ISMARA results: neurod1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for neurod1

Z-value: 1.49

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Transcription factors associated with neurod1

Gene Symbol	Gene ID	Gene Info
neurod1 NCBI UniProt	ENSDARG00000019566	neuronal differentiation 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
neurod1	dr11_v1_chr9_-_44295071_44295071	0.74	9.3e-18	Click!

Activity profile of neurod1 motif

Sorted Z-values of neurod1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_29045426 Show fit	18.70	ENSDART00000019770	gpm6ba NCBI UniProt Show fit	glycoprotein M6Ba
chr8_+_7359294 Show fit	17.50	ENSDART00000121708	pcsk1nl NCBI UniProt Show fit	proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr9_-_44295071 Show fit	17.35	ENSDART00000011837	neurod1 NCBI UniProt Show fit	neuronal differentiation 1
chr10_+_15777258 Show fit	16.37	ENSDART00000140511	apba1b NCBI UniProt Show fit	amyloid beta (A4) precursor protein-binding, family A, member 1b
chr10_+_15777064 Show fit	15.10	ENSDART00000114483	apba1b NCBI UniProt Show fit	amyloid beta (A4) precursor protein-binding, family A, member 1b
chr12_-_14922955 Show fit	14.60	ENSDART00000002078	neurod2 NCBI UniProt Show fit	neurogenic differentiation 2
chr23_+_2778813 Show fit	12.97	ENSDART00000142621	top1 NCBI UniProt Show fit	DNA topoisomerase I
chr22_+_17205608 Show fit	12.81	ENSDART00000181267	rab3b NCBI UniProt Show fit	RAB3B, member RAS oncogene family
chr20_-_25669813 Show fit	12.72	ENSDART00000153118	si:dkeyp-117h8.2 NCBI UniProt Show fit	si:dkeyp-117h8.2
chr7_+_32722227 Show fit	12.67	ENSDART00000126565	si:ch211-150g13.3 NCBI UniProt Show fit	si:ch211-150g13.3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of neurod1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	26.9	GO:0098916	chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.3	26.0	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.1	21.1	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.1	20.9	GO:0048812	neuron projection morphogenesis(GO:0048812)
0.1	19.9	GO:0050767	regulation of neurogenesis(GO:0050767)
0.5	19.4	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
6.2	18.7	GO:0051580	regulation of neurotransmitter uptake(GO:0051580) negative regulation of anion transport(GO:1903792)
1.1	18.7	GO:0048923	posterior lateral line neuromast hair cell differentiation(GO:0048923)
1.0	18.6	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208)
0.0	18.0	GO:0030182	neuron differentiation(GO:0030182)

Showing 1 to 10 of 191 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	41.0	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1	37.4	GO:0043005	neuron projection(GO:0043005)
0.1	18.3	GO:0031012	extracellular matrix(GO:0031012)
1.7	17.3	GO:0042583	chromaffin granule(GO:0042583)
0.5	16.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.2	15.1	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1	13.5	GO:0005802	trans-Golgi network(GO:0005802)
0.3	12.9	GO:0030426	growth cone(GO:0030426)
0.7	12.6	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	12.5	GO:0005884	actin filament(GO:0005884)

Showing 1 to 10 of 79 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	65.2	GO:0046983	protein dimerization activity(GO:0046983)
1.7	41.8	GO:0001540	beta-amyloid binding(GO:0001540)
0.8	36.0	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	28.4	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
2.5	22.8	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.6	18.6	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.4	17.6	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.2	17.5	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	17.3	GO:0005096	GTPase activator activity(GO:0005096)
2.2	15.7	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)

Showing 1 to 10 of 141 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.3	14.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.3	11.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.4	7.8	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	6.2	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2	5.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	5.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4	4.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	4.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	4.3	PID TGFBR PATHWAY	TGF-beta receptor signaling

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	18.6	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	17.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	16.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.9	16.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.8	10.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
2.9	8.8	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4	7.8	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3	7.7	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.5	7.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.4	5.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway

Showing 1 to 10 of 41 entries

Results for neurod1

Z-value: 1.49

Motif logo

Transcription factors associated with neurod1

Activity-expression correlation:

Activity profile of neurod1 motif

Sorted Z-values of neurod1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of neurod1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: