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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for nr1h4
Z-value: 1.38
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Transcription factors associated with nr1h4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr1h4 | dr11_v1_chr18_+_15644559_15644559 | 0.66 | 5.0e-13 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_1769475 Show fit | 30.90 |
ENSDART00000079073
|
serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
|
| chr15_-_462783 Show fit | 23.79 |
ENSDART00000161049
|
Danio rerio uncharacterized LOC100002960 (LOC100002960), mRNA. |
|
| chr2_-_42234484 Show fit | 22.00 |
ENSDART00000132617
ENSDART00000136690 ENSDART00000141358 |
apolipoprotein M |
|
| chr6_-_27139396 Show fit | 21.17 |
ENSDART00000055848
|
zgc:103559 |
|
| chr24_-_21689146 Show fit | 20.11 |
ENSDART00000105917
|
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase |
|
| chr5_+_28830388 Show fit | 18.93 |
ENSDART00000149150
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 |
|
| chr21_+_40092301 Show fit | 18.88 |
ENSDART00000145150
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a |
|
| chr1_+_127250 Show fit | 17.33 |
ENSDART00000003463
|
coagulation factor VIIi |
|
| chr4_+_1530287 Show fit | 17.12 |
ENSDART00000067446
|
solute carrier family 38, member 4 |
|
| chr6_-_609880 Show fit | 15.52 |
ENSDART00000149248
ENSDART00000148867 ENSDART00000149414 ENSDART00000148552 ENSDART00000148391 |
lectin, galactoside-binding, soluble, 2b |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr1h4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 64.1 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 10.3 | 41.3 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 2.1 | 27.1 | GO:0019730 | antimicrobial humoral response(GO:0019730) |
| 2.5 | 17.3 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.3 | 17.1 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.1 | 15.5 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
| 0.8 | 14.9 | GO:0006744 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.4 | 14.0 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.1 | 13.0 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.7 | 12.6 | GO:0048922 | posterior lateral line neuromast deposition(GO:0048922) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 95.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 27.0 | GO:0005576 | extracellular region(GO:0005576) |
| 0.3 | 26.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 24.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.7 | 12.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 12.3 | GO:0005764 | lysosome(GO:0005764) |
| 0.1 | 11.3 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 10.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 9.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 8.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 70.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 27.0 | GO:0005525 | GTP binding(GO:0005525) |
| 8.1 | 24.4 | GO:0042806 | fucose binding(GO:0042806) |
| 0.1 | 24.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 22.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 5.3 | 21.2 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.0 | 20.5 | GO:0005198 | structural molecule activity(GO:0005198) |
| 1.7 | 17.1 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 17.1 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.0 | 15.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 51.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 24.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 9.2 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.4 | 6.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 4.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 1.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 1.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.4 | 10.0 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.5 | 7.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 6.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 4.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 3.9 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.2 | 3.6 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 3.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 3.1 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |