ISMARA results: klf12b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for klf12b

Z-value: 2.10

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Transcription factors associated with klf12b

Gene Symbol	Gene ID	Gene Info
klf12b NCBI UniProt	ENSDARG00000032197	Kruppel-like factor 12b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
klf12b	dr11_v1_chr9_+_30720048_30720048	0.62	3.5e-11	Click!

Activity profile of klf12b motif

Sorted Z-values of klf12b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_13742899 Show fit	57.67	ENSDART00000104722	cdk5r2a NCBI UniProt Show fit	cyclin-dependent kinase 5, regulatory subunit 2a (p39)
chr25_-_4146947 Show fit	30.58	ENSDART00000129268	fads2 NCBI UniProt Show fit	fatty acid desaturase 2
chr9_-_31278048 Show fit	27.34	ENSDART00000022204	zic5 NCBI UniProt Show fit	zic family member 5 (odd-paired homolog, Drosophila)
chr2_-_21082695 Show fit	26.47	ENSDART00000032502	nebl NCBI UniProt Show fit	nebulette
chr11_-_37509001 Show fit	24.17	ENSDART00000109753	bsnb NCBI UniProt Show fit	bassoon (presynaptic cytomatrix protein) b
chr2_+_47582681 Show fit	22.57	ENSDART00000187579	scg2b NCBI UniProt Show fit	secretogranin II (chromogranin C), b
chr8_+_31248917 Show fit	20.76	ENSDART00000112170	unm_hu7912 NCBI UniProt Show fit	un-named hu7912
chr15_+_37197494 Show fit	19.87	ENSDART00000166203	aplp1 NCBI UniProt Show fit	amyloid beta (A4) precursor-like protein 1
chr21_-_43949208 Show fit	19.72	ENSDART00000150983	camk2a NCBI UniProt Show fit	calcium/calmodulin-dependent protein kinase II alpha
chr18_+_18104235 Show fit	19.66	ENSDART00000145342	cbln1 NCBI UniProt Show fit	cerebellin 1 precursor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of klf12b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	49.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.2	48.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.0	33.3	GO:0006797	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.8	29.5	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.5	29.2	GO:0046328	regulation of JNK cascade(GO:0046328)
0.3	28.0	GO:0030865	cortical cytoskeleton organization(GO:0030865)
3.9	27.3	GO:0033278	cell proliferation in midbrain(GO:0033278)
0.5	26.9	GO:0006636	unsaturated fatty acid biosynthetic process(GO:0006636)
2.4	26.1	GO:0097104	presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
2.4	24.2	GO:1904071	presynaptic active zone assembly(GO:1904071)

Showing 1 to 10 of 199 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	100.3	GO:0016021	integral component of membrane(GO:0016021)
0.3	60.3	GO:0045211	postsynaptic membrane(GO:0045211)
11.5	57.7	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	54.1	GO:0043005	neuron projection(GO:0043005)
0.3	34.2	GO:0099572	postsynaptic specialization(GO:0099572)
0.0	25.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
1.7	24.9	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	24.8	GO:0005887	integral component of plasma membrane(GO:0005887)
2.4	24.2	GO:0098982	GABA-ergic synapse(GO:0098982)
0.5	24.1	GO:0005905	clathrin-coated pit(GO:0005905)

Showing 1 to 10 of 83 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.4	57.7	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0	45.8	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0	39.3	GO:0005509	calcium ion binding(GO:0005509)
0.4	37.5	GO:0008201	heparin binding(GO:0008201)
0.3	34.4	GO:0019888	protein phosphatase regulator activity(GO:0019888)
3.0	33.3	GO:0004309	exopolyphosphatase activity(GO:0004309)
1.6	32.2	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
1.0	26.1	GO:0042043	neurexin family protein binding(GO:0042043)
1.3	24.2	GO:0098882	structural constituent of presynaptic active zone(GO:0098882)
2.6	23.8	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)

Showing 1 to 10 of 143 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	13.7	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.7	13.3	PID ARF 3PATHWAY	Arf1 pathway
0.4	13.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.7	12.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	9.9	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.2	9.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.5	8.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.2	8.4	PID NOTCH PATHWAY	Notch signaling pathway
0.4	4.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.4	4.6	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	30.6	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.5	26.2	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
6.6	19.7	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.7	19.1	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
3.7	18.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.3	18.3	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
3.6	18.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.7	16.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
1.4	13.9	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.8	12.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects

Showing 1 to 10 of 43 entries

Results for klf12b

Z-value: 2.10

Motif logo

Transcription factors associated with klf12b

Activity-expression correlation:

Activity profile of klf12b motif

Sorted Z-values of klf12b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of klf12b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: