ISMARA results: myb+mybl1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for myb+mybl1

Z-value: 1.65

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Transcription factors associated with myb+mybl1

Gene Symbol	Gene ID	Gene Info
mybl1 NCBI UniProt	ENSDARG00000030999	v-myb avian myeloblastosis viral oncogene homolog-like 1
myb NCBI UniProt	ENSDARG00000053666	v-myb avian myeloblastosis viral oncogene homolog
myb NCBI UniProt	ENSDARG00000114024	v-myb avian myeloblastosis viral oncogene homolog

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mybl1	dr11_v1_chr24_+_23791758_23791839	0.55	9.0e-09	Click!
myb	dr11_v1_chr23_+_31815423_31815492	0.04	6.9e-01	Click!

Activity profile of myb+mybl1 motif

Sorted Z-values of myb+mybl1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_7974155 Show fit	17.82	ENSDART00000147368 ENSDART00000075524	osbp2 NCBI UniProt Show fit	oxysterol binding protein 2
chr7_+_29148714 Show fit	17.17	ENSDART00000170342	mtbl NCBI UniProt Show fit	metallothionein-B-like
chr12_+_9880493 Show fit	14.95	ENSDART00000055019	ndufa4 NCBI UniProt Show fit	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4
chr10_+_21576909 Show fit	14.16	ENSDART00000168604 ENSDART00000166533	pcdh1a3 NCBI UniProt Show fit	protocadherin 1 alpha 3
chr11_-_6188413 Show fit	14.15	ENSDART00000109972	ccl44 NCBI UniProt Show fit	chemokine (C-C motif) ligand 44
chr19_-_3240605 Show fit	13.86	ENSDART00000105168	si:ch211-133n4.4 NCBI UniProt Show fit	si:ch211-133n4.4
chr24_-_4973765 Show fit	13.81	ENSDART00000127597	zic1 NCBI UniProt Show fit	zic family member 1 (odd-paired homolog, Drosophila)
chr13_-_27660955 Show fit	13.69	ENSDART00000188651 ENSDART00000134494	rims1a NCBI UniProt Show fit	regulating synaptic membrane exocytosis 1a
chr1_+_36436936 Show fit	13.40	ENSDART00000124112	pou4f2 NCBI UniProt Show fit	POU class 4 homeobox 2
chr25_-_20381271 Show fit	13.16	ENSDART00000142665	kctd15a NCBI UniProt Show fit	potassium channel tetramerization domain containing 15a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of myb+mybl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	25.8	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	24.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7	20.3	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.6	19.1	GO:0030073	insulin secretion(GO:0030073)
2.6	18.3	GO:0021534	cell proliferation in hindbrain(GO:0021534)
0.4	18.0	GO:0042752	regulation of circadian rhythm(GO:0042752)
0.0	16.1	GO:0001944	vasculature development(GO:0001944)
0.4	14.2	GO:0060037	pharyngeal system development(GO:0060037)
0.3	14.1	GO:0048247	lymphocyte chemotaxis(GO:0048247)
0.0	13.6	GO:0007420	brain development(GO:0007420)

Showing 1 to 10 of 179 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	24.1	GO:0031225	anchored component of membrane(GO:0031225)
0.2	19.9	GO:0016323	basolateral plasma membrane(GO:0016323)
0.5	19.1	GO:0043204	perikaryon(GO:0043204)
0.0	14.5	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.5	13.7	GO:0048788	cytoskeleton of presynaptic active zone(GO:0048788)
0.1	12.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
1.0	12.2	GO:0031045	dense core granule(GO:0031045)
0.7	12.2	GO:0043209	myelin sheath(GO:0043209)
0.2	9.5	GO:0030426	growth cone(GO:0030426)
0.7	9.3	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)

Showing 1 to 10 of 77 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	46.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0	40.1	GO:0005509	calcium ion binding(GO:0005509)
0.1	28.6	GO:0005096	GTPase activator activity(GO:0005096)
0.2	22.1	GO:0051082	unfolded protein binding(GO:0051082)
0.9	19.4	GO:0046875	ephrin receptor binding(GO:0046875)
4.8	19.1	GO:0016521	pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.7	17.8	GO:0015248	sterol transporter activity(GO:0015248)
0.3	17.8	GO:0044325	ion channel binding(GO:0044325)
0.1	17.2	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.1	15.5	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Showing 1 to 10 of 116 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	14.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	13.4	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	11.9	PID P73PATHWAY	p73 transcription factor network
0.3	8.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	8.7	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.2	8.7	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.9	8.5	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.3	7.9	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	6.2	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.2	6.2	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.9	13.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.2	9.2	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.2	8.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.9	8.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.7	7.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	6.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	6.0	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.7	5.9	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.3	5.7	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs

Showing 1 to 10 of 46 entries

Results for myb+mybl1

Z-value: 1.65

Motif logo

Transcription factors associated with myb+mybl1

Activity-expression correlation:

Activity profile of myb+mybl1 motif

Sorted Z-values of myb+mybl1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of myb+mybl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: