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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for srfa+srfb

Z-value: 2.99

Motif logo

Transcription factors associated with srfa+srfb

Gene Symbol Gene ID Gene Info
ENSDARG00000053918 serum response factor a
ENSDARG00000102867 serum response factor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srfbdr11_v1_chr13_-_51922290_519222900.646.3e-12Click!
srfadr11_v1_chr22_+_35089031_35089031-0.303.1e-03Click!

Activity profile of srfa+srfb motif

Sorted Z-values of srfa+srfb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_9980318 81.33 ENSDART00000080664
zgc:86709
chr12_-_26064480 79.44 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
LIM domain binding 3b
chr12_-_26064105 71.08 ENSDART00000168825
LIM domain binding 3b
chr13_+_24279021 64.83 ENSDART00000058629
actin, alpha 1b, skeletal muscle
chr1_+_53945934 61.72 ENSDART00000052838
actin, alpha 1a, skeletal muscle
chr15_-_551177 54.42 ENSDART00000066774
ENSDART00000154617
transgelin
chr2_+_30916188 45.09 ENSDART00000137012
myomesin 1a (skelemin)
chr22_-_15602760 44.63 ENSDART00000009054
tropomyosin 4a
chr23_+_42813415 40.06 ENSDART00000055577
myosin, light chain 9a, regulatory
chr23_+_44611864 37.42 ENSDART00000145905
ENSDART00000132361
enolase 3, (beta, muscle)
chr7_-_71758613 35.57 ENSDART00000166724
myomesin 1b
chr10_+_6318227 34.87 ENSDART00000170872
ENSDART00000162428
ENSDART00000158994
tropomyosin 2 (beta)
chr8_-_11229523 33.81 ENSDART00000002164
unc-45 myosin chaperone B
chr17_-_25326296 32.46 ENSDART00000168822
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr13_+_33606739 32.14 ENSDART00000026464
cofilin 1 (non-muscle), like
chr14_+_49251331 31.88 ENSDART00000148882
annexin A6
chr12_-_20373058 31.25 ENSDART00000066382
aquaporin 8a, tandem duplicate 1
chr8_+_40628926 31.19 ENSDART00000163598
dual specificity phosphatase 2
chr22_-_15602593 30.88 ENSDART00000036075
tropomyosin 4a
chr20_+_40150612 30.82 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
triadin
chr20_+_53577502 30.09 ENSDART00000126983
myosin, heavy chain 6, cardiac muscle, alpha
chr21_+_25765734 29.95 ENSDART00000021664
claudin b
chr2_+_15100742 28.80 ENSDART00000027171
coagulation factor IIIb
chr5_+_37087583 28.15 ENSDART00000049900
transgelin 2
chr7_+_29952169 27.49 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
alpha-tropomyosin
chr2_-_24269911 27.29 ENSDART00000099532
myosin heavy chain 7
chr19_+_46158078 26.67 ENSDART00000183933
ENSDART00000164055
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr20_-_29420713 26.50 ENSDART00000147464
ryanodine receptor 3
chr22_+_336256 24.68 ENSDART00000019155
B-cell translocation gene 2
chr6_+_1787160 24.29 ENSDART00000113505
myosin, light chain 9b, regulatory
chr5_-_32292965 24.03 ENSDART00000183522
ENSDART00000131983
myosin, heavy polypeptide 1.2, skeletal muscle
chr17_-_15611744 23.83 ENSDART00000010496
four and a half LIM domains 5
chr5_-_32309129 23.48 ENSDART00000123003
myosin, heavy polypeptide 1.1, skeletal muscle
chr19_+_348729 23.17 ENSDART00000114284
MCL1, BCL2 family apoptosis regulator a
chr1_+_9994811 23.02 ENSDART00000143719
ENSDART00000110749
si:dkeyp-75b4.10
chr14_+_34514336 22.01 ENSDART00000024440
forkhead box I3b
chr1_-_14332283 20.57 ENSDART00000090025
Wolfram syndrome 1a (wolframin)
chr13_+_29238850 19.46 ENSDART00000026000
myoferlin like
chr13_+_8840772 19.40 ENSDART00000059321
epithelial cell adhesion molecule
chr7_-_71758307 19.11 ENSDART00000161067
ENSDART00000165253
myomesin 1b
chr12_+_17100021 18.39 ENSDART00000177923
actin, alpha 2, smooth muscle, aorta
chr9_+_6587056 17.80 ENSDART00000193421
four and a half LIM domains 2a
chr5_+_37785152 17.75 ENSDART00000053511
ENSDART00000189812
myosin Ic, paralog a
chr17_-_20118145 17.62 ENSDART00000149737
ENSDART00000165606
ryanodine receptor 2b (cardiac)
chr21_-_17603182 17.40 ENSDART00000020048
ENSDART00000177270
gelsolin a
chr10_-_373575 17.19 ENSDART00000114487
DM1 protein kinase
chr25_+_33192796 17.09 ENSDART00000125892
ENSDART00000121680
ENSDART00000014851
zgc:171719
chr1_+_1805294 17.07 ENSDART00000103850
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr25_+_33192404 16.87 ENSDART00000193592
zgc:171719
chr9_+_6587364 16.67 ENSDART00000122279
four and a half LIM domains 2a
chr2_-_24270062 16.47 ENSDART00000192445
myosin heavy chain 7
chr14_-_32824380 15.62 ENSDART00000172791
ENSDART00000105745
inositol polyphosphate phosphatase-like 1b
chr10_+_15603082 15.31 ENSDART00000024450
zinc finger, AN1-type domain 5b
chr18_+_36770166 14.64 ENSDART00000078151
FBJ murine osteosarcoma viral oncogene homolog B
chr1_-_8651718 14.47 ENSDART00000133319
actin, beta 1
chr1_-_8652648 14.07 ENSDART00000138324
ENSDART00000141407
ENSDART00000054987
actin, beta 1
chr3_-_22228602 13.85 ENSDART00000017750
myosin, light chain 4, alkali; atrial, embryonic
chr7_+_29951997 13.26 ENSDART00000173453
alpha-tropomyosin
chr3_+_58167288 13.23 ENSDART00000155874
ENSDART00000010395
ubiquinol-cytochrome c reductase core protein 2a
chr14_+_164556 12.72 ENSDART00000185606
WD repeat domain 1
chr17_-_43666166 12.69 ENSDART00000077990
early growth response 2a
chr18_-_41650648 12.60 ENSDART00000024087
frizzled class receptor 9b
chr6_-_45905746 12.15 ENSDART00000025428
eph receptor A2 a
chr23_-_35064785 12.02 ENSDART00000172240

chr22_-_17458070 11.60 ENSDART00000139658
si:ch211-197g15.10
chr20_-_14875308 11.32 ENSDART00000141290
dynamin 3a
chr20_-_46554440 11.07 ENSDART00000043298
ENSDART00000060680
v-fos FBJ murine osteosarcoma viral oncogene homolog Ab
chr1_-_69444 10.58 ENSDART00000166954
si:zfos-1011f11.1
chr18_+_36769758 10.38 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
FBJ murine osteosarcoma viral oncogene homolog B
chr6_+_41191482 10.08 ENSDART00000000877
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr17_+_25849332 10.02 ENSDART00000191994
acyl-CoA synthetase short chain family member 1
chr13_+_23132666 9.90 ENSDART00000164639
sorbin and SH3 domain containing 1
chr14_-_30747686 9.04 ENSDART00000008373
FOS-like antigen 1a
chr2_-_24554416 8.96 ENSDART00000052061
calponin 2
chr18_-_46258612 8.71 ENSDART00000153930
si:dkey-244a7.1
chr7_-_18168493 8.62 ENSDART00000127428
pellino E3 ubiquitin protein ligase family member 3
chr5_-_41845116 8.39 ENSDART00000112382
si:dkey-65b12.6
chr1_-_37383741 7.92 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
secretory calcium-binding phosphoprotein 1
chr16_-_17347727 7.85 ENSDART00000144392
zyxin
chr10_-_7892192 7.77 ENSDART00000145480
smoothelin a
chr3_+_1211242 7.77 ENSDART00000171287
ENSDART00000165769
polymerase (DNA-directed), delta interacting protein 3
chr3_+_32410746 7.69 ENSDART00000025496
RAS related
chr20_-_31018569 7.60 ENSDART00000136039
fibronectin type III domain containing 1
chr3_-_18410968 7.43 ENSDART00000041842
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10
chr19_+_43715911 7.37 ENSDART00000006344
CAP, adenylate cyclase-associated protein 1 (yeast)
chr20_+_1996202 7.36 ENSDART00000184143

chr13_-_3155243 6.66 ENSDART00000139183
ENSDART00000050934
protein kinase domain containing, cytoplasmic a
chr7_-_53117131 6.52 ENSDART00000169211
ENSDART00000168890
ENSDART00000172179
ENSDART00000167882
cadherin 1, type 1, E-cadherin (epithelial)
chr6_+_41200500 6.43 ENSDART00000000678
opsin 1 (cone pigments), medium-wave-sensitive, 4
chr11_+_30647545 6.32 ENSDART00000114792
expressed sequence EH507706
chr20_+_46572550 6.16 ENSDART00000139051
ENSDART00000161320
basic leucine zipper transcription factor, ATF-like
chr11_+_6115621 6.01 ENSDART00000165031
ENSDART00000027666
ENSDART00000161458
nuclear receptor subfamily 2, group F, member 6b
chr13_-_9598320 5.94 ENSDART00000184613
carboxypeptidase X (M14 family), member 1a
chr3_-_40529782 5.64 ENSDART00000055194
ENSDART00000141737
actin, beta 2
chr21_+_30043054 5.63 ENSDART00000065448
fatty acid binding protein 6, ileal (gastrotropin)
chr18_+_35407921 5.59 ENSDART00000057733
zgc:153119
chr13_-_40398556 5.55 ENSDART00000191921
NK3 homeobox 3
chr4_-_16644708 5.51 ENSDART00000042307
SIN3-HDAC complex associated factor
chr16_-_31754102 5.48 ENSDART00000185043
protein tyrosine phosphatase, non-receptor type 6
chr21_-_31286428 5.45 ENSDART00000185334
carbonic anhydrase IV c
chr7_-_66868543 5.42 ENSDART00000149680
adenosine monophosphate deaminase 3a
chr16_+_28383758 5.36 ENSDART00000059038
ENSDART00000141061
integrin, alpha 8
chr9_-_44948488 5.33 ENSDART00000059228
villin 1
chr24_+_31277360 5.32 ENSDART00000165993
coagulation factor IIIa
chr19_-_20403845 5.23 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
deleted in azoospermia-like
chr23_+_19655301 5.14 ENSDART00000104441
ENSDART00000135269
abhydrolase domain containing 6b
chr21_+_8533533 5.11 ENSDART00000077924

chr8_+_26059677 5.10 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr14_+_17137023 4.93 ENSDART00000080712
solute carrier family 43, member 3b
chr12_-_20120702 4.85 ENSDART00000153387
ENSDART00000158412
ENSDART00000112768
UBA-like domain containing 1a
chr21_+_21811867 4.80 ENSDART00000185752
sialidase 3 (membrane sialidase), tandem duplicate 4
chr10_+_8101729 4.79 ENSDART00000138875
ENSDART00000123447
ENSDART00000185333
proline-serine-threonine phosphatase interacting protein 2
chr13_-_25303303 4.76 ENSDART00000133153
plasminogen activator, urokinase a
chr25_+_19680962 4.63 ENSDART00000167260
si:dkeyp-110c12.3
chr16_-_30421275 4.56 ENSDART00000003752
chaperonin containing TCP1, subunit 3 (gamma)
chr10_-_15910974 4.42 ENSDART00000148169
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr7_+_24522308 4.32 ENSDART00000173542
bloodthirsty-related gene family, member 9
chr7_+_5494565 4.29 ENSDART00000135271
si:dkeyp-67a8.2
chr3_+_1724941 4.03 ENSDART00000193402

chr23_+_24272421 3.92 ENSDART00000029974
chloride channel K
chr5_+_9428876 3.80 ENSDART00000081791
UDP glucuronosyltransferase 2 family, polypeptide A7
chr4_-_49133107 3.78 ENSDART00000150806
zinc finger protein 1146
chr2_+_24376373 3.70 ENSDART00000135323
nuclear receptor subfamily 2, group F, member 6a
chr22_-_29922872 3.66 ENSDART00000020249
dual specificity phosphatase 5
chr12_-_35054354 3.59 ENSDART00000075351
zgc:112285
chr10_+_42169982 3.47 ENSDART00000190905

chr13_-_28688104 3.46 ENSDART00000133827
polycomb group ring finger 6
chr21_+_42717424 3.39 ENSDART00000166936
ENSDART00000172135
SH3 and PX domains 2B
chr1_+_45754868 3.37 ENSDART00000084512
protein kinase N1a
chr22_-_3275888 3.36 ENSDART00000164743
si:zfos-943e10.1
chr11_+_25459697 3.28 ENSDART00000161481
opsin 1 (cone pigments), short-wave-sensitive 2
chr6_+_58915889 3.26 ENSDART00000083628
DNA-damage-inducible transcript 3
chr2_-_37477654 3.20 ENSDART00000193921
death-associated protein kinase 3
chr19_-_42424599 3.13 ENSDART00000077042
zgc:153441
chr4_+_28997595 3.07 ENSDART00000133357
si:dkey-13e3.1
chr22_+_9206514 3.05 ENSDART00000141625
si:ch211-156p11.1
chr14_+_743346 3.04 ENSDART00000110511
klotho beta
chr20_+_35279968 2.97 ENSDART00000168216
ENSDART00000153332
family with sequence similarity 49, member A
chr5_-_71765780 2.70 ENSDART00000011955
G protein signaling modulator 1b
chr20_+_6590220 2.60 ENSDART00000136567
tensin 3, tandem duplicate 2
chr15_+_2534740 2.52 ENSDART00000138469
cut-like homeobox 1b
chr3_+_28594713 2.52 ENSDART00000179799
septin 12
chr4_+_28998230 2.50 ENSDART00000183828
si:dkey-13e3.1
chr3_+_32553714 2.42 ENSDART00000165638
paired box 10
chr23_+_28378543 2.41 ENSDART00000145327
zgc:153867
chr22_-_382955 2.38 ENSDART00000082406
olfactory receptor class A related 3
chr14_-_10492072 2.37 ENSDART00000182525
lysophosphatidic acid receptor 4
chr10_-_690072 2.35 ENSDART00000164871
ENSDART00000142833
GLIS family zinc finger 3
chr13_+_9496748 2.28 ENSDART00000147050
ENSDART00000102120

chr1_+_50976975 2.18 ENSDART00000022290
ENSDART00000140982
malate dehydrogenase 1Aa, NAD (soluble)
chr2_+_31804582 2.11 ENSDART00000086646
ring finger protein 182
chr2_+_47718605 2.10 ENSDART00000189180
ENSDART00000148824
muscleblind-like splicing regulator 1
chr4_-_22310956 2.09 ENSDART00000162585
hematopoietic cell-specific Lyn substrate 1
chr24_-_20192996 2.07 ENSDART00000011143
myeloid differentiation primary response 88
chr11_+_6281647 2.03 ENSDART00000002459
cystinosin, lysosomal cystine transporter
chr21_+_4313039 1.91 ENSDART00000141146
si:dkey-84o3.4
chr18_+_45504362 1.88 ENSDART00000140089
cyclic nucleotide gated channel beta 1a
chr4_+_33461796 1.85 ENSDART00000150445
si:dkey-247i3.1
chr13_-_50341004 1.74 ENSDART00000038120
CDK2 associated cullin domain 1
chr21_+_6114709 1.73 ENSDART00000065858
folylpolyglutamate synthase
chr16_-_12496632 1.71 ENSDART00000019941
solute carrier family 2 (facilitated glucose transporter), member 3b
chr8_+_26268726 1.69 ENSDART00000180883
solute carrier family 26, member 6
chr3_-_33395233 1.66 ENSDART00000167349
si:dkey-283b1.6
chr7_-_28549361 1.59 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
suppression of tumorigenicity 5
chr21_+_30721733 1.51 ENSDART00000040443
zgc:110224
chr13_-_9091354 1.45 ENSDART00000140319
ENSDART00000142697
si:dkey-112g5.13
chr16_-_24832038 1.44 ENSDART00000153731
si:dkey-79d12.5
chr24_-_7728409 1.44 ENSDART00000131392
protein tyrosine phosphatase, receptor type, h
chr13_-_9070754 1.38 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
chr4_+_12612723 1.32 ENSDART00000133767
LIM domain only 3
chr13_-_377256 1.31 ENSDART00000137398
ch1073-291c23.1
chr13_-_9045879 1.31 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
chr8_+_25902170 1.31 ENSDART00000193130
ras homolog gene family, member Ab
chr21_+_4388489 1.25 ENSDART00000144555
si:dkey-84o3.3
chr14_-_25309058 1.24 ENSDART00000159569
5-hydroxytryptamine receptor 4
chr15_-_39945036 1.23 ENSDART00000192481
mutS homolog 5
chr1_+_44173245 1.23 ENSDART00000159450
ENSDART00000106048
ENSDART00000157763
catenin (cadherin-associated protein), delta 1
chr4_-_49582758 1.19 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
chr20_+_20186706 1.17 ENSDART00000002507
ras homolog family member J
chr13_+_9468535 1.15 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
si:dkey-265c15.6
chr3_+_54761569 1.14 ENSDART00000135913
ENSDART00000180983
si:ch211-74m13.1
chr3_+_3046909 1.09 ENSDART00000122435

chr1_+_44173506 1.00 ENSDART00000170512
catenin (cadherin-associated protein), delta 1
chr1_+_53714734 1.00 ENSDART00000114689
pseudouridylate synthase 10
chr21_-_25555355 0.99 ENSDART00000144228
si:dkey-17e16.9
chr8_+_8937723 0.94 ENSDART00000145970
si:dkey-83k24.5
chr13_-_9111927 0.93 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
si:dkey-19p15.4
si:dkey-112g5.12
chr13_-_9284407 0.92 ENSDART00000164798
ENSDART00000131956
ENSDART00000140150
si:dkey-33c12.14
chr17_+_18031304 0.90 ENSDART00000127259
SET domain containing 3
chr25_-_893464 0.82 ENSDART00000159321
zinc finger protein 609a
chr10_-_32920690 0.67 ENSDART00000136245
cut-like homeobox 1a
chr18_+_50669456 0.67 ENSDART00000163005
si:dkey-151j17.4
chr13_+_9521629 0.67 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
chr3_-_40945710 0.66 ENSDART00000138719
ENSDART00000102416
cytochrome P450, family 3, subfamily C, polypeptide 4
chr1_+_8492379 0.61 ENSDART00000184518
myosin XVAb
chr25_+_17860798 0.47 ENSDART00000146845
parathyroid hormone 1a
chr7_+_71764883 0.43 ENSDART00000166865
myosin, light chain 12, genome duplicate 1
chr19_-_20403507 0.40 ENSDART00000052603
ENSDART00000137590
deleted in azoospermia-like
chr20_-_2949028 0.34 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cyclin-dependent kinase 19
chr1_+_57331813 0.33 ENSDART00000152440
ENSDART00000062841
epsin 3b

Network of associatons between targets according to the STRING database.

First level regulatory network of srfa+srfb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
26.7 80.1 GO:0090131 mesenchyme migration(GO:0090131)
10.7 32.1 GO:0030043 actin filament fragmentation(GO:0030043)
8.0 31.9 GO:0003413 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
7.3 43.8 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
6.0 30.1 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
5.5 22.0 GO:0009957 epidermal cell fate specification(GO:0009957)
4.7 37.4 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
3.3 75.5 GO:0055003 cardiac myofibril assembly(GO:0055003)
2.5 34.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
2.1 6.2 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
1.7 8.6 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
1.7 10.0 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
1.5 23.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
1.3 5.3 GO:2000392 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
1.3 34.0 GO:0019933 cAMP-mediated signaling(GO:0019933)
1.3 44.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
1.1 6.5 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
1.0 2.1 GO:0008063 Toll signaling pathway(GO:0008063)
1.0 175.4 GO:0006936 muscle contraction(GO:0006936)
0.9 5.6 GO:0060149 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.9 17.1 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.9 19.5 GO:0007520 myoblast fusion(GO:0007520)
0.9 95.5 GO:0048747 muscle fiber development(GO:0048747)
0.9 11.1 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.8 3.3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.7 17.4 GO:0051014 actin filament severing(GO:0051014)
0.7 7.7 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.7 18.9 GO:0001757 somite specification(GO:0001757)
0.6 11.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.6 29.9 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.6 3.4 GO:0071800 podosome assembly(GO:0071800)
0.5 5.1 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.5 5.4 GO:0032264 IMP salvage(GO:0032264)
0.5 4.8 GO:0031639 plasminogen activation(GO:0031639)
0.5 20.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.4 2.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.4 1.7 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.4 137.5 GO:0061061 muscle structure development(GO:0061061)
0.4 19.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.4 4.8 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.4 14.0 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.4 18.4 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.3 9.0 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.3 1.5 GO:0000012 single strand break repair(GO:0000012)
0.3 1.7 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.2 12.6 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.2 3.5 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 3.0 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.2 2.0 GO:0070293 renal absorption(GO:0070293)
0.2 26.1 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.2 1.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 1.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 1.0 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.2 34.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.2 13.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 5.5 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 3.9 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 4.6 GO:2000027 regulation of organ morphogenesis(GO:2000027)
0.1 1.2 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 1.2 GO:0032098 regulation of appetite(GO:0032098)
0.1 5.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 3.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.3 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 1.0 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 2.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.9 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 2.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 11.1 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.0 2.5 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.1 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.0 21.4 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.0 2.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 5.5 GO:0045087 innate immune response(GO:0045087)
0.0 3.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.9 GO:0007601 visual perception(GO:0007601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 144.9 GO:0005869 dynactin complex(GO:0005869)
6.8 34.2 GO:0097433 dense body(GO:0097433)
6.3 44.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
4.8 99.8 GO:0031430 M band(GO:0031430)
4.7 37.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
4.4 17.8 GO:0060171 stereocilium membrane(GO:0060171)
3.4 33.8 GO:0031672 A band(GO:0031672)
3.4 158.3 GO:0031941 filamentous actin(GO:0031941)
2.4 158.0 GO:0005884 actin filament(GO:0005884)
1.9 30.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
1.1 5.3 GO:0032433 filopodium tip(GO:0032433)
1.0 122.0 GO:0016459 myosin complex(GO:0016459)
1.0 32.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.8 31.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.8 58.3 GO:0030018 Z disc(GO:0030018)
0.6 11.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.5 5.5 GO:0016580 Sin3 complex(GO:0016580)
0.4 19.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.4 4.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 6.5 GO:0005902 microvillus(GO:0005902)
0.4 15.6 GO:0030175 filopodium(GO:0030175)
0.3 82.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.2 29.9 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2 23.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 19.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 7.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 20.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.5 GO:0035102 PRC1 complex(GO:0035102)
0.1 5.4 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 17.7 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.1 2.5 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 1.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 14.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 12.2 GO:0043235 receptor complex(GO:0043235)
0.0 8.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 34.0 GO:0008179 adenylate cyclase binding(GO:0008179)
8.8 44.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
7.5 150.5 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
6.8 34.2 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
4.7 37.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
3.5 31.2 GO:0015250 water channel activity(GO:0015250)
2.5 34.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
2.3 32.5 GO:0008266 poly(U) RNA binding(GO:0008266)
2.3 33.8 GO:0051879 Hsp90 protein binding(GO:0051879)
1.7 17.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.7 10.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
1.3 484.3 GO:0051015 actin filament binding(GO:0051015)
0.9 5.6 GO:0032052 bile acid binding(GO:0032052)
0.8 5.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.8 12.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 12.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.7 2.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 5.6 GO:0008494 translation activator activity(GO:0008494)
0.5 6.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.5 5.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 4.8 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.4 2.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 19.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.4 3.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3 34.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 15.6 GO:0017124 SH3 domain binding(GO:0017124)
0.3 3.0 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 5.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 3.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 7.7 GO:0019003 GDP binding(GO:0019003)
0.2 5.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 2.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.9 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 18.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 3.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 34.3 GO:0003779 actin binding(GO:0003779)
0.1 1.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 38.3 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.1 6.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 70.7 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 3.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 2.1 GO:0045296 cadherin binding(GO:0045296)
0.1 4.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 29.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.9 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 6.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 11.3 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 1.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.1 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 5.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 2.5 GO:0060090 binding, bridging(GO:0060090)
0.0 2.4 GO:0008134 transcription factor binding(GO:0008134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 17.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.7 71.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.7 7.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.7 16.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.6 5.5 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.4 31.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 10.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 5.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 24.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 7.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 2.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 3.0 PID FGF PATHWAY FGF signaling pathway
0.1 4.5 PID AP1 PATHWAY AP-1 transcription factor network
0.1 3.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 7.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 63.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
2.2 6.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
2.0 10.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.9 43.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.8 37.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.1 5.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
1.0 7.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.9 5.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.8 34.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 5.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.4 3.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3 2.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.3 4.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.3 3.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 4.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 1.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 2.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 3.0 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 7.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases