ISMARA results: mecp2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mecp2

Z-value: 1.66

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Transcription factors associated with mecp2

Gene Symbol	Gene ID	Gene Info
mecp2 NCBI UniProt	ENSDARG00000014218	methyl CpG binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mecp2	dr11_v1_chr8_-_7637626_7637640	0.54	1.4e-08	Click!

Activity profile of mecp2 motif

Sorted Z-values of mecp2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_31278048 Show fit	20.38	ENSDART00000022204	zic5 NCBI UniProt Show fit	zic family member 5 (odd-paired homolog, Drosophila)
chr22_+_11535131 Show fit	17.16	ENSDART00000113930	npb NCBI UniProt Show fit	neuropeptide B
chr16_+_32559821 Show fit	16.72	ENSDART00000093250	pou3f2b NCBI UniProt Show fit	POU class 3 homeobox 2b
chr5_+_64739762 Show fit	16.29	ENSDART00000161112 ENSDART00000135610 ENSDART00000002908	olfm1a NCBI UniProt Show fit	olfactomedin 1a
chr8_+_16004154 Show fit	16.11	ENSDART00000134787 ENSDART00000172510 ENSDART00000141173	elavl4 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr8_+_16004551 Show fit	14.74	ENSDART00000165141	elavl4 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr5_-_13685047 Show fit	14.65	ENSDART00000018351	zgc:65851 NCBI UniProt Show fit	zgc:65851
chr8_+_31119548 Show fit	13.94	ENSDART00000136578	syn1 NCBI UniProt Show fit	synapsin I
chr19_+_5072918 Show fit	13.59	ENSDART00000037126	eno2 NCBI UniProt Show fit	enolase 2
chr1_+_31864404 Show fit	13.06	ENSDART00000075260	inab NCBI UniProt Show fit	internexin neuronal intermediate filament protein, alpha b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	33.6	GO:0008380	RNA splicing(GO:0008380)
0.3	25.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2	23.9	GO:0051260	protein homooligomerization(GO:0051260)
2.9	20.4	GO:0033278	cell proliferation in midbrain(GO:0033278)
0.2	19.2	GO:0007269	neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1	18.3	GO:0034765	regulation of ion transmembrane transport(GO:0034765)
0.8	17.2	GO:0007631	feeding behavior(GO:0007631)
1.8	16.3	GO:0061075	positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1	14.8	GO:0006869	lipid transport(GO:0006869)
0.8	13.0	GO:0097324	melanocyte migration(GO:0097324)

Showing 1 to 10 of 170 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	31.5	GO:0043204	perikaryon(GO:0043204)
0.3	30.0	GO:0005882	intermediate filament(GO:0005882)
0.0	26.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.3	25.3	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	20.9	GO:0005576	extracellular region(GO:0005576)
2.1	15.0	GO:0043194	axon initial segment(GO:0043194)
0.4	13.4	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	13.2	GO:0045202	synapse(GO:0045202)
2.6	13.1	GO:0005883	neurofilament(GO:0005883)
2.9	11.4	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	39.3	GO:0005509	calcium ion binding(GO:0005509)
0.0	28.8	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0	25.3	GO:0003723	RNA binding(GO:0003723)
0.5	22.0	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	15.2	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.5	13.4	GO:0004698	protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0	13.0	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.1	12.8	GO:0001664	G-protein coupled receptor binding(GO:0001664)
0.2	12.7	GO:0045499	chemorepellent activity(GO:0045499)
0.3	12.4	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Showing 1 to 10 of 119 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	12.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	12.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.6	9.6	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.5	9.6	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	7.3	ST GA13 PATHWAY	G alpha 13 Pathway
0.1	7.0	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.6	5.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	5.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	5.2	PID NOTCH PATHWAY	Notch signaling pathway
0.3	3.0	ST G ALPHA S PATHWAY	G alpha s Pathway

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	23.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.3	21.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	15.4	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	13.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6	12.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.8	10.6	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.5	8.9	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.6	8.6	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
1.2	7.0	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	6.9	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis

Showing 1 to 10 of 38 entries

Results for mecp2

Z-value: 1.66

Motif logo

Transcription factors associated with mecp2

Activity-expression correlation:

Activity profile of mecp2 motif

Sorted Z-values of mecp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: