Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for rfx3_rfx2+rfx4

Z-value: 4.31

Motif logo

Transcription factors associated with rfx3_rfx2+rfx4

Gene Symbol Gene ID Gene Info
ENSDARG00000014550 regulatory factor X, 3 (influences HLA class II expression)
ENSDARG00000013575 regulatory factor X, 2 (influences HLA class II expression)
ENSDARG00000026395 regulatory factor X, 4
ENSDARG00000116861 regulatory factor X, 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx4dr11_v1_chr18_-_15373620_153736200.794.8e-21Click!
rfx3dr11_v1_chr10_-_641609_6416090.494.5e-07Click!
rfx2dr11_v1_chr8_-_20138054_20138251-0.132.0e-01Click!

Activity profile of rfx3_rfx2+rfx4 motif

Sorted Z-values of rfx3_rfx2+rfx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_26697536 61.23 ENSDART00000004109
guanine nucleotide binding protein (G protein), gamma 3
chr19_-_9472893 55.81 ENSDART00000045565
ENSDART00000137505
vesicle-associated membrane protein 1
chr20_-_9436521 52.27 ENSDART00000133000
zgc:101840
chr17_-_6759006 46.03 ENSDART00000184692
ENSDART00000180530
visinin-like 1b
chr24_-_24163201 42.43 ENSDART00000140170
MAP7 domain containing 2b
chr23_-_19953089 40.88 ENSDART00000153828
ATPase plasma membrane Ca2+ transporting 3b
chr5_+_32162684 39.43 ENSDART00000134472
TAO kinase 3b
chr5_-_23317477 38.88 ENSDART00000090171
neuroligin 3b
chr10_-_35542071 38.85 ENSDART00000162139
si:ch211-244c8.4
chr13_-_36911118 38.73 ENSDART00000048739
tripartite motif containing 9
chr16_-_13662514 38.73 ENSDART00000146348
shisa family member 7a
chr21_-_43952958 36.64 ENSDART00000039571
calcium/calmodulin-dependent protein kinase II alpha
chr16_+_221739 36.50 ENSDART00000180243
neurensin 1
chr11_-_97817 36.20 ENSDART00000092903
engulfment and cell motility 2
chr6_-_33023745 35.72 ENSDART00000156211
adenylate cyclase activating polypeptide 1b (pituitary) receptor type I
chr7_-_58098814 35.24 ENSDART00000147287
ENSDART00000043984
ankyrin 2b, neuronal
chr20_-_34868814 34.89 ENSDART00000153049
stathmin-like 4
chr5_-_21044693 33.99 ENSDART00000140298
si:dkey-13n15.2
chr3_-_1190132 33.85 ENSDART00000149709
single-pass membrane protein with aspartate-rich tail 1a
chr17_-_14726824 33.33 ENSDART00000162947
si:ch73-305o9.3
chr7_-_52842605 33.25 ENSDART00000083002
microtubule-associated protein 1Aa
chr21_-_15929041 32.98 ENSDART00000080693
LIM homeobox 5
chr5_-_29643930 32.95 ENSDART00000161250
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr24_-_24162930 32.82 ENSDART00000080602
MAP7 domain containing 2b
chr9_-_31747106 32.40 ENSDART00000048469
ENSDART00000145204
ENSDART00000186889
sodium leak channel, non-selective
chr23_+_35708730 32.13 ENSDART00000009277
tubulin, alpha 1a
chr1_+_54908895 32.12 ENSDART00000145652
golgin A7 family, member Ba
chr20_+_20637866 32.11 ENSDART00000060203
ENSDART00000079079
reticulon 1b
chr13_+_28821841 31.65 ENSDART00000179900

chr18_+_7283283 31.50 ENSDART00000141493
si:ch73-86n2.1
chr25_-_13381854 31.46 ENSDART00000164621
ENSDART00000169129
NDRG family member 4
chr13_-_31470439 29.92 ENSDART00000076574
reticulon 1a
chr20_+_20638034 29.83 ENSDART00000189759
reticulon 1b
chr22_+_16418688 29.72 ENSDART00000009360
ankyrin repeat domain 29
chr6_+_13933464 28.87 ENSDART00000109144
protein tyrosine phosphatase, receptor type, Nb
chr13_+_33117528 28.79 ENSDART00000085719
si:ch211-10a23.2
chr25_-_25736958 28.03 ENSDART00000166308
calcium and integrin binding family member 2
chr7_-_52876683 27.83 ENSDART00000172910
microtubule-associated protein 1Aa
chr24_-_205275 27.56 ENSDART00000108762
VOPP1, WBP1/VOPP1 family member
chr17_+_8988374 27.44 ENSDART00000109573
A kinase (PRKA) anchor protein 6
chr17_+_15534815 26.73 ENSDART00000159426
myristoylated alanine-rich protein kinase C substrate b
chr19_-_103289 26.69 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr19_-_8604429 26.31 ENSDART00000151165
tripartite motif containing 46b
chr18_+_50890749 26.01 ENSDART00000174109
si:ch1073-450f2.1
chr9_-_44289636 25.89 ENSDART00000110411
ceramide kinase-like
chr3_-_6767440 25.88 ENSDART00000156174
microtubule associated serine/threonine kinase 1b
chr21_+_41743493 25.03 ENSDART00000192669
protein phosphatase 2, regulatory subunit B, beta b
chr5_+_20148671 24.31 ENSDART00000143205
SV2 related protein a
chr9_-_3671911 24.10 ENSDART00000102900
Sp5 transcription factor a
chr3_-_52644737 23.56 ENSDART00000126180
si:dkey-210j14.3
chr3_-_50277959 23.52 ENSDART00000082773
ENSDART00000139524
ADP-ribosylation factor-like 16
chr20_+_591505 23.44 ENSDART00000046438
potassium channel, subfamily K, member 2b
chr11_-_29650930 23.31 ENSDART00000166969
chromodomain helicase DNA binding protein 5
chr3_+_31945604 23.25 ENSDART00000114957
zgc:193811
chr4_-_8903240 23.21 ENSDART00000129983
metallophosphoesterase domain containing 1
chr14_-_25577094 23.03 ENSDART00000163669
complexin 2
chr17_+_33296436 22.41 ENSDART00000123114
DnaJ (Hsp40) homolog, subfamily C, member 27
chr2_+_18988407 22.16 ENSDART00000170216
glutamate-ammonia ligase (glutamine synthase) a
chr22_+_31930650 21.73 ENSDART00000092090
dedicator of cytokinesis 3
chr2_+_47581997 21.40 ENSDART00000112579
secretogranin II (chromogranin C), b
chr18_+_50275933 21.26 ENSDART00000143911
si:dkey-105e17.1
chr24_-_6678640 21.12 ENSDART00000042478
enkurin, TRPC channel interacting protein
chr18_-_46763170 21.06 ENSDART00000171880
delta/notch-like EGF repeat containing
chr16_-_12984631 21.00 ENSDART00000184863
calcium channel, voltage-dependent, gamma subunit 7b
chr19_+_43123331 20.65 ENSDART00000187836

chr22_-_25033105 20.36 ENSDART00000124220
neuronal pentraxin receptor b
chr5_+_64732036 20.36 ENSDART00000073950
olfactomedin 1a
chr10_+_37145007 20.28 ENSDART00000131777
CUE domain containing 1a
chr21_-_22709251 20.13 ENSDART00000140032
si:dkeyp-69c1.9
chr5_+_20147830 20.07 ENSDART00000098727
SV2 related protein a
chr2_-_1569250 19.98 ENSDART00000167202
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr17_-_40397752 19.91 ENSDART00000178483

chr1_+_45085194 19.82 ENSDART00000193863
si:ch211-151p13.8
chr12_-_41684729 19.79 ENSDART00000184461
Janus kinase and microtubule interacting protein 3
chr1_-_56223913 19.77 ENSDART00000019573
zgc:65894
chr16_+_27957808 19.67 ENSDART00000133696
zinc finger protein 804B
chr15_-_47892583 19.61 ENSDART00000192584
zmp:0000000529
chr16_-_9869056 19.60 ENSDART00000149312
neurocalcin delta a
chr8_-_7504146 18.87 ENSDART00000148339
ENSDART00000140098
cyclin-dependent kinase 20
chr18_-_21271373 18.86 ENSDART00000060001
purine nucleoside phosphorylase 6
chr10_-_17232372 18.65 ENSDART00000135679
RAB36, member RAS oncogene family
chr23_+_19558574 18.61 ENSDART00000137811
ATPase H+ transporting accessory protein 1 like b
chr5_+_66353750 18.49 ENSDART00000143410
si:ch211-261c8.5
chr9_+_2393764 18.48 ENSDART00000172624
chimerin 1
chr16_-_44399335 18.43 ENSDART00000165058
regulating synaptic membrane exocytosis 2a
chr3_-_34337969 18.31 ENSDART00000151634
trinucleotide repeat containing 6C1
chr5_-_57920600 18.25 ENSDART00000132376
si:dkey-27p23.3
chr2_+_47582681 18.16 ENSDART00000187579
secretogranin II (chromogranin C), b
chr16_+_4497302 17.76 ENSDART00000081826
ENSDART00000148096
tetratricopeptide repeat domain 29
chr5_+_66353589 17.55 ENSDART00000138246
si:ch211-261c8.5
chr5_-_46273938 17.51 ENSDART00000080033
si:ch211-130m23.3
chr23_-_28692581 17.34 ENSDART00000078141
RIB43A domain with coiled-coils 1
chr10_-_17231917 17.29 ENSDART00000038577
RAB36, member RAS oncogene family
chr15_-_19669770 17.27 ENSDART00000152707
si:dkey-4p15.3
chr17_-_43558494 17.09 ENSDART00000103830
5'-nucleotidase, cytosolic IAb
chr17_+_33296852 17.05 ENSDART00000154580
DnaJ (Hsp40) homolog, subfamily C, member 27
chr18_+_50276337 16.93 ENSDART00000140352
si:dkey-105e17.1
chr10_+_2234283 16.79 ENSDART00000136363
contactin associated protein like 3
chr2_-_21167652 16.74 ENSDART00000185792
bmi1 polycomb ring finger oncogene 1b
chr6_-_21582444 16.41 ENSDART00000151339
si:dkey-43k4.3
chr16_-_50157187 16.11 ENSDART00000155162
NIMA-related kinase 10
chr2_-_44038698 15.87 ENSDART00000079582
ENSDART00000146804
kirre like nephrin family adhesion molecule 1b
chr18_+_11970987 15.87 ENSDART00000144111
si:dkeyp-2c8.3
chr11_+_45299447 15.86 ENSDART00000172999
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr5_-_30704390 15.85 ENSDART00000016709
intraflagellar transport 22 homolog (Chlamydomonas)
chr2_-_36819624 15.78 ENSDART00000140844
SLIT and NTRK-like family, member 3b
chr14_-_52542928 15.58 ENSDART00000075749
protein phosphatase 2, regulatory subunit B, beta a
chr24_+_744713 15.49 ENSDART00000067764
serine/threonine kinase 17a
chr14_-_9355177 15.36 ENSDART00000138535
family with sequence similarity 46, member D
chr3_-_12026741 15.36 ENSDART00000132238
cilia and flagella associated protein 70
chr20_-_28404362 14.98 ENSDART00000055932
ENSDART00000188161
phosphatidylinositol glycan anchor biosynthesis, class H
chr25_+_25737386 14.97 ENSDART00000108476
leucine rich repeat containing 61
chr17_-_45009782 14.90 ENSDART00000123971
family with sequence similarity 161, member B
chr4_+_4902392 14.82 ENSDART00000133866
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr3_+_33367954 14.76 ENSDART00000103161
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr13_-_6218248 14.63 ENSDART00000159052
si:zfos-1056e6.1
chr1_-_45633955 14.62 ENSDART00000044057
septin 3
chr3_-_12890670 14.59 ENSDART00000159934
ENSDART00000188607
BTB (POZ) domain containing 17b
chr7_-_72423666 14.53 ENSDART00000191214
rabphilin 3A homolog (mouse), b
chr17_+_28882977 14.38 ENSDART00000153937
protein kinase D1
chr11_+_29770966 14.36 ENSDART00000088624
ENSDART00000124471
retinitis pigmentosa GTPase regulator b
chr9_+_54891962 14.25 ENSDART00000148620
ENSDART00000105620
si:ch211-12n8.3
chr9_+_23748342 14.12 ENSDART00000019053
Fas apoptotic inhibitory molecule a
chr20_+_20672163 14.07 ENSDART00000027758
reticulon 1b
chr8_-_19216657 14.07 ENSDART00000135096
ENSDART00000135869
ENSDART00000145951
si:ch73-222f22.2
si:ch73-222f22.2
chr3_-_19899914 14.07 ENSDART00000134969
Rho family GTPase 2
chr16_+_24632096 14.01 ENSDART00000157237
si:dkey-56f14.7
chr5_-_69271450 13.96 ENSDART00000133802
inositol polyphosphate-5-phosphatase Jb
chr10_+_25222367 13.87 ENSDART00000042767
glutamate receptor, metabotropic 5a
chr5_-_64213253 13.81 ENSDART00000171711
G protein signaling modulator 1a
chr3_+_60716904 13.77 ENSDART00000168280
forkhead box J1a
chr17_+_14425219 13.71 ENSDART00000153994
coiled-coil domain containing 175
chr8_-_49345388 13.64 ENSDART00000053203
proteolipid protein 2
chr17_+_33767890 13.63 ENSDART00000193177
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr6_+_58543336 13.63 ENSDART00000157018
stathmin-like 3
chr10_+_36037977 13.63 ENSDART00000164678
katanin p60 subunit A-like 1
chr17_+_3390772 13.52 ENSDART00000160073
syntrophin, gamma 2
chr4_-_27398385 13.48 ENSDART00000142117
ENSDART00000150553
ENSDART00000182746
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr2_+_35728033 13.46 ENSDART00000002094
ankyrin repeat domain 45
chr17_-_39772999 13.34 ENSDART00000155727
Pim proto-oncogene, serine/threonine kinase, related 60
chr21_-_35325466 13.25 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ubiquitin-like domain containing CTD phosphatase 1
chr6_+_10534752 13.18 ENSDART00000090874
potassium channel, voltage gated eag related subfamily H, member 7
chr24_-_32408404 13.03 ENSDART00000144157
si:ch211-56a11.2
chr24_+_26345427 12.92 ENSDART00000089756
leucine rich repeat containing 34
chr17_-_24684687 12.80 ENSDART00000105457
MORN repeat containing 2
chr3_-_22829710 12.73 ENSDART00000055659
cytochrome b561
chr23_-_20133994 12.73 ENSDART00000004871
leucine rich repeat containing 23
chr16_-_45069882 12.71 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr6_-_40744720 12.59 ENSDART00000154916
ENSDART00000186922
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr25_+_35375848 12.51 ENSDART00000155721
anoctamin 3
chr24_+_17262879 12.51 ENSDART00000145949
bmi1 polycomb ring finger oncogene 1a
chr8_-_19216180 12.44 ENSDART00000146162
si:ch73-222f22.2
chr8_-_39859688 12.36 ENSDART00000019907
unc-119 homolog 1
chr18_-_41232297 12.23 ENSDART00000036928
F-box protein 36a
chr4_+_31259 12.23 ENSDART00000166826
putative homeodomain transcription factor 2
chr10_-_36682509 12.19 ENSDART00000148093
ENSDART00000063365
DnaJ (Hsp40) homolog, subfamily B, member 13
chr8_+_23809843 12.16 ENSDART00000099724
si:ch211-163l21.10
chr12_-_47793857 11.97 ENSDART00000161294
DPY30 domain containing 2
chr8_-_18229169 11.90 ENSDART00000131764
ENSDART00000143036
ENSDART00000145986
si:ch211-241d21.5
chr5_-_42661012 11.90 ENSDART00000158339
Pim proto-oncogene, serine/threonine kinase, related 58
chr3_+_50312422 11.88 ENSDART00000157689
growth arrest-specific 7a
chr1_-_45647846 11.84 ENSDART00000186881

chr10_+_34685135 11.83 ENSDART00000184999
neurobeachin a
chr19_+_22062202 11.82 ENSDART00000100181
spalt-like transcription factor 3b
chr5_+_42386705 11.74 ENSDART00000143034
Pim proto-oncogene, serine/threonine kinase, related 58
chr5_+_42407962 11.74 ENSDART00000188489

chr17_-_39779906 11.67 ENSDART00000155181
Pim proto-oncogene, serine/threonine kinase, related 61
chr9_+_23748133 11.63 ENSDART00000180758
Fas apoptotic inhibitory molecule a
chr24_-_1021318 11.48 ENSDART00000181403
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr5_-_23179319 11.43 ENSDART00000161883
ENSDART00000136260
si:dkey-114c15.5
chr13_+_33304187 11.41 ENSDART00000075826
ENSDART00000145295
doublecortin domain containing 2B
chr5_-_38506981 11.40 ENSDART00000097822
ATPase Na+/K+ transporting subunit beta 2b
chr23_+_22335407 11.37 ENSDART00000147696
RAP1 GTPase activating protein
chr2_-_14271874 11.36 ENSDART00000189390
Tctex1 domain containing 1
chr3_-_30123113 11.34 ENSDART00000153562
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr19_-_9712530 11.34 ENSDART00000134816
solute carrier family 2 (facilitated glucose transporter), member 3a
chr13_-_36703164 11.33 ENSDART00000044357
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr14_-_46395659 11.26 ENSDART00000083833
Bardet-Biedl syndrome 7
chr9_-_25255490 11.25 ENSDART00000141502
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
chr8_+_47571211 11.24 ENSDART00000131460
phospholipase C, eta 2a
chr18_+_30028637 11.20 ENSDART00000139750
si:ch211-220f16.1
chr25_+_37480285 11.19 ENSDART00000166187

chr24_+_26345609 11.09 ENSDART00000186844
leucine rich repeat containing 34
chr21_-_22557469 11.09 ENSDART00000167230
cilia and flagella associated protein 53
chr3_-_37351225 11.05 ENSDART00000174685
si:ch211-278a6.1
chr25_+_17862338 11.05 ENSDART00000151853
ENSDART00000090867
BTB (POZ) domain containing 10a
chr9_-_16853462 10.90 ENSDART00000160273

chr21_-_43550120 10.85 ENSDART00000151627
si:ch73-362m14.2
chr12_+_25600685 10.66 ENSDART00000077157
SIX homeobox 3b
chr3_-_23596809 10.57 ENSDART00000156897
ubiquitin-conjugating enzyme E2Z
chr8_-_25814263 10.53 ENSDART00000143397
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr7_+_7279903 10.41 ENSDART00000102603
si:ch211-168d1.3
chr6_-_13308813 10.29 ENSDART00000065372
potassium inwardly-rectifying channel, subfamily J, member 3b
chr2_+_47582488 10.24 ENSDART00000149967
secretogranin II (chromogranin C), b
chr4_-_12388535 10.16 ENSDART00000017180
RERG/RAS-like a
chr15_-_1534232 10.11 ENSDART00000056763
ENSDART00000133943
intraflagellar transport 80 homolog (Chlamydomonas)
chr4_-_9586713 10.10 ENSDART00000145613
SH3 and multiple ankyrin repeat domains 3b
chr11_+_36477481 10.09 ENSDART00000128245
low density lipoprotein receptor class A domain containing 2
chr5_-_71705191 10.02 ENSDART00000187767
adenylate kinase 1
chr17_+_28883353 9.99 ENSDART00000110322
protein kinase D1

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx3_rfx2+rfx4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.9 GO:2000425 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) regulation of apoptotic cell clearance(GO:2000425)
7.0 35.2 GO:0036371 protein localization to T-tubule(GO:0036371)
7.0 21.1 GO:0014014 negative regulation of gliogenesis(GO:0014014)
6.7 26.7 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
6.7 26.6 GO:0007638 mechanosensory behavior(GO:0007638)
6.3 18.8 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
5.2 52.0 GO:0021631 optic nerve morphogenesis(GO:0021631)
4.6 18.5 GO:0021557 oculomotor nerve development(GO:0021557)
4.3 38.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
4.1 24.4 GO:1901490 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
3.9 15.7 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
3.9 27.2 GO:0007288 sperm axoneme assembly(GO:0007288)
3.7 55.8 GO:0035493 SNARE complex assembly(GO:0035493)
3.5 38.9 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
3.2 16.0 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
3.2 22.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
2.7 13.6 GO:0051013 microtubule severing(GO:0051013)
2.5 25.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
2.5 20.0 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
2.5 14.8 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
2.3 61.1 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
2.3 25.8 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
2.3 48.5 GO:0007019 microtubule depolymerization(GO:0007019)
2.3 34.0 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
2.3 15.9 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
2.3 20.4 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
2.2 31.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
2.2 26.7 GO:0050714 positive regulation of protein secretion(GO:0050714)
2.2 15.1 GO:0098815 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
2.1 21.0 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
2.1 29.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
2.0 33.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.9 5.7 GO:1904158 axonemal central apparatus assembly(GO:1904158)
1.8 33.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.8 12.7 GO:0032475 otolith formation(GO:0032475)
1.8 5.4 GO:1903373 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
1.8 7.0 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
1.7 14.0 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
1.7 5.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.6 4.9 GO:0036159 inner dynein arm assembly(GO:0036159)
1.5 7.6 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
1.5 9.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.4 10.0 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
1.4 12.7 GO:0044458 motile cilium assembly(GO:0044458)
1.4 21.0 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
1.3 4.0 GO:0032263 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
1.3 12.0 GO:0006348 chromatin silencing at telomere(GO:0006348)
1.3 17.1 GO:0046085 adenosine metabolic process(GO:0046085)
1.3 14.4 GO:0046548 retinal rod cell development(GO:0046548)
1.3 12.5 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
1.2 49.8 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
1.2 36.7 GO:0032836 glomerular basement membrane development(GO:0032836)
1.2 15.8 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
1.2 2.4 GO:0090660 cerebrospinal fluid circulation(GO:0090660)
1.1 4.6 GO:0046951 ketone body biosynthetic process(GO:0046951)
1.1 18.3 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
1.1 8.9 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
1.1 15.6 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
1.0 18.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.9 5.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.9 13.6 GO:0009086 methionine biosynthetic process(GO:0009086)
0.9 32.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.9 13.6 GO:0036065 fucosylation(GO:0036065)
0.8 4.2 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.8 5.6 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.8 3.1 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.8 10.8 GO:0030317 sperm motility(GO:0030317)
0.8 19.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.8 35.7 GO:0021854 hypothalamus development(GO:0021854)
0.8 11.4 GO:0001964 startle response(GO:0001964)
0.7 11.1 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.7 7.6 GO:0032264 IMP salvage(GO:0032264)
0.7 3.4 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.7 6.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.7 12.4 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.6 19.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.6 4.3 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.6 5.7 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.6 4.6 GO:0036372 opsin transport(GO:0036372)
0.6 10.8 GO:0035082 axoneme assembly(GO:0035082)
0.5 23.0 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.5 8.2 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.5 9.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.5 29.9 GO:0003146 heart jogging(GO:0003146)
0.5 8.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.5 11.4 GO:0032474 otolith morphogenesis(GO:0032474) neuromast hair cell development(GO:0035675)
0.5 24.3 GO:0003341 cilium movement(GO:0003341)
0.5 6.1 GO:0035094 response to nicotine(GO:0035094) response to alkaloid(GO:0043279)
0.5 10.9 GO:0042073 intraciliary transport(GO:0042073)
0.5 7.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.5 2.9 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.5 4.3 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.5 2.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 9.5 GO:0001556 oocyte maturation(GO:0001556)
0.4 18.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4 11.4 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.4 13.8 GO:0000281 mitotic cytokinesis(GO:0000281)
0.4 24.1 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.4 5.9 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.4 5.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.4 23.3 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.4 4.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.4 12.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.4 8.8 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.3 19.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.3 3.3 GO:1902686 positive regulation of mitochondrial membrane permeability(GO:0035794) positive regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902110) mitochondrial outer membrane permeabilization involved in programmed cell death(GO:1902686)
0.3 9.6 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.3 16.6 GO:0030641 regulation of cellular pH(GO:0030641)
0.3 2.0 GO:0060827 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.3 1.6 GO:0007624 ultradian rhythm(GO:0007624)
0.3 14.6 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.3 1.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.3 2.1 GO:0072178 pronephric duct morphogenesis(GO:0039023) nephric duct morphogenesis(GO:0072178)
0.3 8.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 1.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.3 58.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.3 10.4 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.2 15.5 GO:0007416 synapse assembly(GO:0007416)
0.2 1.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 3.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 16.1 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.2 7.1 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 44.4 GO:0006470 protein dephosphorylation(GO:0006470)
0.2 2.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 8.4 GO:0032456 endocytic recycling(GO:0032456)
0.2 9.8 GO:0006986 response to unfolded protein(GO:0006986)
0.2 14.1 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.2 2.5 GO:0021754 facial nucleus development(GO:0021754)
0.2 0.9 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 1.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 0.9 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 71.3 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.2 38.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 1.4 GO:0050482 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.2 3.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 4.0 GO:0001649 osteoblast differentiation(GO:0001649)
0.2 3.0 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.1 11.2 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 8.0 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.1 2.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 0.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 11.5 GO:0017157 regulation of exocytosis(GO:0017157)
0.1 70.0 GO:0006397 mRNA processing(GO:0006397)
0.1 8.3 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.1 19.4 GO:0060026 convergent extension(GO:0060026)
0.1 9.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 9.7 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 8.6 GO:0042472 inner ear morphogenesis(GO:0042472)
0.1 14.1 GO:0006909 phagocytosis(GO:0006909)
0.1 8.2 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 11.5 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 3.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 6.2 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 9.8 GO:0006006 glucose metabolic process(GO:0006006)
0.1 7.0 GO:0031018 endocrine pancreas development(GO:0031018)
0.1 2.1 GO:0006415 translational termination(GO:0006415)
0.1 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 11.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 2.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 0.9 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 1.5 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.8 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 7.0 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.1 4.8 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.1 24.6 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.1 2.1 GO:0009636 response to toxic substance(GO:0009636)
0.1 3.1 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.1 0.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 41.3 GO:0007010 cytoskeleton organization(GO:0007010)
0.1 5.7 GO:0050808 synapse organization(GO:0050808)
0.1 5.3 GO:0030900 forebrain development(GO:0030900)
0.0 0.5 GO:0006032 chitin catabolic process(GO:0006032)
0.0 3.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 8.0 GO:0060070 canonical Wnt signaling pathway(GO:0060070)
0.0 4.0 GO:0010506 regulation of autophagy(GO:0010506)
0.0 1.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 5.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 5.5 GO:0009116 nucleoside metabolic process(GO:0009116)
0.0 1.7 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.1 GO:0006813 potassium ion transport(GO:0006813)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 61.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
3.2 19.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
3.1 18.6 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
3.0 24.1 GO:0034464 BBSome(GO:0034464)
2.9 8.8 GO:0001534 radial spoke(GO:0001534)
2.6 33.9 GO:1990246 uniplex complex(GO:1990246)
2.4 38.7 GO:0032591 dendritic spine membrane(GO:0032591)
2.3 9.0 GO:0097255 R2TP complex(GO:0097255)
2.2 8.8 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
2.2 35.2 GO:0030315 T-tubule(GO:0030315)
2.2 33.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
2.1 32.1 GO:0002178 palmitoyltransferase complex(GO:0002178)
2.1 21.1 GO:0001669 acrosomal vesicle(GO:0001669)
2.0 35.9 GO:0030992 intraciliary transport particle B(GO:0030992)
1.8 5.4 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
1.6 34.0 GO:0030127 COPII vesicle coat(GO:0030127)
1.6 16.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
1.5 9.1 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
1.3 5.2 GO:0042641 actomyosin(GO:0042641)
1.3 40.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.2 29.2 GO:0035102 PRC1 complex(GO:0035102)
1.1 20.2 GO:0097546 ciliary base(GO:0097546)
1.1 8.8 GO:0097225 sperm midpiece(GO:0097225)
1.1 33.1 GO:0099569 presynaptic cytoskeleton(GO:0099569)
1.0 39.8 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
1.0 23.0 GO:0043195 terminal bouton(GO:0043195)
1.0 127.7 GO:0043025 neuronal cell body(GO:0043025)
0.9 68.9 GO:0030141 secretory granule(GO:0030141)
0.8 3.3 GO:0043073 germ cell nucleus(GO:0043073)
0.7 12.0 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.6 1.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.6 13.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.6 4.1 GO:0036156 inner dynein arm(GO:0036156)
0.6 8.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.6 6.6 GO:0030286 dynein complex(GO:0030286)
0.5 25.5 GO:0031514 motile cilium(GO:0031514)
0.5 0.5 GO:0005879 axonemal microtubule(GO:0005879)
0.5 8.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.5 2.9 GO:0060091 kinocilium(GO:0060091)
0.5 18.2 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.4 27.4 GO:0032432 actin filament bundle(GO:0032432)
0.4 15.1 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.4 3.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.4 104.5 GO:0005929 cilium(GO:0005929)
0.3 11.3 GO:0048786 presynaptic active zone(GO:0048786)
0.3 3.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 12.9 GO:0014069 postsynaptic density(GO:0014069)
0.3 13.1 GO:0030496 midbody(GO:0030496)
0.3 86.3 GO:0005874 microtubule(GO:0005874)
0.2 19.6 GO:0031201 SNARE complex(GO:0031201)
0.2 13.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 8.2 GO:0005795 Golgi stack(GO:0005795)
0.2 14.0 GO:0001726 ruffle(GO:0001726)
0.2 14.2 GO:0055037 recycling endosome(GO:0055037)
0.2 16.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 81.3 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.2 2.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 51.6 GO:0045202 synapse(GO:0045202)
0.2 14.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.2 11.9 GO:0005884 actin filament(GO:0005884)
0.2 18.3 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.2 97.4 GO:0043005 neuron projection(GO:0043005)
0.2 1.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 14.2 GO:0043235 receptor complex(GO:0043235)
0.1 3.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 71.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 0.8 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 81.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 10.3 GO:0005938 cell cortex(GO:0005938) cytoplasmic region(GO:0099568)
0.0 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 15.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 12.1 GO:0005730 nucleolus(GO:0005730)
0.0 22.7 GO:0005856 cytoskeleton(GO:0005856)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.5 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.3 GO:0005761 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
3.7 25.9 GO:0001727 lipid kinase activity(GO:0001727)
3.2 12.7 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
3.2 22.2 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
2.9 61.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
2.8 19.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
2.7 18.8 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
2.2 15.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
2.1 18.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
2.0 78.8 GO:0017075 syntaxin-1 binding(GO:0017075)
1.9 35.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
1.7 14.0 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
1.7 15.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
1.6 33.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.6 23.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
1.5 38.9 GO:0042043 neurexin family protein binding(GO:0042043)
1.4 7.2 GO:0004127 cytidylate kinase activity(GO:0004127)
1.4 13.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.4 40.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
1.4 13.6 GO:0008172 S-methyltransferase activity(GO:0008172)
1.3 4.0 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
1.2 31.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
1.2 13.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
1.2 29.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.2 6.1 GO:0005119 smoothened binding(GO:0005119)
1.1 4.6 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
1.1 10.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.1 12.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
1.1 11.2 GO:0004017 adenylate kinase activity(GO:0004017)
1.1 4.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
1.0 58.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.0 5.8 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
1.0 12.6 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.9 5.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.9 24.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.9 42.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.8 49.8 GO:0017124 SH3 domain binding(GO:0017124)
0.8 5.7 GO:0098809 nitrite reductase activity(GO:0098809)
0.8 16.4 GO:0001671 ATPase activator activity(GO:0001671)
0.8 17.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.8 3.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.8 36.3 GO:0008013 beta-catenin binding(GO:0008013)
0.7 10.3 GO:0070840 dynein complex binding(GO:0070840)
0.7 34.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.7 7.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.7 2.1 GO:0015562 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.7 25.1 GO:0019003 GDP binding(GO:0019003)
0.7 3.4 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.6 6.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.6 9.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.6 7.9 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.5 68.8 GO:0005516 calmodulin binding(GO:0005516)
0.5 8.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.5 15.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.5 8.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 6.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 155.4 GO:0015631 tubulin binding(GO:0015631)
0.4 38.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.4 3.3 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 128.3 GO:0003924 GTPase activity(GO:0003924)
0.4 5.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 8.4 GO:0031267 small GTPase binding(GO:0031267)
0.3 12.2 GO:0051087 chaperone binding(GO:0051087)
0.3 5.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 18.4 GO:0044325 ion channel binding(GO:0044325)
0.3 11.2 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.3 2.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 9.2 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.3 1.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 1.9 GO:0008142 oxysterol binding(GO:0008142)
0.3 2.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3 6.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 10.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 8.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 3.9 GO:0038191 neuropilin binding(GO:0038191)
0.3 9.8 GO:0005518 collagen binding(GO:0005518)
0.3 13.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 23.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 21.9 GO:0016247 channel regulator activity(GO:0016247)
0.2 2.3 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 1.1 GO:0010997 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.2 11.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.2 8.3 GO:0045182 translation regulator activity(GO:0045182)
0.2 9.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 9.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 68.9 GO:0030695 GTPase regulator activity(GO:0030695)
0.2 73.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 5.2 GO:0008483 transaminase activity(GO:0008483)
0.2 50.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 3.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 19.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 7.1 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 1.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 8.1 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 0.9 GO:0015232 heme transporter activity(GO:0015232)
0.1 11.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 6.7 GO:0003678 DNA helicase activity(GO:0003678)
0.1 3.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 20.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 3.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 8.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 9.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.9 GO:0045503 dynein light chain binding(GO:0045503)
0.1 3.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 7.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 20.7 GO:0051015 actin filament binding(GO:0051015)
0.1 13.5 GO:0005261 cation channel activity(GO:0005261)
0.1 9.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.6 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 9.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 1.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 6.8 GO:0000287 magnesium ion binding(GO:0000287)
0.0 40.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.5 GO:0004568 chitinase activity(GO:0004568)
0.0 0.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 92.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 32.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.5 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.7 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 3.2 GO:0042802 identical protein binding(GO:0042802)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 26.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.0 25.3 PID IGF1 PATHWAY IGF1 pathway
0.9 36.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.8 27.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4 6.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 10.5 PID MYC PATHWAY C-MYC pathway
0.3 11.7 PID ATM PATHWAY ATM pathway
0.3 11.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 6.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 4.2 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.2 6.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 3.3 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 9.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 4.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 36.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
3.6 61.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
3.4 58.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
2.0 32.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
1.4 12.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.1 19.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.8 4.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.8 24.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.8 8.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.7 6.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.7 15.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.7 8.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 16.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.6 21.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.6 5.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 10.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 8.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 10.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2 17.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 35.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 2.0 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 4.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 2.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 8.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides