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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for onecut2
Z-value: 1.43
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Transcription factors associated with onecut2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| onecut2 | dr11_v1_chr21_-_1742159_1742159 | 0.62 | 2.6e-11 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_37201483 Show fit | 22.50 |
ENSDART00000160930
ENSDART00000173439 ENSDART00000171273 |
zgc:112265 |
|
| chr23_+_28770225 Show fit | 19.16 |
ENSDART00000132179
ENSDART00000142273 |
mannan-binding lectin serine peptidase 2 |
|
| chr1_-_21409877 Show fit | 16.96 |
ENSDART00000102782
|
glutamate receptor, ionotropic, AMPA 2a |
|
| chr6_+_3828560 Show fit | 16.45 |
ENSDART00000185273
ENSDART00000179091 |
glutamate decarboxylase 1b |
|
| chr12_-_22524388 Show fit | 16.24 |
ENSDART00000020942
|
sex hormone-binding globulin |
|
| chr15_-_26552393 Show fit | 15.41 |
ENSDART00000150152
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b |
|
| chr10_+_10801719 Show fit | 13.84 |
ENSDART00000193648
|
alpha-1-microglobulin/bikunin precursor |
|
| chr2_-_39759059 Show fit | 13.68 |
ENSDART00000007333
|
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a |
|
| chr15_-_26552652 Show fit | 13.49 |
ENSDART00000152336
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b |
|
| chr19_+_4916233 Show fit | 12.41 |
ENSDART00000159512
|
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
Network of associatons between targets according to the STRING database.
First level regulatory network of onecut2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 29.3 | GO:0050796 | regulation of insulin secretion(GO:0050796) |
| 0.3 | 28.9 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.2 | 19.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 1.1 | 17.0 | GO:0048899 | anterior lateral line development(GO:0048899) |
| 5.5 | 16.4 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.2 | 14.8 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.3 | 13.8 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 4.6 | 13.7 | GO:1990519 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 3.9 | 11.8 | GO:0016045 | detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581) |
| 0.3 | 11.3 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 48.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 17.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 12.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 12.0 | GO:0009986 | cell surface(GO:0009986) |
| 0.7 | 10.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 9.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.6 | 8.8 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 8.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 6.5 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.0 | 6.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 42.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.7 | 27.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 1.1 | 17.0 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 5.5 | 16.4 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 4.6 | 13.7 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 3.9 | 11.8 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.2 | 11.4 | GO:0042562 | hormone binding(GO:0042562) |
| 0.0 | 11.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 10.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 10.4 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 42.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 16.2 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.7 | 15.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 14.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 7.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.5 | 5.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 4.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.2 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 19.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.8 | 14.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.7 | 12.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 11.9 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.3 | 11.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 7.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.3 | 6.5 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.2 | 5.1 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 4.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 4.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |