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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for nkx3.3-1
Z-value: 1.18
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Transcription factors associated with nkx3.3-1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_2815021 Show fit | 15.36 |
ENSDART00000020472
|
4-hydroxyphenylpyruvate dioxygenase a |
|
| chr7_-_23777445 Show fit | 12.30 |
ENSDART00000173527
|
si:ch211-200p22.4 |
|
| chr2_+_51028269 Show fit | 11.94 |
ENSDART00000161254
|
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) |
|
| chr12_+_31713239 Show fit | 11.68 |
ENSDART00000122379
|
hyaluronan binding protein 2 |
|
| chr8_-_14554785 Show fit | 10.79 |
ENSDART00000057645
|
quiescin Q6 sulfhydryl oxidase 1 |
|
| chr22_+_16022211 Show fit | 10.66 |
ENSDART00000062618
|
serpin peptidase inhibitor, clade C (antithrombin), member 1 |
|
| chr5_+_37978501 Show fit | 10.59 |
ENSDART00000012050
|
apolipoprotein A-Ia |
|
| chr8_-_50147948 Show fit | 10.29 |
ENSDART00000149010
|
haptoglobin |
|
| chr7_+_39446247 Show fit | 9.85 |
ENSDART00000033610
ENSDART00000099015 |
troponin T type 3b (skeletal, fast) |
|
| chr4_-_8030583 Show fit | 8.85 |
ENSDART00000113628
|
si:ch211-240l19.8 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nkx3.3-1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.8 | GO:0006414 | translational elongation(GO:0006414) |
| 2.6 | 15.4 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 15.4 | GO:0006457 | protein folding(GO:0006457) |
| 0.0 | 12.9 | GO:0006412 | translation(GO:0006412) |
| 0.4 | 12.3 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.1 | 11.7 | GO:0007596 | blood coagulation(GO:0007596) |
| 3.6 | 10.7 | GO:2000257 | regulation of protein activation cascade(GO:2000257) |
| 2.1 | 10.6 | GO:0010872 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.4 | 9.9 | GO:0006942 | regulation of striated muscle contraction(GO:0006942) |
| 0.4 | 9.7 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 45.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 13.9 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 12.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.1 | 12.3 | GO:0098894 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894) |
| 1.7 | 11.9 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 11.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 11.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.1 | 11.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.8 | 10.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 8.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 23.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 18.3 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 5.1 | 15.4 | GO:0003868 | 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868) |
| 0.1 | 14.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 12.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 3.6 | 10.8 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 2.1 | 10.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.1 | 10.5 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.0 | 10.5 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 14.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 11.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 2.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.8 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 11.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.9 | 10.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.3 | 9.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 7.4 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 6.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 5.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 4.8 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.4 | 4.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.2 | 4.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |