ISMARA results: mef2b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mef2b

Z-value: 1.39

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Transcription factors associated with mef2b

Gene Symbol	Gene ID	Gene Info
mef2b NCBI UniProt	ENSDARG00000093170	myocyte enhancer factor 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mef2b	dr11_v1_chr22_+_18187857_18187857	0.33	1.0e-03	Click!

Activity profile of mef2b motif

Sorted Z-values of mef2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_61205711 Show fit	32.68	ENSDART00000055062	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr8_+_22930627 Show fit	20.82	ENSDART00000187860	sypa NCBI UniProt Show fit	synaptophysin a
chr11_+_11201096 Show fit	20.57	ENSDART00000171916 ENSDART00000171521 ENSDART00000087105 ENSDART00000159603	myom2a NCBI UniProt Show fit	myomesin 2a
chr5_-_31926906 Show fit	18.64	ENSDART00000187340	ssh1b NCBI UniProt Show fit	slingshot protein phosphatase 1b
chr5_+_64368770 Show fit	17.57	ENSDART00000162246	plpp7 NCBI UniProt Show fit	phospholipid phosphatase 7 (inactive)
chr3_-_32818607 Show fit	17.16	ENSDART00000075465	mylpfa NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle a
chr1_+_45080897 Show fit	17.00	ENSDART00000129819	si:ch211-151p13.8 NCBI UniProt Show fit	si:ch211-151p13.8
chr6_-_40722480 Show fit	15.65	ENSDART00000188187	kbtbd12 NCBI UniProt Show fit	kelch repeat and BTB (POZ) domain containing 12
chr25_+_29160102 Show fit	15.13	ENSDART00000162854	pkmb NCBI UniProt Show fit	pyruvate kinase M1/2b
chr23_+_22658700 Show fit	14.85	ENSDART00000192248	eno1a NCBI UniProt Show fit	enolase 1a, (alpha)

Showing 1 to 10 of 185 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	25.5	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.1	21.9	GO:0006936	muscle contraction(GO:0006936)
1.5	20.7	GO:0051452	vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.2	15.7	GO:0030837	negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.2	15.1	GO:0032869	cellular response to insulin stimulus(GO:0032869)
3.6	14.3	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
1.5	13.5	GO:0051694	pointed-end actin filament capping(GO:0051694)
1.0	13.3	GO:0046314	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.9	13.3	GO:0016486	peptide hormone processing(GO:0016486)
0.0	13.3	GO:0006874	cellular calcium ion homeostasis(GO:0006874)

Showing 1 to 10 of 79 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	32.8	GO:0031430	M band(GO:0031430)
0.3	26.9	GO:0048786	presynaptic active zone(GO:0048786)
2.1	20.7	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2	17.4	GO:0030018	Z disc(GO:0030018)
0.3	16.3	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
2.0	14.3	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.2	13.1	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.3	12.6	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
1.5	12.3	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
2.4	12.1	GO:0043034	costamere(GO:0043034)

Showing 1 to 10 of 37 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	53.2	GO:0005509	calcium ion binding(GO:0005509)
1.1	45.1	GO:0017075	syntaxin-1 binding(GO:0017075)
1.4	20.7	GO:0051117	ATPase binding(GO:0051117)
0.1	18.8	GO:0051015	actin filament binding(GO:0051015)
0.2	18.6	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
2.5	15.1	GO:0004743	pyruvate kinase activity(GO:0004743)
0.1	14.6	GO:0005179	hormone activity(GO:0005179)
0.6	13.5	GO:0005523	tropomyosin binding(GO:0005523)
1.0	13.3	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1	13.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	13.0	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	9.2	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.4	7.6	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3	7.2	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	5.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	4.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	4.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	2.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	2.3	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.7	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	13.3	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
4.2	12.6	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	9.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.2	7.2	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	6.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	4.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	4.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.3	3.4	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.3	2.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	1.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi

Showing 1 to 10 of 13 entries

Results for mef2b

Z-value: 1.39

Motif logo

Transcription factors associated with mef2b

Activity-expression correlation:

Activity profile of mef2b motif

Sorted Z-values of mef2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: