ISMARA results: runx2a+runx2b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for runx2a+runx2b

Z-value: 1.43

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Transcription factors associated with runx2a+runx2b

Gene Symbol	Gene ID	Gene Info
runx2a NCBI UniProt	ENSDARG00000040261	RUNX family transcription factor 2a
runx2b NCBI UniProt	ENSDARG00000059233	RUNX family transcription factor 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
runx2b	dr11_v1_chr20_-_44055095_44055123	0.67	2.1e-13	Click!
runx2a	dr11_v1_chr17_+_5351922_5351922	0.18	8.3e-02	Click!

Activity profile of runx2a+runx2b motif

Sorted Z-values of runx2a+runx2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_+_11334733 Show fit	20.62	ENSDART00000147552 ENSDART00000143171	si:dkey-12l12.1 NCBI UniProt Show fit	si:dkey-12l12.1
chr16_+_11724230 Show fit	17.28	ENSDART00000060266	ceacam1 NCBI UniProt Show fit	carcinoembryonic antigen-related cell adhesion molecule 1
chr5_-_23277939 Show fit	17.04	ENSDART00000003514	plp1b NCBI UniProt Show fit	proteolipid protein 1b
chr10_-_15128771 Show fit	15.95	ENSDART00000101261	spp1 NCBI UniProt Show fit	secreted phosphoprotein 1
chr7_+_25858380 Show fit	14.80	ENSDART00000148780 ENSDART00000079218	mtmr1a NCBI UniProt Show fit	myotubularin related protein 1a
chr19_+_30633453 Show fit	14.07	ENSDART00000052124	fam49al NCBI UniProt Show fit	family with sequence similarity 49, member A-like
chr2_-_44282796 Show fit	12.74	ENSDART00000163040 ENSDART00000166923 ENSDART00000056372 ENSDART00000109251 ENSDART00000132682	mpz NCBI UniProt Show fit	myelin protein zero
chr24_-_4973765 Show fit	12.06	ENSDART00000127597	zic1 NCBI UniProt Show fit	zic family member 1 (odd-paired homolog, Drosophila)
chr5_-_23277385 Show fit	11.76	ENSDART00000134982	plp1b NCBI UniProt Show fit	proteolipid protein 1b
chr20_-_14054083 Show fit	11.13	ENSDART00000009549	rhag NCBI UniProt Show fit	Rh associated glycoprotein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of runx2a+runx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	28.8	GO:0022010	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1	24.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4	23.6	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.4	23.6	GO:0006414	translational elongation(GO:0006414)
0.4	18.1	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2	17.2	GO:0060348	bone development(GO:0060348)
0.1	16.8	GO:0030041	actin filament polymerization(GO:0030041)
1.7	12.1	GO:0021534	cell proliferation in hindbrain(GO:0021534)
0.9	11.2	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.3	11.2	GO:0048247	lymphocyte chemotaxis(GO:0048247)

Showing 1 to 10 of 247 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	63.0	GO:0043209	myelin sheath(GO:0043209)
0.1	17.0	GO:0008021	synaptic vesicle(GO:0008021)
0.4	13.4	GO:0031594	neuromuscular junction(GO:0031594)
0.0	12.4	GO:0005874	microtubule(GO:0005874)
0.3	9.8	GO:0032156	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.6	8.8	GO:0048179	activin receptor complex(GO:0048179)
0.0	8.4	GO:0005794	Golgi apparatus(GO:0005794)
0.1	8.0	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.4	7.9	GO:0044666	MLL3/4 complex(GO:0044666)
0.2	7.9	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Showing 1 to 10 of 105 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	28.8	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.6	27.3	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	26.3	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.1	25.7	GO:0003924	GTPase activity(GO:0003924)
1.5	14.8	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1	12.1	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.3	11.2	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.1	10.9	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.2	10.0	GO:0015485	cholesterol binding(GO:0015485)
0.0	9.5	GO:0061630	ubiquitin protein ligase activity(GO:0061630)

Showing 1 to 10 of 181 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	23.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	9.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	8.5	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	8.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	6.6	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	6.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	5.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.3	5.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.3	4.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.2	4.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 37 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	27.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.6	11.1	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.5	8.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.5	6.7	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.5	6.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.2	5.0	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.5	4.5	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.5	4.2	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.3	4.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	4.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 56 entries

Results for runx2a+runx2b

Z-value: 1.43

Motif logo

Transcription factors associated with runx2a+runx2b

Activity-expression correlation:

Activity profile of runx2a+runx2b motif

Sorted Z-values of runx2a+runx2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of runx2a+runx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: