ISMARA results: onecut1+onecutl

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for onecut1+onecutl

Z-value: 2.30

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Transcription factors associated with onecut1+onecutl

Gene Symbol	Gene ID	Gene Info
onecut1 NCBI UniProt	ENSDARG00000007982	one cut homeobox 1
onecutl NCBI UniProt	ENSDARG00000040253	one cut domain, family member, like
onecut1 NCBI UniProt	ENSDARG00000112251	one cut homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
onecutl	dr11_v1_chr16_-_29528198_29528198	0.75	2.3e-18	Click!
onecut1	dr11_v1_chr18_+_38755023_38755024	0.65	2.3e-12	Click!

Activity profile of onecut1+onecutl motif

Sorted Z-values of onecut1+onecutl motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_7885707 Show fit	29.52	ENSDART00000029981	ppp3cb NCBI UniProt Show fit	protein phosphatase 3, catalytic subunit, beta isozyme
chr15_+_28202170 Show fit	20.78	ENSDART00000077736	vtna NCBI UniProt Show fit	vitronectin a
chr1_+_29759678 Show fit	20.24	ENSDART00000054059 ENSDART00000101856	cpb2 NCBI UniProt Show fit	carboxypeptidase B2 (plasma)
chr6_-_32349153 Show fit	19.77	ENSDART00000140004	angptl3 NCBI UniProt Show fit	angiopoietin-like 3
chr24_-_17444067 Show fit	19.55	ENSDART00000155843	cntnap2a NCBI UniProt Show fit	contactin associated protein like 2a
chr14_+_22172047 Show fit	19.41	ENSDART00000114750 ENSDART00000148259	gabrb2 NCBI UniProt Show fit	gamma-aminobutyric acid (GABA) A receptor, beta 2
chr12_+_24344611 Show fit	19.23	ENSDART00000093094	nrxn1a NCBI UniProt Show fit	neurexin 1a
chr20_+_3108597 Show fit	18.44	ENSDART00000133435	CEP170B (1 of many) NCBI UniProt Show fit	si:ch73-212j7.1
chr15_-_21155641 Show fit	18.20	ENSDART00000061098 ENSDART00000046443	A2ML1 (1 of many) NCBI UniProt Show fit	si:dkey-105h12.2
chr2_+_35240764 Show fit	17.95	ENSDART00000015827	tnr NCBI UniProt Show fit	tenascin R (restrictin, janusin)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut1+onecutl

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	42.0	GO:0002040	sprouting angiogenesis(GO:0002040)
0.3	37.0	GO:0090630	activation of GTPase activity(GO:0090630)
0.3	35.1	GO:0010466	negative regulation of peptidase activity(GO:0010466)
0.7	33.9	GO:0042738	drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1	32.9	GO:0007411	axon guidance(GO:0007411)
0.8	31.4	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
2.4	31.0	GO:0010996	response to auditory stimulus(GO:0010996)
1.8	30.9	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
2.0	29.5	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.9	27.3	GO:0019835	cytolysis(GO:0019835)

Showing 1 to 10 of 147 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	54.2	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	35.4	GO:0043005	neuron projection(GO:0043005)
0.0	34.9	GO:0005615	extracellular space(GO:0005615)
4.9	29.5	GO:0005955	calcineurin complex(GO:0005955)
1.7	27.3	GO:0005579	membrane attack complex(GO:0005579)
0.2	25.0	GO:0045177	apical part of cell(GO:0045177)
0.5	22.5	GO:0032587	ruffle membrane(GO:0032587)
2.4	19.5	GO:0033010	paranodal junction(GO:0033010)
0.2	19.5	GO:0008021	synaptic vesicle(GO:0008021)
0.4	17.9	GO:0043679	axon terminus(GO:0043679)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	41.6	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.5	33.9	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
1.8	31.0	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
4.9	29.5	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	24.6	GO:0008017	microtubule binding(GO:0008017)
2.3	23.4	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.6	23.3	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.8	21.9	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1	21.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	21.5	GO:0005102	receptor binding(GO:0005102)

Showing 1 to 10 of 120 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	29.5	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
1.1	23.4	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
1.1	17.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.6	17.6	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.1	16.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	14.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	9.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	8.9	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.8	8.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.4	8.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	29.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.9	29.0	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.0	27.3	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
2.3	23.4	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.5	17.7	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.8	14.9	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.5	12.7	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.3	11.7	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.3	11.2	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4	10.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus

Showing 1 to 10 of 32 entries

Results for onecut1+onecutl

Z-value: 2.30

Motif logo

Transcription factors associated with onecut1+onecutl

Activity-expression correlation:

Activity profile of onecut1+onecutl motif

Sorted Z-values of onecut1+onecutl motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut1+onecutl

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: