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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr3c1_ar

Z-value: 1.53

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Transcription factors associated with nr3c1_ar

Gene Symbol Gene ID Gene Info
ENSDARG00000025032 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ENSDARG00000112480 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ENSDARG00000116957 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ENSDARG00000067976 androgen receptor
ENSDARG00000114287 androgen receptor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr3c1dr11_v1_chr14_-_23801389_238013890.103.4e-01Click!
ardr11_v1_chr5_+_35561607_35561607-0.084.2e-01Click!

Activity profile of nr3c1_ar motif

Sorted Z-values of nr3c1_ar motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_41096058 48.68 ENSDART00000028373
FK506 binding protein 5
chr6_+_41099787 41.28 ENSDART00000186884
FK506 binding protein 5
chr16_+_50089417 18.63 ENSDART00000153675
nuclear receptor subfamily 1, group D, member 2a
chr7_+_48288762 12.36 ENSDART00000083569
ornithine decarboxylase antizyme 2b
chr16_+_10776688 11.10 ENSDART00000161969
ENSDART00000172657
ATPase Na+/K+ transporting subunit alpha 3b
chr16_+_10777116 9.12 ENSDART00000190902
ATPase Na+/K+ transporting subunit alpha 3b
chr20_+_28266892 7.88 ENSDART00000103330
ChaC, cation transport regulator homolog 1 (E. coli)
chr3_-_5067585 7.63 ENSDART00000169609
thyrotrophic embryonic factor b
chr12_-_46959990 6.93 ENSDART00000084557
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr15_+_40188076 6.78 ENSDART00000063779
EF-hand domain family, member D1
chr1_-_26782573 6.70 ENSDART00000090611
SH3 domain containing GRB2 like 2a, endophilin A1
chr14_-_28001986 6.54 ENSDART00000054115
TSC22 domain family, member 3
chr8_+_7359294 6.31 ENSDART00000121708
proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr10_-_17988779 6.07 ENSDART00000132206
ENSDART00000144841
si:dkey-242g16.2
chr15_-_5742531 5.93 ENSDART00000045985
phosphorylase kinase, gamma 1a (muscle)
chr15_+_37559570 5.90 ENSDART00000085522
heat shock protein, alpha-crystallin-related, b6
chr18_+_17428258 5.52 ENSDART00000010452
zgc:91860
chr19_-_32804535 5.33 ENSDART00000175613
ENSDART00000052098
5'-nucleotidase, cytosolic IAa
chr18_-_19491162 5.26 ENSDART00000090413
small nuclear RNA activating complex, polypeptide 5
chr22_+_5118361 5.07 ENSDART00000168371
ENSDART00000170222
ENSDART00000158846
muscle-specific beta 1 integrin binding protein
chr5_-_43935460 5.05 ENSDART00000166152
ENSDART00000188969
si:ch211-204c21.1
chr19_+_19412692 4.94 ENSDART00000113580
wu:fc38h03
chr21_+_32338897 4.88 ENSDART00000110137
si:ch211-247j9.1
chr15_-_9031996 4.75 ENSDART00000124998
reticulon 2a
chr10_-_43655449 4.62 ENSDART00000099134
myocyte enhancer factor 2ca
chr10_+_37500234 4.53 ENSDART00000132096
ENSDART00000099473
musashi RNA-binding protein 2a
chr11_+_13528437 4.35 ENSDART00000011362
arrestin domain containing 2
chr4_-_20511595 4.23 ENSDART00000185806
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr14_+_46028003 4.12 ENSDART00000113469
nocturnin a
chr12_+_13256415 4.11 ENSDART00000144542
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr17_-_6730247 4.11 ENSDART00000031091
visinin-like 1b
chr18_+_16744307 4.07 ENSDART00000179872
ENSDART00000133490
lymphatic vessel endothelial hyaluronic receptor 1b
chr23_+_44732863 3.99 ENSDART00000160044
ENSDART00000172268
ATPase Na+/K+ transporting subunit beta 2a
chr25_-_3469576 3.99 ENSDART00000186738
HMG-box transcription factor 1
chr22_+_12595144 3.95 ENSDART00000140054
ENSDART00000060979
ENSDART00000139826
zgc:92335
chr15_-_35930070 3.92 ENSDART00000076229
insulin receptor substrate 1
chr21_+_20901505 3.86 ENSDART00000132741
complement component 7b
chr2_-_32512648 3.82 ENSDART00000170674
ATP-binding cassette, sub-family F (GCN20), member 2a
chr18_+_17428506 3.80 ENSDART00000100223
zgc:91860
chr7_+_6969909 3.75 ENSDART00000189886
actinin alpha 3b
chr18_-_35736591 3.75 ENSDART00000036015
ryanodine receptor 1b (skeletal)
chr8_-_11202378 3.73 ENSDART00000147817
ENSDART00000174039
family with sequence similarity 208, member B
chr6_-_40006809 3.72 ENSDART00000085666
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
chr5_+_51909740 3.67 ENSDART00000162541
thrombospondin 4a
chr20_+_34915945 3.67 ENSDART00000153064
synaptosomal-associated protein, 25a
chr10_-_24343507 3.59 ENSDART00000002974
phosphatidylinositol transfer protein, alpha b
chr23_+_37458602 3.59 ENSDART00000181686
cytidine deaminase a
chr10_-_15672862 3.52 ENSDART00000109231
MAM domain containing 2b
chr17_+_29345606 3.52 ENSDART00000086164
potassium channel tetramerization domain containing 3
chr16_+_32559821 3.51 ENSDART00000093250
POU class 3 homeobox 2b
chr21_+_32339158 3.50 ENSDART00000161723
si:ch211-247j9.1
chr1_+_31674297 3.38 ENSDART00000044214
WW domain binding protein 1-like b
chr21_-_30648106 3.35 ENSDART00000160800
ENSDART00000177022
phosphorylase kinase, alpha 1b (muscle)
chr6_-_40029423 3.31 ENSDART00000103230
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
chr6_+_60112200 3.25 ENSDART00000008243
PRELI domain containing 3
chr13_+_912123 3.24 ENSDART00000169931
proprotein convertase subtilisin/kexin type 2
chr20_+_39283849 3.23 ENSDART00000002481
ENSDART00000146683
scavenger receptor class A, member 3
chr5_-_43935119 3.21 ENSDART00000142271
si:ch211-204c21.1
chr4_+_4803698 3.18 ENSDART00000129252
solute carrier family 13 (sodium/sulfate symporter), member 4
chr17_+_33767890 3.17 ENSDART00000193177
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr19_-_32487469 3.13 ENSDART00000050130
guanosine monophosphate reductase
chr3_-_25275364 3.05 ENSDART00000163782
ENSDART00000145420
ENSDART00000133718
ENSDART00000055492
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr25_+_31912153 3.01 ENSDART00000153968
amyloid beta (A4) precursor protein-binding, family A, member 2a
chr18_-_20608300 2.92 ENSDART00000140632
BCL2 like 13
chr1_-_59176949 2.90 ENSDART00000128742

chr23_-_1557195 2.88 ENSDART00000136436
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
chr24_-_24271629 2.84 ENSDART00000135060
ribosomal protein S6 kinase, polypeptide 3b
chr16_+_32736588 2.74 ENSDART00000075191
ENSDART00000168358
zgc:172323
chr4_+_4232562 2.72 ENSDART00000177529
small lysine rich protein 1
chr10_+_29431529 2.72 ENSDART00000158154
discs, large homolog 2 (Drosophila)
chr6_-_41091151 2.71 ENSDART00000154963
ENSDART00000153818
serine/arginine-rich splicing factor 3a
chr3_-_50124413 2.65 ENSDART00000189920
claudin k
chr5_-_41494831 2.60 ENSDART00000051081
eukaryotic translation elongation factor 2, like 2
chr4_-_11163112 2.59 ENSDART00000188854
protein arginine methyltransferase 8b
chr12_-_4683325 2.58 ENSDART00000152771
si:ch211-255p10.3
chr23_-_39849155 2.47 ENSDART00000115330
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr5_-_31901468 2.37 ENSDART00000147814
ENSDART00000141446
coronin, actin binding protein, 1Cb
chr4_+_19534833 2.34 ENSDART00000140028
leucine rich repeat containing 4.1
chr5_+_32206378 2.33 ENSDART00000126873
ENSDART00000051361
myosin, heavy polypeptide 2, fast muscle specific
chr19_+_8985230 2.32 ENSDART00000018973
secretory carrier membrane protein 3
chr23_+_35708730 2.30 ENSDART00000009277
tubulin, alpha 1a
chr23_-_31645760 2.30 ENSDART00000035031
serum/glucocorticoid regulated kinase 1
chr7_-_32833153 2.29 ENSDART00000099871
ENSDART00000099872
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr13_-_226393 2.27 ENSDART00000172677
reticulon 4b
chr23_+_9088191 2.25 ENSDART00000030811
Cdk5 and Abl enzyme substrate 2b
chr3_-_35602233 2.19 ENSDART00000055269
guanine nucleotide binding protein (G protein), gamma 13b
chr20_-_6812688 2.18 ENSDART00000170934
insulin-like growth factor binding protein 1a
chr4_-_15420452 2.13 ENSDART00000016230
plexin A4
chr22_-_968484 2.10 ENSDART00000105895
calcium channel, voltage-dependent, L type, alpha 1S subunit, a
chr1_+_7517454 2.07 ENSDART00000016139
LanC antibiotic synthetase component C-like 1 (bacterial)
chr8_-_45835056 2.05 ENSDART00000022242
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr15_-_23342752 2.04 ENSDART00000020425
melanoma cell adhesion molecule b
chr20_+_54336137 2.04 ENSDART00000113792
CLOCK-interacting pacemaker b
chr20_-_29475172 2.02 ENSDART00000183164
secretogranin V
chr11_+_34522554 2.00 ENSDART00000109833
zinc finger, matrin-type 3
chr11_-_25829712 1.98 ENSDART00000103549
v-ski avian sarcoma viral oncogene homolog b
chr20_-_9273669 1.97 ENSDART00000175069
synaptotagmin XIVb
chr7_+_21752168 1.96 ENSDART00000173641
lysine (K)-specific demethylase 6B, a
chr3_-_36602379 1.96 ENSDART00000161501
ENSDART00000162396
RRN3 homolog, RNA polymerase I transcription factor
chr11_+_37144328 1.94 ENSDART00000162830
WNK lysine deficient protein kinase 2
chr4_-_789645 1.93 ENSDART00000164441
microtubule-associated protein, RP/EB family, member 3b
chr3_+_49397115 1.89 ENSDART00000176042
trans-2,3-enoyl-CoA reductase a
chr14_-_2355833 1.89 ENSDART00000157677
si:ch73-233f7.6
chr20_-_34801181 1.88 ENSDART00000048375
ENSDART00000132426
stathmin-like 4
chr6_-_27057702 1.87 ENSDART00000149363
serine/threonine kinase 25a
chr19_+_30633453 1.87 ENSDART00000052124
family with sequence similarity 49, member A-like
chr3_-_42086577 1.87 ENSDART00000083111
ENSDART00000187312
tweety family member 3a
chr2_-_23768818 1.84 ENSDART00000148685
ENSDART00000191167
xin actin binding repeat containing 1
chr23_+_32039386 1.84 ENSDART00000133801
myosin light chain kinase 2
chr24_-_20956781 1.82 ENSDART00000142080
karyopherin alpha 1 (importin alpha 5)
chr15_-_18429550 1.79 ENSDART00000136208
neural cell adhesion molecule 1b
chr6_-_6254432 1.78 ENSDART00000081952
reticulon 4a
chr6_+_40354424 1.76 ENSDART00000047416
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr15_-_23647078 1.75 ENSDART00000059366
creatine kinase, muscle b
chr19_+_5418006 1.72 ENSDART00000132874
eukaryotic translation initiation factor 1B
chr6_-_22064158 1.72 ENSDART00000153585
cilia and flagella associated protein 100
chr5_+_65492183 1.71 ENSDART00000162804
si:dkey-21e5.1
chr21_-_32462856 1.69 ENSDART00000147318
zgc:123105
chr18_+_50278858 1.69 ENSDART00000014582
si:dkey-105e17.1
chr2_-_3403020 1.67 ENSDART00000092741
synaptosomal-associated protein, 47
chr5_-_23362602 1.66 ENSDART00000137120
glutamate receptor, ionotropic, AMPA 3a
chr24_+_35564668 1.61 ENSDART00000122734
CCAAT/enhancer binding protein (C/EBP), delta
chr16_-_22225295 1.60 ENSDART00000163519

chr21_-_25565392 1.60 ENSDART00000144917
ENSDART00000180102
si:dkey-17e16.10
chr5_+_32162684 1.58 ENSDART00000134472
TAO kinase 3b
chr17_+_31580960 1.58 ENSDART00000188157
si:dkey-13p1.4
chr18_-_44611252 1.58 ENSDART00000173095
sprouty-related, EVH1 domain containing 3
chr22_-_7563593 1.56 ENSDART00000106062

chr18_-_20608025 1.56 ENSDART00000090156
ENSDART00000151980
BCL2 like 13
chr16_-_29194517 1.54 ENSDART00000046114
ENSDART00000148899
myocyte enhancer factor 2d
chr18_+_45114392 1.54 ENSDART00000172328
LARGE xylosyl- and glucuronyltransferase 2
chr16_+_18535618 1.52 ENSDART00000021596
retinoid x receptor, beta b
chr16_+_46430627 1.52 ENSDART00000127681
rapunzel 6
chr8_-_436137 1.51 ENSDART00000187021

chr5_-_23574234 1.51 ENSDART00000002453
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr5_+_51594209 1.51 ENSDART00000164668
ENSDART00000058403
ENSDART00000055857
creatine kinase, mitochondrial 2b (sarcomeric)
chr7_-_35036770 1.50 ENSDART00000123174
galanin receptor 1b
chr6_+_50451337 1.50 ENSDART00000155051
myelocytomatosis oncogene homolog
chr11_+_6152643 1.47 ENSDART00000012789
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr25_-_29363934 1.46 ENSDART00000166889
neuroplastin a
chr6_-_6448519 1.46 ENSDART00000180157
ENSDART00000191112
si:ch211-194e18.2
chr10_-_43611643 1.44 ENSDART00000134953
ENSDART00000134219
ENSDART00000138962
myocyte enhancer factor 2ca
chr17_-_37395460 1.44 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr22_+_19478140 1.42 ENSDART00000135291
ENSDART00000136576
si:dkey-78l4.8
chr2_+_38556195 1.41 ENSDART00000138769
cadherin 24, type 2b
chr8_-_45834825 1.41 ENSDART00000132965
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr13_-_41155472 1.41 ENSDART00000160588
si:dkeyp-86d6.2
chr12_+_49135755 1.38 ENSDART00000153460
si:zfos-911d5.4
chr3_+_62205858 1.37 ENSDART00000126807
zgc:173575
chr2_+_25929619 1.36 ENSDART00000137746
solute carrier family 7, member 14a
chr6_-_46875310 1.36 ENSDART00000154442
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr24_+_21973929 1.34 ENSDART00000042495
spermidine/spermine N1-acetyltransferase 1b
chr16_+_26863414 1.33 ENSDART00000140673
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
chr1_+_26110985 1.29 ENSDART00000054208
methylthioadenosine phosphorylase
chr7_-_41858513 1.29 ENSDART00000109918
myosin light chain kinase 3
chr10_+_21758811 1.29 ENSDART00000188827
protocadherin 1 gamma 11
chr14_-_2270973 1.28 ENSDART00000180729
protocadherin 2 alpha b 9
chr2_+_47708853 1.28 ENSDART00000124307
muscleblind-like splicing regulator 1
chr11_+_13629528 1.28 ENSDART00000186509
si:ch211-1a19.3
chr11_+_13630107 1.26 ENSDART00000172220
si:ch211-1a19.3
chr23_+_6752828 1.25 ENSDART00000105179
zgc:158254
chr24_-_9960290 1.25 ENSDART00000143390
ENSDART00000092975
ENSDART00000184953
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr5_-_54792239 1.24 ENSDART00000056213
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_73821685 1.24 ENSDART00000174141
si:dkey-262g12.12
chr24_-_20641000 1.24 ENSDART00000166135
zinc finger and BTB domain containing 47b
chr2_+_3403264 1.23 ENSDART00000105387
jumonji domain containing 4
chr21_+_6290566 1.23 ENSDART00000161647
formin binding protein 1b
chr17_+_6276559 1.22 ENSDART00000131075
dual specificity phosphatase 23b
chr19_-_41213718 1.22 ENSDART00000077121
pyruvate dehydrogenase kinase, isozyme 4
chr25_-_18330503 1.21 ENSDART00000104496
dual specificity phosphatase 6
chr5_+_19314574 1.21 ENSDART00000133247
RUN and SH3 domain containing 2
chr19_-_205104 1.20 ENSDART00000011890
zinc finger and BTB domain containing 22a
chr9_-_43538328 1.19 ENSDART00000140526
zinc finger protein 385B
chr21_-_131236 1.19 ENSDART00000160005
si:ch1073-398f15.1
chr21_+_28478663 1.19 ENSDART00000077887
ENSDART00000134150
solute carrier family 22 (organic anion transporter), member 6, like
chr9_-_32753535 1.18 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr21_+_30563115 1.17 ENSDART00000028566
si:ch211-200p22.4
chr21_+_5802377 1.17 ENSDART00000151316
cyclin G2
chr11_+_5880562 1.17 ENSDART00000129663
ENSDART00000130768
ENSDART00000160909
DAZ associated protein 1
chr5_+_65536095 1.16 ENSDART00000189898
si:dkey-21e5.1
chr10_-_13178853 1.16 ENSDART00000163740
ENSDART00000166327
ENSDART00000160265
ENSDART00000164299
muscle, skeletal, receptor tyrosine kinase
chr1_+_32521469 1.15 ENSDART00000113818
ENSDART00000152580
neuroligin 4a
chr14_+_22114918 1.14 ENSDART00000166610
thioredoxin-related transmembrane protein 2a
chr14_-_12307522 1.14 ENSDART00000163900
myotilin
chr13_+_24851102 1.13 ENSDART00000187637
si:dkey-24f15.2
chr24_+_7637522 1.12 ENSDART00000082467
caveolae associated protein 1b
chr10_-_20669635 1.12 ENSDART00000131361
Kv channel interacting protein 3b, calsenilin
chr3_-_58543658 1.12 ENSDART00000042386
un-named sa1261
chr12_+_28117365 1.11 ENSDART00000066290
urotensin 2 receptor
chr10_+_34315719 1.11 ENSDART00000135303
StAR-related lipid transfer (START) domain containing 13a
chr3_-_54669185 1.11 ENSDART00000053106
sphingosine-1-phosphate receptor 2
chr9_-_21918963 1.09 ENSDART00000090782
LIM domain 7a
chr11_-_7050825 1.09 ENSDART00000179749
si:ch211-253b8.5
chr1_+_24076243 1.09 ENSDART00000014608
mab-21-like 2
chr13_+_25846528 1.05 ENSDART00000087426
B cell CLL/lymphoma 11Aa
chr6_-_17849786 1.04 ENSDART00000172709
regulatory associated protein of MTOR, complex 1
chr20_+_46586678 1.04 ENSDART00000014166
ENSDART00000179266
Jun dimerization protein 2b
chr23_+_4890693 1.02 ENSDART00000023537
troponin C type 1a (slow)
chr25_+_5044780 1.02 ENSDART00000153980
parvin, beta
chr3_-_35800221 1.00 ENSDART00000031390
CASK interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c1_ar

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 90.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
2.0 6.1 GO:0036076 ligamentous ossification(GO:0036076)
1.4 8.4 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
1.3 24.2 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
1.2 3.6 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.1 5.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.8 8.9 GO:0010955 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.7 3.7 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.7 2.1 GO:0007414 axonal defasciculation(GO:0007414)
0.6 13.7 GO:0006595 polyamine metabolic process(GO:0006595)
0.6 4.6 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.6 2.3 GO:0021557 oculomotor nerve development(GO:0021557)
0.5 4.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.5 2.0 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.5 22.8 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.5 1.4 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.5 2.3 GO:0060231 mesenchymal to epithelial transition(GO:0060231)
0.4 7.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.4 5.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.4 1.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) anterior lateral line neuromast hair cell development(GO:0035676)
0.3 1.0 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.3 1.2 GO:0021742 abducens nucleus development(GO:0021742)
0.3 6.4 GO:0010962 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.3 2.3 GO:0021634 optic nerve formation(GO:0021634)
0.3 2.3 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.3 1.4 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
0.3 1.1 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.3 1.6 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.3 1.3 GO:0071265 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.3 3.3 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 0.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.2 0.7 GO:0034331 cell junction maintenance(GO:0034331)
0.2 3.2 GO:0016486 peptide hormone processing(GO:0016486)
0.2 1.9 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.2 1.3 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.2 6.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.2 0.8 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 5.4 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 2.2 GO:0050909 sensory perception of taste(GO:0050909)
0.2 2.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 3.2 GO:0036065 fucosylation(GO:0036065)
0.2 2.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 0.7 GO:0030091 protein repair(GO:0030091)
0.2 3.9 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 1.2 GO:0045905 positive regulation of translational termination(GO:0045905)
0.2 0.9 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 1.2 GO:2001270 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 1.2 GO:0060420 regulation of heart growth(GO:0060420)
0.2 3.4 GO:0014823 response to activity(GO:0014823)
0.2 0.8 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.2 5.1 GO:0016082 synaptic vesicle priming(GO:0016082)
0.2 0.6 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.2 1.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 1.5 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.2 2.6 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.2 1.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 3.1 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.1 3.9 GO:0019835 cytolysis(GO:0019835)
0.1 0.4 GO:0044650 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 1.0 GO:0090311 regulation of histone deacetylation(GO:0031063) regulation of protein deacetylation(GO:0090311)
0.1 2.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.8 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.1 0.6 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.1 0.4 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 3.1 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 0.5 GO:0097037 heme export(GO:0097037)
0.1 7.0 GO:0015914 phospholipid transport(GO:0015914)
0.1 1.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 1.3 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 1.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 7.0 GO:0071482 cellular response to light stimulus(GO:0071482)
0.1 2.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 1.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.5 GO:2000651 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 1.2 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 2.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 0.8 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 0.9 GO:0030431 sleep(GO:0030431)
0.1 1.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.1 1.8 GO:0015701 bicarbonate transport(GO:0015701)
0.1 3.3 GO:0046883 regulation of hormone secretion(GO:0046883)
0.1 0.4 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.2 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.1 0.8 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.8 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 0.8 GO:0061055 myotome development(GO:0061055)
0.1 0.3 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.1 0.9 GO:0009437 carnitine metabolic process(GO:0009437)
0.1 0.6 GO:0038203 TORC2 signaling(GO:0038203)
0.0 1.1 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.5 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 1.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.4 GO:0001885 endothelial cell development(GO:0001885)
0.0 2.6 GO:0006414 translational elongation(GO:0006414)
0.0 1.2 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.8 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:1900136 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.0 0.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.4 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.3 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 1.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 1.0 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 0.7 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.9 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 7.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 3.9 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.9 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 1.5 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 9.4 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.4 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 7.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.9 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.6 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 1.9 GO:0003401 axis elongation(GO:0003401)
0.0 0.3 GO:0035094 response to nicotine(GO:0035094)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044) chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.3 GO:0097369 sodium ion import(GO:0097369) inorganic cation import into cell(GO:0098659) sodium ion import across plasma membrane(GO:0098719) inorganic ion import into cell(GO:0099587) sodium ion import into cell(GO:1990118)
0.0 2.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.7 GO:0000469 cleavage involved in rRNA processing(GO:0000469)
0.0 1.2 GO:0033673 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.8 GO:0021575 hindbrain morphogenesis(GO:0021575)
0.0 2.5 GO:0006821 chloride transport(GO:0006821)
0.0 0.2 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.1 GO:0014005 microglia development(GO:0014005)
0.0 0.8 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 5.8 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0060118 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 1.1 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 1.7 GO:0006413 translational initiation(GO:0006413)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.4 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.4 GO:0051014 actin filament severing(GO:0051014)
0.0 0.5 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 0.1 GO:0006788 heme oxidation(GO:0006788)
0.0 0.7 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.6 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 1.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0006921 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 1.8 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.1 GO:0061316 canonical Wnt signaling pathway involved in heart development(GO:0061316) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 0.6 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 2.9 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.1 GO:0003321 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.0 0.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:1902560 GMP reductase complex(GO:1902560)
0.9 2.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) anchored component of the cytoplasmic side of the plasma membrane(GO:0098753)
0.7 8.7 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.6 3.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.5 3.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.4 4.0 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.4 6.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 3.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.2 3.9 GO:0005579 membrane attack complex(GO:0005579)
0.2 4.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 2.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.0 GO:0030897 HOPS complex(GO:0030897)
0.1 0.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 4.5 GO:0005844 polysome(GO:0005844)
0.1 0.8 GO:0030891 VCB complex(GO:0030891)
0.1 1.0 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.5 GO:0043291 RAVE complex(GO:0043291)
0.1 1.5 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.1 2.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.7 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.1 1.2 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 2.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 2.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.7 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.1 3.3 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 10.2 GO:0005925 focal adhesion(GO:0005925)
0.1 1.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.7 GO:0043204 perikaryon(GO:0043204)
0.1 7.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.7 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 3.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 2.0 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.1 5.0 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.8 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.8 GO:0000813 ESCRT I complex(GO:0000813)
0.0 2.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0002102 podosome(GO:0002102)
0.0 2.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.5 GO:0031514 motile cilium(GO:0031514)
0.0 0.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.6 GO:0038201 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.0 3.8 GO:0016459 myosin complex(GO:0016459)
0.0 2.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.4 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.6 GO:0030424 axon(GO:0030424)
0.0 0.4 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.7 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 4.0 GO:0043005 neuron projection(GO:0043005)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 4.5 GO:0030054 cell junction(GO:0030054)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 2.2 GO:0016607 nuclear speck(GO:0016607)
0.0 0.9 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.1 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 0.9 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0 0.8 GO:0030496 midbody(GO:0030496)
0.0 22.1 GO:0005829 cytosol(GO:0005829)
0.0 1.1 GO:0030018 Z disc(GO:0030018)
0.0 1.6 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 100.6 GO:0005737 cytoplasm(GO:0005737)
0.0 0.2 GO:0031982 vesicle(GO:0031982)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
22.5 90.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
3.1 12.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
2.0 20.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
2.0 7.9 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
1.7 6.9 GO:0101006 inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
1.1 5.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
1.0 3.1 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.7 3.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.7 5.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.6 2.9 GO:2001070 starch binding(GO:2001070)
0.5 2.6 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.5 3.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.5 3.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 7.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.5 1.9 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.5 3.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 6.1 GO:2001069 glycogen binding(GO:2001069)
0.4 3.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.4 2.1 GO:0043295 glutathione binding(GO:0043295)
0.4 2.6 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.3 3.9 GO:0005158 insulin receptor binding(GO:0005158)
0.3 1.4 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 2.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 4.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.3 1.3 GO:0034046 poly(G) binding(GO:0034046)
0.3 5.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 3.3 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 1.5 GO:0004966 galanin receptor activity(GO:0004966)
0.2 4.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 3.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 2.8 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 0.9 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 0.7 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 4.0 GO:0001671 ATPase activator activity(GO:0001671)
0.2 2.2 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.2 2.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.3 GO:0019809 spermidine binding(GO:0019809)
0.2 3.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 2.3 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.2 0.9 GO:0031705 bombesin receptor binding(GO:0031705)
0.2 1.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.7 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 1.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 18.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.9 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.6 GO:0032183 SUMO binding(GO:0032183)
0.1 1.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 3.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 6.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 0.7 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 4.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.8 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 0.4 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.1 2.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.8 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 3.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 1.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 2.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 3.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 6.9 GO:0008201 heparin binding(GO:0008201)
0.1 0.4 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.9 GO:0031628 opioid receptor binding(GO:0031628)
0.1 2.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.6 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.8 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 2.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.5 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.5 GO:0004067 asparaginase activity(GO:0004067)
0.1 0.3 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 1.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.1 0.3 GO:0004001 adenosine kinase activity(GO:0004001)
0.0 1.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 2.8 GO:0046332 SMAD binding(GO:0046332)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307) actinin binding(GO:0042805)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.1 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.0 1.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.1 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 2.4 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 1.9 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0097001 sphingolipid binding(GO:0046625) ceramide binding(GO:0097001)
0.0 0.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 3.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 11.5 GO:0003779 actin binding(GO:0003779)
0.0 0.2 GO:0042285 xylosyltransferase activity(GO:0042285)
0.0 0.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.1 GO:0016918 retinal binding(GO:0016918)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.1 GO:0070888 E-box binding(GO:0070888)
0.0 19.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 92.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.4 4.9 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 7.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.7 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 3.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 1.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 3.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 3.9 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 1.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 5.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 3.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 0.9 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 2.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.7 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.7 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.5 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 1.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA