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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for myf6
Z-value: 1.47
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Transcription factors associated with myf6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| myf6 | dr11_v1_chr4_+_21717793_21717793 | 0.46 | 3.1e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_13256415 Show fit | 10.70 |
ENSDART00000144542
|
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like |
|
| chr9_-_105135 Show fit | 10.17 |
ENSDART00000180126
|
|
|
| chr2_+_42191592 Show fit | 10.17 |
ENSDART00000144716
|
caveolae associated protein 4a |
|
| chr19_-_5332784 Show fit | 6.86 |
ENSDART00000010373
|
keratin, type 1, gene 19d |
|
| chr18_+_1615 Show fit | 6.80 |
ENSDART00000082450
|
homer scaffolding protein 2 |
|
| chr13_-_214122 Show fit | 5.37 |
ENSDART00000169273
|
protein phosphatase 1, regulatory subunit 21 |
|
| chr13_-_280652 Show fit | 5.14 |
ENSDART00000193627
|
solute carrier family 30 (zinc transporter), member 6 |
|
| chr18_-_50956280 Show fit | 4.83 |
ENSDART00000058457
|
suppression of tumorigenicity 7 |
|
| chr3_-_61203203 Show fit | 4.72 |
ENSDART00000171787
|
parvalbumin 1 |
|
| chr22_+_20720808 Show fit | 4.68 |
ENSDART00000171321
|
si:dkey-211f22.5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of myf6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.1 | 9.9 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.1 | 9.5 | GO:0050922 | negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of chemotaxis(GO:0050922) negative regulation of axon guidance(GO:1902668) |
| 1.8 | 7.4 | GO:0031448 | regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076) |
| 0.2 | 7.3 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.1 | 6.9 | GO:0045732 | positive regulation of protein catabolic process(GO:0045732) |
| 0.8 | 6.8 | GO:0021628 | olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628) |
| 0.2 | 6.6 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) |
| 0.1 | 5.5 | GO:0043297 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.0 | 5.5 | GO:0051169 | nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.6 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 12.7 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.6 | 11.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 8.1 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 7.9 | GO:0030054 | cell junction(GO:0030054) |
| 1.8 | 7.4 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 6.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 5.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 5.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 5.0 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 18.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 17.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 12.6 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 10.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 9.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.5 | 7.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.3 | 7.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.3 | 6.5 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.1 | 6.1 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.1 | 5.3 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 8.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 6.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 5.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 5.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 4.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 4.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 3.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 3.5 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 7.0 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 4.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 4.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 3.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 3.7 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.2 | 3.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 3.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 3.3 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |