ISMARA results: nkx2.3+nkx2.7

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx2.3+nkx2.7

Z-value: 1.20

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Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol	Gene ID	Gene Info
nkx2.7 NCBI UniProt	ENSDARG00000021232	NK2 transcription factor related 7
nkx2.3 NCBI UniProt	ENSDARG00000039095	NK2 homeobox 3
nkx2.3 NCBI UniProt	ENSDARG00000113490	NK2 homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nkx2.7	dr11_v1_chr8_-_50287949_50287949	-0.20	5.6e-02	Click!
nkx2.3	dr11_v1_chr13_-_40411908_40411917	-0.18	7.9e-02	Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_3828560 Show fit	17.83	ENSDART00000185273 ENSDART00000179091	gad1b NCBI UniProt Show fit	glutamate decarboxylase 1b
chr22_-_13851297 Show fit	14.68	ENSDART00000080306	s100b NCBI UniProt Show fit	S100 calcium binding protein, beta (neural)
chr20_+_18551657 Show fit	14.31	ENSDART00000147001	si:dkeyp-72h1.1 NCBI UniProt Show fit	si:dkeyp-72h1.1
chr13_+_38430466 Show fit	13.51	ENSDART00000132691	adgrb3 NCBI UniProt Show fit	adhesion G protein-coupled receptor B3
chr12_-_25916530 Show fit	13.25	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr15_-_15357178 Show fit	12.81	ENSDART00000106120	ywhag2 NCBI UniProt Show fit	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr20_-_39271844 Show fit	12.79	ENSDART00000192708	clu NCBI UniProt Show fit	clusterin
chr17_+_23298928 Show fit	12.27	ENSDART00000153652	zgc:165461 NCBI UniProt Show fit	zgc:165461
chr4_+_21129752 Show fit	11.64	ENSDART00000169764	syt1a NCBI UniProt Show fit	synaptotagmin Ia
chr14_+_29609245 Show fit	11.41	ENSDART00000043058	TENM2 NCBI UniProt Show fit	si:dkey-34l15.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	29.3	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
9.7	29.0	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3	17.2	GO:0050919	negative chemotaxis(GO:0050919)
0.8	16.6	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	14.7	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.6	13.9	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
2.7	13.5	GO:0016322	neuron remodeling(GO:0016322)
0.1	11.4	GO:0007224	smoothened signaling pathway(GO:0007224)
2.2	11.2	GO:0061551	trigeminal ganglion development(GO:0061551)
0.8	10.8	GO:0007035	vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)

Showing 1 to 10 of 189 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	26.1	GO:0043679	axon terminus(GO:0043679)
2.4	24.4	GO:0042583	chromaffin granule(GO:0042583)
0.0	16.7	GO:0043005	neuron projection(GO:0043005)
0.2	14.8	GO:0005871	kinesin complex(GO:0005871)
0.3	14.6	GO:0098839	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
2.3	13.5	GO:0043083	synaptic cleft(GO:0043083)
0.1	13.5	GO:0030424	axon(GO:0030424)
0.1	11.0	GO:0016323	basolateral plasma membrane(GO:0016323)
1.1	10.8	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4	10.2	GO:0046658	anchored component of plasma membrane(GO:0046658)

Showing 1 to 10 of 81 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.7	29.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.6	25.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	21.1	GO:0003924	GTPase activity(GO:0003924)
0.2	18.3	GO:0016247	channel regulator activity(GO:0016247)
3.7	14.7	GO:0044548	S100 protein binding(GO:0044548)
0.0	14.5	GO:0005096	GTPase activator activity(GO:0005096)
0.8	13.6	GO:0048495	Roundabout binding(GO:0048495)
4.4	13.3	GO:1903136	cuprous ion binding(GO:1903136)
0.5	12.5	GO:0051787	misfolded protein binding(GO:0051787)
0.2	11.6	GO:0001786	phosphatidylserine binding(GO:0001786)

Showing 1 to 10 of 126 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	13.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	12.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	11.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.4	10.7	PID RHOA PATHWAY	RhoA signaling pathway
0.1	7.1	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.5	6.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.2	6.2	PID BMP PATHWAY	BMP receptor signaling
0.3	6.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3	5.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	4.9	PID EPHA FWDPATHWAY	EPHA forward signaling

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	14.7	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
1.1	12.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.8	11.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.3	10.7	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.6	9.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.7	7.5	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.4	6.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.7	6.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	5.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5	4.7	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors

Showing 1 to 10 of 44 entries

Results for nkx2.3+nkx2.7

Z-value: 1.20

Motif logo

Transcription factors associated with nkx2.3+nkx2.7

Activity-expression correlation:

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: