ISMARA results: otx2b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for otx2b

Z-value: 1.07

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Transcription factors associated with otx2b

Gene Symbol	Gene ID	Gene Info
otx2b NCBI UniProt	ENSDARG00000011235	orthodenticle homeobox 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
otx2b	dr11_v1_chr17_-_44249538_44249538	0.75	3.7e-18	Click!

Activity profile of otx2b motif

Sorted Z-values of otx2b motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_5103349 Show fit	21.18	ENSDART00000083474	atcaya NCBI UniProt Show fit	ataxia, cerebellar, Cayman type a
chr16_+_32059785 Show fit	17.88	ENSDART00000134459	si:dkey-40m6.8 NCBI UniProt Show fit	si:dkey-40m6.8
chr2_-_30784198 Show fit	16.31	ENSDART00000182523 ENSDART00000147355	rgs20 NCBI UniProt Show fit	regulator of G protein signaling 20
chr14_-_36378494 Show fit	15.62	ENSDART00000058503	gpm6aa NCBI UniProt Show fit	glycoprotein M6Aa
chr17_-_12389259 Show fit	12.62	ENSDART00000185724	snap25b NCBI UniProt Show fit	synaptosomal-associated protein, 25b
chr3_+_34919810 Show fit	12.54	ENSDART00000055264	ca10b NCBI UniProt Show fit	carbonic anhydrase Xb
chr11_-_29082429 Show fit	12.53	ENSDART00000041443	igsf21a NCBI UniProt Show fit	immunoglobin superfamily, member 21a
chr14_-_4273396 Show fit	11.78	ENSDART00000127318	frmpd1b NCBI UniProt Show fit	FERM and PDZ domain containing 1b
chr15_+_33070939 Show fit	11.43	ENSDART00000164928	mab21l1 NCBI UniProt Show fit	mab-21-like 1
chr11_-_29082175 Show fit	11.42	ENSDART00000123245	igsf21a NCBI UniProt Show fit	immunoglobin superfamily, member 21a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of otx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	24.0	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.9	21.2	GO:0006798	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
5.0	15.1	GO:0014814	regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
1.2	14.7	GO:0030202	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0	13.3	GO:0031175	neuron projection development(GO:0031175)
0.9	12.6	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.2	12.5	GO:0036269	swimming behavior(GO:0036269)
2.0	12.0	GO:0035313	wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.2	8.7	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.1	8.4	GO:0060027	convergent extension involved in gastrulation(GO:0060027)

Showing 1 to 10 of 83 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.9	GO:0005912	adherens junction(GO:0005912)
1.3	15.6	GO:0044295	axonal growth cone(GO:0044295)
0.0	13.3	GO:0005856	cytoskeleton(GO:0005856)
2.1	12.6	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	9.9	GO:0000139	Golgi membrane(GO:0000139)
0.0	9.7	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	8.6	GO:0005794	Golgi apparatus(GO:0005794)
0.7	7.5	GO:0098833	presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1	7.3	GO:0043025	neuronal cell body(GO:0043025)
0.1	7.1	GO:0005891	voltage-gated calcium channel complex(GO:0005891)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	21.2	GO:0004309	exopolyphosphatase activity(GO:0004309)
0.1	18.0	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	13.9	GO:0005096	GTPase activator activity(GO:0005096)
0.0	12.9	GO:0008270	zinc ion binding(GO:0008270)
0.3	12.6	GO:0017075	syntaxin-1 binding(GO:0017075)
0.4	12.5	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	12.5	GO:0000989	transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.1	12.1	GO:0042802	identical protein binding(GO:0042802)
0.1	11.4	GO:0016779	nucleotidyltransferase activity(GO:0016779)
0.0	11.2	GO:0008017	microtubule binding(GO:0008017)

Showing 1 to 10 of 69 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	16.3	ST G ALPHA I PATHWAY	G alpha i Pathway
0.9	15.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	3.8	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	3.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	2.9	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	2.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	1.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.7	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.3	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	16.3	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.1	6.8	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.2	6.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	5.3	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.3	4.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.3	3.7	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	3.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	2.7	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	2.0	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.1	1.3	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling

Showing 1 to 10 of 13 entries

Results for otx2b

Z-value: 1.07

Motif logo

Transcription factors associated with otx2b

Activity-expression correlation:

Activity profile of otx2b motif

Sorted Z-values of otx2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of otx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: