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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for patz1
Z-value: 1.93
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Transcription factors associated with patz1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| patz1 | dr11_v1_chr6_+_40951227_40951227 | 0.23 | 2.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of patz1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 47.8 | GO:0006813 | potassium ion transport(GO:0006813) |
| 9.3 | 46.5 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.1 | 33.9 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 1.9 | 30.4 | GO:0046051 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 2.9 | 29.4 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
| 2.1 | 29.1 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.6 | 25.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.2 | 24.5 | GO:0050684 | regulation of mRNA processing(GO:0050684) |
| 0.6 | 24.1 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) regulation of neurotransmitter transport(GO:0051588) |
| 0.2 | 24.1 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 47.9 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 1.9 | 46.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 3.4 | 34.0 | GO:0090533 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
| 0.2 | 33.2 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.1 | 30.9 | GO:0043005 | neuron projection(GO:0043005) |
| 0.6 | 29.8 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 29.2 | GO:0045202 | synapse(GO:0045202) |
| 2.4 | 28.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 27.4 | GO:0031012 | extracellular matrix(GO:0031012) |
| 1.5 | 26.2 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 49.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 2.3 | 47.9 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.8 | 44.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.9 | 37.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 1.0 | 30.4 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 1.0 | 28.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 1.3 | 26.5 | GO:0051393 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.5 | 24.2 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.4 | 24.1 | GO:0019209 | kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295) |
| 0.0 | 23.1 | GO:0046983 | protein dimerization activity(GO:0046983) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 32.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 2.2 | 19.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.3 | 14.0 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.4 | 7.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 5.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 5.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.4 | 4.9 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.9 | 4.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 4.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.3 | 4.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 47.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 2.7 | 46.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 1.2 | 22.0 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.9 | 18.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.8 | 18.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.0 | 14.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.9 | 11.2 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 9.8 | REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | Genes involved in Class I MHC mediated antigen processing & presentation |
| 0.7 | 9.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 1.2 | 8.1 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |