ISMARA results: lef1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for lef1

Z-value: 1.40

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Transcription factors associated with lef1

Gene Symbol	Gene ID	Gene Info
lef1 NCBI UniProt	ENSDARG00000031894	lymphoid enhancer-binding factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
lef1	dr11_v1_chr1_+_49814942_49814942	0.80	7.9e-22	Click!

Activity profile of lef1 motif

Sorted Z-values of lef1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_35487413 Show fit	13.32	ENSDART00000102461	rgs8 NCBI UniProt Show fit	regulator of G protein signaling 8
chr17_+_15535501 Show fit	9.27	ENSDART00000002932	marcksb NCBI UniProt Show fit	myristoylated alanine-rich protein kinase C substrate b
chr23_+_23182037 Show fit	9.03	ENSDART00000137353	klhl17 NCBI UniProt Show fit	kelch-like family member 17
chr4_-_25064510 Show fit	8.15	ENSDART00000025153	gata3 NCBI UniProt Show fit	GATA binding protein 3
chr3_-_55650771 Show fit	7.33	ENSDART00000162413	axin2 NCBI UniProt Show fit	axin 2 (conductin, axil)
chr1_+_17376922 Show fit	7.26	ENSDART00000145068	fat1a NCBI UniProt Show fit	FAT atypical cadherin 1a
chr6_-_43092175 Show fit	6.86	ENSDART00000084389	lrrn1 NCBI UniProt Show fit	leucine rich repeat neuronal 1
chr24_+_25069609 Show fit	6.60	ENSDART00000115165	amer2 NCBI UniProt Show fit	APC membrane recruitment protein 2
chr4_-_77432218 Show fit	6.48	ENSDART00000158683	slco1d1 NCBI UniProt Show fit	solute carrier organic anion transporter family, member 1D1
chr5_-_22082918 Show fit	6.38	ENSDART00000020908	zc4h2 NCBI UniProt Show fit	zinc finger, C4H2 domain containing

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of lef1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	24.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
4.5	17.8	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.6	14.3	GO:0060541	respiratory system development(GO:0060541)
0.0	13.4	GO:0006397	mRNA processing(GO:0006397)
0.9	12.2	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.3	12.2	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1	10.7	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.4	10.6	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.5	10.5	GO:0045582	positive regulation of T cell differentiation(GO:0045582)
1.0	10.3	GO:0035677	posterior lateral line neuromast hair cell development(GO:0035677)

Showing 1 to 10 of 316 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	86.7	GO:0005634	nucleus(GO:0005634)
0.0	27.0	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.0	17.3	GO:0000139	Golgi membrane(GO:0000139)
0.9	15.9	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	14.1	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.3	13.3	GO:0043204	perikaryon(GO:0043204)
0.1	12.1	GO:0036477	somatodendritic compartment(GO:0036477)
0.3	10.7	GO:0017053	transcriptional repressor complex(GO:0017053)
0.2	10.3	GO:0030426	growth cone(GO:0030426)
0.1	9.9	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Showing 1 to 10 of 133 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.2	GO:0005096	GTPase activator activity(GO:0005096)
0.0	25.3	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0	24.0	GO:0005509	calcium ion binding(GO:0005509)
0.0	12.4	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	11.5	GO:0003924	GTPase activity(GO:0003924)
0.0	11.3	GO:0008017	microtubule binding(GO:0008017)
0.1	10.1	GO:0005516	calmodulin binding(GO:0005516)
0.1	9.9	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2	9.8	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
1.0	9.2	GO:0000700	mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)

Showing 1 to 10 of 228 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	13.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.2	8.8	PID BMP PATHWAY	BMP receptor signaling
0.3	8.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.3	8.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	8.1	PID IL27 PATHWAY	IL27-mediated signaling events
0.2	7.9	PID NOTCH PATHWAY	Notch signaling pathway
0.2	7.5	PID AP1 PATHWAY	AP-1 transcription factor network
0.2	7.1	PID CDC42 PATHWAY	CDC42 signaling events
0.2	6.5	ST G ALPHA I PATHWAY	G alpha i Pathway
0.4	6.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	27.8	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.2	11.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	8.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	8.4	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.3	7.9	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.3	7.5	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.2	7.1	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.3	6.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	6.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.7	6.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling

Showing 1 to 10 of 72 entries

Results for lef1

Z-value: 1.40

Motif logo

Transcription factors associated with lef1

Activity-expression correlation:

Activity profile of lef1 motif

Sorted Z-values of lef1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of lef1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: