Project
PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
Navigation
Downloads
Results for smad3a+smad3b
Z-value: 1.45
Motif logo
Transcription factors associated with smad3a+smad3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| smad3b | dr11_v1_chr18_+_19772874_19772874 | -0.40 | 6.6e-05 | Click! |
| smad3a | dr11_v1_chr7_-_34149263_34149263 | -0.37 | 2.1e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_59073203 Show fit | 21.54 |
ENSDART00000149937
ENSDART00000162201 |
si:zfos-2330d3.3 zgc:173915 |
|
| chr7_+_66822229 Show fit | 16.24 |
ENSDART00000112109
|
lymphatic vessel endothelial hyaluronic receptor 1a |
|
| chr18_+_13164325 Show fit | 15.98 |
ENSDART00000189057
|
tyrosine aminotransferase |
|
| chr4_-_11577253 Show fit | 15.88 |
ENSDART00000144452
|
neuroepithelial cell transforming 1 |
|
| chr22_+_661711 Show fit | 15.82 |
ENSDART00000113795
|
E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
|
| chr22_+_661505 Show fit | 15.26 |
ENSDART00000149460
|
E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
|
| chr14_+_38786298 Show fit | 15.19 |
ENSDART00000164440
|
si:ch211-195b11.3 |
|
| chr1_+_59073436 Show fit | 12.53 |
ENSDART00000161642
|
si:zfos-2330d3.3 |
|
| chr23_+_44614056 Show fit | 12.27 |
ENSDART00000188379
|
enolase 3, (beta, muscle) |
|
| chr2_+_32796873 Show fit | 11.66 |
ENSDART00000077511
|
chemokine (C-C motif) receptor 9a |
Network of associatons between targets according to the STRING database.
First level regulatory network of smad3a+smad3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 36.7 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 27.5 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.0 | 24.8 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.2 | 23.7 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.1 | 16.9 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.2 | 16.2 | GO:0001946 | lymphangiogenesis(GO:0001946) |
| 2.7 | 16.0 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.9 | 15.9 | GO:1900107 | regulation of nodal signaling pathway(GO:1900107) |
| 1.5 | 12.3 | GO:0032889 | regulation of vacuole fusion, non-autophagic(GO:0032889) |
| 4.0 | 12.1 | GO:0098543 | detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 21.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 19.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 18.9 | GO:0005829 | cytosol(GO:0005829) |
| 1.5 | 12.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 12.0 | GO:0005764 | lysosome(GO:0005764) |
| 0.1 | 11.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 10.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 10.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 10.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.5 | 37.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 23.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 20.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.5 | 16.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.6 | 16.0 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.3 | 15.9 | GO:0019209 | kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295) |
| 0.1 | 12.4 | GO:0016820 | P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492) |
| 1.5 | 12.3 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 4.0 | 12.1 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 15.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 9.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 6.3 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.2 | 4.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 4.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 3.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 3.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 2.1 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 2.0 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 16.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.6 | 12.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.0 | 11.6 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.5 | 11.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 10.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 7.4 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.5 | 5.9 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 4.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 4.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |