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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr5a1a+nr5a2+nr5a5

Z-value: 1.47

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Transcription factors associated with nr5a1a+nr5a2+nr5a5

Gene Symbol Gene ID Gene Info
ENSDARG00000039116 nuclear receptor subfamily 5, group A, member 5
ENSDARG00000100940 nuclear receptor subfamily 5, group A, member 2
ENSDARG00000103176 nuclear receptor subfamily 5, group A, member 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr5a5dr11_v1_chr3_-_53465223_534652490.295.3e-03Click!
nr5a2dr11_v1_chr22_-_22719440_227194400.161.2e-01Click!
nr5a1adr11_v1_chr8_-_52871056_52871056-0.151.4e-01Click!

Activity profile of nr5a1a+nr5a2+nr5a5 motif

Sorted Z-values of nr5a1a+nr5a2+nr5a5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_24289641 15.25 ENSDART00000128784
ENSDART00000123565
ENSDART00000141922
ENSDART00000184550
ENSDART00000191469
myosin heavy chain 7-like
chr16_+_52512025 12.08 ENSDART00000056095
fatty acid binding protein 10a, liver basic
chr22_-_2886937 10.90 ENSDART00000063533
aquaporin 12
chr8_-_39739056 10.89 ENSDART00000147992
si:ch211-170d8.5
chr21_-_30658509 10.84 ENSDART00000139764
si:dkey-22f5.9
chr22_+_6293563 10.42 ENSDART00000063416
ribonuclease like 2
chr2_-_22152797 9.86 ENSDART00000145188
cytochrome P450, family 7, subfamily A, polypeptide 1
chr23_+_25856541 9.23 ENSDART00000145426
ENSDART00000028236
hepatocyte nuclear factor 4, alpha
chr22_+_38194151 9.19 ENSDART00000121965
ceruloplasmin
chr22_+_7439476 8.96 ENSDART00000021594
ENSDART00000063389
zgc:92041
chr8_+_40476811 8.93 ENSDART00000129772
glucokinase (hexokinase 4)
chr3_+_55288200 8.74 ENSDART00000157002
ENSDART00000155600
si:dkey-114l24.2
chr15_-_26552393 8.68 ENSDART00000150152
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr16_-_25085327 8.51 ENSDART00000077661
protease, serine 1
chr20_+_10539293 8.14 ENSDART00000182265
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr4_+_2620751 7.66 ENSDART00000013924
G protein-coupled receptor 22a
chr17_+_43867889 7.54 ENSDART00000132673
ENSDART00000167214
zgc:66313
chr23_-_19953089 7.53 ENSDART00000153828
ATPase plasma membrane Ca2+ transporting 3b
chr13_-_20540790 7.48 ENSDART00000131467
si:ch1073-126c3.2
chr20_+_10545514 7.33 ENSDART00000153667
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr15_-_26552652 7.22 ENSDART00000152336
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr15_-_21877726 7.07 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
chr20_+_43942278 6.93 ENSDART00000100571
chloride intracellular channel 5b
chr8_+_40477264 6.85 ENSDART00000085559
glucokinase (hexokinase 4)
chr2_-_37967368 6.80 ENSDART00000050345
cerebellin 9
chr25_+_3326885 6.63 ENSDART00000104866
lactate dehydrogenase Bb
chr5_+_28830388 6.58 ENSDART00000149150
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr22_+_7480465 6.28 ENSDART00000034545
zgc:92745
chr22_+_7462997 6.24 ENSDART00000106082
zgc:112368
chr15_+_37105986 6.21 ENSDART00000157762
amyloid beta (A4) precursor-like protein 1
chr12_-_33859950 6.08 ENSDART00000131181
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Gb
chr15_+_19544052 6.02 ENSDART00000062560
zgc:77784
chr17_-_33289304 5.83 ENSDART00000135118
ENSDART00000040346
EFR3 homolog Ba (S. cerevisiae)
chr4_+_72797711 5.76 ENSDART00000190934
ENSDART00000163236
myelin regulatory factor-like
chr22_-_36876133 5.56 ENSDART00000147006
kininogen 1
chr3_-_19899914 5.36 ENSDART00000134969
Rho family GTPase 2
chr17_-_12385308 5.17 ENSDART00000080927
synaptosomal-associated protein, 25b
chr8_+_1769475 5.14 ENSDART00000079073
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr7_+_38716048 5.07 ENSDART00000024590
synaptotagmin XIII
chr15_-_16098531 5.07 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr25_+_3327071 5.06 ENSDART00000136131
ENSDART00000133243
lactate dehydrogenase Bb
chr3_-_21280373 4.98 ENSDART00000003939
synaptogyrin 1a
chr19_-_32487469 4.92 ENSDART00000050130
guanosine monophosphate reductase
chr11_+_23704410 4.72 ENSDART00000112655
neurofascin homolog (chicken) a
chr16_-_17197546 4.70 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
glyceraldehyde-3-phosphate dehydrogenase
chr11_-_7320211 4.69 ENSDART00000091664
adenomatosis polyposis coli 2
chr21_+_198269 4.65 ENSDART00000193485
ENSDART00000163696
gonadal somatic cell derived factor
chr20_+_54738210 4.65 ENSDART00000151399
p21 protein (Cdc42/Rac)-activated kinase 7
chr15_-_30853246 4.60 ENSDART00000112511
A kinase (PRKA) anchor protein 1b
chr8_+_19514294 4.47 ENSDART00000170622
si:ch73-281k2.5
chr1_+_50987535 4.37 ENSDART00000140657
malate dehydrogenase 1Aa, NAD (soluble)
chr16_-_43025885 4.36 ENSDART00000193146
ENSDART00000157302
si:dkey-7j14.5
chr6_-_29143463 4.32 ENSDART00000087440
family with sequence similarity 69, member Ab
chr25_+_36316280 4.31 ENSDART00000152735
si:ch211-113a14.11
chr24_-_30096666 4.25 ENSDART00000183285
phospholipid phosphatase related 4b
chr18_-_8312848 4.18 ENSDART00000092033
mitogen-activated protein kinase 8 interacting protein 2
chr14_-_32016615 4.17 ENSDART00000105761
zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr12_-_3940768 4.17 ENSDART00000134292
zgc:92040
chr3_+_13624815 4.15 ENSDART00000161451
peptidoglycan recognition protein 6
chr22_+_7439186 4.12 ENSDART00000190667
zgc:92041
chr6_+_37894914 4.09 ENSDART00000148817
oculocutaneous albinism II
chr22_-_24900121 4.08 ENSDART00000147643
si:dkey-4c23.3
chr22_+_15624371 4.04 ENSDART00000124868
lipoprotein lipase
chr20_-_14259032 4.00 ENSDART00000169482
discs, large (Drosophila) homolog-associated protein 2b
chr18_-_21188768 3.96 ENSDART00000060166
glutamic-oxaloacetic transaminase 2a, mitochondrial
chr6_+_48618512 3.90 ENSDART00000111190
si:dkey-238f9.1
chr15_+_20403903 3.82 ENSDART00000134182
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr7_+_30875273 3.80 ENSDART00000173693
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr19_-_103289 3.79 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr5_-_25072607 3.76 ENSDART00000145061
patatin-like phospholipase domain containing 7b
chr22_-_24900385 3.69 ENSDART00000179699
si:dkey-4c23.3
chr22_+_7472420 3.68 ENSDART00000132049
si:dkey-57c15.4
chr20_-_40754794 3.68 ENSDART00000187251
connexin 32.3
chr18_+_1703984 3.67 ENSDART00000114010
SLIT and NTRK-like family, member 3a
chr10_+_22775253 3.67 ENSDART00000190141
transmembrane protein 88 a
chr25_-_26758253 3.67 ENSDART00000123004
si:dkeyp-73b11.8
chr25_+_22730490 3.66 ENSDART00000149455
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr19_-_9712530 3.66 ENSDART00000134816
solute carrier family 2 (facilitated glucose transporter), member 3a
chr21_-_10886709 3.64 ENSDART00000134408
si:dkey-277m11.2
chr14_+_8343498 3.63 ENSDART00000164551
neuregulin 2b
chr5_-_35301800 3.62 ENSDART00000085142
microtubule-associated protein 1B
chr17_+_33495194 3.55 ENSDART00000033691
parathyroid hormone 2
chr23_+_6272638 3.50 ENSDART00000190366
synaptotagmin IIa
chr7_-_59256806 3.50 ENSDART00000167955
meiosis 1 associated protein
chr8_-_14052349 3.46 ENSDART00000135811
ATPase plasma membrane Ca2+ transporting 3a
chr15_+_11427620 3.46 ENSDART00000168688
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr4_-_20039635 3.43 ENSDART00000179191

chr24_-_20808283 3.41 ENSDART00000143759
vasoactive intestinal peptide receptor 1b
chr19_-_42945965 3.40 ENSDART00000142858
doublecortin-like kinase 3
chr10_-_32524771 3.37 ENSDART00000066793
diacylglycerol O-acyltransferase 2
chr3_+_43460696 3.35 ENSDART00000164581
galanin receptor 2b
chr8_+_23213320 3.35 ENSDART00000032996
ENSDART00000137536
pancreatic progenitor cell differentiation and proliferation factor a
chr12_+_44610912 3.33 ENSDART00000179030
ENSDART00000178008
family with sequence similarity 196 member A
chr5_+_57328535 3.31 ENSDART00000149646
solute carrier family 31 (copper transporter), member 1
chr22_+_7497319 3.30 ENSDART00000034564
zgc:92511
chr19_-_5103313 3.29 ENSDART00000037007
triosephosphate isomerase 1a
chr18_+_10689772 3.28 ENSDART00000126441
leptin a
chr21_-_12119711 3.27 ENSDART00000131538
CUGBP, Elav-like family member 4
chr4_+_11375894 3.24 ENSDART00000190471
ENSDART00000143963
piccolo presynaptic cytomatrix protein a
chr7_+_67494107 3.22 ENSDART00000185653
copine VII
chr2_-_19109304 3.22 ENSDART00000168028
si:dkey-225f23.5
chr14_-_12253309 3.22 ENSDART00000115101
myotilin
chr13_-_29421331 3.22 ENSDART00000150228
choline O-acetyltransferase a
chr11_+_11230121 3.22 ENSDART00000172438
myomesin 2a
chr14_-_36412473 3.19 ENSDART00000128244
ENSDART00000138376
ankyrin repeat and SOCS box containing 5a
chr16_-_12914288 3.18 ENSDART00000184221
calcium channel, voltage-dependent, gamma subunit 8b
chr13_+_6342410 3.16 ENSDART00000065228
CUB and Sushi multiple domains 1a
chr25_-_10564721 3.16 ENSDART00000154776
galanin/GMAP prepropeptide
chr3_-_40136743 3.14 ENSDART00000149546
myosin XVAa
chr20_+_25575391 3.13 ENSDART00000063108
cytochrome P450, family 2, subfamily P, polypeptide 8
chr9_-_1970071 3.12 ENSDART00000080608
homeobox D10a
chr8_-_53195500 3.11 ENSDART00000132000
gamma-aminobutyric acid (GABA) A receptor, delta
chr8_+_24854600 3.10 ENSDART00000156570
solute carrier family 6 (neutral amino acid transporter), member 17
chr3_-_60142530 3.08 ENSDART00000153247
si:ch211-120g10.1
chr12_+_7865470 3.08 ENSDART00000161683

chr20_-_52967878 3.04 ENSDART00000164460
GATA binding protein 4
chr15_-_7598542 3.04 ENSDART00000173092
glucan (1,4-alpha-), branching enzyme 1b
chr7_-_6279138 3.00 ENSDART00000173299
si:ch211-220f21.2
chr17_-_44776224 3.00 ENSDART00000156195
zinc finger, DHHC-type containing 22
chr6_-_43922813 3.00 ENSDART00000123341
prokineticin 2
chr7_-_26087807 2.98 ENSDART00000052989
acetylcholinesterase
chr1_+_54911458 2.98 ENSDART00000089603
golgin A7 family, member Ba
chr22_+_9472814 2.97 ENSDART00000112125
ENSDART00000138850
calcium channel, voltage-dependent, alpha 2/delta subunit 2b
chr18_+_17583479 2.97 ENSDART00000186977
ENSDART00000010998
solute carrier family 12 (sodium/chloride transporter), member 3
chr11_+_30663300 2.93 ENSDART00000161662
tau tubulin kinase 1a
chr7_+_568819 2.92 ENSDART00000173716
neurexin 2b
chr13_+_2523032 2.89 ENSDART00000172261
luteinizing hormone, beta polypeptide
chr22_-_11606078 2.87 ENSDART00000146026
phosphate cytidylyltransferase 2, ethanolamine
chr19_-_12145765 2.87 ENSDART00000032474
poly A binding protein, cytoplasmic 1 b
chr17_-_43287290 2.86 ENSDART00000156885
si:dkey-1f12.3
chr24_-_9989634 2.85 ENSDART00000115275
zgc:152652
chr7_-_12821277 2.84 ENSDART00000091584
zgc:158785
chr17_-_24717925 2.84 ENSDART00000153725
si:ch211-15d5.11
chr20_+_40237441 2.83 ENSDART00000168928
si:ch211-199i15.5
chr16_+_32559821 2.81 ENSDART00000093250
POU class 3 homeobox 2b
chr23_+_36083529 2.79 ENSDART00000053295
ENSDART00000130260
homeobox C10a
chr10_+_466926 2.79 ENSDART00000145220
ARVCF, delta catenin family member a
chr11_-_29650930 2.77 ENSDART00000166969
chromodomain helicase DNA binding protein 5
chr10_+_34623183 2.76 ENSDART00000114630
neurobeachin a
chr4_+_25627147 2.75 ENSDART00000041965
acyl-CoA thioesterase 15
chr14_-_44841503 2.75 ENSDART00000179114
si:dkey-109l4.6
chr14_-_47314340 2.74 ENSDART00000164851
follistatin-like 5
chr22_+_7742211 2.74 ENSDART00000140896
zgc:92511
chr9_+_32930622 2.72 ENSDART00000100928
cyclic nucleotide gated channel alpha 4
chr22_+_34784075 2.72 ENSDART00000167538
ligand dependent nuclear receptor corepressor
chr3_+_61185660 2.70 ENSDART00000167114

chr2_-_17393216 2.70 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr15_-_7598294 2.70 ENSDART00000165898
glucan (1,4-alpha-), branching enzyme 1b
chr18_+_45504362 2.70 ENSDART00000140089
cyclic nucleotide gated channel beta 1a
chr2_+_34767171 2.69 ENSDART00000145451
astrotactin 1
chr17_-_44584811 2.69 ENSDART00000165059
ENSDART00000165252
solute carrier family 35, member F4
chr16_-_20435475 2.68 ENSDART00000139776
chimerin 2
chr16_+_43219363 2.67 ENSDART00000183610
ADAM metallopeptidase domain 22
chr19_+_14059349 2.67 ENSDART00000166230
trophoblast glycoprotein a
chr23_-_24488696 2.66 ENSDART00000155593
transmembrane protein 82
chr20_-_27857676 2.65 ENSDART00000192934
synapse differentiation inducing 1-like
chr10_+_19338255 2.65 ENSDART00000113737
leucine rich repeat transmembrane neuronal 4 like 1
chr7_-_40578733 2.62 ENSDART00000173926
ENSDART00000010035
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr17_+_33226955 2.61 ENSDART00000063333
proopiomelanocortin a
chr14_-_36397768 2.61 ENSDART00000185199
ENSDART00000052562
spermatogenesis associated 4
chr24_-_31846366 2.58 ENSDART00000155295
STEAP family member 2, metalloreductase
chr12_+_15363463 2.57 ENSDART00000133533
plexin domain containing 1
chr17_-_3303805 2.56 ENSDART00000169136

chr4_+_10365857 2.55 ENSDART00000138890
potassium voltage-gated channel, Shal-related subfamily, member 2
chr4_-_11163112 2.55 ENSDART00000188854
protein arginine methyltransferase 8b
chr2_-_17392799 2.54 ENSDART00000136470
ENSDART00000141188
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr11_-_12998400 2.53 ENSDART00000018614
cholinergic receptor, nicotinic, alpha 4b
chr8_-_48770603 2.52 ENSDART00000159712
Pim proto-oncogene, serine/threonine kinase, related 184
chr18_-_26510545 2.52 ENSDART00000135133
si:ch211-69m14.1
chr19_+_31541607 2.51 ENSDART00000181604
geminin, DNA replication inhibitor
chr14_-_21064199 2.50 ENSDART00000172099
si:dkey-74k8.3
chr23_+_27345826 2.50 ENSDART00000132635
transmembrane (C-terminal) protease, serine 12
chr23_-_18287618 2.50 ENSDART00000112735
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1a
chr2_-_42091926 2.49 ENSDART00000142663
si:dkey-97a13.12
chr9_+_24095677 2.48 ENSDART00000150443
leucine rich repeat (in FLII) interacting protein 1a
chr19_+_6891821 2.48 ENSDART00000160249

chr9_+_17348745 2.48 ENSDART00000147488
SLAIN motif family, member 1a
chr3_-_79366 2.48 ENSDART00000114289
zgc:165518
chr5_+_23118470 2.48 ENSDART00000149893
neurite extension and migration factor a
chr16_-_5721386 2.46 ENSDART00000136655
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3
chr24_+_32411753 2.43 ENSDART00000058530
neuronal differentiation 6a
chr5_-_40178092 2.43 ENSDART00000146664
WD repeat and FYVE domain containing 3
chr7_+_45400716 2.43 ENSDART00000006868
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr25_+_37285737 2.42 ENSDART00000126879
transmembrane p24 trafficking protein 6
chr11_-_43002262 2.42 ENSDART00000172477
ENSDART00000181513

chr6_+_13207139 2.42 ENSDART00000185601
ENSDART00000182182
INO80 complex subunit Db
chr9_+_15893093 2.41 ENSDART00000099483
ENSDART00000134657
si:dkey-14o1.20
chr11_-_10770053 2.40 ENSDART00000179213
solute carrier family 4, sodium bicarbonate transporter, member 10a
chr4_+_29206813 2.40 ENSDART00000131893
si:dkey-23a23.1
chr14_+_15484544 2.40 ENSDART00000188649

chr12_+_45200744 2.39 ENSDART00000098932
WW domain binding protein 2
chr10_-_18463934 2.39 ENSDART00000133116
ENSDART00000113422
si:dkey-28o19.1
chr3_-_52614747 2.38 ENSDART00000154365
tripartite motif containing 35-13
chr15_+_45994123 2.38 ENSDART00000124704
leucine rich repeat and fibronectin type III domain containing 1
chr5_-_57879138 2.37 ENSDART00000145959
salt-inducible kinase 2a
chr14_-_47314011 2.35 ENSDART00000178523
follistatin-like 5
chr8_-_17926814 2.33 ENSDART00000147344
LIM homeobox 8b
chr20_-_33512443 2.31 ENSDART00000061836
papilin b, proteoglycan-like sulfated glycoprotein
chr1_+_45080897 2.30 ENSDART00000129819
si:ch211-151p13.8
chr25_+_28279577 2.29 ENSDART00000073502
ENSDART00000148600
aminoadipate-semialdehyde synthase

Network of associatons between targets according to the STRING database.

First level regulatory network of nr5a1a+nr5a2+nr5a5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 25.2 GO:0001678 cellular glucose homeostasis(GO:0001678)
1.6 6.2 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
1.4 7.1 GO:0010872 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
1.4 4.2 GO:0009595 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
1.3 5.0 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.2 3.7 GO:0061317 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
1.0 3.1 GO:0015824 proline transport(GO:0015824)
1.0 4.0 GO:0006531 aspartate metabolic process(GO:0006531)
0.9 3.8 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.9 3.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.9 4.4 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.8 3.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.8 4.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.8 5.6 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.8 2.3 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.8 2.3 GO:0046184 aldehyde biosynthetic process(GO:0046184)
0.7 15.1 GO:0006825 copper ion transport(GO:0006825)
0.7 3.5 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.7 4.8 GO:0030728 ovulation(GO:0030728)
0.7 2.0 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.7 2.7 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.7 4.0 GO:0071800 podosome assembly(GO:0071800)
0.6 3.8 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.6 2.5 GO:2000048 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.6 9.2 GO:0070365 hepatocyte differentiation(GO:0070365)
0.6 2.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.5 2.2 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.5 2.2 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.5 2.6 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.5 2.1 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.5 1.5 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.5 3.0 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.5 2.5 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.5 10.4 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.5 4.1 GO:0042438 melanin biosynthetic process(GO:0042438)
0.4 37.4 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.4 3.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 2.2 GO:0008584 male gonad development(GO:0008584)
0.4 2.6 GO:0048714 positive regulation of gliogenesis(GO:0014015) positive regulation of glial cell differentiation(GO:0045687) positive regulation of oligodendrocyte differentiation(GO:0048714)
0.4 4.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4 4.7 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.4 20.1 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.4 3.6 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.4 1.6 GO:1901380 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.4 2.0 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.4 5.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.4 6.3 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.4 1.4 GO:0015860 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.4 1.4 GO:1903385 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.4 1.8 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.3 6.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3 1.0 GO:0046546 negative regulation of lipid transport(GO:0032369) development of primary male sexual characteristics(GO:0046546)
0.3 1.7 GO:0030327 prenylated protein catabolic process(GO:0030327) prenylcysteine catabolic process(GO:0030328) prenylcysteine metabolic process(GO:0030329)
0.3 3.0 GO:0035844 cloaca development(GO:0035844)
0.3 10.2 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.3 3.2 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.3 1.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.3 1.8 GO:0006788 heme oxidation(GO:0006788)
0.3 3.6 GO:0001840 neural plate development(GO:0001840)
0.3 2.1 GO:0034389 lipid particle organization(GO:0034389)
0.3 2.0 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753)
0.3 4.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.3 7.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.3 1.1 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.3 0.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 3.0 GO:0030431 sleep(GO:0030431)
0.2 4.2 GO:0001556 oocyte maturation(GO:0001556)
0.2 1.0 GO:0034969 histone arginine methylation(GO:0034969)
0.2 2.9 GO:0035094 response to nicotine(GO:0035094)
0.2 4.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 1.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.2 5.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 1.6 GO:0003321 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.2 2.1 GO:0001780 neutrophil homeostasis(GO:0001780)
0.2 14.9 GO:0051592 response to calcium ion(GO:0051592)
0.2 2.7 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.2 10.7 GO:0018198 peptidyl-cysteine modification(GO:0018198)
0.2 0.8 GO:0035994 response to muscle stretch(GO:0035994)
0.2 1.5 GO:0090177 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 1.6 GO:0051673 membrane disruption in other organism(GO:0051673)
0.2 1.6 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 2.5 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.2 1.2 GO:0048240 sperm capacitation(GO:0048240)
0.2 2.1 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.2 1.1 GO:0035889 otolith tethering(GO:0035889)
0.2 1.7 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.2 3.2 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.2 0.6 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.2 3.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 1.2 GO:0008343 adult feeding behavior(GO:0008343)
0.2 1.2 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.2 1.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 2.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 1.3 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.2 4.7 GO:0019226 transmission of nerve impulse(GO:0019226)
0.1 2.7 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 1.3 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 3.1 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.1 1.2 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005) vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.1 13.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 2.8 GO:0021884 forebrain neuron development(GO:0021884)
0.1 10.1 GO:0007605 sensory perception of sound(GO:0007605)
0.1 5.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 1.8 GO:0016486 peptide hormone processing(GO:0016486)
0.1 1.0 GO:0034381 plasma lipoprotein particle clearance(GO:0034381) long-chain fatty acid import(GO:0044539)
0.1 0.6 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.5 GO:0031053 primary miRNA processing(GO:0031053)
0.1 3.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 6.9 GO:0046328 regulation of JNK cascade(GO:0046328)
0.1 3.2 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 2.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2.1 GO:0015671 oxygen transport(GO:0015671)
0.1 6.1 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 0.4 GO:0016559 peroxisome fission(GO:0016559)
0.1 1.7 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 1.8 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.6 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.1 0.7 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 6.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 1.7 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.1 1.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 1.4 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.1 2.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 4.2 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.1 1.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 2.3 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 1.8 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 1.9 GO:0043171 peptide catabolic process(GO:0043171)
0.1 3.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 0.3 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867) positive regulation of triglyceride metabolic process(GO:0090208)
0.1 0.7 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.1 2.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 1.2 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 3.3 GO:0031017 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.1 0.7 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 10.6 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.1 1.0 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.1 1.2 GO:0009081 branched-chain amino acid metabolic process(GO:0009081)
0.0 0.5 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 2.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 2.8 GO:0007416 synapse assembly(GO:0007416)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.8 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 1.2 GO:0006096 glycolytic process(GO:0006096)
0.0 2.2 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 13.4 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 2.2 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.3 GO:0055015 ventricular cardiac muscle cell development(GO:0055015)
0.0 1.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 2.2 GO:0033339 pectoral fin development(GO:0033339)
0.0 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 1.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.3 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 2.7 GO:0048675 axon extension(GO:0048675)
0.0 5.5 GO:0007601 visual perception(GO:0007601)
0.0 0.6 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 3.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 2.0 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 2.4 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 2.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 3.1 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 1.7 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.8 GO:0006284 base-excision repair(GO:0006284)
0.0 1.1 GO:0010038 response to metal ion(GO:0010038)
0.0 2.1 GO:0050877 neurological system process(GO:0050877)
0.0 0.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 2.5 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 2.2 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.3 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.0 0.8 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 1.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 6.7 GO:0019752 carboxylic acid metabolic process(GO:0019752)
0.0 0.8 GO:0007098 centrosome cycle(GO:0007098)
0.0 1.5 GO:0051321 meiotic cell cycle(GO:0051321)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:1902560 GMP reductase complex(GO:1902560)
0.9 5.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.9 11.1 GO:0042627 chylomicron(GO:0042627)
0.8 2.5 GO:0098753 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) anchored component of the cytoplasmic side of the plasma membrane(GO:0098753)
0.7 3.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.7 4.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.6 4.0 GO:0001891 phagocytic cup(GO:0001891)
0.4 4.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.4 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.4 2.5 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 3.2 GO:0098982 GABA-ergic synapse(GO:0098982)
0.3 8.4 GO:0098978 glutamatergic synapse(GO:0098978)
0.2 0.7 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.2 GO:0000811 GINS complex(GO:0000811)
0.2 3.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 2.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 3.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 2.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 2.3 GO:0036157 outer dynein arm(GO:0036157)
0.2 2.1 GO:0045095 keratin filament(GO:0045095)
0.2 13.1 GO:0070469 respiratory chain(GO:0070469)
0.2 5.0 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.7 GO:0061617 MICOS complex(GO:0061617)
0.2 3.2 GO:0031430 M band(GO:0031430)
0.2 10.0 GO:0034707 chloride channel complex(GO:0034707)
0.1 5.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.0 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.1 1.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 12.1 GO:0016459 myosin complex(GO:0016459)
0.1 1.7 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 11.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.9 GO:0045252 acrosomal vesicle(GO:0001669) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 2.0 GO:0043235 receptor complex(GO:0043235)
0.1 3.2 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 2.6 GO:0043204 perikaryon(GO:0043204)
0.1 2.5 GO:0016605 PML body(GO:0016605)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 4.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 6.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 3.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 58.9 GO:0005615 extracellular space(GO:0005615)
0.0 0.5 GO:0035101 FACT complex(GO:0035101)
0.0 3.5 GO:0043025 neuronal cell body(GO:0043025)
0.0 2.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 2.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 6.2 GO:0030424 axon(GO:0030424)
0.0 2.1 GO:0005930 axoneme(GO:0005930)
0.0 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.8 GO:0042383 sarcolemma(GO:0042383)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.1 GO:0005861 troponin complex(GO:0005861)
0.0 11.5 GO:0043005 neuron projection(GO:0043005)
0.0 1.2 GO:0031514 motile cilium(GO:0031514)
0.0 0.5 GO:0035869 ciliary transition zone(GO:0035869)
0.0 18.5 GO:0005739 mitochondrion(GO:0005739)
0.0 1.1 GO:0016342 catenin complex(GO:0016342)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.5 GO:0043186 P granule(GO:0043186)
0.0 2.6 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.8 GO:0032432 actin filament bundle(GO:0032432)
0.0 93.0 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.8 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.8 GO:0005536 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
2.0 12.1 GO:0032052 bile acid binding(GO:0032052)
1.8 12.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.4 5.7 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
1.4 7.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.4 4.2 GO:0016019 peptidoglycan receptor activity(GO:0016019)
1.3 4.0 GO:0034185 apolipoprotein binding(GO:0034185)
1.3 5.0 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
1.2 4.7 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.0 4.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
1.0 3.1 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.0 4.0 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.9 4.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.7 5.2 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.7 3.7 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.7 3.6 GO:0008432 JUN kinase binding(GO:0008432)
0.7 2.1 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.7 5.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 3.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.6 2.6 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.6 2.6 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.6 9.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6 3.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.6 3.3 GO:0004966 galanin receptor activity(GO:0004966)
0.5 15.8 GO:0030165 PDZ domain binding(GO:0030165)
0.5 4.7 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.5 3.0 GO:0004104 cholinesterase activity(GO:0004104)
0.5 2.4 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.5 1.4 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.5 52.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 1.3 GO:0000996 core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) mitochondrial RNA polymerase binding promoter specificity activity(GO:0034246)
0.4 2.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.4 2.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 1.3 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.4 5.4 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.4 8.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 4.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 2.5 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.4 1.4 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.3 3.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.3 1.7 GO:0001735 prenylcysteine oxidase activity(GO:0001735)
0.3 1.4 GO:0005521 lamin binding(GO:0005521)
0.3 3.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.3 1.0 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.3 2.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.3 1.3 GO:0016842 amidine-lyase activity(GO:0016842)
0.3 2.3 GO:0010181 FMN binding(GO:0010181)
0.3 1.8 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 2.1 GO:0098809 nitrite reductase activity(GO:0098809)
0.3 2.0 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.3 0.8 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.3 0.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 1.0 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.3 2.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 3.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 1.2 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.2 6.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.7 GO:0005131 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.2 1.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 3.6 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.2 2.0 GO:0015250 water channel activity(GO:0015250)
0.2 2.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 5.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 2.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 3.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 4.5 GO:0005112 Notch binding(GO:0005112)
0.2 1.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 1.5 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 0.6 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.2 3.2 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 8.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 2.3 GO:0045503 dynein light chain binding(GO:0045503)
0.2 2.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.1 GO:0005549 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.2 4.3 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 3.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 9.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.3 GO:0004096 catalase activity(GO:0004096)
0.1 5.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 5.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 6.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.5 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 15.6 GO:0005179 hormone activity(GO:0005179)
0.1 1.9 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 10.0 GO:0005254 chloride channel activity(GO:0005254)
0.1 0.7 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.1 6.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.1 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 1.0 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 3.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.7 GO:0030552 cAMP binding(GO:0030552)
0.1 0.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.8 GO:0043515 kinetochore binding(GO:0043515)
0.1 8.8 GO:0004540 ribonuclease activity(GO:0004540)
0.1 1.2 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 2.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 1.9 GO:0031267 small GTPase binding(GO:0031267)
0.1 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 2.9 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 11.0 GO:0042277 peptide binding(GO:0042277)
0.1 6.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 9.1 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 3.3 GO:0044325 ion channel binding(GO:0044325)
0.1 0.2 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 6.2 GO:0008201 heparin binding(GO:0008201)
0.1 0.3 GO:0042285 xylosyltransferase activity(GO:0042285)
0.1 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 14.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 9.3 GO:0008083 growth factor activity(GO:0008083)
0.1 3.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 10.7 GO:0003774 motor activity(GO:0003774)
0.1 0.2 GO:0033745 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.0 2.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.6 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 3.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.9 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 3.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 3.0 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.6 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 3.9 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 2.9 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.5 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 6.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.1 GO:0005507 copper ion binding(GO:0005507)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.1 GO:0008528 peptide receptor activity(GO:0001653) G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 2.4 GO:0015293 symporter activity(GO:0015293)
0.0 1.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 34.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.3 5.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.3 7.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 7.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 3.6 PID REELIN PATHWAY Reelin signaling pathway
0.2 3.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 19.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.1 1.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 1.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 6.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID FOXO PATHWAY FoxO family signaling
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
1.3 25.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
1.2 8.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.8 6.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.6 12.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.5 2.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.4 3.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.4 4.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 5.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 2.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.3 4.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.3 3.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 1.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 3.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 2.5 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.2 4.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 2.9 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 10.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 12.9 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 1.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 8.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.5 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 4.0 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 7.9 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.1 0.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.9 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 2.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.8 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 0.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.4 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 1.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 4.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation