ISMARA results: pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation

Downloads

Results for pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Z-value: 2.65

Motif logo

Transcription factors associated with pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Gene Symbol	Gene ID	Gene Info
pbx3b NCBI UniProt	ENSDARG00000013615	pre-B-cell leukemia homeobox 3b
pbx2 NCBI UniProt	ENSDARG00000019717	pre-B-cell leukemia homeobox 2
pbx3a NCBI UniProt	ENSDARG00000089262	pre-B-cell leukemia homeobox 3a
pbx1a NCBI UniProt	ENSDARG00000100494	pre-B-cell leukemia homeobox 1a
pbx1b NCBI UniProt	ENSDARG00000101131	pre-B-cell leukemia homeobox 1b
pbx3b NCBI UniProt	ENSDARG00000110194	pre-B-cell leukemia homeobox 3b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pbx3b	dr11_v1_chr8_-_34065573_34065573	0.66	7.9e-13	Click!
pbx1b	dr11_v1_chr6_+_2271559_2271559	0.61	7.8e-11	Click!
pbx1a	dr11_v1_chr2_-_18830722_18830783	0.60	2.4e-10	Click!
pbx3a	dr11_v1_chr5_-_5394335_5394468	0.42	2.8e-05	Click!
pbx2	dr11_v1_chr16_+_48631412_48631412	-0.27	8.5e-03	Click!

Activity profile of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_62380146 Show fit	41.50	ENSDART00000155853	gprc5ba NCBI UniProt Show fit	G protein-coupled receptor, class C, group 5, member Ba
chr22_-_13851297 Show fit	36.37	ENSDART00000080306	s100b NCBI UniProt Show fit	S100 calcium binding protein, beta (neural)
chr2_-_44283554 Show fit	26.20	ENSDART00000184684	mpz NCBI UniProt Show fit	myelin protein zero
chr18_+_13792490 Show fit	23.72	ENSDART00000136754	cdh13 NCBI UniProt Show fit	cadherin 13, H-cadherin (heart)
chr9_-_44295071 Show fit	21.83	ENSDART00000011837	neurod1 NCBI UniProt Show fit	neuronal differentiation 1
chr2_-_44946094 Show fit	21.38	ENSDART00000036997	camk2n1a NCBI UniProt Show fit	calcium/calmodulin-dependent protein kinase II inhibitor 1a
chr20_-_29420713 Show fit	21.23	ENSDART00000147464	ryr3 NCBI UniProt Show fit	ryanodine receptor 3
chr25_+_21324588 Show fit	21.17	ENSDART00000151842	lrrn3a NCBI UniProt Show fit	leucine rich repeat neuronal 3a
chr1_-_6494384 Show fit	20.61	ENSDART00000109356	klf7a NCBI UniProt Show fit	Kruppel-like factor 7a
chr9_+_27411502 Show fit	20.34	ENSDART00000143994	si:dkey-193n17.9 NCBI UniProt Show fit	si:dkey-193n17.9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx1b+pbx2+pbx3a+pbx3b

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	56.8	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.2	41.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.2	34.9	GO:0070831	basement membrane assembly(GO:0070831)
1.2	34.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.1	33.2	GO:0006813	potassium ion transport(GO:0006813)
1.1	32.4	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.0	31.9	GO:0051209	release of sequestered calcium ion into cytosol(GO:0051209)
0.6	31.6	GO:0071277	cellular response to calcium ion(GO:0071277)
0.3	25.2	GO:0007416	synapse assembly(GO:0007416)
0.1	24.5	GO:0070588	calcium ion transmembrane transport(GO:0070588)

Showing 1 to 10 of 227 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	52.8	GO:0005911	cell-cell junction(GO:0005911)
2.4	43.0	GO:0043209	myelin sheath(GO:0043209)
6.7	40.1	GO:0070062	extracellular exosome(GO:0070062)
0.6	36.2	GO:0031225	anchored component of membrane(GO:0031225)
0.3	35.1	GO:0043025	neuronal cell body(GO:0043025)
4.6	31.9	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
1.4	31.1	GO:0043256	basal lamina(GO:0005605) laminin complex(GO:0043256)
1.3	30.6	GO:0034706	voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1	27.9	GO:0005667	transcription factor complex(GO:0005667)
0.4	25.6	GO:0016342	catenin complex(GO:0016342)

Showing 1 to 10 of 93 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	185.6	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1	58.9	GO:0005509	calcium ion binding(GO:0005509)
0.7	41.5	GO:0019209	kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
1.9	40.9	GO:0046875	ephrin receptor binding(GO:0046875)
9.1	36.4	GO:0044548	S100 protein binding(GO:0044548)
0.2	36.1	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4	35.0	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.9	31.1	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.2	25.9	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.3	25.6	GO:0045296	cadherin binding(GO:0045296)

Showing 1 to 10 of 156 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	28.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	22.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.6	14.9	PID RAS PATHWAY	Regulation of Ras family activation
0.6	14.8	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	12.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.5	12.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.4	7.6	PID EPHB FWD PATHWAY	EPHB forward signaling
0.4	7.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5	6.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.4	6.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.0	36.4	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
1.1	26.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.8	18.8	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
1.1	16.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	12.8	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.1	12.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	10.4	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.4	9.8	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.2	8.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.3	8.0	REACTOME AMYLOIDS	Genes involved in Amyloids

Showing 1 to 10 of 44 entries

Results for pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Z-value: 2.65

Motif logo

Transcription factors associated with pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Activity-expression correlation:

Activity profile of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx1b+pbx2+pbx3a+pbx3b

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: