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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for klf12b

Z-value: 2.10

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Transcription factors associated with klf12b

Gene Symbol Gene ID Gene Info
ENSDARG00000032197 Kruppel-like factor 12b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf12bdr11_v1_chr9_+_30720048_307200480.623.5e-11Click!

Activity profile of klf12b motif

Sorted Z-values of klf12b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_13742899 57.67 ENSDART00000104722
cyclin-dependent kinase 5, regulatory subunit 2a (p39)
chr25_-_4146947 30.58 ENSDART00000129268
fatty acid desaturase 2
chr9_-_31278048 27.34 ENSDART00000022204
zic family member 5 (odd-paired homolog, Drosophila)
chr2_-_21082695 26.47 ENSDART00000032502
nebulette
chr11_-_37509001 24.17 ENSDART00000109753
bassoon (presynaptic cytomatrix protein) b
chr2_+_47582681 22.57 ENSDART00000187579
secretogranin II (chromogranin C), b
chr8_+_31248917 20.76 ENSDART00000112170
un-named hu7912
chr15_+_37197494 19.87 ENSDART00000166203
amyloid beta (A4) precursor-like protein 1
chr21_-_43949208 19.72 ENSDART00000150983
calcium/calmodulin-dependent protein kinase II alpha
chr18_+_18104235 19.66 ENSDART00000145342
cerebellin 1 precursor
chr12_+_24344963 19.38 ENSDART00000191648
ENSDART00000183180
ENSDART00000088178
ENSDART00000189696
neurexin 1a
chr7_-_18601206 18.82 ENSDART00000111636
si:ch211-119e14.2
chr20_-_39219537 18.42 ENSDART00000005764
cytochrome P450, family 39, subfamily A, polypeptide 1
chr5_-_55395964 18.18 ENSDART00000145791
prune homolog 2 (Drosophila)
chr8_+_31119548 18.17 ENSDART00000136578
synapsin I
chr5_-_22501663 18.11 ENSDART00000133174
si:dkey-27p18.5
chr7_-_30082931 18.06 ENSDART00000075600
tetraspanin 3b
chr2_+_24203229 17.56 ENSDART00000138088
microtubule associated protein 4 like
chr17_+_15433518 17.53 ENSDART00000026180
fatty acid binding protein 7, brain, a
chr1_-_21483832 17.33 ENSDART00000102790
glycine receptor, beta a
chr25_-_13842618 17.26 ENSDART00000160258
mitogen-activated protein kinase 8 interacting protein 1a
chr8_-_14050758 17.24 ENSDART00000133922
ATPase plasma membrane Ca2+ transporting 3a
chr20_+_18580176 17.10 ENSDART00000185310
si:dkeyp-72h1.1
chr6_+_27667359 16.79 ENSDART00000159624
ENSDART00000049177
RAB6B, member RAS oncogene family a
chr12_+_16233077 16.60 ENSDART00000152409
membrane protein, palmitoylated 3b (MAGUK p55 subfamily member 3)
chr17_-_52643970 16.53 ENSDART00000190594
sprouty-related, EVH1 domain containing 1
chr12_+_9817440 16.23 ENSDART00000137081
ENSDART00000123712
RUN domain containing 3Ab
chr16_-_12173554 16.04 ENSDART00000110567
ENSDART00000155935
calsyntenin 3
chr2_-_14390627 15.90 ENSDART00000172367
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr5_-_23317477 15.90 ENSDART00000090171
neuroligin 3b
chr1_+_14283692 15.71 ENSDART00000017679
protein phosphatase 2, regulatory subunit B, gamma a
chr6_+_24817852 15.41 ENSDART00000165609
BarH-like homeobox 2
chr8_-_7232413 15.21 ENSDART00000092426
glutamate receptor interacting protein 2a
chr9_-_32753535 15.04 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr5_-_25174420 14.76 ENSDART00000141554
ATP-binding cassette, sub-family A (ABC1), member 2
chr10_-_20637098 14.47 ENSDART00000080391
shadow of prion protein 2
chr19_-_13733870 14.36 ENSDART00000177773
erythrocyte membrane protein band 4.1a
chr25_+_12640211 14.07 ENSDART00000165108
junctophilin 3
chr6_-_30210378 14.00 ENSDART00000157359
ENSDART00000113924
leucine rich repeat containing 7
chr11_+_36989696 13.98 ENSDART00000045888
transketolase a
chr1_+_38776294 13.89 ENSDART00000170546
WD repeat domain 17
chr2_+_22694382 13.87 ENSDART00000139196
kinesin family member 1Ab
chr3_-_18710009 13.86 ENSDART00000142478
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, a
chr23_+_16633951 13.70 ENSDART00000109537
ENSDART00000193323
syntaphilin b
chr15_-_12319065 13.60 ENSDART00000162973
ENSDART00000170543
FXYD domain containing ion transport regulator 6
chr3_-_32320537 13.45 ENSDART00000113550
ENSDART00000168483
si:dkey-16p21.7
chr4_+_6643421 13.28 ENSDART00000099462
G protein-coupled receptor 85
chr7_+_26224211 13.19 ENSDART00000173999
VGF nerve growth factor inducible
chr8_+_28900689 13.12 ENSDART00000141634
glutamate receptor, ionotropic, delta 2
chr23_-_12345764 13.05 ENSDART00000133956
phosphatase and actin regulator 3a
chr16_+_20161805 12.80 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr25_-_19090479 12.56 ENSDART00000027465
ENSDART00000177670
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr11_+_23957440 12.39 ENSDART00000190721
contactin 2
chr23_-_8373676 12.32 ENSDART00000105135
ENSDART00000158531
opiate receptor-like 1
chr3_-_19091024 12.18 ENSDART00000188485
ENSDART00000110554
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr16_-_29458806 12.11 ENSDART00000047931
leucine rich repeat and Ig domain containing 4b
chr17_-_36896560 11.87 ENSDART00000045287
microtubule-associated protein, RP/EB family, member 3a
chr7_-_19940473 11.84 ENSDART00000127669
prospero homeobox 1b
chr20_+_5564042 11.82 ENSDART00000090934
ENSDART00000127050
neurexin 3b
chr25_+_19955598 11.71 ENSDART00000091547
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr14_+_32022272 11.66 ENSDART00000105760
zic family member 6
chr7_-_43840680 11.59 ENSDART00000002279
cadherin 11, type 2, OB-cadherin (osteoblast)
chr14_-_27121854 11.57 ENSDART00000173119
protocadherin 11
chr22_+_5103349 11.48 ENSDART00000083474
ataxia, cerebellar, Cayman type a
chr2_+_27010439 11.45 ENSDART00000030547
cadherin 7a
chr17_+_18117029 11.43 ENSDART00000154646
ENSDART00000179739
B cell CLL/lymphoma 11Ba
chr15_+_32821392 11.34 ENSDART00000158272
doublecortin-like kinase 1b
chr8_+_36803415 11.29 ENSDART00000111680
IQ motif and Sec7 domain 2b
chr1_+_20084389 11.13 ENSDART00000140263
protease, serine, 12 (neurotrypsin, motopsin)
chr3_-_28750495 11.12 ENSDART00000054408
gsg1-like
chr10_+_5159475 11.12 ENSDART00000142507
CDC42 small effector 2
chr20_-_19422496 11.09 ENSDART00000143658
si:ch211-278j3.3
chr9_-_35155089 11.06 ENSDART00000077901
amyloid beta (A4) precursor protein b
chr10_+_29698467 11.06 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr4_+_19535946 10.93 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
leucine rich repeat containing 4.1
chr17_+_18117358 10.87 ENSDART00000144894
B cell CLL/lymphoma 11Ba
chr9_-_27442339 10.79 ENSDART00000138602
syntaxin binding protein 5-like
chr10_+_21776911 10.69 ENSDART00000163077
ENSDART00000186093
protocadherin 1 gamma 22
chr20_-_47704973 10.68 ENSDART00000174808
transcription factor AP-2 beta
chr4_-_1324141 10.65 ENSDART00000180720
pleiotrophin
chr19_-_26863626 10.43 ENSDART00000145568
proline-rich transmembrane protein 1
chr3_-_38692920 10.36 ENSDART00000155042
membrane protein, palmitoylated 3a (MAGUK p55 subfamily member 3)
chr10_+_22381802 10.17 ENSDART00000112484
neuroligin 2b
chr22_-_26323893 10.16 ENSDART00000105099
calpain 1, (mu/I) large subunit b
chr24_-_21989406 10.15 ENSDART00000032963
apolipoprotein O, b
chr25_+_37126921 10.11 ENSDART00000124331
si:ch1073-174d20.1
chr11_+_23933016 10.04 ENSDART00000000486
contactin 2
chr24_+_32472155 10.02 ENSDART00000098859
neuronal differentiation 6a
chr20_+_17739923 9.89 ENSDART00000024627
cadherin 2, type 1, N-cadherin (neuronal)
chr7_-_57933736 9.89 ENSDART00000142580
ankyrin 2b, neuronal
chr23_+_35714574 9.79 ENSDART00000164616
tubulin, alpha 1c
chr5_+_20148671 9.63 ENSDART00000143205
SV2 related protein a
chr4_+_5741733 9.61 ENSDART00000110243
POU class 3 homeobox 2a
chr7_+_33314925 9.61 ENSDART00000148590
coronin, actin binding protein, 2Ba
chr4_+_8168514 9.52 ENSDART00000150830
ninjurin 2
chr18_-_16179129 9.44 ENSDART00000125353
solute carrier family 6 (neutral amino acid transporter), member 15
chr3_-_37476475 9.43 ENSDART00000148107
si:ch211-278a6.1
chr19_-_43552252 9.42 ENSDART00000138308
G protein-coupled receptor 186
chr8_-_12468744 9.40 ENSDART00000135019
si:dkeyp-51b7.3
chr17_-_3303805 9.33 ENSDART00000169136

chr24_-_10828560 9.31 ENSDART00000132282
family with sequence similarity 49, member Bb
chr15_-_11341635 9.28 ENSDART00000055220
RAB30, member RAS oncogene family
chr15_-_8517555 9.19 ENSDART00000140213
neuronal PAS domain protein 1
chr7_-_34413392 9.14 ENSDART00000173673
ENSDART00000047208
ENSDART00000174546
MAP-kinase activating death domain
chr23_-_24450686 9.09 ENSDART00000189161
spen family transcriptional repressor
chr4_-_28158335 9.00 ENSDART00000134605
GRAM domain containing 4a
chr12_+_2381213 8.98 ENSDART00000188007

chr3_-_19133003 8.93 ENSDART00000145215
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr21_-_24632778 8.92 ENSDART00000132533
ENSDART00000058370
Rho GTPase activating protein 32b
chr14_-_2209742 8.88 ENSDART00000054889
protocadherin 2 alpha b 5
chr24_-_11325849 8.86 ENSDART00000182485
myosin VIIA and Rab interacting protein
chr2_+_33368414 8.81 ENSDART00000077462
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_57172294 8.71 ENSDART00000063774
Rac family small GTPase 1, like
chr8_+_26868105 8.70 ENSDART00000005337
ribosomal modification protein rimK-like family member A
chr20_+_38201644 8.70 ENSDART00000022694
EH-domain containing 3
chr12_+_21299338 8.69 ENSDART00000074540
ENSDART00000133188
carbonic anhydrase Xa
chr4_-_23643272 8.53 ENSDART00000112301
ENSDART00000133184
thyrotropin releasing hormone degrading enzyme, tandem duplicate 2
chr19_-_44089509 8.52 ENSDART00000189136
RAD21 cohesin complex component b
chr5_-_51903243 8.52 ENSDART00000125535
metaxin 3
chr13_-_31470439 8.49 ENSDART00000076574
reticulon 1a
chr15_+_29472065 8.47 ENSDART00000154343
glycerophosphodiester phosphodiesterase domain containing 5b
chr5_-_31897139 8.47 ENSDART00000191957
coronin, actin binding protein, 1Cb
chr3_+_32391540 8.38 ENSDART00000156608
adaptor-related protein complex 2, alpha 1 subunit
chr4_-_18201622 8.23 ENSDART00000133509
ankyrin repeat and sterile alpha motif domain containing 1B
chr21_-_12272543 8.22 ENSDART00000081510
ENSDART00000151297
CUGBP, Elav-like family member 4
chr22_+_12431608 8.11 ENSDART00000108609
Rho family GTPase 3a
chr22_-_600016 8.08 ENSDART00000086434
transmembrane and coiled-coil domain family 2
chr5_-_21970881 8.07 ENSDART00000182907
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr13_+_4505232 8.07 ENSDART00000007500
ENSDART00000161684
phosphodiesterase 10A
chr5_-_38506981 8.07 ENSDART00000097822
ATPase Na+/K+ transporting subunit beta 2b
chr15_+_40188076 8.06 ENSDART00000063779
EF-hand domain family, member D1
chr18_+_18612388 8.02 ENSDART00000186455
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr23_-_24483311 7.99 ENSDART00000185793
ENSDART00000109248
spen family transcriptional repressor
chr16_+_37470717 7.93 ENSDART00000112003
ENSDART00000188431
ENSDART00000192837
adhesion G protein-coupled receptor B1a
chr15_+_47418565 7.87 ENSDART00000155709
ClpB homolog, mitochondrial AAA ATPase chaperonin
chr2_+_31833997 7.86 ENSDART00000066788
ependymin related 1
chr14_-_44841503 7.85 ENSDART00000179114
si:dkey-109l4.6
chr18_-_14937211 7.78 ENSDART00000141893
megalencephalic leukoencephalopathy with subcortical cysts 1
chr21_+_26748141 7.75 ENSDART00000169025
pyruvate carboxylase a
chr13_+_19322686 7.75 ENSDART00000058036
empty spiracles homeobox 2
chr10_+_25222367 7.62 ENSDART00000042767
glutamate receptor, metabotropic 5a
chr3_+_54047342 7.62 ENSDART00000178486
olfactomedin 2a
chr2_+_50094873 7.57 ENSDART00000132307
zinc finger, CCHC domain containing 2
chr22_-_22130623 7.49 ENSDART00000113168

chr14_-_2213660 7.48 ENSDART00000162537
protocadherin 2 alpha b 3
chr12_+_42574148 7.40 ENSDART00000157855
early B cell factor 3a
chr3_-_22829710 7.36 ENSDART00000055659
cytochrome b561
chr20_+_26349002 7.34 ENSDART00000152842
spectrin repeat containing, nuclear envelope 1a
chr6_-_20875111 7.33 ENSDART00000115118
ENSDART00000159916
tensin 1a
chr9_+_40939336 7.31 ENSDART00000100386
myostatin b
chr2_-_36818132 7.27 ENSDART00000110447
SLIT and NTRK-like family, member 3b
chr11_+_14004236 7.26 ENSDART00000162478
ENSDART00000171076
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr15_-_20024205 7.24 ENSDART00000161379
autism susceptibility candidate 2b
chr23_+_16638639 7.13 ENSDART00000143545
syntaphilin b
chr16_-_44512882 7.07 ENSDART00000191241

chr7_+_61906903 7.00 ENSDART00000108540
tudor domain containing 7 b
chr24_+_24461558 6.99 ENSDART00000182424
basic helix-loop-helix family, member e22
chr1_+_29183962 6.93 ENSDART00000113735
cysteinyl-tRNA synthetase 2, mitochondrial
chr24_+_29382109 6.88 ENSDART00000184620
ENSDART00000188414
ENSDART00000186132
ENSDART00000191489
netrin g1a
chr19_+_27479838 6.86 ENSDART00000103922
alpha tubulin acetyltransferase 1
chr4_-_76484737 6.84 ENSDART00000183816
finTRIM family, member 51
chr5_+_33301005 6.75 ENSDART00000006021
ubiquitin specific peptidase 20
chr20_-_23226453 6.69 ENSDART00000142721
DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
chr20_+_14977260 6.68 ENSDART00000186424
vesicle-associated membrane protein 4
chr1_+_1599979 6.67 ENSDART00000097626
urotensin II-related peptide
chr17_-_12758171 6.66 ENSDART00000131564
breast cancer metastasis-suppressor 1-like a
chr17_-_8692722 6.53 ENSDART00000148931
ENSDART00000192891
C-terminal binding protein 2a
chr24_-_10919588 6.50 ENSDART00000131204
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr14_-_39074539 6.50 ENSDART00000030509
glycine receptor, alpha 4a
chr8_+_42998944 6.45 ENSDART00000048819
Ras association (RalGDS/AF-6) domain family member 2a
chr6_-_7842078 6.45 ENSDART00000065507
phospholipid phosphatase related 2b
chr4_+_23223881 6.44 ENSDART00000133056
ENSDART00000089126
thyrotropin releasing hormone degrading enzyme, tandem duplicate 1
chr16_-_44649053 6.41 ENSDART00000184807

chr19_-_3488860 6.39 ENSDART00000172520
human immunodeficiency virus type I enhancer binding protein 1
chr5_+_52039067 6.33 ENSDART00000143276
SET binding protein 1
chr8_-_53108207 6.29 ENSDART00000111023
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr11_-_42554290 6.24 ENSDART00000130573
ATPase H+ transporting accessory protein 1 like a
chr14_+_28281744 6.21 ENSDART00000173292
midline 2
chr16_+_14812585 6.20 ENSDART00000134087
collagen, type XIV, alpha 1a
chr18_-_26675699 6.10 ENSDART00000113280
si:ch211-69m14.1
chr5_+_22098591 6.00 ENSDART00000143676
zinc finger CCCH-type containing 12B
chr8_+_25247245 5.98 ENSDART00000045798
adenosine monophosphate deaminase 2b
chr15_+_1397811 5.96 ENSDART00000102125
schwannomin interacting protein 1
chr24_+_26134029 5.96 ENSDART00000185134
teleost multiple tissue opsin b
chr18_-_41211980 5.93 ENSDART00000171431
zinc finger and BTB domain containing 38
chr14_-_2322484 5.89 ENSDART00000167806
si:ch73-379j16.2
chr23_+_19590598 5.87 ENSDART00000170149
sarcolemma associated protein b
chr23_+_11669337 5.84 ENSDART00000131355
contactin 3a, tandem duplicate 1
chr7_+_44713135 5.84 ENSDART00000170721
si:dkey-56m19.5
chr23_+_11669109 5.84 ENSDART00000091416
contactin 3a, tandem duplicate 1
chr17_+_16564921 5.82 ENSDART00000151904
forkhead box N3
chr15_+_34062460 5.82 ENSDART00000164654
si:dkey-30e9.6
chr20_-_31781941 5.77 ENSDART00000139417
syntaxin binding protein 5a (tomosyn)
chr18_-_15373620 5.76 ENSDART00000031752
regulatory factor X, 4
chr8_+_47342586 5.73 ENSDART00000007624
phospholipase C, eta 2a
chr5_+_11812089 5.71 ENSDART00000111359
F-box protein 21
chr25_+_8662469 5.68 ENSDART00000154680
ENSDART00000188568
mannosidase, alpha, class 2A, member 2
chr3_-_17871846 5.67 ENSDART00000074478
ENSDART00000187941
NFKB inhibitor interacting Ras-like 2
chr13_+_4505079 5.63 ENSDART00000144312
phosphodiesterase 10A
chr19_+_19028633 5.61 ENSDART00000158618
copine IVb

Network of associatons between targets according to the STRING database.

First level regulatory network of klf12b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 22.4 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
4.2 20.8 GO:0051659 maintenance of mitochondrion location(GO:0051659)
3.9 27.3 GO:0033278 cell proliferation in midbrain(GO:0033278)
3.8 15.0 GO:0021742 abducens nucleus development(GO:0021742)
3.4 20.4 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
3.3 9.9 GO:0021577 hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
3.0 33.3 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
2.8 14.0 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
2.7 13.7 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
2.5 7.6 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
2.4 24.2 GO:1904071 presynaptic active zone assembly(GO:1904071)
2.4 26.1 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
2.4 9.4 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
2.3 20.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.3 9.0 GO:0034164 regulation of toll-like receptor 9 signaling pathway(GO:0034163) negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
2.2 6.7 GO:2000434 regulation of protein neddylation(GO:2000434)
2.2 8.8 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
2.2 23.8 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
2.2 10.8 GO:0006011 UDP-glucose metabolic process(GO:0006011)
2.0 9.9 GO:0036371 protein localization to T-tubule(GO:0036371)
1.8 7.3 GO:0045843 negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
1.7 6.9 GO:0021828 pallium development(GO:0021543) cerebral cortex cell migration(GO:0021795) cerebral cortex tangential migration(GO:0021800) cerebral cortex tangential migration using cell-axon interactions(GO:0021824) substrate-dependent cerebral cortex tangential migration(GO:0021825) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) cerebral cortex development(GO:0021987)
1.7 6.7 GO:0090161 Golgi ribbon formation(GO:0090161)
1.6 15.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
1.4 4.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.3 11.9 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
1.3 49.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
1.3 3.8 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
1.2 23.6 GO:0060079 excitatory postsynaptic potential(GO:0060079)
1.1 4.6 GO:0045730 respiratory burst(GO:0045730)
1.1 3.4 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
1.1 20.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.1 9.5 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
1.0 14.0 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
1.0 6.0 GO:0035332 positive regulation of hippo signaling(GO:0035332)
1.0 7.8 GO:0046958 nonassociative learning(GO:0046958) habituation(GO:0046959)
1.0 7.7 GO:0060118 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.9 12.3 GO:0019233 sensory perception of pain(GO:0019233)
0.9 5.7 GO:0006013 mannose metabolic process(GO:0006013)
0.9 4.6 GO:0061072 iris morphogenesis(GO:0061072)
0.9 3.7 GO:0003232 bulbus arteriosus development(GO:0003232)
0.9 8.5 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.8 12.6 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.8 29.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.8 5.0 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.8 4.1 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.8 4.8 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.8 15.2 GO:0008354 germ cell migration(GO:0008354)
0.8 9.9 GO:0046549 retinal cone cell development(GO:0046549)
0.7 16.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 7.9 GO:0034605 cellular response to heat(GO:0034605)
0.7 7.8 GO:0034394 protein localization to cell surface(GO:0034394)
0.7 10.1 GO:0042407 cristae formation(GO:0042407)
0.7 21.6 GO:0032482 Rab protein signal transduction(GO:0032482)
0.7 8.0 GO:0061300 cerebellum vasculature development(GO:0061300)
0.6 3.8 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.6 17.8 GO:0070831 basement membrane assembly(GO:0070831)
0.6 3.8 GO:0006699 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.6 8.1 GO:0001964 startle response(GO:0001964)
0.6 2.3 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.6 22.6 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.5 26.9 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.5 17.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.5 3.2 GO:0043091 amino acid import(GO:0043090) L-arginine import(GO:0043091) L-amino acid import(GO:0043092) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.5 16.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.5 8.1 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.5 29.2 GO:0046328 regulation of JNK cascade(GO:0046328)
0.5 1.4 GO:0019408 dolichol biosynthetic process(GO:0019408)
0.5 8.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.4 2.6 GO:0008584 male gonad development(GO:0008584)
0.4 6.0 GO:0032264 IMP salvage(GO:0032264)
0.4 16.6 GO:0050708 regulation of protein secretion(GO:0050708)
0.4 11.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.4 9.3 GO:0050870 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.4 21.4 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.4 3.8 GO:2000144 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.4 9.5 GO:0043171 peptide catabolic process(GO:0043171)
0.3 2.4 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 2.0 GO:0042670 retinal cone cell differentiation(GO:0042670)
0.3 2.3 GO:0016266 O-glycan processing(GO:0016266)
0.3 5.4 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.3 1.6 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.3 3.2 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.3 14.2 GO:0032456 endocytic recycling(GO:0032456)
0.3 2.2 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.3 4.9 GO:0007254 JNK cascade(GO:0007254)
0.3 2.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.3 5.0 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.3 1.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.3 12.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 5.8 GO:0007418 ventral midline development(GO:0007418)
0.3 2.3 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.3 8.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.3 28.0 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.3 2.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.3 6.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.3 3.1 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 1.1 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.3 3.0 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.3 1.9 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.3 5.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 6.0 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.2 48.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.7 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.2 2.1 GO:0045738 negative regulation of DNA repair(GO:0045738) negative regulation of double-strand break repair(GO:2000780)
0.2 12.3 GO:0003146 heart jogging(GO:0003146)
0.2 2.0 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.2 1.1 GO:0072574 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.2 10.0 GO:0031638 zymogen activation(GO:0031638)
0.2 13.4 GO:0008360 regulation of cell shape(GO:0008360)
0.2 4.3 GO:0007020 microtubule nucleation(GO:0007020) microtubule anchoring(GO:0034453)
0.2 11.1 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.2 1.4 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.2 8.4 GO:0036269 swimming behavior(GO:0036269)
0.2 1.2 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902229)
0.2 1.4 GO:0045475 locomotor rhythm(GO:0045475)
0.2 1.9 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 2.5 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.2 0.6 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.2 1.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 0.9 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.2 5.2 GO:0019835 cytolysis(GO:0019835)
0.2 3.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 9.6 GO:0003401 axis elongation(GO:0003401)
0.2 3.3 GO:0043489 RNA stabilization(GO:0043489)
0.2 2.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 2.9 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.2 21.0 GO:0051260 protein homooligomerization(GO:0051260)
0.2 1.0 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.2 10.4 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.2 2.7 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.2 1.4 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 3.1 GO:0040001 establishment of mitotic spindle localization(GO:0040001)
0.1 1.6 GO:0021537 telencephalon development(GO:0021537)
0.1 17.9 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 1.4 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 3.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 1.8 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 3.9 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.1 7.8 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.1 2.6 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.0 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.1 5.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 15.3 GO:0045216 cell-cell junction organization(GO:0045216)
0.1 6.7 GO:0016575 histone deacetylation(GO:0016575)
0.1 1.2 GO:0060325 face morphogenesis(GO:0060325)
0.1 2.1 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.2 GO:0046379 hyaluronan biosynthetic process(GO:0030213) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 10.9 GO:0002040 sprouting angiogenesis(GO:0002040)
0.1 0.3 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.1 7.4 GO:0022900 electron transport chain(GO:0022900)
0.1 2.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 0.8 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 1.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 3.6 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.1 1.1 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.2 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 2.2 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 1.9 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 3.4 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 5.7 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.1 0.6 GO:0090303 positive regulation of wound healing(GO:0090303)
0.1 1.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 6.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 0.9 GO:0038203 TORC2 signaling(GO:0038203)
0.1 4.5 GO:0008217 regulation of blood pressure(GO:0008217)
0.1 0.8 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.1 3.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 2.1 GO:0045727 positive regulation of cellular amide metabolic process(GO:0034250) positive regulation of translation(GO:0045727)
0.1 19.8 GO:0000377 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1 4.5 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 2.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 6.9 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 13.7 GO:0007018 microtubule-based movement(GO:0007018)
0.1 0.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 1.7 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 0.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 1.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 8.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.3 GO:0034340 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.3 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 1.7 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.9 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 0.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.7 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.6 GO:0033344 cholesterol efflux(GO:0033344)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 5.8 GO:0007005 mitochondrion organization(GO:0007005)
0.0 0.7 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 1.4 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 3.3 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 1.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 2.0 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.2 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.0 1.2 GO:0006261 DNA-dependent DNA replication(GO:0006261)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 57.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
3.4 10.2 GO:0060077 inhibitory synapse(GO:0060077)
2.4 24.2 GO:0098982 GABA-ergic synapse(GO:0098982)
1.9 11.1 GO:0043083 synaptic cleft(GO:0043083)
1.7 20.8 GO:0044295 axonal growth cone(GO:0044295)
1.7 24.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.4 13.9 GO:0030122 AP-2 adaptor complex(GO:0030122)
1.3 8.9 GO:0001650 fibrillar center(GO:0001650)
1.2 8.5 GO:0030892 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
1.1 8.5 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
1.0 6.2 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.9 10.1 GO:0061617 MICOS complex(GO:0061617)
0.9 11.7 GO:0033270 paranode region of axon(GO:0033270) juxtaparanode region of axon(GO:0044224)
0.8 8.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.8 5.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.8 6.2 GO:0005614 interstitial matrix(GO:0005614)
0.8 9.9 GO:0014704 intercalated disc(GO:0014704)
0.7 3.4 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.7 3.4 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.6 9.9 GO:0030315 T-tubule(GO:0030315)
0.6 9.7 GO:0031209 SCAR complex(GO:0031209)
0.6 4.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 11.6 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.5 11.9 GO:0060170 ciliary membrane(GO:0060170)
0.5 24.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 7.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 15.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 11.9 GO:0035371 microtubule plus-end(GO:0035371)
0.5 2.3 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.4 18.7 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.4 3.5 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.4 2.4 GO:0005955 calcineurin complex(GO:0005955)
0.4 1.8 GO:0070724 BMP receptor complex(GO:0070724)
0.4 1.4 GO:1904423 dehydrodolichyl diphosphate synthase complex(GO:1904423)
0.4 18.2 GO:0016342 catenin complex(GO:0016342)
0.3 1.3 GO:0016460 myosin II complex(GO:0016460)
0.3 34.2 GO:0099572 postsynaptic specialization(GO:0099572)
0.3 6.7 GO:0070822 Sin3-type complex(GO:0070822)
0.3 18.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 60.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 3.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 4.7 GO:0042555 MCM complex(GO:0042555)
0.3 21.8 GO:0031201 SNARE complex(GO:0031201)
0.3 22.6 GO:0030141 secretory granule(GO:0030141)
0.2 0.7 GO:0070578 RISC-loading complex(GO:0070578)
0.2 11.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.2 3.8 GO:0042734 presynaptic membrane(GO:0042734)
0.2 6.2 GO:0005844 polysome(GO:0005844)
0.2 2.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 4.8 GO:0032587 ruffle membrane(GO:0032587)
0.2 15.3 GO:0005871 kinesin complex(GO:0005871)
0.2 4.3 GO:0045180 basal cortex(GO:0045180)
0.2 9.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 5.1 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.1 1.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 4.1 GO:0035869 ciliary transition zone(GO:0035869)
0.1 54.1 GO:0043005 neuron projection(GO:0043005)
0.1 10.7 GO:0005925 focal adhesion(GO:0005925)
0.1 3.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 4.6 GO:0016605 PML body(GO:0016605)
0.1 4.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 2.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 11.9 GO:0005802 trans-Golgi network(GO:0005802)
0.1 1.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 16.6 GO:0005938 cell cortex(GO:0005938)
0.1 2.1 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 12.7 GO:0035770 ribonucleoprotein granule(GO:0035770)
0.1 2.1 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 20.3 GO:0045202 synapse(GO:0045202)
0.1 17.8 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 0.8 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 2.5 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 25.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.5 GO:0031902 late endosome membrane(GO:0031902)
0.0 24.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.8 GO:0055037 recycling endosome(GO:0055037)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 100.3 GO:0016021 integral component of membrane(GO:0016021)
0.0 5.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.3 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 57.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
3.0 33.3 GO:0004309 exopolyphosphatase activity(GO:0004309)
2.9 8.7 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
2.7 13.7 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
2.6 23.8 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
2.6 7.8 GO:0004736 pyruvate carboxylase activity(GO:0004736)
2.5 7.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
2.3 14.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
2.2 10.8 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
1.9 9.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.8 5.5 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
1.6 32.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.4 12.3 GO:0004985 opioid receptor activity(GO:0004985)
1.3 24.2 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
1.3 3.9 GO:0030882 lipid antigen binding(GO:0030882)
1.2 17.5 GO:0005504 fatty acid binding(GO:0005504)
1.1 7.6 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
1.1 17.9 GO:0045159 myosin II binding(GO:0045159)
1.0 5.2 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
1.0 4.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
1.0 26.1 GO:0042043 neurexin family protein binding(GO:0042043)
1.0 3.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.9 3.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.9 8.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.7 23.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.7 8.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.6 15.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.6 13.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.6 4.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.6 17.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.6 3.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 6.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.5 2.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.5 8.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.5 20.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 9.9 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.5 6.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.5 12.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.5 13.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 4.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.5 17.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.5 3.2 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.5 2.3 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.5 2.3 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.4 3.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 14.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 13.1 GO:0004970 ionotropic glutamate receptor activity(GO:0004970)
0.4 13.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.4 1.6 GO:0051800 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.4 8.1 GO:0001671 ATPase activator activity(GO:0001671)
0.4 2.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.4 19.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.4 8.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 37.5 GO:0008201 heparin binding(GO:0008201)
0.4 1.4 GO:0045547 dehydrodolichyl diphosphate synthase activity(GO:0045547)
0.3 34.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.3 8.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 2.8 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.3 9.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 8.9 GO:0017022 myosin binding(GO:0017022)
0.3 6.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.3 4.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 3.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.3 1.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 3.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 6.3 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2 21.6 GO:0045296 cadherin binding(GO:0045296)
0.2 3.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 5.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 3.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 8.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 0.9 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.2 0.9 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.2 1.4 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 2.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.7 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) pre-miRNA binding(GO:0070883)
0.2 2.8 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.2 1.8 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 8.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 1.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.2 5.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.2 1.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 2.7 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.2 3.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 0.5 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 20.2 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 1.8 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 6.3 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 2.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 2.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 10.9 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 2.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 3.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 2.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 9.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 6.0 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 1.1 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 11.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 4.0 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 6.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 2.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.7 GO:0002039 p53 binding(GO:0002039)
0.1 18.4 GO:0019901 protein kinase binding(GO:0019901)
0.1 3.9 GO:0042054 histone methyltransferase activity(GO:0042054)
0.1 13.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.9 GO:0030145 manganese ion binding(GO:0030145)
0.1 3.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 17.3 GO:0008017 microtubule binding(GO:0008017)
0.1 5.2 GO:0016209 antioxidant activity(GO:0016209)
0.1 4.4 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.1 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 5.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 39.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 11.1 GO:0003682 chromatin binding(GO:0003682)
0.0 12.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.9 GO:0000339 RNA cap binding(GO:0000339)
0.0 2.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 12.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.2 GO:0046332 SMAD binding(GO:0046332)
0.0 0.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.0 1.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.8 GO:0017069 snRNA binding(GO:0017069)
0.0 2.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 45.8 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.7 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 9.2 GO:0016491 oxidoreductase activity(GO:0016491)
0.0 9.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 12.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.7 13.3 PID ARF 3PATHWAY Arf1 pathway
0.5 8.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.5 3.7 PID S1P S1P2 PATHWAY S1P2 pathway
0.4 3.8 PID S1P S1P3 PATHWAY S1P3 pathway
0.4 4.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 4.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 13.1 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 13.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3 9.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 9.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 8.4 PID NOTCH PATHWAY Notch signaling pathway
0.2 2.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 2.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 0.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 1.9 SIG CHEMOTAXIS Genes related to chemotaxis
0.1 1.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.7 PID MYC PATHWAY C-MYC pathway
0.0 4.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.6 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.7 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
3.7 18.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
3.6 18.2 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
3.1 30.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
1.7 19.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
1.4 13.9 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
1.3 18.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.9 8.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.8 12.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.7 7.1 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.7 16.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.5 3.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.5 26.2 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.4 10.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 6.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.4 5.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3 4.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 6.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.3 4.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 0.9 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 5.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 4.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 1.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 2.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 5.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.7 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 4.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.2 REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR Genes involved in Downstream signaling of activated FGFR
0.1 5.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 3.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases