ISMARA results: nr4a1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr4a1

Z-value: 1.26

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Transcription factors associated with nr4a1

Gene Symbol	Gene ID	Gene Info
nr4a1 NCBI UniProt	ENSDARG00000000796	nuclear receptor subfamily 4, group A, member 1
nr4a1 NCBI UniProt	ENSDARG00000109473	nuclear receptor subfamily 4, group A, member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr4a1	dr11_v1_chr23_-_32162810_32162810	-0.22	3.0e-02	Click!

Activity profile of nr4a1 motif

Sorted Z-values of nr4a1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_17745345 Show fit	21.52	ENSDART00000132690 ENSDART00000135376	si:dkey-200l5.4 NCBI UniProt Show fit	si:dkey-200l5.4
chr6_-_31348999 Show fit	21.36	ENSDART00000153734	dnajc6 NCBI UniProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 6
chr5_+_1278092 Show fit	16.37	ENSDART00000147972 ENSDART00000159783	dnm1a NCBI UniProt Show fit	dynamin 1a
chr8_-_14052349 Show fit	12.11	ENSDART00000135811	atp2b3a NCBI UniProt Show fit	ATPase plasma membrane Ca2+ transporting 3a
chr14_+_14225048 Show fit	11.04	ENSDART00000168749	nlgn3a NCBI UniProt Show fit	neuroligin 3a
chr20_-_10120442 Show fit	10.55	ENSDART00000144970	meis2b NCBI UniProt Show fit	Meis homeobox 2b
chr4_+_12615836 Show fit	9.56	ENSDART00000003583	lmo3 NCBI UniProt Show fit	LIM domain only 3
chr3_-_22212764 Show fit	8.85	ENSDART00000155490	maptb NCBI UniProt Show fit	microtubule-associated protein tau b
chr2_-_11912347 Show fit	8.57	ENSDART00000023851	abhd3 NCBI UniProt Show fit	abhydrolase domain containing 3
chr12_+_9817440 Show fit	8.36	ENSDART00000137081 ENSDART00000123712	rundc3ab NCBI UniProt Show fit	RUN domain containing 3Ab

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	21.4	GO:0016191	synaptic vesicle uncoating(GO:0016191)
1.6	17.9	GO:0097090	presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.9	17.5	GO:0098884	postsynaptic neurotransmitter receptor internalization(GO:0098884)
1.9	13.4	GO:0021534	cell proliferation in hindbrain(GO:0021534)
0.1	12.1	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.2	11.0	GO:0019226	transmission of nerve impulse(GO:0019226)
0.8	10.6	GO:0003209	cardiac atrium morphogenesis(GO:0003209)
0.0	8.8	GO:0000226	microtubule cytoskeleton organization(GO:0000226)
1.7	8.6	GO:0051792	medium-chain fatty acid biosynthetic process(GO:0051792)
0.4	8.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Showing 1 to 10 of 89 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	54.4	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	35.9	GO:0099572	postsynaptic specialization(GO:0099572)
0.9	17.5	GO:0098844	postsynaptic endocytic zone membrane(GO:0098844)
0.0	16.3	GO:0005615	extracellular space(GO:0005615)
0.0	10.6	GO:0043005	neuron projection(GO:0043005)
0.1	10.0	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	7.9	GO:0031012	extracellular matrix(GO:0031012)
0.2	7.5	GO:0030426	growth cone(GO:0030426)
0.6	7.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.3	6.8	GO:0034706	voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)

Showing 1 to 10 of 39 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.7	GO:0008017	microtubule binding(GO:0008017)
0.2	20.1	GO:0030276	clathrin binding(GO:0030276)
0.7	18.4	GO:0042043	neurexin family protein binding(GO:0042043)
0.4	12.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
2.9	8.6	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4	8.1	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	8.1	GO:0005096	GTPase activator activity(GO:0005096)
0.3	7.5	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	7.3	GO:0003924	GTPase activity(GO:0003924)
0.0	7.1	GO:0005516	calmodulin binding(GO:0005516)

Showing 1 to 10 of 66 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.7	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.4	4.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	4.8	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	4.5	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	3.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	2.3	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	2.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	1.9	PID P73PATHWAY	p73 transcription factor network

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	21.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
1.2	10.0	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	5.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	4.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.4	4.5	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.2	2.9	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	2.6	REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.2	2.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	2.1	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport

Showing 1 to 10 of 14 entries

Results for nr4a1

Z-value: 1.26

Motif logo

Transcription factors associated with nr4a1

Activity-expression correlation:

Activity profile of nr4a1 motif

Sorted Z-values of nr4a1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: