Project
PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
Navigation
Downloads
Results for nfkb1_rela
Z-value: 1.62
Motif logo
Transcription factors associated with nfkb1_rela
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfkb1 | dr11_v1_chr14_-_49859747_49859823 | 0.49 | 6.0e-07 | Click! |
| rela | dr11_v1_chr7_-_804515_804515 | 0.30 | 3.0e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_18716 Show fit | 21.53 |
ENSDART00000172454
ENSDART00000161190 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta |
|
| chr24_+_26006730 Show fit | 21.12 |
ENSDART00000140384
ENSDART00000139184 |
chemokine (C-C motif) ligand 20b |
|
| chr20_+_16881883 Show fit | 19.49 |
ENSDART00000130107
|
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a |
|
| chr20_-_51307815 Show fit | 19.06 |
ENSDART00000098833
|
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
|
| chr2_+_42191592 Show fit | 17.31 |
ENSDART00000144716
|
caveolae associated protein 4a |
|
| chr7_+_12950507 Show fit | 16.77 |
ENSDART00000067629
ENSDART00000158004 |
serum amyloid A |
|
| chr8_+_24281512 Show fit | 16.09 |
ENSDART00000062845
|
matrix metallopeptidase 9 |
|
| chr1_-_37377509 Show fit | 16.01 |
ENSDART00000113542
|
TNFAIP3 interacting protein 2 |
|
| chr1_-_52437056 Show fit | 13.78 |
ENSDART00000138337
|
si:ch211-217k17.12 |
|
| chr7_-_34262080 Show fit | 13.65 |
ENSDART00000183246
|
si:ch211-98n17.5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nfkb1_rela
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 40.8 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 3.3 | 20.0 | GO:0051883 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883) |
| 6.5 | 19.5 | GO:1901533 | negative regulation of hematopoietic progenitor cell differentiation(GO:1901533) |
| 6.1 | 18.4 | GO:0034138 | toll-like receptor 3 signaling pathway(GO:0034138) |
| 0.2 | 18.3 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 5.4 | 16.1 | GO:0002631 | granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676) |
| 0.1 | 15.9 | GO:0045087 | innate immune response(GO:0045087) |
| 0.7 | 15.2 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 5.0 | 14.9 | GO:0002468 | dendritic cell antigen processing and presentation(GO:0002468) |
| 0.3 | 14.7 | GO:0007259 | JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 73.5 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 46.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.7 | 28.7 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 18.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 1.1 | 16.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 15.8 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 13.9 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 13.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.9 | 13.0 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 12.2 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 52.6 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 1.0 | 43.9 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.9 | 31.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 21.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 1.4 | 21.2 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 18.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 16.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.2 | 15.3 | GO:0008118 | N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118) |
| 0.1 | 13.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 3.3 | 13.2 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 24.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 1.1 | 21.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 1.0 | 19.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.7 | 19.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 1.2 | 18.1 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.7 | 13.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.6 | 12.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.2 | 9.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.4 | 8.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 8.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 33.7 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.5 | 24.2 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.5 | 17.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.6 | 17.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 2.3 | 16.1 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 11.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 2.2 | 11.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.8 | 10.7 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.3 | 8.6 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.4 | 8.4 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |