ISMARA results: mafk

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mafk

Z-value: 1.19

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Transcription factors associated with mafk

Gene Symbol	Gene ID	Gene Info
mafk NCBI UniProt	ENSDARG00000100947	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mafk	dr11_v1_chr3_-_42981739_42981739	-0.17	9.6e-02	Click!

Activity profile of mafk motif

Sorted Z-values of mafk motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_32818607 Show fit	18.58	ENSDART00000075465	mylpfa NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle a
chr22_-_13857729 Show fit	14.90	ENSDART00000177971	s100b NCBI UniProt Show fit	S100 calcium binding protein, beta (neural)
chr12_-_4683325 Show fit	13.47	ENSDART00000152771	si:ch211-255p10.3 NCBI UniProt Show fit	si:ch211-255p10.3
chr23_-_29376859 Show fit	13.03	ENSDART00000146411	sst6 NCBI UniProt Show fit	somatostatin 6
chr16_-_16182319 Show fit	12.46	ENSDART00000103815	stmn2a NCBI UniProt Show fit	stathmin 2a
chr15_+_37559570 Show fit	12.09	ENSDART00000085522	hspb6 NCBI UniProt Show fit	heat shock protein, alpha-crystallin-related, b6
chr23_-_15878879 Show fit	12.08	ENSDART00000010119	eef1a2 NCBI UniProt Show fit	eukaryotic translation elongation factor 1 alpha 2
chr22_-_26595027 Show fit	11.98	ENSDART00000184162	CABZ01072309.1 NCBI UniProt Show fit
chr7_+_39386982 Show fit	11.40	ENSDART00000146702	tnni2b.2 NCBI UniProt Show fit	troponin I type 2b (skeletal, fast), tandem duplicate 2
chr2_-_2020044 Show fit	10.65	ENSDART00000024135	tubb2 NCBI UniProt Show fit	tubulin, beta 2A class IIa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mafk

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	32.8	GO:0007019	microtubule depolymerization(GO:0007019)
0.1	17.2	GO:0030334	regulation of cell migration(GO:0030334)
0.0	15.6	GO:0099536	synaptic signaling(GO:0099536)
0.5	13.2	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
3.1	12.3	GO:0021557	oculomotor nerve development(GO:0021557)
0.2	12.1	GO:0006414	translational elongation(GO:0006414)
0.2	11.4	GO:0003009	skeletal muscle contraction(GO:0003009)
0.1	11.0	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.2	10.7	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.7	10.1	GO:0043248	proteasome assembly(GO:0043248)

Showing 1 to 10 of 142 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	22.4	GO:0030426	growth cone(GO:0030426)
0.2	19.2	GO:0005882	intermediate filament(GO:0005882)
0.0	18.8	GO:0045202	synapse(GO:0045202)
0.3	18.7	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1	15.3	GO:0043025	neuronal cell body(GO:0043025)
0.3	13.5	GO:0005758	mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.3	11.9	GO:0031941	filamentous actin(GO:0031941)
0.1	10.9	GO:0030018	Z disc(GO:0030018)
0.1	9.8	GO:0031201	SNARE complex(GO:0031201)
0.9	9.1	GO:0042583	chromaffin granule(GO:0042583)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.4	GO:0015631	tubulin binding(GO:0015631)
0.0	23.1	GO:0003779	actin binding(GO:0003779)
0.0	20.6	GO:0005509	calcium ion binding(GO:0005509)
3.7	14.9	GO:0044548	S100 protein binding(GO:0044548)
2.7	13.5	GO:0016531	copper chaperone activity(GO:0016531)
0.1	12.9	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.3	12.1	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	11.4	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.3	11.2	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2	11.0	GO:0005200	structural constituent of cytoskeleton(GO:0005200)

Showing 1 to 10 of 101 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	10.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.3	8.9	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	3.6	PID NOTCH PATHWAY	Notch signaling pathway
0.0	2.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.7	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.2	2.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	2.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	1.8	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	1.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	14.9	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.2	9.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	9.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.9	7.1	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	4.7	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.6	2.9	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	2.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	2.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	2.4	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.3	2.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors

Showing 1 to 10 of 27 entries

Results for mafk

Z-value: 1.19

Motif logo

Transcription factors associated with mafk

Activity-expression correlation:

Activity profile of mafk motif

Sorted Z-values of mafk motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mafk

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: