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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for rargb_pparab
Z-value: 1.94
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Transcription factors associated with rargb_pparab
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pparab | dr11_v1_chr25_+_2198781_2198781 | -0.28 | 5.5e-03 | Click! |
| rargb | dr11_v1_chr11_+_2089461_2089461 | -0.02 | 8.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of rargb_pparab
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 87.8 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.3 | 61.6 | GO:0060538 | skeletal muscle organ development(GO:0060538) |
| 1.9 | 48.3 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.3 | 44.5 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.2 | 30.0 | GO:0006821 | chloride transport(GO:0006821) |
| 0.5 | 24.7 | GO:0022900 | electron transport chain(GO:0022900) |
| 1.2 | 23.5 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.8 | 22.9 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 3.8 | 22.8 | GO:0003272 | endocardial cushion formation(GO:0003272) |
| 0.8 | 20.5 | GO:0007007 | inner mitochondrial membrane organization(GO:0007007) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 62.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.5 | 60.9 | GO:0016459 | myosin complex(GO:0016459) |
| 1.3 | 58.9 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.7 | 53.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.8 | 43.7 | GO:0036379 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 1.5 | 40.8 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 38.6 | GO:0005829 | cytosol(GO:0005829) |
| 1.6 | 31.1 | GO:0031430 | M band(GO:0031430) |
| 5.1 | 25.6 | GO:0043034 | costamere(GO:0043034) |
| 1.7 | 25.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 153.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 8.4 | 66.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 64.0 | GO:0003779 | actin binding(GO:0003779) |
| 2.4 | 47.6 | GO:0051393 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 1.2 | 33.1 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.4 | 30.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 25.4 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.3 | 24.4 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.1 | 24.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.1 | 23.2 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.3 | 14.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 13.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 12.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 9.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 6.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 5.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 5.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 5.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 97.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.1 | 31.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 17.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.1 | 15.7 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.8 | 15.6 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 1.0 | 14.9 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 1.2 | 14.7 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.8 | 12.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 12.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.8 | 11.7 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |