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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for neurod1

Z-value: 1.49

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Transcription factors associated with neurod1

Gene Symbol Gene ID Gene Info
ENSDARG00000019566 neuronal differentiation 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
neurod1dr11_v1_chr9_-_44295071_442950710.749.3e-18Click!

Activity profile of neurod1 motif

Sorted Z-values of neurod1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_29045426 18.70 ENSDART00000019770
glycoprotein M6Ba
chr8_+_7359294 17.50 ENSDART00000121708
proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr9_-_44295071 17.35 ENSDART00000011837
neuronal differentiation 1
chr10_+_15777258 16.37 ENSDART00000140511
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr10_+_15777064 15.10 ENSDART00000114483
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr12_-_14922955 14.60 ENSDART00000002078
neurogenic differentiation 2
chr23_+_2778813 12.97 ENSDART00000142621
DNA topoisomerase I
chr22_+_17205608 12.81 ENSDART00000181267
RAB3B, member RAS oncogene family
chr20_-_25669813 12.72 ENSDART00000153118
si:dkeyp-117h8.2
chr7_+_32722227 12.67 ENSDART00000126565
si:ch211-150g13.3
chr11_+_35364445 12.64 ENSDART00000125766
CaM kinase-like vesicle-associated b
chr6_-_35487413 12.61 ENSDART00000102461
regulator of G protein signaling 8
chr19_-_32888758 12.23 ENSDART00000052080
lysosomal protein transmembrane 4 beta
chr23_+_20563779 12.16 ENSDART00000146008
CaM kinase-like vesicle-associated, like
chr13_-_30027730 12.13 ENSDART00000044009
stearoyl-CoA desaturase b
chr16_-_29334672 12.11 ENSDART00000162835
brevican
chr21_+_25181003 11.64 ENSDART00000169700
si:dkey-183i3.9
chr24_-_17444067 11.56 ENSDART00000155843
contactin associated protein like 2a
chr6_-_43092175 11.56 ENSDART00000084389
leucine rich repeat neuronal 1
chr12_-_16084835 11.46 ENSDART00000090881
potassium voltage-gated channel, subfamily J, member 19b
chr6_-_11780070 11.20 ENSDART00000151195
membrane-associated ring finger (C3HC4) 7
chr7_+_29133321 11.05 ENSDART00000052346
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr3_-_46818001 11.05 ENSDART00000166505
ELAV like neuron-specific RNA binding protein 3
chr2_+_50626476 10.79 ENSDART00000018150
neuronal differentiation 6b
chr7_+_26224211 10.71 ENSDART00000173999
VGF nerve growth factor inducible
chr23_-_5032587 10.46 ENSDART00000163903
potassium voltage-gated channel, shaker-related subfamily, member 2b
chr18_-_38087875 10.38 ENSDART00000111301
leucine zipper protein 2
chr7_+_30823749 10.36 ENSDART00000085661
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr12_-_41618844 10.31 ENSDART00000160054
dihydropyrimidinase-like 4
chr12_+_31744217 10.30 ENSDART00000190361
si:dkey-49c17.3
chr20_+_405811 10.14 ENSDART00000149311
G protein-coupled receptor 63
chr13_+_22104298 10.12 ENSDART00000115393
si:dkey-174i8.1
chr6_+_22597362 9.93 ENSDART00000131242
cytoglobin 2
chr20_-_39273987 9.85 ENSDART00000127173
clusterin
chr3_-_46817838 9.76 ENSDART00000028610
ELAV like neuron-specific RNA binding protein 3
chr1_-_38709551 9.45 ENSDART00000128794
glycoprotein M6Ab
chr16_-_8927425 9.28 ENSDART00000000382
trio Rho guanine nucleotide exchange factor b
chr14_-_21219659 9.18 ENSDART00000089867
protein phosphatase 2, regulatory subunit B, gamma b
chr19_-_9882821 9.16 ENSDART00000147128
calcium channel, voltage-dependent, gamma subunit 7a
chr5_-_51819027 8.96 ENSDART00000164267
homer scaffolding protein 1b
chr21_-_43952958 8.82 ENSDART00000039571
calcium/calmodulin-dependent protein kinase II alpha
chr25_+_14017609 8.80 ENSDART00000129105
ENSDART00000125733
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr1_-_14233815 8.75 ENSDART00000044896
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr7_-_58130703 8.73 ENSDART00000172082
ankyrin 2b, neuronal
chr1_-_40227166 8.73 ENSDART00000146680
si:ch211-113e8.3
chr13_+_36633355 8.62 ENSDART00000135612
si:ch211-67f24.7
chr13_+_51579851 8.58 ENSDART00000163847
NK6 homeobox 2
chr10_-_24362775 8.42 ENSDART00000182104
phosphatidylinositol transfer protein, alpha b
chr12_-_41619257 8.31 ENSDART00000162967
dihydropyrimidinase-like 4
chr5_-_23280098 8.28 ENSDART00000126540
ENSDART00000051533
proteolipid protein 1b
chr12_+_21525496 8.26 ENSDART00000152974
carbonic anhydrase Xa
chr6_+_46341306 8.22 ENSDART00000111905

chr5_+_3501859 8.17 ENSDART00000080486
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr5_-_10768258 8.09 ENSDART00000157043
reticulon 4 receptor
chr25_+_7670683 8.07 ENSDART00000040275
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr5_-_40190949 8.06 ENSDART00000175588
WD repeat and FYVE domain containing 3
chr16_-_29480335 7.91 ENSDART00000148930
leucine rich repeat and Ig domain containing 4b
chr23_-_18057851 7.89 ENSDART00000173075
ENSDART00000173230
ENSDART00000173135
ENSDART00000173431
ENSDART00000173068
ENSDART00000172987
zgc:92287
chr18_+_48576527 7.78 ENSDART00000167555
potassium inwardly-rectifying channel, subfamily J, member 5
chr6_+_21095918 7.72 ENSDART00000167225
SPEG complex locus a
chr13_-_39830999 7.69 ENSDART00000115089
zgc:171482
chr4_+_15968483 7.60 ENSDART00000101575
si:dkey-117n7.5
chr24_+_32472155 7.57 ENSDART00000098859
neuronal differentiation 6a
chr3_+_33340939 7.53 ENSDART00000128786
peptide YYa
chr20_-_39273505 7.46 ENSDART00000153114
clusterin
chr18_-_38088099 7.44 ENSDART00000146120
leucine zipper protein 2
chr21_+_13353263 7.42 ENSDART00000114677
si:ch73-62l21.1
chr3_+_50310684 7.31 ENSDART00000112152
growth arrest-specific 7a
chr10_-_24371312 7.24 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr17_-_20717845 7.23 ENSDART00000150037
ankyrin 3b
chr18_+_9635178 7.22 ENSDART00000183486
piccolo presynaptic cytomatrix protein b
chr4_-_1324141 7.22 ENSDART00000180720
pleiotrophin
chr25_+_37130450 7.16 ENSDART00000183358
si:ch1073-174d20.1
chr13_+_28854438 7.14 ENSDART00000193407
ENSDART00000189554

chr2_-_21352101 7.02 ENSDART00000057021
hedgehog acyltransferase like, a
chr25_-_554142 6.98 ENSDART00000028997
myosin IXAb
chr7_-_23996133 6.80 ENSDART00000173761
si:dkey-183c6.8
chr20_-_18731268 6.74 ENSDART00000183893
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr22_-_33679277 6.73 ENSDART00000169948

chr14_-_32258759 6.69 ENSDART00000052949
fibroblast growth factor 13a
chr21_-_16632808 6.59 ENSDART00000172645
unc-5 netrin receptor Da
chr8_-_17064243 6.55 ENSDART00000185313
RAB3C, member RAS oncogene family
chr10_-_17103651 6.48 ENSDART00000108959
ring finger protein 208
chr17_-_44584811 6.45 ENSDART00000165059
ENSDART00000165252
solute carrier family 35, member F4
chr10_+_29431529 6.41 ENSDART00000158154
discs, large homolog 2 (Drosophila)
chr7_+_10351038 6.36 ENSDART00000173256
si:cabz01029535.1
chr3_-_21061931 6.32 ENSDART00000036741
family with sequence similarity 57, member Ba
chr15_+_24691088 6.30 ENSDART00000110618
si:dkey-151p21.7
chr13_+_24287093 6.26 ENSDART00000058628
centriole, cilia and spindle-associated protein b
chr25_-_16818978 6.19 ENSDART00000104140
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr10_+_17875891 6.13 ENSDART00000191744
PHD finger protein 24
chr11_+_24925434 6.09 ENSDART00000131431
sulfatase 2a
chr24_+_29449690 6.06 ENSDART00000105743
ENSDART00000193556
ENSDART00000145816
netrin g1a
chr19_-_27261102 6.02 ENSDART00000143919
gamma-aminobutyric acid (GABA) B receptor, 1b
chr2_-_24348948 5.98 ENSDART00000136559
anoctamin 8a
chr5_-_46896541 5.91 ENSDART00000133240
EGF-like repeats and discoidin I-like domains 3a
chr11_-_28911172 5.89 ENSDART00000168493
immunoglobin superfamily, member 21a
chr5_+_36768674 5.87 ENSDART00000146854
MAP/microtubule affinity-regulating kinase 4a
chr13_-_40499296 5.82 ENSDART00000158338
Danio rerio cyclin and CBS domain divalent metal cation transport mediator 1 (cnnm1), mRNA.
chr1_+_32521469 5.77 ENSDART00000113818
ENSDART00000152580
neuroligin 4a
chr18_-_39787040 5.74 ENSDART00000169916
Dmx-like 2
chr23_+_35708730 5.71 ENSDART00000009277
tubulin, alpha 1a
chr9_+_22929675 5.66 ENSDART00000061299
translin
chr14_-_27121854 5.62 ENSDART00000173119
protocadherin 11
chr23_-_18057553 5.59 ENSDART00000173102
ENSDART00000058742
zgc:92287
chr24_+_24461341 5.49 ENSDART00000147658
basic helix-loop-helix family, member e22
chr2_-_24348642 5.49 ENSDART00000181739
anoctamin 8a
chr1_+_38775041 5.46 ENSDART00000110824
WD repeat domain 17
chr3_+_50312422 5.45 ENSDART00000157689
growth arrest-specific 7a
chr18_-_42313798 5.44 ENSDART00000098639
contactin 5
chr7_-_50914526 5.41 ENSDART00000160398
ankyrin repeat domain 46b
chr21_-_12030654 5.37 ENSDART00000139145
tubulin polyglutamylase complex subunit 2
chr12_+_5189776 5.35 ENSDART00000081298
leucine-rich, glioma inactivated 1b
chr11_-_32723851 5.35 ENSDART00000155592
protocadherin 17
chr17_-_36988455 5.30 ENSDART00000187180
ENSDART00000126823
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr19_+_24882845 5.26 ENSDART00000010580
si:ch211-195b13.1
chr21_+_7900107 5.25 ENSDART00000056560
cholesterol 25-hydroxylase like 2
chr4_-_9667380 5.23 ENSDART00000189671
ENSDART00000133214
cyclin D binding myb-like transcription factor 1
chr7_+_39389273 5.20 ENSDART00000191298
troponin I type 2b (skeletal, fast), tandem duplicate 2
chr2_-_22230326 5.15 ENSDART00000127810
family with sequence similarity 110, member B
chr12_-_3453589 5.12 ENSDART00000175918

chr16_-_41515662 5.11 ENSDART00000166201
ENSDART00000127243
sialic acid binding Ig-like lectin 15, like
chr6_+_54142311 5.10 ENSDART00000154115
high mobility group AT-hook 1b
chr2_+_31475772 5.02 ENSDART00000130722
calcium channel, voltage-dependent, beta 2b
chr2_+_31476065 4.99 ENSDART00000049219
calcium channel, voltage-dependent, beta 2b
chr22_+_3232925 4.98 ENSDART00000166754

chr13_-_44285793 4.96 ENSDART00000167383

chr13_+_25428677 4.92 ENSDART00000186284
si:dkey-51a16.9
chr5_+_20147830 4.90 ENSDART00000098727
SV2 related protein a
chr5_-_19932621 4.90 ENSDART00000088881
G protein-coupled receptor kinase interacting ArfGAP 2a
chr13_+_3954540 4.87 ENSDART00000092646
leucine rich repeat containing 73
chr1_+_9557212 4.85 ENSDART00000111131
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr14_-_21218891 4.82 ENSDART00000158294
protein phosphatase 2, regulatory subunit B, gamma b
chr24_+_24461558 4.80 ENSDART00000182424
basic helix-loop-helix family, member e22
chr10_-_5847904 4.70 ENSDART00000161096
ankyrin repeat domain 55
chr2_-_36819624 4.66 ENSDART00000140844
SLIT and NTRK-like family, member 3b
chr15_+_19293744 4.63 ENSDART00000184994
ENSDART00000123815
junctional adhesion molecule 3a
chr11_-_37359416 4.58 ENSDART00000159184
ELKS/RAB6-interacting/CAST family member 2
chr6_+_58492201 4.57 ENSDART00000156375
potassium voltage-gated channel, KQT-like subfamily, member 2b
chr2_-_9544161 4.49 ENSDART00000124425
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, like
chr9_-_4606463 4.46 ENSDART00000179110
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr24_-_34335265 4.46 ENSDART00000128690
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr8_+_36500061 4.45 ENSDART00000185840
solute carrier family 7, member 4
chr16_+_11151699 4.44 ENSDART00000140674
capicua transcriptional repressor b
chr16_+_46000956 4.42 ENSDART00000101753
ENSDART00000162393
myotubularin related protein 11
chr15_+_28955004 4.37 ENSDART00000029459
gastric inhibitory polypeptide receptor
chr7_-_28463106 4.37 ENSDART00000137799
tripartite motif containing 66
chr23_+_20705849 4.35 ENSDART00000079538
coiled-coil domain containing 30
chr8_-_26609259 4.34 ENSDART00000027301
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr17_-_2535682 4.34 ENSDART00000155227
coiled-coil domain containing 9B
chr19_+_12801940 4.31 ENSDART00000040073
melanocortin 5a receptor
chr14_-_33083539 4.28 ENSDART00000160173
discs, large homolog 3 (Drosophila)
chr12_+_5190049 4.28 ENSDART00000126667
leucine-rich, glioma inactivated 1b
chr5_-_38342992 4.26 ENSDART00000140337
misshapen-like kinase 1
chr5_+_42912966 4.20 ENSDART00000039973
RUN and FYVE domain containing 3
chr22_+_465269 4.17 ENSDART00000145767
cadherin, EGF LAG seven-pass G-type receptor 2
chr5_-_46329880 4.15 ENSDART00000156577
si:ch211-130m23.5
chr17_-_52579709 4.14 ENSDART00000156806
ribosomal protein S6 kinase-like 1
chr1_+_21937201 4.11 ENSDART00000087729
lysine (K)-specific demethylase 4C
chr20_-_44576949 4.10 ENSDART00000148639
UBX domain protein 2A
chr3_-_60886984 4.09 ENSDART00000170974
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_-_10320676 4.08 ENSDART00000151247
sodium channel, voltage-gated, type I like, alpha b
chr4_-_20081621 4.04 ENSDART00000024647
DENN/MADD domain containing 6B
chr21_+_39100289 4.01 ENSDART00000075958
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr23_-_18057270 4.01 ENSDART00000173385
zgc:92287
chr12_+_26632448 4.00 ENSDART00000185762
Rho GTPase activating protein 12b
chr13_-_8785610 3.99 ENSDART00000021083
calmodulin 2b, (phosphorylase kinase, delta)
chr11_-_11625369 3.95 ENSDART00000112328
si:dkey-28e7.3
chr24_+_166892 3.94 ENSDART00000100417
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr9_+_28693592 3.93 ENSDART00000110198
zgc:162780
chr5_-_40734045 3.93 ENSDART00000010896
ISL LIM homeobox 1
chr19_+_33553586 3.90 ENSDART00000183477
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr8_+_8298439 3.90 ENSDART00000170566
SRSF protein kinase 3
chr25_-_16818380 3.86 ENSDART00000155401
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr7_+_74134010 3.85 ENSDART00000164874
claudin domain containing 1a
chr7_-_18881358 3.85 ENSDART00000021502
MLLT3, super elongation complex subunit
chr6_-_51101834 3.83 ENSDART00000092493
protein tyrosine phosphatase, receptor type, t
chr5_-_69923241 3.81 ENSDART00000187389
fukutin
chr21_+_44300689 3.80 ENSDART00000186298
ENSDART00000142810
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr19_-_38872650 3.80 ENSDART00000146641
adhesion G protein-coupled receptor B2
chr21_-_25601648 3.80 ENSDART00000042578
EGF containing fibulin extracellular matrix protein 2b
chr24_+_18714212 3.79 ENSDART00000171181
centrosome and spindle pole associated protein 1a
chr11_+_37049347 3.78 ENSDART00000109235
bicaudal D homolog 2 (Drosophila)
chr3_-_1204341 3.78 ENSDART00000089646
family with sequence similarity 234, member B
chr16_+_10963602 3.77 ENSDART00000141032
POU class 2 homeobox 2a
chr21_+_27382893 3.77 ENSDART00000005682
actinin alpha 3a
chr14_-_39074539 3.73 ENSDART00000030509
glycine receptor, alpha 4a
chr2_+_21309272 3.70 ENSDART00000141322
zinc finger and BTB domain containing 47a
chr20_-_27325258 3.68 ENSDART00000152917
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr18_+_45550783 3.67 ENSDART00000138075
kinesin family member C3
chr11_-_11625630 3.63 ENSDART00000161821
ENSDART00000193152
si:dkey-28e7.3
chr15_+_15516612 3.63 ENSDART00000016024
tnf receptor-associated factor 4a
chr8_+_25254435 3.62 ENSDART00000143554
adenosine monophosphate deaminase 2b
chr1_+_55294009 3.60 ENSDART00000128979
zgc:172106
chr3_+_38793499 3.59 ENSDART00000083394
potassium voltage-gated channel subfamily J member 19a
chr15_-_31508221 3.58 ENSDART00000121464
si:dkey-1m11.5
chr14_-_4556896 3.54 ENSDART00000044678
ENSDART00000192863
gamma-aminobutyric acid type A receptor alpha2 subunit
chr15_-_20954552 3.53 ENSDART00000006910
tubulin folding cofactor E-like a
chr10_-_31440500 3.51 ENSDART00000024778
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr3_-_30885250 3.48 ENSDART00000109104
lysine methyltransferase 5C

Network of associatons between targets according to the STRING database.

First level regulatory network of neurod1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.7 GO:0051580 regulation of neurotransmitter uptake(GO:0051580) negative regulation of anion transport(GO:1903792)
3.6 14.6 GO:0060074 synapse maturation(GO:0060074)
3.4 13.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
3.0 12.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
2.5 2.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
2.3 7.0 GO:0050748 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
2.3 11.6 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
1.9 5.7 GO:1901546 regulation of cellular pH reduction(GO:0032847) synaptic vesicle lumen acidification(GO:0097401) regulation of synaptic vesicle lumen acidification(GO:1901546)
1.7 8.7 GO:0036371 protein localization to T-tubule(GO:0036371)
1.5 6.0 GO:0035095 behavioral response to nicotine(GO:0035095)
1.4 11.6 GO:0021627 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
1.4 14.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
1.4 7.0 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
1.4 4.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
1.3 1.3 GO:0072578 neurotransmitter-gated ion channel clustering(GO:0072578) gamma-aminobutyric acid receptor clustering(GO:0097112)
1.3 9.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
1.3 7.6 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
1.3 6.3 GO:0060295 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
1.2 3.5 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
1.1 18.7 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
1.0 18.6 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.9 3.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.9 4.4 GO:0045124 regulation of bone resorption(GO:0045124)
0.9 3.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.8 13.0 GO:0006265 DNA topological change(GO:0006265)
0.8 3.8 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.7 2.2 GO:0036076 ligamentous ossification(GO:0036076)
0.7 7.2 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.7 2.1 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.7 2.1 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.6 2.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.6 10.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.6 6.3 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.6 6.8 GO:1990709 presynaptic active zone organization(GO:1990709)
0.6 1.8 GO:0006589 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.6 6.6 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.6 9.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.6 1.7 GO:0030186 melatonin metabolic process(GO:0030186)
0.5 11.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.5 7.7 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.5 1.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.5 8.6 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.5 9.9 GO:0015671 oxygen transport(GO:0015671)
0.5 6.6 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.5 2.8 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.5 19.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.5 3.7 GO:0021634 optic nerve formation(GO:0021634)
0.4 2.2 GO:0048025 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.4 3.0 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.4 8.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.4 2.9 GO:0016266 O-glycan processing(GO:0016266)
0.4 10.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.4 1.6 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.4 1.2 GO:0097264 self proteolysis(GO:0097264)
0.4 8.1 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.4 2.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.4 10.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.4 1.1 GO:0035973 aggrephagy(GO:0035973)
0.3 1.0 GO:0021519 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519)
0.3 5.1 GO:0035108 limb morphogenesis(GO:0035108)
0.3 3.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 26.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.3 4.2 GO:0021754 facial nucleus development(GO:0021754)
0.3 3.5 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.3 1.9 GO:0044241 lipid digestion(GO:0044241)
0.3 12.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.3 3.7 GO:0001964 startle response(GO:0001964)
0.3 3.1 GO:0061709 reticulophagy(GO:0061709)
0.3 2.7 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.3 5.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.3 7.5 GO:0007631 feeding behavior(GO:0007631)
0.3 1.7 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 10.2 GO:0033500 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.3 1.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 2.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.3 10.4 GO:1901214 regulation of neuron death(GO:1901214)
0.3 3.6 GO:0032264 IMP salvage(GO:0032264)
0.3 3.5 GO:0016199 axon midline choice point recognition(GO:0016199) commissural neuron axon guidance(GO:0071679)
0.3 11.5 GO:0036269 swimming behavior(GO:0036269)
0.2 0.7 GO:0060571 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 4.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.2 1.2 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.2 1.6 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.2 2.6 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.2 1.2 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.2 6.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.1 GO:1903146 regulation of mitophagy(GO:1903146)
0.2 2.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 9.3 GO:0048854 brain morphogenesis(GO:0048854)
0.2 6.1 GO:0070831 basement membrane assembly(GO:0070831)
0.2 2.4 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.2 3.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 0.6 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 0.8 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.2 0.2 GO:2000402 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.2 1.9 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.2 0.5 GO:1901232 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.2 3.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 1.8 GO:0070475 rRNA base methylation(GO:0070475)
0.2 3.1 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.2 7.2 GO:0051781 positive regulation of cell division(GO:0051781)
0.2 5.3 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.2 3.8 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.2 2.5 GO:0045116 protein neddylation(GO:0045116)
0.2 6.9 GO:0016126 sterol biosynthetic process(GO:0016126)
0.2 9.3 GO:0015914 phospholipid transport(GO:0015914)
0.2 1.7 GO:0046548 retinal rod cell development(GO:0046548)
0.2 0.9 GO:0060997 dendritic spine development(GO:0060996) dendritic spine morphogenesis(GO:0060997)
0.2 8.8 GO:0003146 heart jogging(GO:0003146)
0.1 2.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.0 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031) cellular response to leucine starvation(GO:1990253)
0.1 5.7 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.1 3.4 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 21.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 16.4 GO:0051260 protein homooligomerization(GO:0051260)
0.1 1.6 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 1.5 GO:0007398 ectoderm development(GO:0007398)
0.1 7.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 2.1 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 2.9 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 3.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 2.2 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 0.3 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.1 0.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.5 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 1.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.8 GO:0021576 hindbrain formation(GO:0021576)
0.1 1.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 0.2 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.1 3.2 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.1 1.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 2.9 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.8 GO:0099536 synaptic signaling(GO:0099536)
0.1 3.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 3.7 GO:0060048 cardiac muscle contraction(GO:0060048)
0.1 0.7 GO:0061099 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 3.7 GO:0055013 cardiac muscle cell development(GO:0055013)
0.1 0.4 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.8 GO:0046847 filopodium assembly(GO:0046847)
0.1 1.3 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 26.9 GO:0098916 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.1 2.0 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.1 20.9 GO:0048812 neuron projection morphogenesis(GO:0048812)
0.1 1.0 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 0.8 GO:0051928 positive regulation of calcium ion transport(GO:0051928)
0.1 1.6 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 0.7 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.1 0.7 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 1.0 GO:0001757 somite specification(GO:0001757) segment specification(GO:0007379)
0.1 1.6 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 3.3 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.1 19.9 GO:0050767 regulation of neurogenesis(GO:0050767)
0.0 6.8 GO:0048511 rhythmic process(GO:0048511)
0.0 1.3 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.6 GO:0021983 pituitary gland development(GO:0021983)
0.0 2.9 GO:0070509 calcium ion import(GO:0070509)
0.0 3.3 GO:0001755 neural crest cell migration(GO:0001755)
0.0 18.0 GO:0030182 neuron differentiation(GO:0030182)
0.0 4.5 GO:0006865 amino acid transport(GO:0006865)
0.0 0.8 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 1.4 GO:0032456 endocytic recycling(GO:0032456)
0.0 2.5 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 1.6 GO:0042552 myelination(GO:0042552)
0.0 0.3 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 1.4 GO:0060560 developmental growth involved in morphogenesis(GO:0060560)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 2.2 GO:0007030 Golgi organization(GO:0007030)
0.0 0.1 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 3.3 GO:0060070 canonical Wnt signaling pathway(GO:0060070)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 1.4 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.4 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 1.1 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 4.2 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.1 GO:1901906 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 5.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.9 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 0.2 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.2 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 17.3 GO:0042583 chromaffin granule(GO:0042583)
1.4 11.6 GO:0033010 paranodal junction(GO:0033010)
1.4 5.7 GO:0043291 RAVE complex(GO:0043291)
1.4 5.6 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.9 10.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.8 9.4 GO:0044295 axonal growth cone(GO:0044295)
0.8 6.0 GO:0097648 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.7 7.2 GO:0098982 GABA-ergic synapse(GO:0098982)
0.7 12.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.7 4.6 GO:0043194 axon initial segment(GO:0043194)
0.6 1.9 GO:1990745 EARP complex(GO:1990745)
0.6 3.1 GO:0008091 spectrin(GO:0008091)
0.6 9.2 GO:0030315 T-tubule(GO:0030315)
0.5 1.6 GO:0033268 node of Ranvier(GO:0033268)
0.5 16.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 8.3 GO:0043209 myelin sheath(GO:0043209)
0.4 1.3 GO:0060077 inhibitory synapse(GO:0060077)
0.4 41.0 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.4 6.8 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.3 12.9 GO:0030426 growth cone(GO:0030426)
0.3 9.9 GO:0043204 perikaryon(GO:0043204)
0.3 9.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 1.9 GO:0030891 VCB complex(GO:0030891)
0.3 2.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.3 2.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 6.1 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.3 1.4 GO:0071439 clathrin complex(GO:0071439)
0.3 6.2 GO:0005771 multivesicular body(GO:0005771)
0.2 2.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 1.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 0.8 GO:0035339 SPOTS complex(GO:0035339)
0.2 1.2 GO:0070062 extracellular exosome(GO:0070062)
0.2 11.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 3.8 GO:0032590 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.2 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 2.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 0.8 GO:0005899 insulin receptor complex(GO:0005899)
0.2 1.3 GO:0016586 RSC complex(GO:0016586)
0.2 10.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 15.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.2 GO:0001772 immunological synapse(GO:0001772)
0.1 1.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 9.9 GO:0014069 postsynaptic density(GO:0014069)
0.1 1.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 5.2 GO:0005861 troponin complex(GO:0005861)
0.1 4.3 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 0.4 GO:0031213 RSF complex(GO:0031213)
0.1 12.5 GO:0005884 actin filament(GO:0005884)
0.1 13.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 1.8 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.6 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.4 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.1 5.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.2 GO:0005811 lipid particle(GO:0005811)
0.1 0.3 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.1 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.1 37.4 GO:0043005 neuron projection(GO:0043005)
0.1 4.0 GO:0055037 recycling endosome(GO:0055037)
0.1 3.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.4 GO:0097546 ciliary base(GO:0097546)
0.1 10.6 GO:0008021 synaptic vesicle(GO:0008021)
0.1 4.4 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 9.7 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.1 0.2 GO:0070209 ASTRA complex(GO:0070209)
0.1 0.7 GO:0099572 postsynaptic specialization(GO:0099572)
0.1 18.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 4.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 8.2 GO:0005874 microtubule(GO:0005874)
0.0 3.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.4 GO:0044545 NSL complex(GO:0044545)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.1 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
2.5 22.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
2.2 15.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
2.2 11.1 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.8 9.0 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
1.7 41.8 GO:0001540 beta-amyloid binding(GO:0001540)
1.6 18.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
1.5 7.5 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
1.4 9.9 GO:0098809 nitrite reductase activity(GO:0098809)
1.2 3.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
1.1 10.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
1.0 3.1 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
1.0 13.0 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
1.0 3.0 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.9 4.4 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.9 2.6 GO:0097643 amylin receptor activity(GO:0097643)
0.8 6.5 GO:0034452 dynactin binding(GO:0034452)
0.8 14.0 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.8 6.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.8 6.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.8 36.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.8 5.3 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.7 2.1 GO:0042166 neurotransmitter binding(GO:0042165) acetylcholine binding(GO:0042166)
0.7 2.7 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.7 6.6 GO:0005042 netrin receptor activity(GO:0005042)
0.6 1.8 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.6 7.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 8.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.6 2.8 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.6 8.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.5 2.1 GO:0071253 connexin binding(GO:0071253)
0.5 3.2 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.5 8.1 GO:0048495 Roundabout binding(GO:0048495)
0.5 4.3 GO:0004977 melanocortin receptor activity(GO:0004977)
0.5 8.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.5 2.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 1.7 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.4 12.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 3.7 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.4 17.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.4 2.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.4 2.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 2.9 GO:0004985 opioid receptor activity(GO:0004985)
0.3 4.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 3.6 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 10.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 8.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 4.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 3.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 9.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.3 4.3 GO:0038191 neuropilin binding(GO:0038191)
0.3 3.8 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.3 6.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 9.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 6.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 1.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 1.2 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.2 5.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 1.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 2.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 5.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 0.7 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.2 0.9 GO:0042903 tubulin deacetylase activity(GO:0042903) acetylspermidine deacetylase activity(GO:0047611)
0.2 3.5 GO:0050811 GABA receptor binding(GO:0050811)
0.2 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 8.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 1.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 2.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 4.9 GO:0051787 misfolded protein binding(GO:0051787)
0.2 5.8 GO:0051020 GTPase binding(GO:0051020)
0.2 0.8 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.2 17.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 4.7 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.2 9.1 GO:0005178 integrin binding(GO:0005178)
0.2 1.6 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.2 1.8 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 2.7 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.0 GO:0070728 leucine binding(GO:0070728)
0.1 0.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 11.1 GO:0016247 channel regulator activity(GO:0016247)
0.1 2.9 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 3.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.4 GO:0009384 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 0.6 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 2.3 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 65.2 GO:0046983 protein dimerization activity(GO:0046983)
0.1 2.0 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 6.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 4.0 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.1 0.4 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 1.0 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 1.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 4.1 GO:0008013 beta-catenin binding(GO:0008013)
0.1 6.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 1.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.9 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.1 1.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.1 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.4 GO:0042164 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.1 0.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 4.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.1 2.0 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.8 GO:0005112 Notch binding(GO:0005112)
0.1 1.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 2.1 GO:0017022 myosin binding(GO:0017022)
0.1 1.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 3.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 2.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 0.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.7 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 3.8 GO:0008201 heparin binding(GO:0008201)
0.0 5.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 17.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 4.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 2.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 3.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0031628 opioid receptor binding(GO:0031628)
0.0 2.8 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 28.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 5.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 1.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 3.3 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
0.0 2.7 GO:0004672 protein kinase activity(GO:0004672)
0.0 0.9 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 7.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3 11.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 14.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.3 15.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 5.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 1.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 2.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 6.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 5.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 4.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 4.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 0.9 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 2.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.2 PID AURORA A PATHWAY Aurora A signaling
0.1 2.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.7 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.5 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 1.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 3.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.7 18.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.9 16.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.8 10.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.5 7.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 3.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.4 4.4 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.4 3.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 7.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 5.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 3.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 4.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 1.5 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.3 7.7 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.3 4.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 4.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 17.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 16.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.2 1.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 1.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 2.6 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.2 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 3.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.7 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 1.2 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.1 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.0 1.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 1.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 2.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation