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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for onecut2

Z-value: 1.43

Motif logo

Transcription factors associated with onecut2

Gene Symbol Gene ID Gene Info
ENSDARG00000090387 one cut homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
onecut2dr11_v1_chr21_-_1742159_17421590.622.6e-11Click!

Activity profile of onecut2 motif

Sorted Z-values of onecut2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_37201483 22.50 ENSDART00000160930
ENSDART00000173439
ENSDART00000171273
zgc:112265
chr23_+_28770225 19.16 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr1_-_21409877 16.96 ENSDART00000102782
glutamate receptor, ionotropic, AMPA 2a
chr6_+_3828560 16.45 ENSDART00000185273
ENSDART00000179091
glutamate decarboxylase 1b
chr12_-_22524388 16.24 ENSDART00000020942
sex hormone-binding globulin
chr15_-_26552393 15.41 ENSDART00000150152
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr10_+_10801719 13.84 ENSDART00000193648
alpha-1-microglobulin/bikunin precursor
chr2_-_39759059 13.68 ENSDART00000007333
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a
chr15_-_26552652 13.49 ENSDART00000152336
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr19_+_4916233 12.41 ENSDART00000159512
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_+_26628822 11.29 ENSDART00000191030
ENSDART00000186113
ENSDART00000186764
ENSDART00000165158
IQ motif and Sec7 domain 3a
chr7_+_20535869 10.73 ENSDART00000078181
zgc:158423
chr23_+_25832689 10.44 ENSDART00000138907
hepatocyte nuclear factor 4, alpha
chr9_+_44430705 10.08 ENSDART00000190696
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr5_-_29643930 9.98 ENSDART00000161250
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr8_-_45279411 9.05 ENSDART00000175207
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr9_+_44430974 9.03 ENSDART00000056846
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr25_-_9805269 8.80 ENSDART00000192048
leucine rich repeat containing 4C
chr1_+_16144615 8.79 ENSDART00000054707
tumor suppressor candidate 3
chr24_+_25692802 8.39 ENSDART00000190493
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr18_+_50276653 8.32 ENSDART00000192120
si:dkey-105e17.1
chr20_-_40755614 8.26 ENSDART00000061247
connexin 32.3
chr21_+_19070921 8.13 ENSDART00000029874
NK6 homeobox 1
chr3_-_28665291 7.99 ENSDART00000151670
F-box and leucine-rich repeat protein 16
chr4_+_13810811 7.89 ENSDART00000067168
PDZ domain containing ring finger 4
chr19_-_17526735 7.85 ENSDART00000189391
thyroid hormone receptor beta
chr18_+_642889 7.53 ENSDART00000189007

chr4_-_8903240 7.52 ENSDART00000129983
metallophosphoesterase domain containing 1
chr2_+_5563077 7.45 ENSDART00000111220
Mab-21 domain containing 2
chr21_+_3901775 7.35 ENSDART00000053609
dolichyldiphosphatase 1
chr1_-_9249943 7.33 ENSDART00000055011
zgc:136472
chr17_-_25737452 7.33 ENSDART00000152021
si:ch211-214p16.3
chr4_-_5291256 7.29 ENSDART00000150864
si:ch211-214j24.9
chr18_+_15644559 7.24 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr18_+_50276337 7.20 ENSDART00000140352
si:dkey-105e17.1
chr2_-_32505091 7.09 ENSDART00000141884
ENSDART00000056639
Fas apoptotic inhibitory molecule 2a
chr25_+_7229046 6.99 ENSDART00000149965
ENSDART00000041820
leucine rich repeat and Ig domain containing 1a
chr5_+_27267186 6.73 ENSDART00000182238
ENSDART00000087857
unc-5 netrin receptor Db
chr2_+_42871831 6.53 ENSDART00000171393
EFR3 homolog A (S. cerevisiae)
chr6_-_8498908 6.43 ENSDART00000149222
peptidoglycan recognition protein 2
chr5_+_61301525 6.43 ENSDART00000128773
double C2-like domains, beta
chr5_+_19309877 6.41 ENSDART00000190338
RUN and SH3 domain containing 2
chr2_-_31735142 5.85 ENSDART00000130903
RALY RNA binding protein like
chr6_-_16456093 5.72 ENSDART00000083305
ENSDART00000181640
solute carrier family 19 (thiamine transporter), member 2
chr10_-_15405564 5.71 ENSDART00000020665
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr23_-_3721444 5.65 ENSDART00000141682
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr7_+_25036188 5.49 ENSDART00000163957
ENSDART00000169749
sb:cb1058
chr25_-_21085661 5.45 ENSDART00000099355
proline rich 5a (renal)
chr21_-_27881752 5.43 ENSDART00000132583
neurexin 2a
chr6_-_8498676 5.41 ENSDART00000148627
peptidoglycan recognition protein 2
chr20_-_40754794 5.40 ENSDART00000187251
connexin 32.3
chr17_-_14700889 5.34 ENSDART00000179975
protein tyrosine phosphatase type IVA, member 2a
chr3_+_39853788 5.33 ENSDART00000154869
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr14_-_2348917 5.18 ENSDART00000159004
si:ch73-233f7.8
chr4_-_8902406 5.13 ENSDART00000192962
metallophosphoesterase domain containing 1
chr15_-_5467477 5.13 ENSDART00000123839
arrestin, beta 1
chr8_-_37263524 5.09 ENSDART00000061327
Rh50-like protein
chr17_-_14701529 5.03 ENSDART00000185142
protein tyrosine phosphatase type IVA, member 2a
chr18_+_50890749 4.89 ENSDART00000174109
si:ch1073-450f2.1
chr20_-_6812688 4.85 ENSDART00000170934
insulin-like growth factor binding protein 1a
chr16_-_16701718 4.81 ENSDART00000143550
si:dkey-8k3.2
chr24_-_37955993 4.77 ENSDART00000041805
meteorin, glial cell differentiation regulator
chr21_-_43482426 4.65 ENSDART00000192901
ankyrin repeat domain 46a
chr19_-_27391179 4.58 ENSDART00000181108
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase b
chr14_+_7932973 4.56 ENSDART00000109941
CXXC finger protein 5b
chr7_-_71434298 4.55 ENSDART00000180507
leucine-rich repeat LGI family, member 2a
chr16_+_5612547 4.51 ENSDART00000140226
ENSDART00000189352
si:dkey-283b15.4
chr1_-_23157583 4.51 ENSDART00000144208
adhesion G protein-coupled receptor L3.1
chr4_+_7827261 4.51 ENSDART00000129568
phytanoyl-CoA 2-hydroxylase
chr20_-_19422496 4.33 ENSDART00000143658
si:ch211-278j3.3
chr8_+_40477264 4.29 ENSDART00000085559
glucokinase (hexokinase 4)
chr17_-_8169774 4.23 ENSDART00000091828
spectrin repeat containing, nuclear envelope 1b
chr18_-_37007294 4.18 ENSDART00000088309
mitogen-activated protein kinase kinase kinase 10
chr25_-_7753207 4.04 ENSDART00000126499
PHD finger protein 21Ab
chr3_-_28120092 4.00 ENSDART00000151143
RNA binding fox-1 homolog 1
chr25_+_19955598 3.96 ENSDART00000091547
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr20_-_6196989 3.92 ENSDART00000013343
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr5_-_23675222 3.88 ENSDART00000135153
si:dkey-110k5.6
chr22_+_18156000 3.75 ENSDART00000143483
ENSDART00000136133
nuclear receptor 2C2-associated protein
chr21_+_22878991 3.74 ENSDART00000186399
PCF11 cleavage and polyadenylation factor subunit
chr18_-_44847855 3.72 ENSDART00000086823
signal recognition particle receptor (docking protein)
chr18_-_37007061 3.72 ENSDART00000136432
mitogen-activated protein kinase kinase kinase 10
chr12_+_26467847 3.67 ENSDART00000022495
nudE neurodevelopment protein 1-like 1a
chr19_-_41991104 3.62 ENSDART00000087055
trio Rho guanine nucleotide exchange factor a
chr13_-_30713236 3.56 ENSDART00000112372
ENSDART00000142221
transmembrane protein 72
chr7_-_49651378 3.52 ENSDART00000015040
-Ha-ras Harvey rat sarcoma viral oncogene homolog b
chr19_-_32641725 3.41 ENSDART00000165006
ENSDART00000188185
hippocalcin
chr17_+_6957042 3.36 ENSDART00000103839
zgc:172341
chr8_-_14484599 3.35 ENSDART00000057644
LIM homeobox 4
chr22_-_7129631 3.34 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr17_-_45247332 3.30 ENSDART00000016815
tau tubulin kinase 2a
chr23_+_12454542 3.20 ENSDART00000182259
ENSDART00000193043
si:ch211-153a8.4
chr16_-_26255877 3.17 ENSDART00000146214
Ets2 repressor factor like 1
chr18_-_20560007 3.15 ENSDART00000141367
ENSDART00000090186
si:ch211-238n5.4
chr1_+_45958904 3.12 ENSDART00000108528
Rho guanine nucleotide exchange factor (GEF) 7b
chr25_+_18964782 3.05 ENSDART00000017299
thymine DNA glycosylase, tandem duplicate 1
chr21_-_41369370 2.99 ENSDART00000159290
cytoplasmic polyadenylation element binding protein 4b
chr2_-_32387441 2.99 ENSDART00000148202
upstream binding transcription factor, like
chr18_-_25051846 2.92 ENSDART00000013082
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr17_+_43623598 2.90 ENSDART00000154138
zinc finger protein 365
chr8_-_23081511 2.84 ENSDART00000142015
ENSDART00000135764
ENSDART00000147021
si:dkey-70p6.1
chr21_+_22878834 2.80 ENSDART00000065562
PCF11 cleavage and polyadenylation factor subunit
chr3_-_30434016 2.79 ENSDART00000150958
leucine rich repeat containing 4Ba
chr13_+_36144341 2.77 ENSDART00000182930
ENSDART00000187327
si:ch211-259k16.3
chr5_+_34549365 2.73 ENSDART00000009500
allograft inflammatory factor 1-like
chr4_-_39111612 2.69 ENSDART00000150394
si:dkey-122c11.8
chr5_+_34549845 2.67 ENSDART00000139317
allograft inflammatory factor 1-like
chr6_-_49861506 2.65 ENSDART00000121809
GNAS complex locus
chr11_-_426525 2.63 ENSDART00000157054
zinc finger protein 831
chr5_-_63286077 2.60 ENSDART00000131274
tubulin folding cofactor E-like b
chr4_-_14531687 2.60 ENSDART00000182093
ENSDART00000159447
plexin b2a
chr3_-_46811611 2.59 ENSDART00000134092
ELAV like neuron-specific RNA binding protein 3
chr19_+_41006975 2.57 ENSDART00000138555
ENSDART00000049842
CAS1 domain containing 1
chr8_+_9866351 2.45 ENSDART00000133985
potassium voltage-gated channel, Shal-related subfamily, member 1
chr15_+_11381532 2.40 ENSDART00000124172
si:ch73-321d9.2
chr13_+_22316746 2.35 ENSDART00000188968
ubiquitin specific peptidase 54a
chr8_+_35664152 2.26 ENSDART00000144520
si:dkeyp-14d3.1
chr7_-_25895189 2.21 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
CD99 molecule-like 2
chr11_+_5817202 2.06 ENSDART00000126084
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3
chr17_+_21760032 2.04 ENSDART00000190425
IKAROS family zinc finger 5
chr19_-_18855513 1.95 ENSDART00000162708
palmitoyl-protein thioesterase 2
chr21_-_7687544 1.91 ENSDART00000134519
phosphodiesterase 8B
chr5_-_65158203 1.89 ENSDART00000171656
SH2 domain containing 3Cb
chr12_-_43428542 1.88 ENSDART00000192266
protein tyrosine phosphatase, receptor type, E, a
chr15_+_17446796 1.84 ENSDART00000157189
sorting nexin 19b
chr16_-_44127307 1.82 ENSDART00000104583
ENSDART00000151936
ENSDART00000058685
ENSDART00000190830
zinc finger protein, FOG family member 2a
chr18_-_21806613 1.77 ENSDART00000145721
neuritin 1-like a
chr7_-_41693004 1.77 ENSDART00000121509
MAM and LDL receptor class A domain containing 1
chr13_-_32648382 1.72 ENSDART00000138571
ENSDART00000132820
BEN domain containing 3
chr19_-_18855717 1.70 ENSDART00000158192
palmitoyl-protein thioesterase 2
chr7_+_42206847 1.64 ENSDART00000149250
phosphorylase kinase, beta
chr17_-_43623356 1.62 ENSDART00000075596
ENSDART00000136431
rhotekin 2a
chr17_-_14451405 1.61 ENSDART00000146786
jnk1/mapk8 associated membrane protein
chr16_-_2650341 1.53 ENSDART00000128169
ENSDART00000155432
ENSDART00000103722
lysophospholipase-like 1
chr5_+_58455488 1.43 ENSDART00000038602
ENSDART00000127958
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr4_-_76488854 1.33 ENSDART00000132323
finTRIM family, member 51
chr6_+_46431848 1.30 ENSDART00000181056
ENSDART00000144569
ENSDART00000064865
ENSDART00000133992
staufen double-stranded RNA binding protein 1
chr22_-_38360205 1.27 ENSDART00000162055
MAP/microtubule affinity-regulating kinase 1
chr21_+_20229926 1.20 ENSDART00000025860
si:dkey-247m21.3
chr4_-_4261673 1.19 ENSDART00000150694
CD9 molecule b
chr5_+_37406358 1.19 ENSDART00000162811
kelch-like family member 13
chr23_-_19434199 1.14 ENSDART00000132543
kelch domain containing 8B
chr6_-_2627488 1.12 ENSDART00000044089
ENSDART00000158333
ENSDART00000155109
hydroxypyruvate isomerase
chr7_+_15266093 1.08 ENSDART00000124676
synaptic vesicle glycoprotein 2Ba
chr8_-_32385989 0.99 ENSDART00000143716
ENSDART00000098850
lipase, endothelial
chr4_+_8016457 0.95 ENSDART00000014036
optineurin
chr8_+_20503842 0.94 ENSDART00000100328
casein kinase 1, gamma 2b
chr21_+_17005737 0.94 ENSDART00000101246
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr2_-_17044959 0.92 ENSDART00000090260
chloride channel, voltage-sensitive 2a
chr5_+_56268436 0.72 ENSDART00000021159
LIM homeobox 1b
chr20_+_54274431 0.69 ENSDART00000099338
ARP10 actin related protein 10 homolog
chr3_+_39958407 0.66 ENSDART00000099754
coiled-coil domain containing 97
chr9_+_7732714 0.65 ENSDART00000145853
si:ch1073-349o24.2
chr9_-_7287128 0.62 ENSDART00000176281
ENSDART00000065803
MIT, microtubule interacting and transport, domain containing 1
chr10_-_28761454 0.61 ENSDART00000129400
activated leukocyte cell adhesion molecule a
chr7_-_68419830 0.58 ENSDART00000191606

chr7_+_38265363 0.50 ENSDART00000009386
G patch domain containing 1
chr15_+_21947117 0.45 ENSDART00000156234
tetratricopeptide repeat domain 12
chr18_+_36769758 0.43 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
FBJ murine osteosarcoma viral oncogene homolog B
chr9_-_7287375 0.40 ENSDART00000128352
MIT, microtubule interacting and transport, domain containing 1
chr1_+_37391716 0.37 ENSDART00000191986
SPARC-like 1
chr11_-_22605981 0.34 ENSDART00000186923
myogenin
chr18_+_14529005 0.31 ENSDART00000186379
potassium voltage-gated channel, subfamily G, member 4a
chr22_-_4812755 0.25 ENSDART00000191739

chr16_-_13612650 0.22 ENSDART00000080372
D site albumin promoter binding protein b
chr22_-_7669624 0.16 ENSDART00000189617

chr23_-_15216654 0.16 ENSDART00000131649
sulfatase 2b
chr7_+_65939098 0.06 ENSDART00000193599
Ras association domain family member 10
chr12_-_25217217 0.04 ENSDART00000152931
potassium voltage-gated channel, subfamily G, member 3
chr3_-_60142530 0.03 ENSDART00000153247
si:ch211-120g10.1
chr21_-_17037907 0.02 ENSDART00000101263
ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.4 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
4.6 13.7 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
3.9 11.8 GO:0016045 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
2.0 7.9 GO:0046552 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
1.9 5.7 GO:1903332 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
1.3 5.1 GO:1900136 microglial cell activation(GO:0001774) regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
1.3 29.3 GO:0050796 regulation of insulin secretion(GO:0050796)
1.2 19.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.1 5.7 GO:1901910 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
1.1 17.0 GO:0048899 anterior lateral line development(GO:0048899)
1.0 3.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.9 6.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.6 4.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.6 5.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.6 3.7 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.6 5.7 GO:0045117 azole transport(GO:0045117)
0.6 10.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.5 2.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.5 8.8 GO:0015693 magnesium ion transport(GO:0015693)
0.5 5.5 GO:0038203 TORC2 signaling(GO:0038203)
0.5 5.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.5 1.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.5 3.3 GO:0070207 protein homotrimerization(GO:0070207)
0.5 7.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.4 4.8 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.4 3.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.4 3.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.4 7.9 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.3 2.0 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.3 28.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.3 5.3 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.3 1.7 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.3 13.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.3 5.4 GO:0097178 ruffle assembly(GO:0097178)
0.3 11.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 1.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 2.6 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.2 4.0 GO:0060324 face development(GO:0060324)
0.2 0.7 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 14.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 4.2 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.2 1.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.2 7.0 GO:0031103 axon regeneration(GO:0031103)
0.1 2.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 1.5 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.4 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 8.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 8.4 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 1.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 4.8 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.1 4.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 1.2 GO:0032098 regulation of appetite(GO:0032098)
0.1 1.9 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 0.3 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 4.0 GO:0021854 hypothalamus development(GO:0021854)
0.1 2.8 GO:1903038 negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.1 4.3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 8.9 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.1 1.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 6.8 GO:0051260 protein homooligomerization(GO:0051260)
0.0 3.2 GO:0007098 centrosome cycle(GO:0007098)
0.0 3.8 GO:0006865 amino acid transport(GO:0006865)
0.0 0.6 GO:0010770 positive regulation of cell morphogenesis involved in differentiation(GO:0010770)
0.0 0.8 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 1.6 GO:0044042 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 4.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 7.8 GO:0016311 dephosphorylation(GO:0016311)
0.0 2.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 3.5 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 3.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.8 GO:0007338 single fertilization(GO:0007338)
0.0 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 2.8 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0072380 TRC complex(GO:0072380)
0.8 3.2 GO:0005880 nuclear microtubule(GO:0005880)
0.7 10.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.6 8.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.4 17.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 4.0 GO:0044224 paranode region of axon(GO:0033270) juxtaparanode region of axon(GO:0044224)
0.3 6.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.2 4.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 5.5 GO:0031932 TORC2 complex(GO:0031932)
0.2 5.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 3.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 5.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 8.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.3 GO:0035869 ciliary transition zone(GO:0035869)
0.1 0.9 GO:0030904 retromer complex(GO:0030904)
0.1 9.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 6.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.7 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 2.6 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 48.7 GO:0005615 extracellular space(GO:0005615)
0.0 12.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.1 GO:0030027 lamellipodium(GO:0030027)
0.0 12.0 GO:0009986 cell surface(GO:0009986)
0.0 2.5 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 2.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0005776 autophagosome(GO:0005776)
0.0 1.1 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.4 GO:0004351 glutamate decarboxylase activity(GO:0004351)
4.6 13.7 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
3.9 11.8 GO:0016019 peptidoglycan receptor activity(GO:0016019)
2.0 7.9 GO:0070324 thyroid hormone binding(GO:0070324)
1.4 8.4 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
1.3 3.9 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
1.2 7.2 GO:0032052 bile acid binding(GO:0032052)
1.1 4.6 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
1.1 17.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.1 5.7 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
1.0 2.9 GO:0030882 lipid antigen binding(GO:0030882)
0.9 7.9 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.8 5.3 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.7 5.7 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.7 4.3 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.7 3.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.7 27.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 5.4 GO:0005042 netrin receptor activity(GO:0005042)
0.5 2.6 GO:0031852 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.5 10.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.5 1.4 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.4 4.8 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.4 2.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 42.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 2.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.3 3.1 GO:0008263 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.3 7.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 6.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 2.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 5.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 2.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 11.4 GO:0042562 hormone binding(GO:0042562)
0.2 3.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 10.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 4.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 3.5 GO:0019003 GDP binding(GO:0019003)
0.1 4.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 10.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1 1.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 1.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 4.5 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 1.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 6.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 9.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 11.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.2 GO:0005179 hormone activity(GO:0005179)
0.0 1.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 5.1 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 1.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 3.2 GO:0060090 binding, bridging(GO:0060090)
0.0 7.3 GO:0051015 actin filament binding(GO:0051015)
0.0 4.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.4 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 6.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 15.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.5 16.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.5 5.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 14.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 7.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 42.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 19.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.8 14.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.7 12.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 7.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 6.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.3 11.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 5.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 4.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.6 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 1.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 11.9 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 3.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 4.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels