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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for onecut3a+onecut3b

Z-value: 1.18

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Transcription factors associated with onecut3a+onecut3b

Gene Symbol Gene ID Gene Info
ENSDARG00000056395 one cut homeobox 3a
ENSDARG00000091059 one cut homeobox 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
onecut3adr11_v1_chr22_+_20461488_204614880.372.0e-04Click!

Activity profile of onecut3a+onecut3b motif

Sorted Z-values of onecut3a+onecut3b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_35748385 18.87 ENSDART00000064617
ENSDART00000074671
ENSDART00000172803
glutamate receptor, ionotropic, AMPA 2b
chr14_+_35748206 18.71 ENSDART00000177391
glutamate receptor, ionotropic, AMPA 2b
chr1_-_21409877 18.47 ENSDART00000102782
glutamate receptor, ionotropic, AMPA 2a
chr19_+_25649626 17.47 ENSDART00000146947
tachykinin 1
chr6_+_3828560 16.10 ENSDART00000185273
ENSDART00000179091
glutamate decarboxylase 1b
chr19_-_17526735 15.15 ENSDART00000189391
thyroid hormone receptor beta
chr2_+_47581997 14.45 ENSDART00000112579
secretogranin II (chromogranin C), b
chr16_-_12173554 13.93 ENSDART00000110567
ENSDART00000155935
calsyntenin 3
chr8_-_14052349 13.47 ENSDART00000135811
ATPase plasma membrane Ca2+ transporting 3a
chr4_-_5291256 13.24 ENSDART00000150864
si:ch211-214j24.9
chr3_-_28665291 12.63 ENSDART00000151670
F-box and leucine-rich repeat protein 16
chr10_-_31782616 11.81 ENSDART00000128839
fasciculation and elongation protein zeta 1 (zygin I)
chr1_+_16144615 11.49 ENSDART00000054707
tumor suppressor candidate 3
chr18_+_642889 11.48 ENSDART00000189007

chr11_-_10798021 11.15 ENSDART00000167112
ENSDART00000179725
ENSDART00000091923
ENSDART00000185825
solute carrier family 4, sodium bicarbonate transporter, member 10a
chr25_-_11088839 10.01 ENSDART00000154748
synaptic vesicle glycoprotein 2Bb
chr5_-_71460556 9.89 ENSDART00000108804
bone morphogenetic protein/retinoic acid inducible neural-specific 1
chr2_-_39759059 9.70 ENSDART00000007333
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a
chr24_-_23320223 9.26 ENSDART00000135846
zinc finger homeobox 4
chr17_-_20897250 8.81 ENSDART00000088106
ankyrin 3b
chr14_+_21783229 8.79 ENSDART00000170784
ankyrin repeat domain 13 family, member D
chr2_+_5887626 8.12 ENSDART00000147831
si:ch211-168b3.1
chr20_-_30931139 7.97 ENSDART00000006778
ENSDART00000146376
acetyl-CoA acetyltransferase 2
chr17_+_23937262 7.87 ENSDART00000113276
si:ch211-189k9.2
chr10_+_10801719 7.86 ENSDART00000193648
alpha-1-microglobulin/bikunin precursor
chr21_-_17482465 7.73 ENSDART00000004548
BarH-like homeobox 1b
chr10_-_15405564 7.67 ENSDART00000020665
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr1_-_23157583 7.49 ENSDART00000144208
adhesion G protein-coupled receptor L3.1
chr11_+_6819050 7.32 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr5_+_19309877 7.27 ENSDART00000190338
RUN and SH3 domain containing 2
chr23_+_12454542 7.25 ENSDART00000182259
ENSDART00000193043
si:ch211-153a8.4
chr11_+_25064519 6.89 ENSDART00000016181
ndrg family member 3a
chr3_+_39853788 6.88 ENSDART00000154869
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr16_-_12173399 6.58 ENSDART00000142574
calsyntenin 3
chr15_-_34418525 6.47 ENSDART00000147582
alkylglycerol monooxygenase
chr2_+_47582488 6.41 ENSDART00000149967
secretogranin II (chromogranin C), b
chr25_-_9805269 6.41 ENSDART00000192048
leucine rich repeat containing 4C
chr3_-_28120092 6.24 ENSDART00000151143
RNA binding fox-1 homolog 1
chr15_+_17441734 5.97 ENSDART00000153729
sorting nexin 19b
chr23_-_28025943 5.79 ENSDART00000181146
Sp5 transcription factor-like
chr21_+_3901775 5.79 ENSDART00000053609
dolichyldiphosphatase 1
chr6_-_17999776 5.75 ENSDART00000183048
ENSDART00000181577
ENSDART00000170597
regulatory associated protein of MTOR, complex 1
chr18_-_20560007 5.70 ENSDART00000141367
ENSDART00000090186
si:ch211-238n5.4
chr13_+_36144341 5.67 ENSDART00000182930
ENSDART00000187327
si:ch211-259k16.3
chr18_-_44611252 5.37 ENSDART00000173095
sprouty-related, EVH1 domain containing 3
chr21_-_43482426 5.33 ENSDART00000192901
ankyrin repeat domain 46a
chr2_-_56387041 5.01 ENSDART00000036240
ceramide synthase 4b
chr21_-_23475361 5.00 ENSDART00000156658
ENSDART00000157454
neural cell adhesion molecule 1a
chr2_+_42871831 4.99 ENSDART00000171393
EFR3 homolog A (S. cerevisiae)
chr2_-_32505091 4.89 ENSDART00000141884
ENSDART00000056639
Fas apoptotic inhibitory molecule 2a
chr7_-_49651378 4.86 ENSDART00000015040
-Ha-ras Harvey rat sarcoma viral oncogene homolog b
chr4_-_4261673 4.78 ENSDART00000150694
CD9 molecule b
chr9_+_32358514 4.75 ENSDART00000144608
phospholipase C like 1
chr4_+_7827261 4.62 ENSDART00000129568
phytanoyl-CoA 2-hydroxylase
chr22_+_17359346 4.60 ENSDART00000145434
G protein-coupled receptor 52
chr23_+_28770225 4.55 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr1_-_36151377 4.49 ENSDART00000037516
zinc finger protein 827
chr7_+_63325819 4.41 ENSDART00000085612
ENSDART00000161436
protocadherin 7b
chr14_+_36628131 4.36 ENSDART00000188625
ENSDART00000125345
si:dkey-237h12.3
chr19_-_18855513 4.33 ENSDART00000162708
palmitoyl-protein thioesterase 2
chr2_+_44781185 4.30 ENSDART00000187103
ENSDART00000147292
ENSDART00000098123
endothelin converting enzyme 2a
chr5_+_50788329 4.25 ENSDART00000050979
family with sequence similarity 81, member B
chr17_-_8169774 4.16 ENSDART00000091828
spectrin repeat containing, nuclear envelope 1b
chr19_-_18855717 4.04 ENSDART00000158192
palmitoyl-protein thioesterase 2
chr23_-_15216654 4.04 ENSDART00000131649
sulfatase 2b
chr14_-_4044545 3.96 ENSDART00000169527
sorting nexin 25
chr24_-_15131831 3.93 ENSDART00000028410
CD226 molecule
chr2_+_25860344 3.88 ENSDART00000178841
solute carrier family 7, member 14a
chr7_+_40658003 3.87 ENSDART00000172435
limb development membrane protein 1
chr3_+_32443395 3.83 ENSDART00000188447
proline rich 12b
chr3_-_30434016 3.71 ENSDART00000150958
leucine rich repeat containing 4Ba
chr11_+_5817202 3.67 ENSDART00000126084
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3
chr2_+_21309272 3.65 ENSDART00000141322
zinc finger and BTB domain containing 47a
chr20_-_3403033 3.63 ENSDART00000092264
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr10_-_28835771 3.61 ENSDART00000192220
ENSDART00000188436
activated leukocyte cell adhesion molecule a
chr15_+_17446796 3.52 ENSDART00000157189
sorting nexin 19b
chr6_-_58764672 3.44 ENSDART00000154322
sterol O-acyltransferase 2
chr9_+_19421841 3.43 ENSDART00000159090
ENSDART00000084771
phosphodiesterase 9A
chr19_-_21766461 3.39 ENSDART00000104279
zinc finger protein 516
chr12_+_10116912 3.39 ENSDART00000189630
si:dkeyp-118b1.2
chr12_+_32729470 3.28 ENSDART00000175712
RNA binding fox-1 homolog 3a
chr11_+_24815667 3.24 ENSDART00000141730
RAB interacting factor
chr8_+_9866351 3.19 ENSDART00000133985
potassium voltage-gated channel, Shal-related subfamily, member 1
chr14_+_11946395 3.18 ENSDART00000193290
FERM and PDZ domain containing 3
chr17_-_20897407 3.17 ENSDART00000149481
ankyrin 3b
chr15_+_11381532 3.10 ENSDART00000124172
si:ch73-321d9.2
chr21_-_39058490 2.99 ENSDART00000114885
aldehyde dehydrogenase 3 family, member A2b
chr3_+_1492174 2.95 ENSDART00000112979
SRY (sex determining region Y)-box 10
chr10_+_7593185 2.86 ENSDART00000162617
ENSDART00000162590
ENSDART00000171744
protein phosphatase 2, catalytic subunit, beta isozyme
chr1_-_46663997 2.86 ENSDART00000134450
emopamil binding protein-like
chr25_-_13789955 2.80 ENSDART00000167742
ENSDART00000165116
ENSDART00000171461
cytoskeleton associated protein 5
chr14_-_31893996 2.74 ENSDART00000173222
G protein-coupled receptor 101
chr21_-_41369370 2.71 ENSDART00000159290
cytoplasmic polyadenylation element binding protein 4b
chr11_+_25259058 2.68 ENSDART00000154109
tumor protein p53 inducible nuclear protein 2
chr17_-_45247332 2.61 ENSDART00000016815
tau tubulin kinase 2a
chr6_-_40352215 2.47 ENSDART00000103992
tubulin tyrosine ligase-like family, member 3
chr22_-_3564563 2.46 ENSDART00000145114
protein tyrosine phosphatase, receptor type, s, a
chr12_-_43428542 2.39 ENSDART00000192266
protein tyrosine phosphatase, receptor type, E, a
chr16_-_44127307 2.35 ENSDART00000104583
ENSDART00000151936
ENSDART00000058685
ENSDART00000190830
zinc finger protein, FOG family member 2a
chr3_-_48612078 2.35 ENSDART00000169923
nudE neurodevelopment protein 1-like 1b
chr11_+_24815927 2.34 ENSDART00000146838
RAB interacting factor
chr16_-_54942532 2.25 ENSDART00000078887
ENSDART00000101402
transmembrane protein 222a
chr23_+_25832689 2.19 ENSDART00000138907
hepatocyte nuclear factor 4, alpha
chr7_+_73649686 2.16 ENSDART00000185589
si:dkey-46i9.1
chr20_-_23171430 2.14 ENSDART00000109234
spermatogenesis associated 18
chr24_-_38113208 2.11 ENSDART00000079003
c-reactive protein, pentraxin-related
chr1_+_51391082 2.06 ENSDART00000063936
autophagy related 4D, cysteine peptidase a
chr9_-_20853439 2.04 ENSDART00000028247
ENSDART00000133321
ganglioside induced differentiation associated protein 2
chr10_-_11840353 2.02 ENSDART00000127581
tripartite motif containing 23
chr6_-_16456093 2.00 ENSDART00000083305
ENSDART00000181640
solute carrier family 19 (thiamine transporter), member 2
chr16_-_26435431 1.98 ENSDART00000187526
multiple EGF-like-domains 8
chr12_-_47793857 1.94 ENSDART00000161294
DPY30 domain containing 2
chr16_+_21738194 1.93 ENSDART00000163688
Danio rerio si:ch211-154o6.4 (si:ch211-154o6.4), mRNA.
chr9_+_27329640 1.93 ENSDART00000111039
si:rp71-84d19.3
chr13_-_37383625 1.91 ENSDART00000192888
ENSDART00000100322
ENSDART00000138934
potassium voltage-gated channel, subfamily H (eag-related), member 5b
chr17_-_14451405 1.91 ENSDART00000146786
jnk1/mapk8 associated membrane protein
chr2_-_6112862 1.86 ENSDART00000164269
peroxiredoxin 1
chr8_-_23081511 1.85 ENSDART00000142015
ENSDART00000135764
ENSDART00000147021
si:dkey-70p6.1
chr12_+_48204891 1.85 ENSDART00000190534
ENSDART00000164427
nodal-related 2
chr7_-_24022340 1.83 ENSDART00000149133
cell death-inducing DFFA-like effector b
chr7_-_56831621 1.81 ENSDART00000182912
SUMO/sentrin peptidase family member, NEDD8 specific
chr13_-_31166544 1.81 ENSDART00000146250
ENSDART00000132129
ENSDART00000139591
mitogen-activated protein kinase 8a
chr13_-_4664403 1.81 ENSDART00000023803
ENSDART00000177957
C1D nuclear receptor corepressor
chr4_+_27018663 1.80 ENSDART00000180778

chr22_-_38360205 1.72 ENSDART00000162055
MAP/microtubule affinity-regulating kinase 1
chr4_+_8016457 1.70 ENSDART00000014036
optineurin
chr20_+_23440632 1.64 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr3_+_39958407 1.64 ENSDART00000099754
coiled-coil domain containing 97
chr8_-_14484599 1.60 ENSDART00000057644
LIM homeobox 4
chr18_+_3579829 1.52 ENSDART00000158763
ENSDART00000182850
ENSDART00000162754
ENSDART00000178789
ENSDART00000172656
leucine-rich repeats and calponin homology (CH) domain containing 3
chr1_+_37391716 1.51 ENSDART00000191986
SPARC-like 1
chr4_-_76488854 1.50 ENSDART00000132323
finTRIM family, member 51
chr13_-_30713236 1.49 ENSDART00000112372
ENSDART00000142221
transmembrane protein 72
chr5_-_57652168 1.49 ENSDART00000166245
expressed sequence EH456644
chr18_+_15876385 1.48 ENSDART00000142527
early endosome antigen 1
chr4_+_25691642 1.42 ENSDART00000139053
acyl-CoA thioesterase 18
chr9_+_38503233 1.39 ENSDART00000140331
leishmanolysin-like (metallopeptidase M8 family)
chr10_-_28761454 1.38 ENSDART00000129400
activated leukocyte cell adhesion molecule a
chr2_+_45300512 1.33 ENSDART00000144704
calmodulin regulated spectrin-associated protein family, member 2b
chr12_+_47794089 1.30 ENSDART00000160726
polymerase (RNA) III (DNA directed) polypeptide A
chr8_+_40477264 1.27 ENSDART00000085559
glucokinase (hexokinase 4)
chr5_+_56268436 1.25 ENSDART00000021159
LIM homeobox 1b
chr17_-_26507289 1.24 ENSDART00000155616
coiled-coil serine-rich protein 2a
chr14_+_49376011 1.23 ENSDART00000020961
TNFAIP3 interacting protein 1
chr6_+_40992409 1.22 ENSDART00000151419
transforming growth factor, alpha
chr3_-_60142530 1.21 ENSDART00000153247
si:ch211-120g10.1
chr24_+_23730061 1.15 ENSDART00000080343
protein phosphatase 1, regulatory subunit 42
chr13_+_49727333 1.15 ENSDART00000168799
ENSDART00000037559
geranylgeranyl diphosphate synthase 1
chr20_+_16639848 1.13 ENSDART00000063944
ENSDART00000152359
transmembrane protein 30Ab
chr5_+_58455488 1.12 ENSDART00000038602
ENSDART00000127958
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr11_+_37201483 1.11 ENSDART00000160930
ENSDART00000173439
ENSDART00000171273
zgc:112265
chr19_+_11984725 1.10 ENSDART00000185960
sperm associated antigen 1a
chr21_+_6212844 1.06 ENSDART00000150301
formin binding protein 1b
chr7_-_68419830 0.99 ENSDART00000191606

chr22_-_7669624 0.98 ENSDART00000189617

chr5_+_3118231 0.96 ENSDART00000179809
SPT4 homolog, DSIF elongation factor subunit
chr18_-_44847855 0.96 ENSDART00000086823
signal recognition particle receptor (docking protein)
chr7_-_41693004 0.91 ENSDART00000121509
MAM and LDL receptor class A domain containing 1
chr16_-_26255877 0.91 ENSDART00000146214
Ets2 repressor factor like 1
chr2_+_13462305 0.90 ENSDART00000149309
ENSDART00000080900
cilia and flagella associated protein 57
chr12_-_35582683 0.89 ENSDART00000167933
SEC24 homolog C, COPII coat complex component
chr2_-_17044959 0.87 ENSDART00000090260
chloride channel, voltage-sensitive 2a
chr1_+_47391404 0.86 ENSDART00000113559
B cell CLL/lymphoma 9
chr1_+_12177195 0.82 ENSDART00000146842
ENSDART00000142081
STRA6-like
chr25_+_22017182 0.76 ENSDART00000156517
si:dkey-217l24.1
chr3_-_58165254 0.75 ENSDART00000093031
SNU13 homolog, small nuclear ribonucleoprotein a (U4/U6.U5)
chr19_+_43256986 0.74 ENSDART00000182336
diacylglycerol kinase delta
chr6_-_33707278 0.68 ENSDART00000188103
microtubule associated serine/threonine kinase 2
chr7_-_36096582 0.68 ENSDART00000188507

chr16_-_2650341 0.68 ENSDART00000128169
ENSDART00000155432
ENSDART00000103722
lysophospholipase-like 1
chr15_+_21947117 0.68 ENSDART00000156234
tetratricopeptide repeat domain 12
chr20_+_42978499 0.67 ENSDART00000138793
si:ch211-203k16.3
chr11_+_691734 0.67 ENSDART00000191463
TIMP metallopeptidase inhibitor 4, tandem duplicate 1
chr16_+_23960744 0.64 ENSDART00000058965
apolipoprotein Eb
chr3_+_24050043 0.62 ENSDART00000151788
chromobox homolog 1a (HP1 beta homolog Drosophila)
chr8_+_12925385 0.57 ENSDART00000085377
zgc:103670
chr16_+_33655890 0.57 ENSDART00000143757
four and a half LIM domains 3a
chr9_+_907459 0.54 ENSDART00000034850
ENSDART00000144114
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr2_-_59145027 0.54 ENSDART00000128320

chr20_-_40367493 0.53 ENSDART00000075096
sphingomyelin phosphodiesterase, acid-like 3A
chr12_-_18883079 0.53 ENSDART00000178619
shisa family member 8b
chr22_-_3092136 0.53 ENSDART00000157620
inhibitor of growth family, member 5a
chr22_-_16494406 0.50 ENSDART00000062727
syntaxin 6
chr24_-_25030173 0.48 ENSDART00000126395
ENSDART00000019350
nucleoporin 58
chr15_-_7598542 0.47 ENSDART00000173092
glucan (1,4-alpha-), branching enzyme 1b
chr22_-_9839003 0.45 ENSDART00000193573
si:dkey-253d23.2
chr22_+_9872323 0.34 ENSDART00000129240
si:dkey-253d23.4
chr16_-_47426482 0.30 ENSDART00000148631
ENSDART00000149723
septin 7b
chr10_-_28477023 0.28 ENSDART00000137008
bobby sox homolog (Drosophila)
chr15_-_7598294 0.20 ENSDART00000165898
glucan (1,4-alpha-), branching enzyme 1b
chr2_-_39086540 0.20 ENSDART00000110826
si:ch73-170l17.1
chr22_+_25554232 0.16 ENSDART00000131218
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr19_-_874888 0.13 ENSDART00000007206
eomesodermin homolog a
chr3_+_32689707 0.12 ENSDART00000029262
si:dkey-16l2.17
chr21_+_18877130 0.11 ENSDART00000136893
si:dkey-65l23.2
chr19_-_48039400 0.11 ENSDART00000166748
ENSDART00000165921
colony stimulating factor 3 (granulocyte) b
chr16_-_26232411 0.09 ENSDART00000139355
Rho guanine nucleotide exchange factor (GEF) 1b
chr11_-_22605981 0.09 ENSDART00000186923
myogenin
chr20_+_34151670 0.08 ENSDART00000152870
ENSDART00000010329
ENSDART00000145852
actin related protein 2/3 complex, subunit 5B
chr16_+_35728992 0.04 ENSDART00000158442
MAP7 domain containing 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut3a+onecut3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.8 15.2 GO:0042671 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
3.5 17.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
3.2 9.7 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
2.8 2.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
2.6 7.7 GO:1903334 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
2.4 7.3 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
2.3 20.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.7 5.0 GO:0021961 posterior commissure morphogenesis(GO:0021961)
1.3 3.9 GO:0002347 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.3 6.5 GO:0046485 ether lipid metabolic process(GO:0046485)
1.2 18.5 GO:0048899 anterior lateral line development(GO:0048899)
1.1 3.4 GO:0046069 cGMP catabolic process(GO:0046069)
1.0 9.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.9 5.4 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.7 11.5 GO:0015693 magnesium ion transport(GO:0015693)
0.7 4.6 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.5 4.7 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.5 20.9 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.5 11.2 GO:0015701 bicarbonate transport(GO:0015701)
0.4 1.7 GO:0090161 Golgi ribbon formation(GO:0090161)
0.4 6.9 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.4 3.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.4 2.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.4 3.4 GO:0034433 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.4 1.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 5.4 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.3 1.8 GO:0001709 cell fate determination(GO:0001709)
0.3 4.0 GO:0010573 vascular endothelial growth factor production(GO:0010573) regulation of vascular endothelial growth factor production(GO:0010574) positive regulation of vascular endothelial growth factor production(GO:0010575) esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.3 4.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 5.8 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.2 1.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 0.6 GO:0034380 high-density lipoprotein particle assembly(GO:0034380) chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.2 2.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 2.1 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.2 1.6 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 2.0 GO:0045117 azole transport(GO:0045117)
0.2 8.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 1.9 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 2.2 GO:0070365 hepatocyte differentiation(GO:0070365)
0.2 5.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.2 4.2 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.2 0.8 GO:0071938 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.2 7.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 7.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 3.6 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 2.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 0.7 GO:0032655 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.1 1.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 5.0 GO:0060536 cartilage morphogenesis(GO:0060536)
0.1 6.2 GO:0021854 hypothalamus development(GO:0021854)
0.1 1.3 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 1.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.1 0.7 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 7.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.9 GO:0061316 canonical Wnt signaling pathway involved in heart development(GO:0061316) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 7.2 GO:0007098 centrosome cycle(GO:0007098)
0.1 5.6 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 1.4 GO:0048885 neuromast deposition(GO:0048885)
0.1 4.8 GO:0048916 posterior lateral line development(GO:0048916)
0.1 2.7 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.1 5.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 10.0 GO:0006836 neurotransmitter transport(GO:0006836)
0.1 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 3.6 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 2.0 GO:0060972 left/right pattern formation(GO:0060972)
0.1 3.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 1.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.7 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.8 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 1.8 GO:1903038 negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0 2.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.1 GO:0060571 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.0 0.8 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.9 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 5.0 GO:1990778 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 1.1 GO:0045332 phospholipid translocation(GO:0045332)
0.0 2.1 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 1.7 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 1.1 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 1.0 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 5.3 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.5 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 3.2 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 4.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0048278 vesicle docking(GO:0048278)
0.0 1.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.4 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 1.1 GO:0016125 sterol metabolic process(GO:0016125)
0.0 0.7 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 2.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 GO:0072380 TRC complex(GO:0072380)
1.8 7.2 GO:0005880 nuclear microtubule(GO:0005880)
1.3 56.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.8 11.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.7 5.7 GO:0031931 TORC1 complex(GO:0031931)
0.3 1.0 GO:0032044 DSIF complex(GO:0032044)
0.3 6.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.3 3.6 GO:0042575 DNA polymerase complex(GO:0042575)
0.2 20.9 GO:0030141 secretory granule(GO:0030141)
0.2 4.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 2.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 0.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 10.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 2.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 9.9 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.8 GO:0000178 exosome (RNase complex)(GO:0000178)
0.1 31.6 GO:0030424 axon(GO:0030424)
0.1 1.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 11.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 17.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 7.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 2.6 GO:0035869 ciliary transition zone(GO:0035869)
0.1 5.9 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 4.4 GO:0005776 autophagosome(GO:0005776)
0.1 8.8 GO:0005770 late endosome(GO:0005770)
0.1 1.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 6.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.9 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 2.5 GO:0005930 axoneme(GO:0005930)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 16.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 14.5 GO:0009986 cell surface(GO:0009986)
0.0 0.5 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.8 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 7.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.1 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 1.7 GO:0036477 dendrite(GO:0030425) somatodendritic compartment(GO:0036477)
0.0 0.6 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.5 GO:0031834 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
5.4 16.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
3.8 15.2 GO:0070324 thyroid hormone binding(GO:0070324)
3.7 56.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
3.2 9.7 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
2.7 8.0 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
1.0 6.9 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.9 3.4 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.8 2.5 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.8 11.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.7 6.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.5 3.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 13.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.4 2.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 1.1 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.3 5.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 3.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 1.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 3.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.3 1.8 GO:0070698 type I activin receptor binding(GO:0070698)
0.2 2.0 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.2 4.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 4.7 GO:0050811 GABA receptor binding(GO:0050811)
0.2 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 1.3 GO:0005536 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 1.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 0.7 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.2 2.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 3.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 4.9 GO:0019003 GDP binding(GO:0019003)
0.1 1.2 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.3 GO:0030507 spectrin binding(GO:0030507)
0.1 1.7 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 5.8 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 7.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.6 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 12.3 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 1.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.3 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 5.0 GO:0060090 binding, bridging(GO:0060090)
0.0 1.1 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 1.5 GO:0005518 collagen binding(GO:0005518)
0.0 2.1 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 10.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.7 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 2.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.9 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 4.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 7.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 8.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 6.6 GO:0008017 microtubule binding(GO:0008017)
0.0 3.5 GO:0042802 identical protein binding(GO:0042802)
0.0 4.7 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 3.4 GO:0030246 carbohydrate binding(GO:0030246)
0.0 3.7 GO:0008168 methyltransferase activity(GO:0008168)
0.0 10.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.4 GO:0000149 SNARE binding(GO:0000149)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 15.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.8 PID LKB1 PATHWAY LKB1 signaling events
0.1 1.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.8 PID AURORA A PATHWAY Aurora A signaling
0.1 3.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 12.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 2.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 1.8 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.6 5.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.4 17.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 5.8 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 3.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 2.9 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 3.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 4.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 11.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 11.1 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 3.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.0 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 2.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 3.6 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades