ISMARA results: onecut3a+onecut3b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for onecut3a+onecut3b

Z-value: 1.18

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Transcription factors associated with onecut3a+onecut3b

Gene Symbol	Gene ID	Gene Info
onecut3a NCBI UniProt	ENSDARG00000056395	one cut homeobox 3a
onecut3b NCBI UniProt	ENSDARG00000091059	one cut homeobox 3b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
onecut3a	dr11_v1_chr22_+_20461488_20461488	0.37	2.0e-04	Click!

Activity profile of onecut3a+onecut3b motif

Sorted Z-values of onecut3a+onecut3b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_35748385 Show fit	18.87	ENSDART00000064617 ENSDART00000074671 ENSDART00000172803	gria2b NCBI UniProt Show fit	glutamate receptor, ionotropic, AMPA 2b
chr14_+_35748206 Show fit	18.71	ENSDART00000177391	gria2b NCBI UniProt Show fit	glutamate receptor, ionotropic, AMPA 2b
chr1_-_21409877 Show fit	18.47	ENSDART00000102782	gria2a NCBI UniProt Show fit	glutamate receptor, ionotropic, AMPA 2a
chr19_+_25649626 Show fit	17.47	ENSDART00000146947	tac1 NCBI UniProt Show fit	tachykinin 1
chr6_+_3828560 Show fit	16.10	ENSDART00000185273 ENSDART00000179091	gad1b NCBI UniProt Show fit	glutamate decarboxylase 1b
chr19_-_17526735 Show fit	15.15	ENSDART00000189391	thrb NCBI UniProt Show fit	thyroid hormone receptor beta
chr2_+_47581997 Show fit	14.45	ENSDART00000112579	scg2b NCBI UniProt Show fit	secretogranin II (chromogranin C), b
chr16_-_12173554 Show fit	13.93	ENSDART00000110567 ENSDART00000155935	clstn3 NCBI UniProt Show fit	calsyntenin 3
chr8_-_14052349 Show fit	13.47	ENSDART00000135811	atp2b3a NCBI UniProt Show fit	ATPase plasma membrane Ca2+ transporting 3a
chr4_-_5291256 Show fit	13.24	ENSDART00000150864	SNAP91 (1 of many) NCBI UniProt Show fit	si:ch211-214j24.9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut3a+onecut3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	20.9	GO:1903670	regulation of sprouting angiogenesis(GO:1903670)
2.3	20.5	GO:0051965	positive regulation of synapse assembly(GO:0051965)
1.2	18.5	GO:0048899	anterior lateral line development(GO:0048899)
3.5	17.5	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
5.4	16.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.8	15.2	GO:0042671	retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.7	11.5	GO:0015693	magnesium ion transport(GO:0015693)
0.5	11.2	GO:0015701	bicarbonate transport(GO:0015701)
0.1	10.0	GO:0006836	neurotransmitter transport(GO:0006836)
1.0	9.9	GO:0071300	cellular response to retinoic acid(GO:0071300)

Showing 1 to 10 of 95 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	56.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	31.6	GO:0030424	axon(GO:0030424)
0.2	20.9	GO:0030141	secretory granule(GO:0030141)
0.1	17.7	GO:0045211	postsynaptic membrane(GO:0045211)
0.0	16.5	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	14.5	GO:0009986	cell surface(GO:0009986)
0.8	11.5	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	11.2	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	10.5	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	9.9	GO:0043025	neuronal cell body(GO:0043025)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	56.1	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
5.8	17.5	GO:0031834	neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
5.4	16.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
3.8	15.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.5	13.5	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.1	12.3	GO:0035091	phosphatidylinositol binding(GO:0035091)
0.8	11.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	10.2	GO:0005509	calcium ion binding(GO:0005509)
0.0	10.1	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
3.2	9.7	GO:0015218	pyrimidine nucleotide transmembrane transporter activity(GO:0015218)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	15.2	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	12.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	5.8	PID LKB1 PATHWAY	LKB1 signaling events
0.1	3.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	3.4	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	2.9	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	2.8	PID AURORA A PATHWAY	Aurora A signaling
0.1	2.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	2.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	17.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	11.2	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	11.1	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
0.6	6.7	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.6	5.8	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.3	5.8	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2	4.6	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.2	3.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	3.6	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.2	3.4	REACTOME CGMP EFFECTS	Genes involved in cGMP effects

Showing 1 to 10 of 23 entries

Results for onecut3a+onecut3b

Z-value: 1.18

Motif logo

Transcription factors associated with onecut3a+onecut3b

Activity-expression correlation:

Activity profile of onecut3a+onecut3b motif

Sorted Z-values of onecut3a+onecut3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut3a+onecut3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: