ISMARA results: sp2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sp2

Z-value: 1.24

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Transcription factors associated with sp2

Gene Symbol	Gene ID	Gene Info
sp2 NCBI UniProt	ENSDARG00000076763	sp2 transcription factor
sp2 NCBI UniProt	ENSDARG00000113443	sp2 transcription factor
sp2 NCBI UniProt	ENSDARG00000115477	sp2 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp2	dr11_v1_chr11_-_12008001_12008001	0.42	2.2e-05	Click!

Activity profile of sp2 motif

Sorted Z-values of sp2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_-_39219537 Show fit	23.17	ENSDART00000005764	cyp39a1 NCBI UniProt Show fit	cytochrome P450, family 39, subfamily A, polypeptide 1
chr10_+_1849874 Show fit	11.50	ENSDART00000158897 ENSDART00000149956	apc NCBI UniProt Show fit	adenomatous polyposis coli
chr3_-_36440705 Show fit	10.92	ENSDART00000162875	rogdi NCBI UniProt Show fit	rogdi homolog (Drosophila)
chr2_-_11912347 Show fit	10.89	ENSDART00000023851	abhd3 NCBI UniProt Show fit	abhydrolase domain containing 3
chr6_-_13408680 Show fit	10.76	ENSDART00000151566	fmnl2b NCBI UniProt Show fit	formin-like 2b
chr2_+_24868010 Show fit	10.63	ENSDART00000078838	rab3aa NCBI UniProt Show fit	RAB3A, member RAS oncogene family, a
chr23_+_44732863 Show fit	10.51	ENSDART00000160044 ENSDART00000172268	atp1b2a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 2a
chr19_-_15855427 Show fit	10.43	ENSDART00000133059	cited4a NCBI UniProt Show fit	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr8_-_4618653 Show fit	9.63	ENSDART00000025535	sept5a NCBI UniProt Show fit	septin 5a
chr8_+_23165749 Show fit	9.60	ENSDART00000063057	dnajc5aa NCBI UniProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 5aa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.9	23.2	GO:0006699	bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.2	21.6	GO:0008360	regulation of cell shape(GO:0008360)
5.9	17.7	GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.9	16.5	GO:0036376	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0	13.1	GO:0007268	chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
1.7	12.2	GO:0098971	dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
2.9	11.5	GO:0061031	endodermal digestive tract morphogenesis(GO:0061031) Wnt signaling pathway involved in somitogenesis(GO:0090244) negative regulation of canonical Wnt signaling pathway involved in heart development(GO:1905067)
2.2	10.9	GO:0051792	medium-chain fatty acid biosynthetic process(GO:0051792)
0.2	9.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.9	8.5	GO:0031269	pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)

Showing 1 to 10 of 126 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	27.7	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	17.0	GO:0008021	synaptic vesicle(GO:0008021)
1.7	16.5	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1	14.1	GO:0043197	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1	12.0	GO:0005871	kinesin complex(GO:0005871)
1.6	11.5	GO:0030877	beta-catenin destruction complex(GO:0030877)
2.7	10.9	GO:0043291	RAVE complex(GO:0043291)
0.1	10.7	GO:0043025	neuronal cell body(GO:0043025)
0.3	10.0	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3	9.6	GO:0005940	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	26.2	GO:0003924	GTPase activity(GO:0003924)
0.3	21.6	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	16.6	GO:0015631	tubulin binding(GO:0015631)
0.8	16.5	GO:0001671	ATPase activator activity(GO:0001671)
0.6	15.4	GO:0001540	beta-amyloid binding(GO:0001540)
3.6	10.9	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.3	10.8	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2	9.8	GO:0017124	SH3 domain binding(GO:0017124)
0.0	9.4	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2	8.7	GO:0008013	beta-catenin binding(GO:0008013)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	11.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	6.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.3	3.0	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	2.7	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.3	2.4	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	2.4	PID RHOA PATHWAY	RhoA signaling pathway
0.2	1.4	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	0.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.6	23.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.8	11.5	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.5	6.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.4	6.3	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.2	5.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.4	5.0	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	3.8	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.8	3.0	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.2	3.0	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.2	2.8	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway

Showing 1 to 10 of 27 entries

Results for sp2

Z-value: 1.24

Motif logo

Transcription factors associated with sp2

Activity-expression correlation:

Activity profile of sp2 motif

Sorted Z-values of sp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: