ISMARA results: pitx2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pitx2

Z-value: 1.19

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Transcription factors associated with pitx2

Gene Symbol	Gene ID	Gene Info
pitx2 NCBI UniProt	ENSDARG00000036194	paired-like homeodomain 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pitx2	dr11_v1_chr14_+_36218072_36218072	-0.11	2.8e-01	Click!

Activity profile of pitx2 motif

Sorted Z-values of pitx2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_-_45510977 Show fit	22.92	ENSDART00000090596	fgf12b NCBI UniProt Show fit	fibroblast growth factor 12b
chr12_+_47917971 Show fit	12.06	ENSDART00000185933	tbata NCBI UniProt Show fit	thymus, brain and testes associated
chr13_+_24280380 Show fit	9.33	ENSDART00000184115	acta1b NCBI UniProt Show fit	actin, alpha 1b, skeletal muscle
chr5_+_24287927 Show fit	7.26	ENSDART00000143563	zdhhc23a NCBI UniProt Show fit	zinc finger, DHHC-type containing 23a
chr9_-_34974143 Show fit	6.91	ENSDART00000127295	zgc:172067 NCBI UniProt Show fit	zgc:172067
chr23_+_28731379 Show fit	6.84	ENSDART00000047378	cort NCBI UniProt Show fit	cortistatin
chr9_-_34974416 Show fit	6.78	ENSDART00000077790	zgc:172067 NCBI UniProt Show fit	zgc:172067
chr19_+_12762887 Show fit	6.18	ENSDART00000139909	mc5ra NCBI UniProt Show fit	melanocortin 5a receptor
chr21_+_22630627 Show fit	6.15	ENSDART00000193092	si:dkeyp-69c1.7 NCBI UniProt Show fit	si:dkeyp-69c1.7
chr25_+_6306885 Show fit	6.02	ENSDART00000142705 ENSDART00000067510	crabp1a NCBI UniProt Show fit	cellular retinoic acid binding protein 1a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	22.9	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.2	22.5	GO:0007160	cell-matrix adhesion(GO:0007160)
0.1	14.4	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.7	13.7	GO:0018023	peptidyl-lysine trimethylation(GO:0018023)
0.0	9.7	GO:0034765	regulation of ion transmembrane transport(GO:0034765)
0.1	9.3	GO:0014904	myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0	9.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.2	8.8	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3	8.8	GO:0007340	acrosome reaction(GO:0007340)
0.2	8.7	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)

Showing 1 to 10 of 144 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.0	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.5	8.8	GO:0030315	T-tubule(GO:0030315)
0.1	8.8	GO:0043197	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.5	8.6	GO:0005869	dynactin complex(GO:0005869)
0.1	8.3	GO:0045211	postsynaptic membrane(GO:0045211)
0.2	7.8	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	7.0	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.2	6.8	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3	5.9	GO:0031430	M band(GO:0031430)
1.8	5.5	GO:0060077	inhibitory synapse(GO:0060077)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	26.0	GO:0017080	sodium channel regulator activity(GO:0017080)
0.2	16.2	GO:0016278	lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2	14.8	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.2	11.0	GO:0005178	integrin binding(GO:0005178)
0.0	10.4	GO:0004930	G-protein coupled receptor activity(GO:0004930)
2.2	8.8	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2	8.7	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.0	8.1	GO:0001972	retinoic acid binding(GO:0001972)
0.0	7.4	GO:0003924	GTPase activity(GO:0003924)
0.0	7.1	GO:0005179	hormone activity(GO:0005179)

Showing 1 to 10 of 100 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	PID RAS PATHWAY	Regulation of Ras family activation
0.0	2.1	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.9	PID FGF PATHWAY	FGF signaling pathway
0.1	1.8	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	1.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	1.1	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	1.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.7	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.3	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.8	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	5.0	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	4.4	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.2	3.7	REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.9	3.4	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1	3.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	2.9	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	2.8	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3	2.6	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2	2.0	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters

Showing 1 to 10 of 25 entries

Results for pitx2

Z-value: 1.19

Motif logo

Transcription factors associated with pitx2

Activity-expression correlation:

Activity profile of pitx2 motif

Sorted Z-values of pitx2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: