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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for nfatc2a
Z-value: 1.26
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Transcription factors associated with nfatc2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfatc2a | dr11_v1_chr23_+_39089574_39089574 | -0.07 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_60551133 Show fit | 13.42 |
ENSDART00000148038
|
leucine rich repeat and fibronectin type III domain containing 4b |
|
| chr6_+_3827751 Show fit | 11.41 |
ENSDART00000003008
ENSDART00000122348 |
glutamate decarboxylase 1b |
|
| chr16_-_16182319 Show fit | 10.85 |
ENSDART00000103815
|
stathmin 2a |
|
| chr19_-_31522625 Show fit | 10.06 |
ENSDART00000158438
ENSDART00000035049 |
N-terminal EF-hand calcium binding protein 1 |
|
| chr5_-_13835461 Show fit | 9.48 |
ENSDART00000148297
ENSDART00000114841 |
adducin 2 (beta) |
|
| chr6_+_48618512 Show fit | 9.36 |
ENSDART00000111190
|
si:dkey-238f9.1 |
|
| chr4_-_15420452 Show fit | 8.73 |
ENSDART00000016230
|
plexin A4 |
|
| chr22_-_13851297 Show fit | 8.71 |
ENSDART00000080306
|
S100 calcium binding protein, beta (neural) |
|
| chr8_+_22931427 Show fit | 8.61 |
ENSDART00000063096
|
synaptophysin a |
|
| chr6_+_13920479 Show fit | 8.40 |
ENSDART00000155480
|
protein tyrosine phosphatase, receptor type, Nb |
Network of associatons between targets according to the STRING database.
First level regulatory network of nfatc2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 70.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 24.3 | GO:0000226 | microtubule cytoskeleton organization(GO:0000226) |
| 0.1 | 20.2 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.8 | 20.0 | GO:0031114 | regulation of microtubule depolymerization(GO:0031114) |
| 0.9 | 15.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 15.1 | GO:1990778 | protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778) |
| 0.3 | 15.0 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 12.1 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.4 | 11.8 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.5 | 11.5 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 119.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 64.2 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 51.1 | GO:0043005 | neuron projection(GO:0043005) |
| 0.5 | 20.5 | GO:0043679 | axon terminus(GO:0043679) |
| 0.3 | 19.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.4 | 15.9 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.2 | 15.3 | GO:0030141 | secretory granule(GO:0030141) |
| 0.3 | 14.5 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.3 | 14.1 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.9 | 13.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 58.3 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 36.9 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.0 | 28.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 26.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 23.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.2 | 21.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.5 | 21.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 18.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 17.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.6 | 16.9 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.2 | 8.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 4.5 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 4.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 4.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.6 | 3.7 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.2 | 3.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.9 | 8.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.9 | 7.9 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.5 | 6.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 5.7 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 5.6 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.4 | 5.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.7 | 5.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.9 | 5.1 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.4 | 4.2 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |