ISMARA results: nfil3-5

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nfil3-5

Z-value: 1.45

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Transcription factors associated with nfil3-5

Gene Symbol	Gene ID	Gene Info
nfil3-5 NCBI UniProt	ENSDARG00000094965	nuclear factor, interleukin 3 regulated, member 5
nfil3-5 NCBI UniProt	ENSDARG00000113345	nuclear factor, interleukin 3 regulated, member 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nfil3-5	dr11_v1_chr6_+_8172227_8172227	0.57	2.8e-09	Click!

Activity profile of nfil3-5 motif

Sorted Z-values of nfil3-5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr25_+_34984333 Show fit	32.29	ENSDART00000154760	ccdc136b NCBI UniProt Show fit	coiled-coil domain containing 136b
chr21_-_22114625 Show fit	25.89	ENSDART00000177426 ENSDART00000135410	elmod1 NCBI UniProt Show fit	ELMO/CED-12 domain containing 1
chr5_+_37837245 Show fit	25.46	ENSDART00000171617	epd NCBI UniProt Show fit	ependymin
chr24_-_38079261 Show fit	23.47	ENSDART00000105662	crp1 NCBI UniProt Show fit	C-reactive protein 1
chr17_-_43466317 Show fit	23.12	ENSDART00000155313	hspa4l NCBI UniProt Show fit	heat shock protein 4 like
chr3_-_46818001 Show fit	22.93	ENSDART00000166505	elavl3 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 3
chr14_+_33458294 Show fit	22.09	ENSDART00000075278	atp1b4 NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 4
chr3_+_16612574 Show fit	22.07	ENSDART00000104481	slc17a7a NCBI UniProt Show fit	solute carrier family 17 (vesicular glutamate transporter), member 7a
chr17_-_20979077 Show fit	19.73	ENSDART00000006676	phyhipla NCBI UniProt Show fit	phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr10_-_24371312 Show fit	19.35	ENSDART00000149362	pitpnab NCBI UniProt Show fit	phosphatidylinositol transfer protein, alpha b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nfil3-5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	40.7	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.7	33.7	GO:0014046	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
2.5	32.3	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.3	31.3	GO:0006836	neurotransmitter transport(GO:0006836)
3.8	30.5	GO:0098700	neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2	28.5	GO:0006814	sodium ion transport(GO:0006814)
0.1	25.9	GO:0031175	neuron projection development(GO:0031175)
0.3	23.4	GO:0060216	definitive hemopoiesis(GO:0060216)
1.5	21.6	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.3	20.7	GO:0006414	translational elongation(GO:0006414)

Showing 1 to 10 of 171 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	60.6	GO:0070382	exocytic vesicle(GO:0070382)
0.1	55.3	GO:0043005	neuron projection(GO:0043005)
0.6	36.8	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3	30.7	GO:0014069	postsynaptic density(GO:0014069)
2.0	30.5	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.9	29.0	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
2.2	22.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.4	21.6	GO:0030426	growth cone(GO:0030426)
0.3	20.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.6	18.4	GO:0000159	protein phosphatase type 2A complex(GO:0000159)

Showing 1 to 10 of 72 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	70.6	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.1	49.0	GO:0003924	GTPase activity(GO:0003924)
0.1	48.6	GO:0005096	GTPase activator activity(GO:0005096)
2.3	30.5	GO:0005326	neurotransmitter transporter activity(GO:0005326)
0.6	30.0	GO:0001786	phosphatidylserine binding(GO:0001786)
1.7	24.3	GO:0008503	benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1	23.8	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.2	23.6	GO:0019208	phosphatase regulator activity(GO:0019208)
0.8	21.6	GO:0017080	sodium channel regulator activity(GO:0017080)
0.5	20.7	GO:0003746	translation elongation factor activity(GO:0003746)

Showing 1 to 10 of 117 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	35.9	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.7	20.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.5	10.1	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	8.2	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.8	7.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	4.6	PID AURORA B PATHWAY	Aurora B signaling
0.2	4.3	PID RHOA PATHWAY	RhoA signaling pathway
0.5	3.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	2.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	23.4	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
4.8	14.5	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.5	12.4	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.5	10.8	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.9	10.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1	9.4	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.5	7.7	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3	7.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.4	6.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	5.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides

Showing 1 to 10 of 36 entries

Results for nfil3-5

Z-value: 1.45

Motif logo

Transcription factors associated with nfil3-5

Activity-expression correlation:

Activity profile of nfil3-5 motif

Sorted Z-values of nfil3-5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nfil3-5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: