ISMARA results: meis2a+meis2b_FO834857.1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Z-value: 1.30

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Transcription factors associated with meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Gene Symbol	Gene ID	Gene Info
meis2b NCBI UniProt	ENSDARG00000077840	Meis homeobox 2a
meis2a NCBI UniProt	ENSDARG00000098240	Meis homeobox 2a
FO834857.1 NCBI UniProt	ENSDARG00000112895	homeobox protein TGIF2-like
pknox1.1 NCBI UniProt	ENSDARG00000018765	pbx/knotted 1 homeobox 1.1
pknox1.2 NCBI UniProt	ENSDARG00000036542	pbx/knotted 1 homeobox 1.2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pknox1.2	dr11_v1_chr1_-_46981134_46981134	0.34	8.8e-04	Click!
meis2b	dr11_v1_chr20_-_10118818_10118818	-0.28	5.9e-03	Click!
pknox1.1	dr11_v1_chr9_+_19529951_19529951	0.22	3.4e-02	Click!
FO834857.1	dr11_v1_chr6_-_1820606_1820606	0.07	5.3e-01	Click!
meis2a	dr11_v1_chr17_+_52823015_52823138	-0.06	5.5e-01	Click!

Activity profile of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Sorted Z-values of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_58332000 Show fit	17.04	ENSDART00000145234	ggt1l2.1 NCBI UniProt Show fit	gamma-glutamyltransferase 1 like 2.1
chr3_-_36612877 Show fit	13.88	ENSDART00000167164	si:dkeyp-72e1.7 NCBI UniProt Show fit	si:dkeyp-72e1.7
chr7_+_14291323 Show fit	11.82	ENSDART00000053521	rhcga NCBI UniProt Show fit	Rh family, C glycoprotein a
chr21_-_38153824 Show fit	11.27	ENSDART00000151226	klf5l NCBI UniProt Show fit	Kruppel-like factor 5 like
chr19_-_5369486 Show fit	10.64	ENSDART00000105004	krt17 NCBI UniProt Show fit	keratin 17
chr5_-_12587053 Show fit	8.77	ENSDART00000162780	vsig10 NCBI UniProt Show fit	V-set and immunoglobulin domain containing 10
chr19_+_7567763 Show fit	8.70	ENSDART00000140411	s100a11 NCBI UniProt Show fit	S100 calcium binding protein A11
chr8_+_34731982 Show fit	8.60	ENSDART00000066050	hpdb NCBI UniProt Show fit	4-hydroxyphenylpyruvate dioxygenase b
chr21_+_45627775 Show fit	8.58	ENSDART00000185466	irf1b NCBI UniProt Show fit	interferon regulatory factor 1b
chr7_+_51103416 Show fit	8.37	ENSDART00000174236	col4a5 NCBI UniProt Show fit	collagen, type IV, alpha 5 (Alport syndrome)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	17.9	GO:0031179	peptide modification(GO:0031179)
0.1	17.2	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.1	15.6	GO:0031101	fin regeneration(GO:0031101)
1.5	11.8	GO:0072488	ammonium transmembrane transport(GO:0072488)
3.6	10.9	GO:0072025	distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.1	10.1	GO:0030837	negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1	9.7	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	9.1	GO:0006887	exocytosis(GO:0006887)
0.7	8.6	GO:0050688	regulation of defense response to virus(GO:0050688)
1.7	8.4	GO:0007412	axon target recognition(GO:0007412)

Showing 1 to 10 of 224 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	55.5	GO:0005615	extracellular space(GO:0005615)
0.2	16.2	GO:0005882	intermediate filament(GO:0005882)
0.0	12.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	11.9	GO:0005576	extracellular region(GO:0005576)
0.0	11.1	GO:0000139	Golgi membrane(GO:0000139)
0.1	10.9	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.5	10.8	GO:0005605	basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0	8.6	GO:0005654	nucleoplasm(GO:0005654)
0.1	8.4	GO:0005604	basement membrane(GO:0005604)
0.1	8.3	GO:0005681	spliceosomal complex(GO:0005681)

Showing 1 to 10 of 108 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	28.7	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.2	24.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	21.0	GO:0003779	actin binding(GO:0003779)
2.0	17.9	GO:0036374	peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.1	15.1	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.5	11.8	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.2	11.6	GO:0001786	phosphatidylserine binding(GO:0001786)
0.1	9.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	9.8	GO:0030695	GTPase regulator activity(GO:0030695)
2.9	8.6	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)

Showing 1 to 10 of 166 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	13.2	NABA COLLAGENS	Genes encoding collagen proteins
0.1	13.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	11.1	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.6	7.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.3	6.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	5.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	5.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	4.4	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.2	4.0	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.5	8.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.3	7.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	7.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	6.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	6.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.2	5.9	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.4	4.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.5	4.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	4.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+

Showing 1 to 10 of 50 entries

Results for meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Z-value: 1.30

Motif logo

Transcription factors associated with meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Activity-expression correlation:

Activity profile of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Sorted Z-values of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: