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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mafa+mafbb

Z-value: 1.39

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Transcription factors associated with mafa+mafbb

Gene Symbol Gene ID Gene Info
ENSDARG00000015890 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
ENSDARG00000070542 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb
ENSDARG00000099120 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mafbbdr11_v1_chr11_-_25384213_253842130.205.4e-02Click!
mafadr11_v1_chr18_+_29403017_294030170.187.5e-02Click!

Activity profile of mafa+mafbb motif

Sorted Z-values of mafa+mafbb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_18030938 33.90 ENSDART00000013540
si:ch73-141c7.1
chr13_-_20381485 31.01 ENSDART00000131351
si:ch211-270n8.1
chr22_-_24738188 23.83 ENSDART00000050238
vitellogenin 1
chr2_+_25816843 21.26 ENSDART00000078639
solute carrier family 2 (facilitated glucose transporter), member 2
chr10_+_10801564 20.16 ENSDART00000027026
alpha-1-microglobulin/bikunin precursor
chr10_+_10801719 19.59 ENSDART00000193648
alpha-1-microglobulin/bikunin precursor
chr24_-_12938922 19.40 ENSDART00000024084
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr13_+_2908764 19.33 ENSDART00000162362
wu:fj16a03
chr22_-_24880824 18.22 ENSDART00000061165
vitellogenin 2
chr22_-_24757785 17.53 ENSDART00000078225
vitellogenin 5
chr10_+_28428222 16.65 ENSDART00000135003
si:ch211-222e20.4
chr15_+_21202820 13.90 ENSDART00000154036
si:dkey-52d15.2
chr23_-_31428763 12.75 ENSDART00000053545
zgc:153284
chr10_+_38708099 11.77 ENSDART00000172306
transmembrane protease, serine 2
chr20_+_38285671 10.90 ENSDART00000061432
chemokine (C-C motif) ligand 38, duplicate 4
chr16_+_18974064 10.44 ENSDART00000079248
solute carrier family 6 (neutral amino acid transporter), member 19b
chr11_-_5865744 10.19 ENSDART00000104360
guanidinoacetate N-methyltransferase
chr13_-_25196758 10.17 ENSDART00000184722
adenosine kinase a
chr5_-_37116265 10.00 ENSDART00000057613
interleukin 13 receptor, alpha 2
chr10_+_26747755 9.92 ENSDART00000100329
coagulation factor IXb
chr19_-_35428815 9.67 ENSDART00000169006
ENSDART00000003167
adenylate kinase 2
chr5_-_30615901 9.26 ENSDART00000147769
si:ch211-117m20.5
chr1_-_54706039 8.38 ENSDART00000083633
exosome component 1
chr16_+_46294337 8.36 ENSDART00000040769
nuclear receptor subfamily 2, group F, member 5
chr16_-_12319822 8.30 ENSDART00000127453
ENSDART00000184526
transient receptor potential cation channel, subfamily V, member 6
chr12_-_44043285 8.07 ENSDART00000163074
si:ch211-182p11.1
chr17_-_53359028 7.97 ENSDART00000185218

chr19_+_7567763 7.52 ENSDART00000140411
S100 calcium binding protein A11
chr21_-_43328056 7.44 ENSDART00000114955
sosondowah ankyrin repeat domain family member Aa
chr11_-_40128722 7.29 ENSDART00000165781
family with sequence similarity 83, member E
chr11_-_33960318 7.10 ENSDART00000087597
collagen, type VI, alpha 2
chr12_-_3940768 7.06 ENSDART00000134292
zgc:92040
chr10_+_10387328 6.61 ENSDART00000080904
sarcosine dehydrogenase
chr8_-_554540 6.56 ENSDART00000163934
Danio rerio uncharacterized LOC100329294 (LOC100329294), mRNA.
chr16_+_46410520 6.38 ENSDART00000131072
rapunzel 2
chr11_-_23501467 6.20 ENSDART00000169066
pleckstrin homology domain containing, family A member 6
chr17_-_20236228 6.19 ENSDART00000136490
ENSDART00000029380
BCL2 interacting protein 4
chr24_-_42090635 6.15 ENSDART00000166413
signal sequence receptor, alpha
chr19_+_1465004 6.08 ENSDART00000159157

chr12_+_34258139 6.04 ENSDART00000153127
suppressor of cytokine signaling 3b
chr4_+_68562464 6.02 ENSDART00000192954

chr13_-_31025505 5.92 ENSDART00000137709
WDFY family member 4
chr21_-_28523548 5.87 ENSDART00000077910
ependymin-like 2
chr21_+_43199237 5.72 ENSDART00000151748
AF4/FMR2 family, member 4
chr6_-_26895750 5.63 ENSDART00000011863
high density lipoprotein binding protein a
chr8_-_41228530 5.51 ENSDART00000165949
ENSDART00000173055
fumarylacetoacetate hydrolase domain containing 2A
chr5_+_9377005 5.48 ENSDART00000124924
UDP glucuronosyltransferase 2 family, polypeptide A7
chr17_-_53353653 5.46 ENSDART00000180744
ENSDART00000026879
un-named sa911
chr23_+_7518294 5.31 ENSDART00000081536
HCK proto-oncogene, Src family tyrosine kinase
chr20_-_43079478 5.27 ENSDART00000060982
sorting nexin 9b
chr14_+_3507326 5.23 ENSDART00000159326
glutathione S-transferase pi 1
chr4_-_71708855 5.23 ENSDART00000158819
si:dkeyp-4f2.1
chr19_+_48024457 5.09 ENSDART00000163823
karyopherin (importin) beta 1
chr17_+_6217704 5.03 ENSDART00000129100

chr1_-_52498146 5.00 ENSDART00000122217
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr18_+_10926197 4.92 ENSDART00000192387
tetratricopeptide repeat domain 38
chr12_+_20552190 4.85 ENSDART00000113224
guanine nucleotide binding protein (G protein), alpha 13a
chr5_-_65004578 4.74 ENSDART00000169287
zgc:110283
chr24_-_26369185 4.72 ENSDART00000080039
leucine rich repeat containing 31
chr13_-_25199260 4.66 ENSDART00000057605
adenosine kinase a
chr14_+_146857 4.61 ENSDART00000122521

chr9_-_55586151 4.53 ENSDART00000181886
arylsulfatase H
chr9_+_28116079 4.49 ENSDART00000101338
isocitrate dehydrogenase 1 (NADP+), soluble
chr14_-_49859747 4.37 ENSDART00000169456
ENSDART00000164967
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr24_+_19518303 4.36 ENSDART00000027022
ENSDART00000056080
sulfatase 1
chr8_-_22538588 4.33 ENSDART00000144041
cold shock domain containing E1, RNA-binding
chr20_-_14054083 4.32 ENSDART00000009549
Rh associated glycoprotein
chr23_-_16666583 4.21 ENSDART00000189804
ENSDART00000136496
syndecan binding protein (syntenin) 2
chr5_-_65004791 4.21 ENSDART00000180023
zgc:110283
chr5_-_32338866 4.14 ENSDART00000017956
ENSDART00000047670
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr1_-_52497834 3.97 ENSDART00000136469
ENSDART00000004233
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr7_+_61764040 3.88 ENSDART00000056745
acyl-CoA oxidase 3, pristanoyl
chr20_+_46385907 3.82 ENSDART00000060710
adhesion G protein-coupled receptor G11
chr8_+_31435452 3.79 ENSDART00000145282
selenoprotein P
chr24_-_23998897 3.75 ENSDART00000130053
zmp:0000000991
chr4_-_71708567 3.72 ENSDART00000182645
si:dkeyp-4f2.1
chr3_+_23063718 3.71 ENSDART00000140225
ENSDART00000184431
beta-1,4-N-acetyl-galactosaminyl transferase 2, tandem duplicate 1
chr7_-_19043401 3.62 ENSDART00000158796
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr7_+_3442834 3.60 ENSDART00000138247
si:ch211-285c6.2
chr18_-_45617146 3.60 ENSDART00000146543
wilms tumor 1b
chr2_+_19163965 3.58 ENSDART00000166073
ELOVL fatty acid elongase 1a
chr3_+_14463941 3.49 ENSDART00000170927
calponin 1, basic, smooth muscle, b
chr1_-_30457062 3.43 ENSDART00000185318
ENSDART00000157924
ENSDART00000161380
insulin-like growth factor 2 mRNA binding protein 2b
chr1_-_30510839 3.42 ENSDART00000168189
ENSDART00000174868
insulin-like growth factor 2 mRNA binding protein 2b
chr5_+_38684651 3.40 ENSDART00000137852
si:dkey-58f10.10
chr8_+_28629741 3.34 ENSDART00000163915
si:dkey-109a10.2
chr15_+_34069746 3.34 ENSDART00000163513
ADP-ribosylation factor-like 4aa
chr23_+_42304602 3.34 ENSDART00000166004
cytochrome P450, family 2, subfamily AA, polypeptide 11
chr8_+_50190742 3.31 ENSDART00000099863
solute carrier family 25 (mitochondrial iron transporter), member 37
chr5_+_38679623 3.27 ENSDART00000131879
ENSDART00000170010
si:dkey-58f10.11
si:dkey-58f10.10
chr23_-_44848961 3.27 ENSDART00000136839
wu:fb72h05
chr3_-_7948799 3.26 ENSDART00000163714
tripartite motif containing 35-24
chr10_-_29120515 3.15 ENSDART00000162016
ENSDART00000149140
zona pellucida-like domain containing 1a
chr1_+_54766943 3.14 ENSDART00000144759
NLR family CARD domain containing 6
chr5_-_67471375 3.08 ENSDART00000147009
si:dkey-251i10.2
chr22_-_263117 3.05 ENSDART00000158134
zgc:66156
chr16_-_51299061 3.03 ENSDART00000148677
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr21_+_19347655 3.02 ENSDART00000093155
heparanase
chr18_+_14595805 2.99 ENSDART00000167825
WAP four-disulfide core domain 1
chr7_-_25697285 2.99 ENSDART00000082620
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
chr15_+_41932069 2.99 ENSDART00000143007
si:ch211-191a16.2
chr16_-_16481046 2.95 ENSDART00000158704
neurobeachin-like 2
chr15_+_3790556 2.94 ENSDART00000181467
ring finger protein 14
chr16_+_23326085 2.94 ENSDART00000180935
keratinocyte associated protein 2
chr7_+_57108823 2.93 ENSDART00000184943
ENSDART00000055956
enolase superfamily member 1
chr14_-_25928541 2.91 ENSDART00000145850
GTPase activating protein (SH3 domain) binding protein 1
chr20_-_23852174 2.82 ENSDART00000122414
si:dkey-15j16.6
chr15_-_41762530 2.82 ENSDART00000187125
ENSDART00000154971
finTRIM family, member 91
chr10_+_8527196 2.80 ENSDART00000141147
si:ch211-193e13.5
chr4_-_58964138 2.79 ENSDART00000150259
si:ch211-64i20.3
chr16_-_33806390 2.73 ENSDART00000160671
R-spondin 1
chr4_-_70131926 2.68 ENSDART00000108511
si:ch211-208f21.3
chr4_+_77709678 2.66 ENSDART00000036856

chr12_+_16967715 2.65 ENSDART00000138174
solute carrier family 16, member 12b
chr7_+_27317174 2.59 ENSDART00000193058
SRY (sex determining region Y)-box 6
chr2_-_38256589 2.57 ENSDART00000173064
si:ch211-14a17.10
chr6_-_35439406 2.42 ENSDART00000073784
regulator of G protein signaling 5a
chr8_+_23439340 2.36 ENSDART00000109932
ENSDART00000185469
forkhead box P3b
chr22_-_24285432 2.35 ENSDART00000164083
si:ch211-117l17.4
chr6_-_426041 2.33 ENSDART00000162789
family with sequence similarity 83, member Fb
chr19_-_7441686 2.30 ENSDART00000168194
GA binding protein transcription factor, beta subunit 2a
chr7_+_35068036 2.30 ENSDART00000022139
zgc:136461
chr12_-_44019561 2.29 ENSDART00000165900
si:dkey-31i7.1
chr5_-_26893310 2.28 ENSDART00000126669
lectin, mannose-binding 2-like b
chr19_+_23308419 2.24 ENSDART00000141558
immunity-related GTPase family, f2
chr18_+_22302635 2.17 ENSDART00000141051
capping protein regulator and myosin 1 linker 2
chr7_-_6415991 2.15 ENSDART00000173349
Histone H3.2
chr4_+_5317483 2.12 ENSDART00000150366
si:ch211-214j24.10
chr14_-_4076480 2.11 ENSDART00000059231
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr4_+_65057234 2.09 ENSDART00000162985
si:dkey-14o6.2
chr11_+_42641404 2.06 ENSDART00000172641
ENSDART00000169938
interleukin 17 receptor D
chr4_-_67909331 2.04 ENSDART00000191908
si:ch211-66c13.1
chr14_-_7786585 2.04 ENSDART00000186440
transmembrane protein 173
chr20_-_20410029 2.02 ENSDART00000192177
ENSDART00000063483
protein kinase C, eta, b
chr4_+_42878556 2.02 ENSDART00000171047
si:zfos-451d2.2
chr18_-_6151793 2.02 ENSDART00000122307
glycine cleavage system protein H (aminomethyl carrier), a
chr11_+_42422638 2.01 ENSDART00000042599
ENSDART00000181175
DENN/MADD domain containing 6Aa
chr9_+_32930622 2.01 ENSDART00000100928
cyclic nucleotide gated channel alpha 4
chr19_-_43639331 1.96 ENSDART00000138009
ENSDART00000086138
family with sequence similarity 83, member Hb
chr3_-_33997763 1.94 ENSDART00000151461
ENSDART00000151307
immunoglobulin heavy constant zeta
chr16_+_17089114 1.90 ENSDART00000173223
CD27 molecule
chr5_+_18014931 1.90 ENSDART00000142562
activating signal cointegrator 1 complex subunit 2
chr3_-_19517462 1.82 ENSDART00000162027

chr1_+_29862074 1.82 ENSDART00000133905
ENSDART00000136786
ENSDART00000135252
propionyl CoA carboxylase, alpha polypeptide
chr5_+_38685089 1.79 ENSDART00000139743
si:dkey-58f10.10
chr10_-_40462894 1.77 ENSDART00000147924
trace amine associated receptor 20b1
chr25_-_13558172 1.73 ENSDART00000139970
ENSDART00000133789
ENSDART00000144426
anoctamin 10b
chr20_-_39219537 1.71 ENSDART00000005764
cytochrome P450, family 39, subfamily A, polypeptide 1
chr17_-_19345521 1.65 ENSDART00000082085
goosecoid
chr4_+_47257854 1.63 ENSDART00000173868
crestin
chr1_+_19303241 1.60 ENSDART00000129970
si:dkeyp-118a3.2
chr20_-_16972351 1.59 ENSDART00000148312
ENSDART00000186702
si:ch73-74h11.1
chr8_+_23436411 1.57 ENSDART00000140044
forkhead box P3b
chr23_+_24124684 1.57 ENSDART00000144478
si:dkey-21o19.2
chr23_+_30707837 1.54 ENSDART00000016096
DnaJ (Hsp40) homolog, subfamily C, member 11a
chr9_+_13985567 1.52 ENSDART00000102296
CD28 molecule
chr5_-_43959972 1.50 ENSDART00000180517
si:ch211-204c21.1
chr2_-_4496358 1.47 ENSDART00000158216
adiponectin, C1Q and collagen domain containing, b
chr23_+_7379728 1.46 ENSDART00000012194
GATA binding protein 5
chr9_+_6802641 1.46 ENSDART00000187278

chr4_-_36032930 1.45 ENSDART00000191414
zgc:174180
chr14_-_24001825 1.44 ENSDART00000130704
interleukin 4
chr4_-_42397126 1.43 ENSDART00000162437
si:ch211-129p6.2
chr4_+_34121902 1.41 ENSDART00000170225
si:ch211-223g7.6
chr19_-_7441948 1.40 ENSDART00000003544
GA binding protein transcription factor, beta subunit 2a
chr10_-_40514643 1.40 ENSDART00000140705
trace amine associated receptor 19k
chr6_-_13783604 1.38 ENSDART00000149536
ENSDART00000041269
ENSDART00000150102
crystallin, beta A2a
chr6_-_29515709 1.34 ENSDART00000180205
peroxisomal biogenesis factor 5-like a
chr4_-_39448829 1.33 ENSDART00000168526
si:dkey-261o4.9
chr1_+_54124209 1.30 ENSDART00000187730

chr7_+_20393386 1.29 ENSDART00000173471
si:dkey-33c9.6
chr22_+_2510828 1.28 ENSDART00000115348
ENSDART00000145611
zgc:173726
chr1_-_5745420 1.25 ENSDART00000166779
neuropilin 2a
chr4_+_54645654 1.20 ENSDART00000192864
si:ch211-227e10.1
chr13_+_25199849 1.17 ENSDART00000139209
ENSDART00000130876
adaptor-related protein complex 3, mu 1 subunit
chr22_-_9973918 1.16 ENSDART00000146598
ENSDART00000106026
NLR family CARD domain containing 7
chr3_+_15394428 1.16 ENSDART00000133168
ataxin 2-like
chr13_-_33153889 1.16 ENSDART00000141451
tandem C2 domains, nuclear
chr24_-_37225877 1.16 ENSDART00000087438
component of oligomeric golgi complex 7
chr22_-_10354381 1.15 ENSDART00000092050
stabilin 1
chr2_-_9748039 1.11 ENSDART00000134870
si:ch1073-170o4.1
chr16_-_42175617 1.10 ENSDART00000084715
alkB homolog 8, tRNA methyltransferase
chr12_+_22628704 1.09 ENSDART00000168935
major facilitator superfamily domain containing 8
chr12_+_46608361 1.09 ENSDART00000189164
fatty acid desaturase 6
chr9_-_8670158 1.09 ENSDART00000077296
collagen, type IV, alpha 1
chr13_-_35459928 1.08 ENSDART00000144109
SLX4 interacting protein
chr21_-_2621127 1.06 ENSDART00000172363
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein b
chr2_+_38370535 1.06 ENSDART00000179614
proteasome subunit beta 11a
chr20_-_23946296 1.03 ENSDART00000143005
midasin AAA ATPase 1
chr24_-_30843250 0.99 ENSDART00000162920
polypyrimidine tract binding protein 2a
chr19_+_170705 0.97 ENSDART00000053622
ring finger protein 139
chr2_-_24554416 0.96 ENSDART00000052061
calponin 2
chr4_-_57340828 0.95 ENSDART00000193689
zgc:194906
chr6_-_33925381 0.93 ENSDART00000137268
ENSDART00000145019
ENSDART00000141822
aldo-keto reductase family 1, member A1b (aldehyde reductase)
chr10_-_300000 0.93 ENSDART00000183273
EMSY BRCA2-interacting transcriptional repressor
chr2_+_9755422 0.91 ENSDART00000018524
phosphate cytidylyltransferase 1, choline, alpha a
chr24_+_1023839 0.88 ENSDART00000082526
zgc:111976
chr21_+_38745094 0.84 ENSDART00000113316
HEAT repeat containing 6
chr3_+_634682 0.84 ENSDART00000164305
diverse immunoglobulin domain-containing protein 1.1
chr6_-_48087152 0.84 ENSDART00000180614
solute carrier family 2 (facilitated glucose transporter), member 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of mafa+mafbb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 21.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
4.9 19.4 GO:0019626 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
3.5 21.2 GO:0050764 regulation of phagocytosis(GO:0050764)
3.4 10.2 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
2.5 14.8 GO:0044209 AMP salvage(GO:0044209)
2.2 6.6 GO:1901052 sarcosine metabolic process(GO:1901052)
2.1 8.3 GO:0070317 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
1.5 30.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
1.5 4.5 GO:0006097 glyoxylate cycle(GO:0006097)
1.4 7.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
1.4 9.7 GO:0009180 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
1.2 4.8 GO:0031584 activation of phospholipase D activity(GO:0031584) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.1 41.4 GO:0032355 response to estradiol(GO:0032355)
1.1 4.3 GO:0015840 urea transport(GO:0015840)
1.0 2.9 GO:0042543 protein N-linked glycosylation via arginine(GO:0042543)
1.0 3.9 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.9 3.7 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.8 39.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.7 2.9 GO:0036344 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.7 2.1 GO:0019695 choline metabolic process(GO:0019695)
0.7 6.2 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.6 3.8 GO:0001887 selenium compound metabolic process(GO:0001887)
0.5 4.4 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.5 4.1 GO:2000725 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.5 2.0 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.5 1.4 GO:0002369 T cell cytokine production(GO:0002369)
0.4 11.8 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.4 1.5 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.3 0.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.3 1.2 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.3 1.7 GO:0008206 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.3 8.4 GO:0032526 response to retinoic acid(GO:0032526)
0.3 2.6 GO:0060612 adipose tissue development(GO:0060612)
0.3 2.8 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.3 10.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 1.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.2 3.6 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 5.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 0.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 2.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 7.3 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 3.6 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 1.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 10.0 GO:0007596 blood coagulation(GO:0007596)
0.1 6.0 GO:0007259 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.1 3.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 13.9 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 1.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.1 1.7 GO:0010717 regulation of epithelial to mesenchymal transition(GO:0010717)
0.1 1.5 GO:0042407 cristae formation(GO:0042407)
0.1 2.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 5.3 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 4.0 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.1 0.5 GO:0090342 regulation of cell aging(GO:0090342)
0.1 0.5 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.1 1.8 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 1.0 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.1 3.3 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1 1.9 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.1 7.5 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 4.2 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.1 1.5 GO:0042098 T cell proliferation(GO:0042098) regulation of T cell proliferation(GO:0042129)
0.1 0.2 GO:0097240 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 2.0 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 7.7 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 1.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 3.4 GO:0007030 Golgi organization(GO:0007030)
0.0 5.1 GO:0048747 muscle fiber development(GO:0048747)
0.0 0.4 GO:0003207 cardiac chamber formation(GO:0003207)
0.0 0.5 GO:0016926 protein desumoylation(GO:0016926)
0.0 2.4 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.1 GO:1904182 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.0 2.6 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 8.2 GO:0045087 innate immune response(GO:0045087)
0.0 2.9 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 3.6 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.7 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.8 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 2.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 1.4 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.2 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 1.0 GO:0036503 ERAD pathway(GO:0036503)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0032998 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.8 8.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.7 5.7 GO:0032783 ELL-EAF complex(GO:0032783)
0.7 2.0 GO:0005960 glycine cleavage complex(GO:0005960)
0.5 4.8 GO:0031526 brush border membrane(GO:0031526)
0.2 7.7 GO:0005844 polysome(GO:0005844)
0.2 9.7 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.2 3.0 GO:0030315 T-tubule(GO:0030315)
0.2 2.0 GO:0045095 keratin filament(GO:0045095)
0.1 1.5 GO:0061617 MICOS complex(GO:0061617)
0.1 4.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 66.3 GO:0009986 cell surface(GO:0009986)
0.1 37.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 6.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 10.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.1 9.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.6 GO:0030057 desmosome(GO:0030057)
0.1 3.0 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.7 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 6.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 5.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 2.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 7.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.8 GO:0030686 90S preribosome(GO:0030686)
0.0 5.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.4 GO:0016459 myosin complex(GO:0016459)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.0 3.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.0 GO:0055037 recycling endosome(GO:0055037)
0.0 13.4 GO:0005739 mitochondrion(GO:0005739)
0.0 0.8 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 3.5 GO:0005764 lysosome(GO:0005764)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 19.6 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 59.6 GO:0045735 nutrient reservoir activity(GO:0045735)
3.8 33.9 GO:0048039 ubiquinone binding(GO:0048039)
3.2 22.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
3.0 14.8 GO:0004001 adenosine kinase activity(GO:0004001)
1.8 7.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
1.7 6.6 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
1.6 4.8 GO:0031752 D5 dopamine receptor binding(GO:0031752)
1.5 4.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.4 4.2 GO:0045545 syndecan binding(GO:0045545)
1.2 3.6 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
0.8 9.0 GO:0004046 aminoacylase activity(GO:0004046)
0.8 3.9 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.8 3.8 GO:0008430 selenium binding(GO:0008430)
0.7 9.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.5 19.4 GO:0030145 manganese ion binding(GO:0030145)
0.4 12.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.4 8.9 GO:0004065 arylsulfatase activity(GO:0004065)
0.4 3.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.4 1.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 3.2 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.3 36.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 5.1 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.3 1.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 7.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 10.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 1.8 GO:0016421 CoA carboxylase activity(GO:0016421)
0.2 1.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.2 4.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 5.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 6.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 2.3 GO:0005537 mannose binding(GO:0005537)
0.2 2.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 3.6 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 1.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 2.0 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 8.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 1.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 24.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 5.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 9.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 10.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 3.7 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 1.8 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 2.0 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.5 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 5.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 8.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1 5.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 13.4 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 3.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.0 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 1.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)
0.0 4.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 3.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 4.4 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 1.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 3.0 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 3.6 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 3.4 GO:0003774 motor activity(GO:0003774)
0.0 15.5 GO:0003723 RNA binding(GO:0003723)
0.0 1.4 GO:0005126 cytokine receptor binding(GO:0005126)
0.0 3.6 GO:0008289 lipid binding(GO:0008289)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 10.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.5 21.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 11.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.3 9.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.3 5.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 8.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.3 11.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.3 1.4 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 8.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 15.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 1.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 22.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.1 PID FGF PATHWAY FGF signaling pathway
0.1 1.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 7.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 21.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
1.0 5.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.8 19.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.8 8.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.7 4.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.5 3.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 1.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.4 8.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 4.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.4 5.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 5.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 8.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 1.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 4.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 3.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 6.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.8 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 0.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 0.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 9.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.1 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex