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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for sox5
Z-value: 1.42
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Transcription factors associated with sox5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sox5 | dr11_v1_chr4_-_17055782_17055782 | 0.53 | 5.3e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of sox5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.1 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.3 | 19.9 | GO:0021549 | cerebellum development(GO:0021549) |
| 0.6 | 17.9 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.0 | 17.8 | GO:0030182 | neuron differentiation(GO:0030182) |
| 0.2 | 17.0 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.2 | 15.6 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.4 | 14.1 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.1 | 14.0 | GO:0000398 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.2 | 13.7 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 1.0 | 13.5 | GO:0021754 | facial nucleus development(GO:0021754) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 36.0 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 1.6 | 28.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 20.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 2.9 | 17.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.3 | 16.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 13.6 | GO:0030424 | axon(GO:0030424) |
| 0.3 | 12.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 1.9 | 11.7 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 11.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 10.8 | GO:0005667 | transcription factor complex(GO:0005667) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 26.7 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 25.5 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 1.6 | 24.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.0 | 22.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 21.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 17.9 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 16.5 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.3 | 16.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.5 | 14.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 1.1 | 9.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 8.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.2 | 7.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 7.3 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.3 | 4.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 3.9 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.4 | 3.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 2.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.4 | 9.1 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.3 | 7.7 | REACTOME FRS2 MEDIATED CASCADE | Genes involved in FRS2-mediated cascade |
| 0.1 | 6.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.4 | 6.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 5.7 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.2 | 5.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 4.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 3.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 3.9 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |