ISMARA results: sox21b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox21b

Z-value: 1.28

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Transcription factors associated with sox21b

Gene Symbol	Gene ID	Gene Info
sox21b NCBI UniProt	ENSDARG00000008540	SRY-box transcription factor 21b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sox21b	dr11_v1_chr9_+_53276356_53276356	0.58	1.3e-09	Click!

Activity profile of sox21b motif

Sorted Z-values of sox21b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_54387550 Show fit	22.62	ENSDART00000097388	napgb NCBI UniProt Show fit	N-ethylmaleimide-sensitive factor attachment protein, gamma b
chr16_+_37582872 Show fit	20.78	ENSDART00000169331	adgrb1a NCBI UniProt Show fit	adhesion G protein-coupled receptor B1a
chr8_-_49431939 Show fit	20.71	ENSDART00000011453 ENSDART00000088240 ENSDART00000114173	sypb NCBI UniProt Show fit	synaptophysin b
chr14_+_49135264 Show fit	19.86	ENSDART00000084119	si:ch1073-44g3.1 NCBI UniProt Show fit	si:ch1073-44g3.1
chr13_-_24448278 Show fit	16.77	ENSDART00000057584	slc1a4 NCBI UniProt Show fit	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr19_-_7450796 Show fit	16.67	ENSDART00000104750	mllt11 NCBI UniProt Show fit	MLLT11, transcription factor 7 cofactor
chr15_+_28685892 Show fit	16.54	ENSDART00000155815 ENSDART00000060244	nova2 NCBI UniProt Show fit	neuro-oncological ventral antigen 2
chr25_-_12203952 Show fit	15.96	ENSDART00000158204 ENSDART00000091727	ntrk3a NCBI UniProt Show fit	neurotrophic tyrosine kinase, receptor, type 3a
chr7_+_73630751 Show fit	15.73	ENSDART00000159745	PCP4L1 NCBI UniProt Show fit	si:dkey-46i9.1
chr25_+_4837915 Show fit	14.83	ENSDART00000168016	gnb5a NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), beta 5a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sox21b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	32.7	GO:0006468	protein phosphorylation(GO:0006468)
0.8	28.9	GO:0043652	engulfment of apoptotic cell(GO:0043652)
0.3	26.8	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
5.1	25.6	GO:0070208	protein heterotrimerization(GO:0070208)
0.5	25.3	GO:0007019	microtubule depolymerization(GO:0007019)
0.9	22.9	GO:0048168	regulation of neuronal synaptic plasticity(GO:0048168)
0.0	22.1	GO:0006886	intracellular protein transport(GO:0006886)
0.1	18.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.3	16.7	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
1.0	16.0	GO:1990089	response to nerve growth factor(GO:1990089) cellular response to nerve growth factor stimulus(GO:1990090)

Showing 1 to 10 of 126 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	28.9	GO:0014069	postsynaptic density(GO:0014069)
0.8	28.5	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1	26.4	GO:0045202	synapse(GO:0045202)
0.3	20.8	GO:0031201	SNARE complex(GO:0031201)
0.4	20.7	GO:0048786	presynaptic active zone(GO:0048786)
0.1	19.4	GO:0043005	neuron projection(GO:0043005)
0.0	18.3	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	18.2	GO:0005815	microtubule organizing center(GO:0005815)
0.3	16.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	16.0	GO:0030424	axon(GO:0030424)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	40.5	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
5.3	31.9	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.1	29.1	GO:0015631	tubulin binding(GO:0015631)
1.8	25.6	GO:0008503	benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.5	20.9	GO:0017075	syntaxin-1 binding(GO:0017075)
0.6	20.3	GO:0004707	MAP kinase activity(GO:0004707)
0.0	19.8	GO:0005509	calcium ion binding(GO:0005509)
0.1	18.0	GO:0015293	symporter activity(GO:0015293)
0.0	17.7	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
2.7	16.0	GO:0005030	neurotrophin receptor activity(GO:0005030)

Showing 1 to 10 of 87 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	9.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.7	9.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	7.7	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.4	5.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	5.0	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.3	3.6	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	2.6	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	1.7	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	1.7	PID RAS PATHWAY	Regulation of Ras family activation
0.1	1.4	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	25.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.9	18.6	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.7	16.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.4	9.1	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.7	7.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	7.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	7.3	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.8	6.4	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
1.3	5.2	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	5.0	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis

Showing 1 to 10 of 35 entries

Results for sox21b

Z-value: 1.28

Motif logo

Transcription factors associated with sox21b

Activity-expression correlation:

Activity profile of sox21b motif

Sorted Z-values of sox21b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sox21b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: