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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr1d2a

Z-value: 1.23

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Transcription factors associated with nr1d2a

Gene Symbol Gene ID Gene Info
ENSDARG00000003820 nuclear receptor subfamily 1, group D, member 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr1d2adr11_v1_chr16_+_50100420_501004200.241.9e-02Click!

Activity profile of nr1d2a motif

Sorted Z-values of nr1d2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_70155935 28.92 ENSDART00000165570
regulator of G protein signaling 3a
chr17_-_6738538 26.20 ENSDART00000157125
visinin-like 1b
chr18_-_39473055 20.69 ENSDART00000122930
secretogranin III
chr7_+_40228422 20.55 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr17_-_15528597 19.13 ENSDART00000150232
FYN proto-oncogene, Src family tyrosine kinase a
chr23_+_19564392 16.82 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr6_+_57541776 16.04 ENSDART00000157330
N-terminal EF-hand calcium binding protein 3
chr25_+_6306885 15.95 ENSDART00000142705
ENSDART00000067510
cellular retinoic acid binding protein 1a
chr2_-_16380283 15.40 ENSDART00000149992
si:dkey-231j24.3
chr3_+_35298078 14.61 ENSDART00000110126
calcium channel, voltage-dependent, gamma subunit 3b
chr6_-_39605734 14.43 ENSDART00000044276
ENSDART00000179059
disco-interacting protein 2 homolog Bb
chr5_-_67878064 13.69 ENSDART00000111203
transgelin 3a
chr1_-_44704261 13.46 ENSDART00000133210
si:dkey-28b4.8
chr22_+_17828267 12.98 ENSDART00000136016
hyaluronan and proteoglycan link protein 4
chr20_+_16750177 12.87 ENSDART00000185357
calmodulin 1b
chr12_+_28574863 12.85 ENSDART00000153284
TBK1 binding protein 1
chr20_+_36233873 12.61 ENSDART00000131867
cornichon family AMPA receptor auxiliary protein 3
chr2_+_20430366 12.51 ENSDART00000155108
si:ch211-153l6.6
chr24_-_32408404 12.15 ENSDART00000144157
si:ch211-56a11.2
chr6_-_49159207 11.95 ENSDART00000041942
tetraspanin 2a
chr8_-_33114202 11.95 ENSDART00000098840
Ral GEF with PH domain and SH3 binding motif 1
chr17_-_7371564 11.00 ENSDART00000060336
RAB32b, member RAS oncogene family
chr16_+_12632428 10.68 ENSDART00000184600
ENSDART00000180537
N-acetyltransferase 14 (GCN5-related, putative)
chr17_-_42213285 10.66 ENSDART00000140549
NK2 homeobox 2a
chr5_-_11573490 10.28 ENSDART00000109577

chr8_+_21146262 8.93 ENSDART00000045684
porcupine O-acyltransferase
chr11_+_30672282 8.84 ENSDART00000023981
ENSDART00000188846
tau tubulin kinase 1a
chr19_-_15335787 8.37 ENSDART00000187131
human immunodeficiency virus type I enhancer binding protein 3a
chr22_-_11124419 8.12 ENSDART00000149634
ATPase H+ transporting accessory protein 2
chr16_-_8927425 8.06 ENSDART00000000382
trio Rho guanine nucleotide exchange factor b
chr18_-_35736591 8.05 ENSDART00000036015
ryanodine receptor 1b (skeletal)
chr12_-_3756405 8.03 ENSDART00000150839
family with sequence similarity 57, member Bb
chr18_-_42313798 7.98 ENSDART00000098639
contactin 5
chr25_+_14165447 7.86 ENSDART00000145387
SH3 and multiple ankyrin repeat domains 2
chr7_+_15871156 7.79 ENSDART00000145946
paired box 6b
chr18_+_22302635 7.77 ENSDART00000141051
capping protein regulator and myosin 1 linker 2
chr1_+_9708801 7.68 ENSDART00000189621
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr3_+_32698424 7.58 ENSDART00000055340
FUS RNA binding protein
chr9_+_17982737 7.48 ENSDART00000192569
A kinase (PRKA) anchor protein 11
chr25_-_17918810 7.36 ENSDART00000023959
aryl hydrocarbon receptor nuclear translocator-like 1a
chr1_-_30039331 7.30 ENSDART00000086935
ENSDART00000143800
zgc:153256
chr12_+_19305390 7.27 ENSDART00000183987
ENSDART00000066391
casein kinase 1, epsilon
chr3_-_26190804 7.21 ENSDART00000136001
yippee-like 3
chr22_-_834106 7.19 ENSDART00000105873
cryptochrome circadian clock 4
chr5_-_30079434 7.06 ENSDART00000133981
beta-carotene oxygenase 2a
chr14_-_42997145 6.71 ENSDART00000172801
protocadherin 10b
chr7_+_66048102 6.22 ENSDART00000104523
aryl hydrocarbon receptor nuclear translocator-like 1b
chr1_-_49498116 6.19 ENSDART00000137357
zgc:175214
chr16_-_24561354 5.81 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
chr3_-_16039619 5.73 ENSDART00000143324
splA/ryanodine receptor domain and SOCS box containing 3a
chr1_+_19930520 5.48 ENSDART00000158344
amyloid beta (A4) precursor protein-binding, family B, member 2b
chr12_+_12112384 5.33 ENSDART00000152431
glutamate receptor, ionotropic, delta 1b
chr9_-_43207768 5.26 ENSDART00000192523
SEC14 and spectrin domains 1
chr12_-_32013125 5.08 ENSDART00000153355
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr6_+_32415132 4.85 ENSDART00000155790
KN motif and ankyrin repeat domains 4
chr10_-_25628555 4.82 ENSDART00000143978
T cell lymphoma invasion and metastasis 1a
chr19_-_8732037 4.75 ENSDART00000138971
si:ch211-39a7.1
chr22_-_38480186 4.69 ENSDART00000171704
heme-binding protein soul4
chr14_-_25111496 4.63 ENSDART00000158108
si:rp71-1d10.8
chr25_-_17918536 4.56 ENSDART00000148660
aryl hydrocarbon receptor nuclear translocator-like 1a
chr25_-_1235457 4.44 ENSDART00000093093
coronin, actin binding protein, 2Bb
chr10_+_2232023 4.35 ENSDART00000097695
contactin associated protein like 3
chr5_-_23179319 4.21 ENSDART00000161883
ENSDART00000136260
si:dkey-114c15.5
chr8_+_43016714 3.95 ENSDART00000142671
Ras association (RalGDS/AF-6) domain family member 2a
chr19_+_24896409 3.94 ENSDART00000049840
EYA transcriptional coactivator and phosphatase 3
chr10_-_7988396 3.93 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr18_+_907266 3.89 ENSDART00000171729
pyruvate kinase M1/2a
chr17_+_5793248 3.78 ENSDART00000153743
retinitis pigmentosa 1-like 1a
chr20_+_34320635 3.75 ENSDART00000153207
influenza virus NS1A binding protein a
chr13_+_30172645 3.60 ENSDART00000137114
phosphatase domain containing, paladin 1b
chr15_+_17100412 3.56 ENSDART00000154418
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr18_+_27738349 3.46 ENSDART00000187816
tetraspanin 18b
chr2_-_42558549 3.39 ENSDART00000025997
disco-interacting protein 2 homolog Cb
chr21_-_40557281 3.27 ENSDART00000172327
TAO kinase 1b
chr9_-_43213229 3.14 ENSDART00000139775
SEC14 and spectrin domains 1
chr10_+_44692272 3.14 ENSDART00000157458
ubiquitin C
chr6_-_45995401 3.10 ENSDART00000154392
carbonic anhydrase XVI b
chr4_-_22519516 3.10 ENSDART00000130409
ENSDART00000186258
ENSDART00000002851
ENSDART00000123801
lysine (K)-specific demethylase 7Aa
chr20_-_14680897 3.10 ENSDART00000063857
ENSDART00000161314
secernin 2
chr7_+_15871408 2.96 ENSDART00000014572
paired box 6b
chr17_-_42213822 2.92 ENSDART00000187904
ENSDART00000180029
NK2 homeobox 2a
chr22_+_786556 2.83 ENSDART00000125347
cryptochrome circadian clock 1bb
chr5_-_13778726 2.82 ENSDART00000051655
small nuclear ribonucleoprotein 27 (U4/U6.U5)
chr8_+_21225064 2.68 ENSDART00000129210
cryptochrome circadian clock 1ba
chr22_-_29689485 2.68 ENSDART00000182173
programmed cell death 4b
chr5_-_35888499 2.57 ENSDART00000193932
relaxin/insulin-like family peptide receptor 2, like
chr3_+_52684556 2.56 ENSDART00000139037
6-phosphogluconolactonase
chr22_-_15704704 2.54 ENSDART00000017838
ENSDART00000130238
scaffold attachment factor B
chr16_+_8716800 2.41 ENSDART00000124693
ENSDART00000181961
cabz01093075.1
chr9_+_35860975 2.27 ENSDART00000134447
regulator of calcineurin 1a
chr23_-_36003282 2.17 ENSDART00000103150
calcium binding and coiled-coil domain 1a
chr8_+_42917515 2.00 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr15_-_24178893 2.00 ENSDART00000077980
pipecolic acid oxidase
chr3_-_2592350 1.94 ENSDART00000192325
si:dkey-217f16.5
chr16_+_26612401 1.85 ENSDART00000145571
erythrocyte membrane protein band 4.1 like 4B
chr23_+_44427188 1.79 ENSDART00000160207
eukaryotic translation initiation factor 4E family member 2 related sequence 1
chr11_+_5666325 1.70 ENSDART00000092270
R3H domain containing 4
chr21_-_2209012 1.62 ENSDART00000158345
zgc:162971
chr19_+_4990320 1.61 ENSDART00000147056
zgc:91968
chr15_+_17100697 1.57 ENSDART00000183565
ENSDART00000123197
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr23_+_41831224 1.47 ENSDART00000171885
sterol carrier protein 2b
chr1_-_21297748 1.46 ENSDART00000142109
neuropeptide Y receptor Y1
chr12_-_979789 1.44 ENSDART00000128188
diacylglycerol lipase, beta
chr1_-_31140096 1.36 ENSDART00000172243
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr5_+_43470544 1.34 ENSDART00000111587
Rho-related BTB domain containing 2a
chr21_-_32781612 1.34 ENSDART00000031028
CCR4-NOT transcription complex, subunit 6a
chr7_+_22313533 1.33 ENSDART00000123457
si:dkey-11f12.2
chr3_+_34985895 1.33 ENSDART00000121981
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr11_-_21303946 1.33 ENSDART00000185786
si:dkey-85p17.3
chr4_+_7876197 1.31 ENSDART00000111986
ENSDART00000189601
cell division cycle 123 homolog (S. cerevisiae)
chr10_-_7555660 1.28 ENSDART00000163689
Werner syndrome
chr12_-_7234915 1.27 ENSDART00000048866
inositol polyphosphate multikinase b
chr11_-_39118882 1.27 ENSDART00000113185
ENSDART00000156526
adaptor-related protein complex 5, beta 1 subunit
chr12_+_23912074 1.26 ENSDART00000152864
supervillin a
chr8_+_30452945 1.24 ENSDART00000062303
forkhead box D5
chr14_-_29859067 1.23 ENSDART00000136380
sorbin and SH3 domain containing 2b
chr9_-_43213057 1.18 ENSDART00000059448
ENSDART00000133589
SEC14 and spectrin domains 1
chr14_-_22390821 1.14 ENSDART00000054396
F-box and leucine-rich repeat protein 3, like
chr12_+_30789611 1.08 ENSDART00000181501
aldehyde dehydrogenase 18 family, member A1
chr10_-_1788376 1.07 ENSDART00000123842
erythrocyte membrane protein band 4.1 like 4A
chr17_+_49500820 1.06 ENSDART00000170306
apoptosis resistant E3 ubiquitin protein ligase 1
chr23_+_21278948 1.04 ENSDART00000156701
ENSDART00000033970
ubiquitin protein ligase E3 component n-recognin 4
chr9_-_48937089 1.04 ENSDART00000193442
ceramide synthase 6
chr2_+_35733335 0.88 ENSDART00000113489
RAS protein activator like 2
chr12_+_9542124 0.87 ENSDART00000127952
prolyl 4-hydroxylase, alpha polypeptide I a
chr16_+_4838808 0.84 ENSDART00000179363
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr1_+_26667872 0.76 ENSDART00000152803
ENSDART00000152144
ENSDART00000152785
ENSDART00000152393
hemogen
chr3_+_57997980 0.73 ENSDART00000168477
ENSDART00000193840
pyrroline-5-carboxylate reductase 1a
chr2_+_33189582 0.67 ENSDART00000145588
ENSDART00000136330
ENSDART00000139295
ENSDART00000086340
ring finger protein 220a
chr23_-_27442544 0.66 ENSDART00000019521
disco-interacting protein 2 homolog Ba
chr1_-_21714025 0.65 ENSDART00000129066
zinc finger, CCHC domain containing 7
chr10_-_7555326 0.65 ENSDART00000162191
ENSDART00000186945
Werner syndrome
chr7_+_71586485 0.60 ENSDART00000165582
structural maintenance of chromosomes flexible hinge domain containing 1
chr4_-_7875808 0.60 ENSDART00000162276
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr21_+_27189490 0.57 ENSDART00000125349
BCL2 associated agonist of cell death a
chr9_+_33267211 0.44 ENSDART00000025635
ubiquitin specific peptidase 9
chr16_-_47427016 0.40 ENSDART00000074575
septin 7b
chr3_-_2591942 0.36 ENSDART00000127971
si:dkey-217f16.5
chr15_-_34322915 0.33 ENSDART00000190543
ENSDART00000019651
ENSDART00000193601
diacylglycerol kinase, beta
chr9_+_35876927 0.31 ENSDART00000138834
mab-21-like 3
chr8_-_18899427 0.31 ENSDART00000079840
RAR-related orphan receptor C a
chr3_-_5555500 0.29 ENSDART00000176133
ENSDART00000057464
tripartite motif containing 35-31
chr17_-_29271359 0.27 ENSDART00000104219
REST corepressor 1
chr15_+_2559875 0.26 ENSDART00000178505
SH2B adaptor protein 2
chr7_-_8577190 0.21 ENSDART00000173174
jacalin 3
chr14_-_29858883 0.20 ENSDART00000141034
sorbin and SH3 domain containing 2b
chr24_-_23716097 0.15 ENSDART00000084954
ENSDART00000129028
phosphatidylinositol glycan anchor biosynthesis, class N
chr6_-_40768654 0.13 ENSDART00000184668
ENSDART00000146470
actin related protein 2/3 complex, subunit 4
chr6_+_37752781 0.11 ENSDART00000154364
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr23_-_44233408 0.10 ENSDART00000149318
ENSDART00000085528
zgc:158659
chr8_+_2530065 0.10 ENSDART00000063943
mitochondrial ribosomal protein L40
chr6_-_40312091 0.01 ENSDART00000154878
collagen, type VII, alpha 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nr1d2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 28.9 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
4.5 13.6 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
3.2 16.0 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
3.0 8.9 GO:0061355 Wnt protein secretion(GO:0061355)
2.4 19.1 GO:0034334 adherens junction maintenance(GO:0034334)
2.3 16.0 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
1.6 8.0 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
1.5 10.8 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.9 14.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.8 26.5 GO:0009648 photoperiodism(GO:0009648)
0.7 6.7 GO:0021794 thalamus development(GO:0021794)
0.7 2.0 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.6 12.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 7.8 GO:0030011 maintenance of cell polarity(GO:0030011)
0.5 3.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.5 2.0 GO:0046440 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.5 1.9 GO:0010259 multicellular organism aging(GO:0010259) G-quadruplex DNA unwinding(GO:0044806)
0.4 3.9 GO:0016576 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.4 5.1 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.4 8.1 GO:0032438 melanosome organization(GO:0032438)
0.4 1.4 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.4 3.9 GO:0051256 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.3 9.1 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.3 12.1 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.3 8.1 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.3 1.5 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.3 16.8 GO:0030641 regulation of cellular pH(GO:0030641)
0.2 2.6 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.2 1.8 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 2.6 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.2 2.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 1.3 GO:0003160 endocardium morphogenesis(GO:0003160)
0.1 12.8 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.1 7.3 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.1 2.7 GO:0003171 atrioventricular valve development(GO:0003171)
0.1 3.3 GO:0097194 execution phase of apoptosis(GO:0097194)
0.1 6.9 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.1 1.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 19.3 GO:0006470 protein dephosphorylation(GO:0006470)
0.1 6.1 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 0.7 GO:1901985 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1 4.8 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.1 3.8 GO:0035082 axoneme assembly(GO:0035082)
0.1 1.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 1.3 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 3.9 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.1 7.6 GO:0048675 axon extension(GO:0048675)
0.0 4.3 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 17.7 GO:0033365 protein localization to organelle(GO:0033365)
0.0 0.9 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 9.0 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 8.1 GO:0007411 axon guidance(GO:0007411)
0.0 1.1 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.8 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.8 GO:0006413 translational initiation(GO:0006413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 16.8 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
1.3 18.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
1.1 8.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.9 20.7 GO:0030667 secretory granule membrane(GO:0030667)
0.5 8.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.4 9.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 14.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 5.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 20.6 GO:0030141 secretory granule(GO:0030141)
0.2 8.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 16.0 GO:0031985 Golgi cisterna(GO:0031985)
0.1 19.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 8.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 6.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 13.3 GO:0030425 dendrite(GO:0030425)
0.0 5.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.3 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 1.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 2.0 GO:0005930 axoneme(GO:0005930)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 7.2 GO:0005730 nucleolus(GO:0005730)
0.0 1.4 GO:0005925 focal adhesion(GO:0005925)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 4.8 GO:0045202 synapse(GO:0045202)
0.0 79.1 GO:0005634 nucleus(GO:0005634)
0.0 15.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 16.0 GO:0001972 retinoic acid binding(GO:0001972)
1.6 8.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
1.3 12.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.8 3.1 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.6 3.9 GO:0004743 pyruvate kinase activity(GO:0004743)
0.6 3.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.5 9.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 1.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.4 2.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 2.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.3 8.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 5.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 8.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 19.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 5.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 7.5 GO:0051018 protein kinase A binding(GO:0051018)
0.2 1.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 1.9 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 3.1 GO:0031386 protein tag(GO:0031386)
0.2 14.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.7 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 4.3 GO:0004970 ionotropic glutamate receptor activity(GO:0004970)
0.1 7.2 GO:0009881 photoreceptor activity(GO:0009881)
0.1 1.8 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 22.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 9.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 1.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 19.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.6 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 18.1 GO:0046983 protein dimerization activity(GO:0046983)
0.0 33.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 11.4 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 40.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 4.7 GO:0020037 heme binding(GO:0020037)
0.0 2.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 14.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 4.4 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 13.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 8.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 8.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.9 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 20.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 7.3 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 1.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 7.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling