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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx3-1

Z-value: 1.26

Motif logo

Transcription factors associated with nkx3-1

Gene Symbol Gene ID Gene Info
ENSDARG00000078280 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx3-1dr11_v1_chr8_-_50259448_502594480.372.0e-04Click!

Activity profile of nkx3-1 motif

Sorted Z-values of nkx3-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_11623063 17.28 ENSDART00000145653
glucagon a
chr11_-_30636163 16.19 ENSDART00000140516
zgc:153665
chr8_-_40464935 13.19 ENSDART00000040013
myosin, light chain 7, regulatory
chr19_-_5699703 13.08 ENSDART00000082050
zgc:174904
chr9_+_8396755 12.84 ENSDART00000043067
zgc:171776
chr24_-_26328721 11.68 ENSDART00000125468
apolipoprotein Db
chr1_-_5542565 11.34 ENSDART00000160791
ENSDART00000103754
fibronectin 1b
chr7_+_22680560 10.63 ENSDART00000133761
plac8 onzin related protein 4
chr11_-_5865744 10.48 ENSDART00000104360
guanidinoacetate N-methyltransferase
chr17_+_24615091 9.35 ENSDART00000064739
ribosomal protein L13a
chr20_+_25552057 8.63 ENSDART00000102913
cytochrome P450, family 2, subfamily V, polypeptide 1
chr8_+_6576940 8.46 ENSDART00000138135
V-set and immunoglobulin domain containing 8b
chr23_+_31431956 8.45 ENSDART00000138350
ENSDART00000053542
ribosomal protein S12
chr8_-_39739627 8.44 ENSDART00000135422
ENSDART00000067844
si:ch211-170d8.5
chr7_+_22657566 8.20 ENSDART00000141048
plac8 onzin related protein 5
chr2_+_4208323 7.72 ENSDART00000167906
GATA binding protein 6
chr24_-_30263301 7.57 ENSDART00000162328
sorting nexin 7
chr14_+_52440161 7.45 ENSDART00000168437
DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like
chr2_+_1486822 7.40 ENSDART00000132500
complement component 8, alpha polypeptide
chr9_+_44994214 7.40 ENSDART00000141434
retinol saturase (all-trans-retinol 13,14-reductase) like
chr4_-_9891874 7.21 ENSDART00000067193
adrenomedullin 2a
chr2_+_1487118 7.20 ENSDART00000147283
complement component 8, alpha polypeptide
chr23_-_10254288 7.13 ENSDART00000081215
keratin 8
chr6_-_11091449 7.00 ENSDART00000127209
PTTG1 interacting protein a
chr6_+_7466223 6.98 ENSDART00000148908
erb-b2 receptor tyrosine kinase 3a
chr21_-_35419486 6.96 ENSDART00000138529
si:dkeyp-23e4.3
chr13_-_15700060 6.93 ENSDART00000170689
ENSDART00000010986
ENSDART00000101741
ENSDART00000139124
creatine kinase, brain a
chr17_-_1705013 6.87 ENSDART00000182864

chr17_+_30894431 6.81 ENSDART00000127996
delta(4)-desaturase, sphingolipid 2
chr2_+_11031360 6.71 ENSDART00000180020
ENSDART00000145093
acyl-CoA thioesterase 11a
chr3_+_22377312 6.50 ENSDART00000155597
Rho GTPase activating protein 27, like
chr3_+_29942338 6.38 ENSDART00000158220
interferon-induced protein 35
chr6_+_11438972 6.34 ENSDART00000029314
collagen, type V, alpha 2b
chr8_-_39739056 6.22 ENSDART00000147992
si:ch211-170d8.5
chr25_+_31323978 6.03 ENSDART00000067030
lymphocyte-specific protein 1
chr15_+_29025090 6.00 ENSDART00000131755
si:ch211-137a8.2
chr16_+_33142734 5.95 ENSDART00000138244
rhomboid, veinlet-like 2 (Drosophila)
chr22_+_12770877 5.94 ENSDART00000044683
formimidoyltransferase cyclodeaminase
chr25_-_13050959 5.93 ENSDART00000169041
chemokine (C-C motif) ligand 35, duplicate 1
chr20_-_22464250 5.90 ENSDART00000165904
platelet-derived growth factor receptor, alpha polypeptide
chr24_-_27473771 5.90 ENSDART00000139874
CX chemokine ligand 34b, duplicate 11
chr3_+_3139240 5.81 ENSDART00000105014
si:dkey-30g5.1
chr11_-_40128722 5.74 ENSDART00000165781
family with sequence similarity 83, member E
chr12_+_17100021 5.74 ENSDART00000177923
actin, alpha 2, smooth muscle, aorta
chr22_+_25236657 5.72 ENSDART00000138012
zgc:172218
chr15_-_39969988 5.71 ENSDART00000146054
ribosomal protein S5
chr5_-_10082244 5.57 ENSDART00000036421
checkpoint kinase 2
chr16_+_31922065 5.57 ENSDART00000131661
ENSDART00000144194
ENSDART00000145510
ribosomal protein S9
chr21_+_25236297 5.49 ENSDART00000112783
transmembrane protein 45B
chr3_+_16922226 5.47 ENSDART00000017646
ATPase H+ transporting V0 subunit a1a
chr11_+_24729346 5.44 ENSDART00000087740
zgc:153953
chr18_+_6558338 5.41 ENSDART00000110892
beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr7_-_34192834 5.40 ENSDART00000125131
SMAD family member 6a
chr14_+_3495542 5.36 ENSDART00000168934
glutathione S-transferase pi 2
chr2_-_7757273 5.34 ENSDART00000136074
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5b
chr8_-_38317914 5.18 ENSDART00000125920
PDZ and LIM domain 2 (mystique)
chr23_-_40295610 5.17 ENSDART00000186719

chr4_+_76705830 5.15 ENSDART00000064312
membrane-spanning 4-domains, subfamily A, member 17A.7
chr22_+_25249193 5.09 ENSDART00000171851
si:ch211-226h8.11
chr14_+_48903640 5.03 ENSDART00000165323
zgc:154054
chr4_-_4570475 4.98 ENSDART00000184955
Ras association (RalGDS/AF-6) domain family member 3
chr18_+_35861930 4.97 ENSDART00000185223
protein phosphatase 1, regulatory subunit 13 like
chr3_+_25849560 4.86 ENSDART00000007119
major facilitator superfamily domain containing 6-like
chr5_-_23795688 4.83 ENSDART00000099084
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr5_-_37900350 4.81 ENSDART00000084839
ENSDART00000084841
ENSDART00000133437
transmembrane protease, serine 13b
chr9_-_51563575 4.74 ENSDART00000167034
ENSDART00000148918
TRAF family member-associated NFKB activator
chr10_-_3427589 4.73 ENSDART00000133452
ENSDART00000037183
transmembrane p24 trafficking protein 2
chr17_-_43031763 4.72 ENSDART00000132754
ENSDART00000050399
Niemann-Pick disease, type C2
chr22_-_10541712 4.72 ENSDART00000013933
si:dkey-42i9.4
chr21_+_19547806 4.71 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
retinoic acid induced 14
chr5_-_25037454 4.70 ENSDART00000027237
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr19_-_42556086 4.69 ENSDART00000051731
si:dkey-267n13.1
chr19_-_3821678 4.59 ENSDART00000169639
si:dkey-206d17.12
chr18_-_16801033 4.54 ENSDART00000100100
adrenomedullin b
chr17_+_14886828 4.51 ENSDART00000010507
ENSDART00000131052
prostaglandin E receptor 2a (subtype EP2)
chr11_+_20899029 4.47 ENSDART00000163029
zgc:162182
chr4_-_4119396 4.41 ENSDART00000067409
ENSDART00000138221
leiomodin 2 (cardiac) b
chr25_-_13403726 4.41 ENSDART00000056723
GINS complex subunit 3
chr6_-_54826061 4.38 ENSDART00000149982
troponin I type 1b (skeletal, slow)
chr3_+_29941777 4.33 ENSDART00000113889
interferon-induced protein 35
chr14_+_14806851 4.31 ENSDART00000169235
FH2 domain containing 2
chr7_+_8358547 4.27 ENSDART00000173016
jacalin 7
chr4_+_76671012 4.24 ENSDART00000005585
membrane-spanning 4-domains, subfamily A, member 17a.2
chr8_-_38105053 4.23 ENSDART00000131546
adhesion G protein-coupled receptor A2
chr18_+_40471826 4.22 ENSDART00000098806
UDP glucuronosyltransferase 5 family, polypeptide C3
chr2_+_15100742 4.16 ENSDART00000027171
coagulation factor IIIb
chr5_-_67499279 4.16 ENSDART00000128050
si:dkey-251i10.3
chr2_-_10877228 4.15 ENSDART00000138718
ENSDART00000034246
cell division cycle 7 homolog (S. cerevisiae)
chr5_+_36666715 4.14 ENSDART00000097686
zgc:153990
chr7_+_17947217 4.13 ENSDART00000101601
cysteine three histidine 1
chr20_-_25902141 4.10 ENSDART00000142611
ENSDART00000024821
ELM2 and Myb/SANT-like domain containing 1a
chr9_-_12888082 4.07 ENSDART00000133135
ENSDART00000134415
si:ch211-167j6.3
chr24_-_31904924 4.04 ENSDART00000156060
ENSDART00000129741
ENSDART00000154276
si:ch73-78o10.1
chr18_+_2228737 4.02 ENSDART00000165301
RAB27A, member RAS oncogene family
chr23_+_25832689 4.02 ENSDART00000138907
hepatocyte nuclear factor 4, alpha
chr8_+_25616946 3.99 ENSDART00000133983
solute carrier family 38, member 5a
chr1_-_58002973 3.94 ENSDART00000140390
si:ch211-114l13.9
chr7_+_12950507 3.92 ENSDART00000067629
ENSDART00000158004
serum amyloid A
chr19_+_4051695 3.83 ENSDART00000166368
bloodthirsty-related gene family, member 24
chr5_+_51594209 3.71 ENSDART00000164668
ENSDART00000058403
ENSDART00000055857
creatine kinase, mitochondrial 2b (sarcomeric)
chr9_-_8296723 3.57 ENSDART00000139867
si:ch211-145c1.1
chr1_-_354115 3.56 ENSDART00000141590
ENSDART00000098627
protein S
chr21_-_30658509 3.53 ENSDART00000139764
si:dkey-22f5.9
chr8_+_2319091 3.50 ENSDART00000140265
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr3_-_20957011 3.49 ENSDART00000159787
ENSDART00000180531
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4, like
chr22_+_13886821 3.47 ENSDART00000130585
ENSDART00000105711
SH3-domain binding protein 4a
chr19_-_31372896 3.46 ENSDART00000046609
scinderin
chr6_-_54107269 3.42 ENSDART00000190017
hyaluronoglucosaminidase 2a
chr1_+_580642 3.41 ENSDART00000147633
mitochondrial ribosomal protein L39
chr16_+_54641230 3.33 ENSDART00000157641
ENSDART00000159540
F-box protein 43
chr25_-_13703826 3.32 ENSDART00000163398
phospholipase A2, group XV
chr13_-_37647209 3.32 ENSDART00000189102
si:dkey-188i13.10
chr16_-_31686602 3.30 ENSDART00000170357
complement component 1, s subcomponent
chr7_+_2259413 3.28 ENSDART00000173420
si:dkey-187j14.7
chr24_+_26017094 3.28 ENSDART00000137851
transferrin receptor 1b
chr4_+_76735113 3.25 ENSDART00000075602
membrane-spanning 4-domains, subfamily A, member 17A.6
chr20_+_33904258 3.25 ENSDART00000170930
retinoid X receptor, gamma b
chr5_+_1933131 3.25 ENSDART00000061693
si:ch73-55i23.1
chr15_-_28805493 3.23 ENSDART00000179617
CD3e molecule, epsilon associated protein
chr13_-_48058779 3.21 ENSDART00000186623
ENSDART00000045475
integrin, alpha 9
chr1_+_32054159 3.17 ENSDART00000181442
steroid sulfatase (microsomal), isozyme S
chr19_+_43359075 3.09 ENSDART00000148287
ENSDART00000149856
ENSDART00000188236
ENSDART00000136695
ENSDART00000193859
Yes-related kinase
chr16_-_51299061 3.06 ENSDART00000148677
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr22_-_23000815 2.94 ENSDART00000137111
protein tyrosine phosphatase, receptor type, C
chr7_+_58179513 2.90 ENSDART00000123117
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr9_-_50001606 2.80 ENSDART00000161648
ENSDART00000168514
sodium channel, voltage-gated, type I, alpha
chr3_-_22366562 2.78 ENSDART00000129447
interferon phi 1
chr3_-_13921173 2.78 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
chr1_-_2457546 2.76 ENSDART00000103795
gamma-glutamylamine cyclotransferase, tandem duplicate 1
chr20_-_33566640 2.74 ENSDART00000159729
si:dkey-65b13.9
chr10_+_38512270 2.71 ENSDART00000109752
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a
chr21_+_25198637 2.66 ENSDART00000164972
si:dkey-183i3.6
chr5_+_26795773 2.58 ENSDART00000145631
transcobalamin II
chr19_-_10330778 2.58 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
coiled-coil domain containing 106b
chr15_+_37331585 2.57 ENSDART00000170715
zgc:171592
chr7_-_20464468 2.54 ENSDART00000134700
canopy4
chr3_-_36419641 2.54 ENSDART00000173545
component of oligomeric golgi complex 1
chr22_-_11626014 2.50 ENSDART00000063133
ENSDART00000160085
glucagon a
chr25_+_3318192 2.43 ENSDART00000146154
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b
chr13_-_40237121 2.41 ENSDART00000145635
lysyl oxidase-like 4
chr12_-_13155653 2.41 ENSDART00000152467
CX chemokine ligand 34c
chr5_-_16475682 2.40 ENSDART00000090695
piwi-like RNA-mediated gene silencing 2
chr15_+_25452092 2.38 ENSDART00000009545
p21 protein (Cdc42/Rac)-activated kinase 4
chr16_-_41535690 2.35 ENSDART00000102662
ribonuclease P/MRP 25 subunit-like
chr12_-_31461219 2.34 ENSDART00000148954
acyl-CoA synthetase long chain family member 5
chr5_-_16475374 2.29 ENSDART00000134274
ENSDART00000136004
piwi-like RNA-mediated gene silencing 2
chr17_+_6538733 2.26 ENSDART00000193712
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr19_+_7424347 2.26 ENSDART00000004622
splicing factor 3b, subunit 4
chr21_-_11286483 2.25 ENSDART00000074845
rhotekin 2b
chr21_-_21781158 2.25 ENSDART00000113734
chordin-like 2
chr5_+_27429872 2.18 ENSDART00000087894
zgc:165555
chr16_-_4203022 2.17 ENSDART00000018686
ribosomal RNA processing 15 homolog
chr10_+_585719 2.16 ENSDART00000180167
SMAD family member 4a
chr3_-_506241 2.14 ENSDART00000150141
si:dkey-12f6.5
chr12_-_28548789 2.10 ENSDART00000153062
si:ch73-180n10.1
chr5_-_57204352 2.09 ENSDART00000171252
ENSDART00000180727
mannosidase, alpha, class 2A, member 1
chr19_+_33139164 2.09 ENSDART00000043039
family with sequence similarity 84, member B
chr13_+_27328098 2.07 ENSDART00000037585
Mab-21 domain containing 1
chr20_-_33507458 2.06 ENSDART00000140287
papilin b, proteoglycan-like sulfated glycoprotein
chr16_-_9425451 2.05 ENSDART00000149163
chemokine (C-C motif) receptor 8.1
chr23_+_4362463 2.04 ENSDART00000039829
zgc:112175
chr25_+_10953351 2.03 ENSDART00000154050
major histocompatibility complex class I LDA
chr7_-_25697285 2.02 ENSDART00000082620
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
chr7_-_26518086 2.00 ENSDART00000058913
eukaryotic translation initiation factor 4A1A
chr14_-_498979 1.96 ENSDART00000171976
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr9_-_52386733 1.95 ENSDART00000171721
death associated protein 1b
chr5_-_24997293 1.95 ENSDART00000177478
EMI domain containing 1
chr23_+_19813677 1.93 ENSDART00000139192
ENSDART00000142308
emerin (Emery-Dreifuss muscular dystrophy)
chr18_-_1258777 1.91 ENSDART00000077106
ENSDART00000129065
UDP glucuronosyltransferase 5 family, polypeptide F1
chr18_-_6766354 1.90 ENSDART00000132611
adrenomedullin 2b
chr7_+_48667081 1.89 ENSDART00000083473
transient receptor potential cation channel, subfamily M, member 5
chr12_-_30548244 1.86 ENSDART00000193616
zgc:158404
chr22_-_5252005 1.85 ENSDART00000132942
ENSDART00000081801
nicalin
chr2_-_27575803 1.81 ENSDART00000014568
uroporphyrinogen decarboxylase
chr4_-_67800414 1.80 ENSDART00000160213
si:ch211-66c13.1
chr25_-_173165 1.79 ENSDART00000193594

chr25_+_34749187 1.74 ENSDART00000141473
WW domain containing E3 ubiquitin protein ligase 2
chr9_+_35016201 1.74 ENSDART00000182404
GA binding protein transcription factor, alpha subunit
chr1_-_55248496 1.72 ENSDART00000098615
nanos homolog 3
chr14_+_14806692 1.71 ENSDART00000193050
FH2 domain containing 2
chr23_+_36340520 1.70 ENSDART00000011201
coatomer protein complex, subunit zeta 1
chr4_-_7673165 1.69 ENSDART00000028171
leukotriene A4 hydrolase
chr21_-_40835069 1.68 ENSDART00000004686
LIM domain kinase 1b
chr4_+_7514687 1.65 ENSDART00000067350
ENSDART00000169998
ENSDART00000162082
troponin T2e, cardiac
chr19_-_18152942 1.63 ENSDART00000190182
nuclear factor, erythroid 2-like 3
chr4_+_76745015 1.61 ENSDART00000155883
membrane-spanning 4-domains, subfamily A, member 17A.10
chr1_+_24365582 1.60 ENSDART00000169389
Pim proto-oncogene, serine/threonine kinase, related 178
chr14_+_8715527 1.58 ENSDART00000170754
potassium channel, subfamily K, member 4a
chr12_+_23850661 1.57 ENSDART00000152921
supervillin a
chr13_+_7242916 1.57 ENSDART00000184238
apoptosis-inducing factor, mitochondrion-associated, 2
chr24_+_26328787 1.57 ENSDART00000003884
myoneurin
chr1_+_44056129 1.56 ENSDART00000161114

chr20_-_18535502 1.55 ENSDART00000049437
CDC42 binding protein kinase beta (DMPK-like)
chr20_-_13625588 1.53 ENSDART00000078893
synaptotagmin-like 3
chr13_-_31370184 1.51 ENSDART00000034829
ribosomal RNA processing 12 homolog
chr18_-_49318823 1.48 ENSDART00000098419
sb:cb81
chr13_-_36680531 1.47 ENSDART00000085298
L-2-hydroxyglutarate dehydrogenase
chr16_+_11603096 1.46 ENSDART00000146286
si:dkey-11o1.3
chr4_-_18434924 1.46 ENSDART00000190271
suppressor of cytokine signaling 2
chr12_-_5418340 1.45 ENSDART00000028043
NOC3-like DNA replication regulator

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
2.2 13.2 GO:0055014 ventricular cardiac myofibril assembly(GO:0055005) atrial cardiac muscle cell development(GO:0055014)
2.2 15.3 GO:0006953 acute-phase response(GO:0006953)
2.0 5.9 GO:0043606 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
1.9 5.7 GO:0090131 mesenchyme migration(GO:0090131)
1.8 9.2 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
1.6 6.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
1.4 4.2 GO:0022009 central nervous system vasculogenesis(GO:0022009)
1.4 5.6 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.2 3.6 GO:0042730 fibrinolysis(GO:0042730)
1.2 5.9 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
1.1 4.6 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
1.0 4.0 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.9 4.5 GO:0071380 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.9 3.5 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.9 2.6 GO:0006824 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.8 23.8 GO:0003323 type B pancreatic cell development(GO:0003323)
0.8 3.3 GO:0015682 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.8 10.6 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.8 4.7 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.8 2.3 GO:2000193 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) positive regulation of lipid transport(GO:0032370) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.8 5.4 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.7 2.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.7 2.0 GO:0003156 regulation of organ formation(GO:0003156)
0.6 4.4 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.6 1.2 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.6 2.3 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.6 9.5 GO:0030259 lipid glycosylation(GO:0030259)
0.5 2.0 GO:0001778 plasma membrane repair(GO:0001778) monocyte activation(GO:0042117)
0.5 4.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.5 6.8 GO:0034311 diol metabolic process(GO:0034311)
0.4 5.5 GO:0001845 phagolysosome assembly(GO:0001845)
0.4 12.1 GO:0019835 cytolysis(GO:0019835)
0.4 3.3 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.4 1.2 GO:0065001 specification of axis polarity(GO:0065001)
0.4 1.9 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.4 11.7 GO:0007568 aging(GO:0007568)
0.4 1.1 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.4 1.1 GO:0034214 protein hexamerization(GO:0034214)
0.3 2.8 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.3 1.0 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.3 1.7 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.3 2.3 GO:0032185 septin ring organization(GO:0031106) septin cytoskeleton organization(GO:0032185)
0.3 1.9 GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.3 4.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.3 1.4 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.3 3.2 GO:0050909 sensory perception of taste(GO:0050909)
0.3 3.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.3 2.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 5.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 1.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 1.1 GO:0019482 uracil catabolic process(GO:0006212) beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483) uracil metabolic process(GO:0019860) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 1.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2 5.6 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.2 6.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 3.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.2 8.6 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.2 5.0 GO:0051014 actin filament severing(GO:0051014)
0.2 5.4 GO:0009636 response to toxic substance(GO:0009636)
0.1 3.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 2.4 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 5.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 1.4 GO:0043545 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 2.7 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.1 3.1 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 2.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.7 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 2.7 GO:0030199 collagen fibril organization(GO:0030199)
0.1 8.3 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 1.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 5.7 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 3.3 GO:0032526 response to retinoic acid(GO:0032526)
0.1 0.9 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 10.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 4.0 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.1 2.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 2.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.5 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 10.0 GO:0017148 negative regulation of translation(GO:0017148)
0.1 1.1 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 0.6 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 1.3 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.9 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 3.5 GO:0017038 protein import(GO:0017038)
0.1 2.2 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.1 4.7 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.1 0.4 GO:0090133 establishment or maintenance of cytoskeleton polarity(GO:0030952) mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.1 1.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.0 GO:0060021 palate development(GO:0060021)
0.1 1.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 4.2 GO:0007596 blood coagulation(GO:0007596)
0.1 1.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 1.6 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.1 4.7 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.1 1.4 GO:0007520 myoblast fusion(GO:0007520)
0.1 6.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 3.3 GO:0031638 zymogen activation(GO:0031638)
0.1 2.0 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.1 1.4 GO:0046847 filopodium assembly(GO:0046847)
0.1 0.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 7.2 GO:0006364 rRNA processing(GO:0006364)
0.1 2.0 GO:0042742 defense response to bacterium(GO:0042742)
0.1 3.2 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 1.0 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 4.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.0 GO:0035141 medial fin morphogenesis(GO:0035141)
0.0 1.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.6 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.8 GO:0060232 delamination(GO:0060232)
0.0 2.9 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 3.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 2.2 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 1.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 8.7 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.0 8.4 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.7 GO:0045214 sarcomere organization(GO:0045214)
0.0 2.5 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 8.5 GO:0006412 translation(GO:0006412)
0.0 0.1 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.0 9.3 GO:0043066 negative regulation of apoptotic process(GO:0043066)
0.0 9.8 GO:0006955 immune response(GO:0006955)
0.0 1.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 5.8 GO:0006915 apoptotic process(GO:0006915)
0.0 3.0 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.3 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.2 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0005588 collagen type V trimer(GO:0005588)
1.1 4.2 GO:1990909 Wnt signalosome(GO:1990909)
0.9 4.7 GO:1990923 PET complex(GO:1990923)
0.9 14.6 GO:0005579 membrane attack complex(GO:0005579)
0.9 4.4 GO:0000811 GINS complex(GO:0000811)
0.6 7.1 GO:0045095 keratin filament(GO:0045095)
0.6 3.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.5 5.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 19.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 7.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 5.7 GO:0005869 dynactin complex(GO:0005869)
0.3 2.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 1.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.3 7.0 GO:0009925 basal plasma membrane(GO:0009925)
0.3 2.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 6.0 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.3 3.5 GO:0017119 Golgi transport complex(GO:0017119)
0.3 3.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 3.5 GO:0002102 podosome(GO:0002102)
0.2 1.4 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.2 7.2 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 4.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 10.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 10.4 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.2 5.6 GO:0032040 small-subunit processome(GO:0032040)
0.2 1.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 9.3 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 5.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 2.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 5.2 GO:0031941 filamentous actin(GO:0031941)
0.1 0.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 2.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 3.2 GO:0008305 integrin complex(GO:0008305)
0.1 1.1 GO:0000813 ESCRT I complex(GO:0000813)
0.1 1.7 GO:0043186 P granule(GO:0043186)
0.1 110.6 GO:0005576 extracellular region(GO:0005576)
0.1 2.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.5 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 4.6 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 0.7 GO:0005903 brush border(GO:0005903)
0.0 0.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.4 GO:0005840 ribosome(GO:0005840)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 1.4 GO:0030018 Z disc(GO:0030018)
0.0 1.2 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.2 GO:0031514 motile cilium(GO:0031514)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 19.8 GO:0031769 glucagon receptor binding(GO:0031769)
2.5 7.5 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
1.8 5.3 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
1.5 5.9 GO:0016841 ammonia-lyase activity(GO:0016841)
1.5 5.9 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
1.4 11.3 GO:0043394 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
1.4 7.0 GO:0038131 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
1.1 3.3 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
1.1 5.4 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
1.0 6.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.9 2.8 GO:0005132 type I interferon receptor binding(GO:0005132)
0.9 3.5 GO:0008384 IkappaB kinase activity(GO:0008384)
0.9 3.4 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.8 3.3 GO:0004998 transferrin receptor activity(GO:0004998)
0.8 10.6 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.6 4.7 GO:0034584 piRNA binding(GO:0034584)
0.6 2.3 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.6 1.7 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.5 1.6 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.5 2.0 GO:0070513 death domain binding(GO:0070513)
0.5 1.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.5 4.5 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.4 7.6 GO:0070411 I-SMAD binding(GO:0070411)
0.4 5.4 GO:0051117 ATPase binding(GO:0051117)
0.4 3.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 7.6 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.3 5.9 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.3 1.4 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.3 2.7 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.3 4.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 2.6 GO:0031419 cobalamin binding(GO:0031419)
0.3 6.2 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.3 3.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 6.1 GO:0005523 tropomyosin binding(GO:0005523)
0.3 1.1 GO:0015369 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.3 1.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.3 12.7 GO:0019843 rRNA binding(GO:0019843)
0.2 2.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.2 3.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 1.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 8.3 GO:0008009 chemokine activity(GO:0008009)
0.2 1.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 2.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 2.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 3.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 2.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 8.6 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 3.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.7 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 17.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 6.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 5.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 4.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 25.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.6 GO:0008312 7S RNA binding(GO:0008312)
0.1 4.7 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 4.6 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.3 GO:0072571 ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.1 2.7 GO:0005518 collagen binding(GO:0005518)
0.1 2.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 1.6 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.1 1.4 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.6 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 6.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 5.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 6.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 5.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 6.8 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.0 1.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0034246 core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) mitochondrial RNA polymerase binding promoter specificity activity(GO:0034246)
0.0 2.9 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 3.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 4.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 5.7 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 1.3 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 5.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 7.1 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.6 GO:0017069 snRNA binding(GO:0017069)
0.0 4.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 6.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 2.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.3 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 1.3 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0043035 chromatin insulator sequence binding(GO:0043035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 3.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.2 3.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 5.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.2 7.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 10.5 PID P53 REGULATION PATHWAY p53 pathway
0.2 7.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 5.3 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 4.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 4.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 0.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.8 17.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.5 5.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 4.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.4 2.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.4 3.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.4 19.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.4 10.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 2.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3 7.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 3.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.3 5.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 4.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 4.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 4.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 1.7 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 2.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.2 2.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 9.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.8 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 4.1 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 0.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.5 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 7.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 0.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 6.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.3 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.1 3.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 1.3 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 5.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation