptor A2
chr4_+_73215536 2.94 ENSDART00000174290
Danio rerio protein NLRC3-like (LOC101883187), mRNA.
chr24_-_5932982 2.93 ENSDART00000138412
ENSDART00000135124
ENSDART00000007373
acyl-CoA binding domain containing 5a
chr6_+_37655078 2.88 ENSDART00000122199
ENSDART00000065127
cytoplasmic FMR1 interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of stat1a+stat2-1_stat1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 27.5 GO:0009595 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
6.0 18.1 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
6.0 17.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
5.6 16.7 GO:0009397 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
4.3 12.9 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
4.2 16.9 GO:0002532 production of molecular mediator involved in inflammatory response(GO:0002532)
4.0 27.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
3.4 13.8 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
3.2 9.7 GO:0019628 urate catabolic process(GO:0019628) urate metabolic process(GO:0046415)
3.2 15.9 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
2.8 8.3 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
2.7 10.8 GO:0060467 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468) cortical granule exocytosis(GO:0060471)
2.6 7.7 GO:0045649 regulation of macrophage differentiation(GO:0045649)
2.4 11.9 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
2.3 13.6 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
2.1 10.7 GO:0046952 ketone body catabolic process(GO:0046952)
2.1 8.5 GO:0015677 copper ion import(GO:0015677)
2.1 16.6 GO:0043330 response to exogenous dsRNA(GO:0043330)
1.9 11.6 GO:0045064 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) T-helper 2 cell differentiation(GO:0045064) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.9 9.6 GO:0002184 cytoplasmic translational termination(GO:0002184)
1.9 22.5 GO:0050688 regulation of defense response to virus(GO:0050688)
1.9 7.5 GO:0010039 response to iron ion(GO:0010039)
1.9 5.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.7 8.6 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
1.7 10.2 GO:0051883 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
1.4 4.2 GO:0002831 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) regulation of response to biotic stimulus(GO:0002831) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.4 11.0 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
1.3 7.9 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
1.1 6.6 GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
1.0 3.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785) negative regulation of cell maturation(GO:1903430)
1.0 6.0 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
1.0 3.0 GO:0022009 central nervous system vasculogenesis(GO:0022009)
1.0 10.8 GO:0060337 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.8 2.4 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.8 11.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.7 2.2 GO:0033632 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.7 2.9 GO:0099563 modification of synaptic structure(GO:0099563)
0.7 2.1 GO:0045226 renal water homeostasis(GO:0003091) renal water transport(GO:0003097) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.7 2.8 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.7 2.7 GO:0015871 choline transport(GO:0015871)
0.6 1.9 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.6 1.9 GO:0055026 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.6 7.3 GO:0043651 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.5 14.4 GO:0060030 dorsal convergence(GO:0060030)
0.5 3.5 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.5 2.9 GO:0030242 pexophagy(GO:0030242)
0.5 16.9 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.5 5.8 GO:0050892 intestinal absorption(GO:0050892)
0.5 1.8 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.4 3.1 GO:0050820 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.4 8.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.4 17.2 GO:0002548 monocyte chemotaxis(GO:0002548)
0.4 5.9 GO:0060325 face morphogenesis(GO:0060325)
0.4 21.3 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.4 9.4 GO:0071456 cellular response to hypoxia(GO:0071456)
0.4 5.8 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.4 3.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 5.2 GO:0016486 peptide hormone processing(GO:0016486)
0.3 4.5 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.3 4.1 GO:0048246 macrophage chemotaxis(GO:0048246)
0.3 7.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 30.4 GO:0072376 protein activation cascade(GO:0072376)
0.3 2.2 GO:0009180 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.3 3.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 4.0 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.3 3.1 GO:0001541 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698)
0.3 6.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.3 2.5 GO:0006465 signal peptide processing(GO:0006465)
0.3 0.8 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.3 1.3 GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515)
0.3 17.6 GO:1990266 neutrophil migration(GO:1990266)
0.2 13.4 GO:0048821 erythrocyte development(GO:0048821)
0.2 0.7 GO:1905072 cardiac jelly development(GO:1905072)
0.2 5.7 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.2 2.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 7.0 GO:0045332 phospholipid translocation(GO:0045332)
0.2 2.0 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.2 13.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.2 2.0 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.2 8.1 GO:0031102 neuron projection regeneration(GO:0031102)
0.2 10.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.2 6.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 4.3 GO:0010634 positive regulation of epithelial cell migration(GO:0010634)
0.2 1.1 GO:0070527 platelet aggregation(GO:0070527)
0.2 2.4 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.2 0.5 GO:0080182 histone H3-K4 trimethylation(GO:0080182) histone H3-K36 dimethylation(GO:0097676)
0.1 6.2 GO:0051896 regulation of protein kinase B signaling(GO:0051896)
0.1 3.1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) regulation of cell junction assembly(GO:1901888)
0.1 1.3 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 3.4 GO:0001843 neural tube closure(GO:0001843)
0.1 4.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.2 GO:0016540 protein autoprocessing(GO:0016540)
0.1 7.1 GO:0031638 zymogen activation(GO:0031638)
0.1 0.6 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.1 2.3 GO:0002574 thrombocyte differentiation(GO:0002574)
0.1 0.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 4.3 GO:2001236 regulation of extrinsic apoptotic signaling pathway(GO:2001236)
0.1 1.3 GO:0035437 maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 1.4 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.1 4.7 GO:0001946 lymphangiogenesis(GO:0001946)
0.1 7.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.4 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 2.0 GO:0002685 regulation of leukocyte migration(GO:0002685)
0.1 4.2 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.1 10.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 6.5 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 0.8 GO:0055062 phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)
0.1 8.2 GO:0001817 regulation of cytokine production(GO:0001817)
0.1 4.0 GO:0001570 vasculogenesis(GO:0001570)
0.1 3.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 1.9 GO:0030497 fatty acid elongation(GO:0030497)
0.1 21.0 GO:0009116 nucleoside metabolic process(GO:0009116)
0.1 1.7 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.4 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 1.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 2.6 GO:0030261 chromosome condensation(GO:0030261)
0.1 0.2 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.1 4.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.4 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 2.1 GO:0032963 collagen metabolic process(GO:0032963) multicellular organismal macromolecule metabolic process(GO:0044259)
0.1 1.0 GO:0009988 cell-cell recognition(GO:0009988) sperm-egg recognition(GO:0035036)
0.1 0.8 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 1.1 GO:0034453 microtubule anchoring(GO:0034453)
0.1 4.0 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.3 GO:0030325 adrenal gland development(GO:0030325)
0.0 2.7 GO:0035082 axoneme assembly(GO:0035082)
0.0 10.4 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.7 GO:0016926 protein desumoylation(GO:0016926)
0.0 1.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 4.4 GO:0045087 innate immune response(GO:0045087)
0.0 2.1 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 0.9 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.6 GO:0019835 cytolysis(GO:0019835)
0.0 3.8 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.0 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.4 GO:1902808 positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0 19.9 GO:0042981 regulation of apoptotic process(GO:0042981)
0.0 2.6 GO:0031101 fin regeneration(GO:0031101)
0.0 2.5 GO:0030048 actin filament-based movement(GO:0030048)
0.0 4.7 GO:0006914 autophagy(GO:0006914)
0.0 0.1 GO:0055071 manganese ion homeostasis(GO:0055071)
0.0 0.1 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.0 0.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 1.4 GO:0021536 diencephalon development(GO:0021536)
0.0 0.9 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 4.1 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.9 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.3 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.3 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.4 GO:0005577 fibrinogen complex(GO:0005577)
2.9 8.6 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
2.0 15.9 GO:0001772 immunological synapse(GO:0001772)
1.9 9.6 GO:0018444 translation release factor complex(GO:0018444)
1.4 11.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.8 15.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.8 11.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.8 44.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.8 3.0 GO:1990909 Wnt signalosome(GO:1990909)
0.7 4.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.6 2.5 GO:0005787 signal peptidase complex(GO:0005787)
0.5 7.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 24.1 GO:0019814 immunoglobulin complex(GO:0019814)
0.3 2.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 0.8 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 1.2 GO:0043034 costamere(GO:0043034)
0.2 3.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 11.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 2.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.2 2.9 GO:0031209 SCAR complex(GO:0031209)
0.2 23.0 GO:0016324 apical plasma membrane(GO:0016324)
0.2 11.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 15.3 GO:0005581 collagen trimer(GO:0005581)
0.2 7.1 GO:0008305 integrin complex(GO:0008305)
0.1 7.9 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 5.5 GO:0016605 PML body(GO:0016605)
0.1 0.4 GO:0034457 Mpp10 complex(GO:0034457)
0.1 3.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.6 GO:0030669 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 1.4 GO:0016580 Sin3 complex(GO:0016580)
0.1 7.4 GO:0030018 Z disc(GO:0030018)
0.1 1.5 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 9.4 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 7.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 8.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 5.1 GO:0055037 recycling endosome(GO:0055037)
0.1 16.6 GO:0000785 chromatin(GO:0000785)
0.1 0.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 55.3 GO:0005615 extracellular space(GO:0005615)
0.0 9.4 GO:0010008 endosome membrane(GO:0010008)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 3.8 GO:0005884 actin filament(GO:0005884)
0.0 6.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.4 GO:0005930 axoneme(GO:0005930)
0.0 2.2 GO:0030055 cell-substrate junction(GO:0030055)
0.0 1.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.2 GO:0070449 elongin complex(GO:0070449)
0.0 4.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 4.0 GO:0005730 nucleolus(GO:0005730)
0.0 1.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 27.5 GO:0016019 peptidoglycan receptor activity(GO:0016019)
5.6 16.7 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
3.4 13.8 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
3.2 15.9 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
2.6 23.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
2.5 7.5 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
2.1 6.4 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
2.1 10.7 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
2.1 8.5 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
2.1 8.4 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
1.9 11.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.5 7.7 GO:0008097 5S rRNA binding(GO:0008097)
1.4 11.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.3 44.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
1.2 9.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.0 9.6 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.9 8.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.9 2.7 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.8 4.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.7 2.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.7 2.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.7 2.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.6 7.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.6 6.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.6 6.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 2.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.5 3.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.5 5.1 GO:0005522 profilin binding(GO:0005522)
0.5 10.8 GO:0070492 oligosaccharide binding(GO:0070492)
0.5 54.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 1.9 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.5 6.0 GO:0001968 fibronectin binding(GO:0001968)
0.4 3.1 GO:1903924 estradiol binding(GO:1903924)
0.4 5.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 2.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.4 3.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.4 7.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.4 17.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.4 3.1 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.4 1.1 GO:0070051 fibrinogen binding(GO:0070051)
0.4 6.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.4 2.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.3 3.5 GO:0050700 CARD domain binding(GO:0050700)
0.3 1.0 GO:0003913 DNA photolyase activity(GO:0003913)
0.3 12.2 GO:0004707 MAP kinase activity(GO:0004707)
0.3 2.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 21.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.3 5.9 GO:0042379 chemokine activity(GO:0008009) chemokine receptor binding(GO:0042379)
0.3 2.4 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.3 12.9 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.3 5.8 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.3 4.0 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.3 7.4 GO:0042805 actinin binding(GO:0042805)
0.2 0.7 GO:0047690 aspartyltransferase activity(GO:0047690)
0.2 1.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 5.9 GO:0005112 Notch binding(GO:0005112)
0.2 3.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.2 27.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 1.8 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.2 2.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 3.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 17.8 GO:0019838 growth factor binding(GO:0019838)
0.2 2.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 2.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.2 1.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.2 2.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 8.9 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.3 GO:0016936 galactoside binding(GO:0016936)
0.1 7.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 18.1 GO:0020037 heme binding(GO:0020037)
0.1 8.6 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 2.4 GO:0035497 cAMP response element binding(GO:0035497)
0.1 4.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 6.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.6 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 1.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 8.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 4.0 GO:0005109 frizzled binding(GO:0005109)
0.1 8.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 4.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 1.4 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 2.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.0 GO:0019843 rRNA binding(GO:0019843)
0.1 3.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 13.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.8 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 3.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.3 GO:0016878 acid-thiol ligase activity(GO:0016878)
0.0 0.7 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.2 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.0 0.2 GO:1990757 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.0 6.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.3 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 16.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 73.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0032190 acrosin binding(GO:0032190)
0.0 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 5.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 5.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 12.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 9.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.5 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 1.6 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.0 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.8 11.4 PID IL5 PATHWAY IL5-mediated signaling events
0.7 11.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.6 7.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.6 4.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.5 4.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.5 6.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.5 3.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4 17.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.4 7.7 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.4 14.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 7.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.3 7.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 3.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.2 0.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 7.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 3.8 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 5.9 PID NOTCH PATHWAY Notch signaling pathway
0.1 3.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 9.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 3.3 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 4.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.6 PID BCR 5PATHWAY BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 17.7 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
1.2 19.7 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
1.1 33.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
1.0 5.9 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
1.0 11.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.8 6.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.6 1.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 7.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.5 11.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 11.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.4 4.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.4 3.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 7.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 15.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 10.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 2.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 3.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.2 2.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 2.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 2.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 2.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 7.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 6.0 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 4.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.6 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 11.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.2 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 1.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 3.8 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase