ISMARA results: sp1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sp1

Z-value: 2.07

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Transcription factors associated with sp1

Gene Symbol	Gene ID	Gene Info
sp1 NCBI UniProt	ENSDARG00000088347	sp1 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp1	dr11_v1_chr11_-_28747_28747	0.16	1.4e-01	Click!

Activity profile of sp1 motif

Sorted Z-values of sp1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_5254699 Show fit	29.85	ENSDART00000081951	stx1b NCBI UniProt Show fit	syntaxin 1B
chr13_+_1100197 Show fit	23.87	ENSDART00000139560	ppp3r1a NCBI UniProt Show fit	protein phosphatase 3, regulatory subunit B, alpha a
chr8_-_4618653 Show fit	23.70	ENSDART00000025535	sept5a NCBI UniProt Show fit	septin 5a
chr7_+_568819 Show fit	22.91	ENSDART00000173716	nrxn2b NCBI UniProt Show fit	neurexin 2b
chr2_+_58221163 Show fit	22.80	ENSDART00000157939	FO704813.1 NCBI UniProt Show fit
chr21_+_26697536 Show fit	22.12	ENSDART00000004109	gng3 NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), gamma 3
chr7_+_73630751 Show fit	20.88	ENSDART00000159745	PCP4L1 NCBI UniProt Show fit	si:dkey-46i9.1
chr15_-_47956388 Show fit	20.20	ENSDART00000116506	si:ch1073-111c8.3 NCBI UniProt Show fit	si:ch1073-111c8.3
chr3_-_62380146 Show fit	19.79	ENSDART00000155853	gprc5ba NCBI UniProt Show fit	G protein-coupled receptor, class C, group 5, member Ba
chr11_-_32723851 Show fit	18.65	ENSDART00000155592	pcdh17 NCBI UniProt Show fit	protocadherin 17

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	54.2	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.8	38.4	GO:0007019	microtubule depolymerization(GO:0007019)
0.1	37.4	GO:0007264	small GTPase mediated signal transduction(GO:0007264)
1.3	32.3	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
1.7	32.2	GO:0030007	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1	31.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
6.0	29.8	GO:0098967	exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.3	28.2	GO:0008360	regulation of cell shape(GO:0008360)
0.7	25.3	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
3.6	25.1	GO:0098971	dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)

Showing 1 to 10 of 383 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	139.0	GO:0043005	neuron projection(GO:0043005)
0.6	87.2	GO:0008021	synaptic vesicle(GO:0008021)
0.0	77.2	GO:0005886	plasma membrane(GO:0005886)
1.8	51.6	GO:0048788	cytoskeleton of presynaptic active zone(GO:0048788)
2.4	41.2	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
3.9	39.4	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.4	36.6	GO:0043025	neuronal cell body(GO:0043025)
0.4	35.0	GO:0005871	kinesin complex(GO:0005871)
1.2	29.8	GO:0048787	presynaptic active zone membrane(GO:0048787)
1.6	29.4	GO:0043209	myelin sheath(GO:0043209)

Showing 1 to 10 of 139 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	62.0	GO:0005509	calcium ion binding(GO:0005509)
1.0	59.5	GO:0044325	ion channel binding(GO:0044325)
0.1	55.0	GO:0003924	GTPase activity(GO:0003924)
0.2	51.7	GO:0015631	tubulin binding(GO:0015631)
0.4	49.9	GO:0005516	calmodulin binding(GO:0005516)
2.0	41.2	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.6	41.0	GO:0005484	SNAP receptor activity(GO:0005484)
0.8	38.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
1.4	34.7	GO:0030371	translation repressor activity(GO:0030371)
2.1	32.2	GO:0005504	fatty acid binding(GO:0005504)

Showing 1 to 10 of 249 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	20.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.6	20.0	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.5	19.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.6	19.3	SIG CHEMOTAXIS	Genes related to chemotaxis
0.9	18.8	PID REELIN PATHWAY	Reelin signaling pathway
0.8	16.2	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.4	10.7	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.9	9.7	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4	9.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	9.7	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 62 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	48.2	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
1.8	29.8	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.4	16.9	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
1.2	15.3	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	14.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	13.5	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.6	10.8	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.4	10.5	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
1.3	10.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	9.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing

Showing 1 to 10 of 83 entries

Results for sp1

Z-value: 2.07

Motif logo

Transcription factors associated with sp1

Activity-expression correlation:

Activity profile of sp1 motif

Sorted Z-values of sp1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: