ISMARA results: junba+junbb

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for junba+junbb

Z-value: 2.39

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Transcription factors associated with junba+junbb

Gene Symbol	Gene ID	Gene Info
junba NCBI UniProt	ENSDARG00000074378	JunB proto-oncogene, AP-1 transcription factor subunit a
junbb NCBI UniProt	ENSDARG00000104773	JunB proto-oncogene, AP-1 transcription factor subunit b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
junba	dr11_v1_chr1_-_51734524_51734535	-0.29	3.9e-03	Click!
junbb	dr11_v1_chr3_-_7656059_7656059	-0.05	6.2e-01	Click!

Activity profile of junba+junbb motif

Sorted Z-values of junba+junbb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_12385308 Show fit	62.94	ENSDART00000080927	snap25b NCBI UniProt Show fit	synaptosomal-associated protein, 25b
chr6_+_27667359 Show fit	41.60	ENSDART00000159624 ENSDART00000049177	rab6ba NCBI UniProt Show fit	RAB6B, member RAS oncogene family a
chr20_+_34913069 Show fit	39.22	ENSDART00000007584	snap25a NCBI UniProt Show fit	synaptosomal-associated protein, 25a
chr14_+_34486629 Show fit	32.37	ENSDART00000131861	tmsb2 NCBI UniProt Show fit	thymosin beta 2
chr2_-_11512819 Show fit	32.08	ENSDART00000142013	penka NCBI UniProt Show fit	proenkephalin a
chr16_-_17207754 Show fit	29.24	ENSDART00000063804	wu:fj39g12 NCBI UniProt Show fit	wu:fj39g12
chr10_-_39011514 Show fit	28.95	ENSDART00000075123	pcp4a NCBI UniProt Show fit	Purkinje cell protein 4a
chr3_-_36115339 Show fit	27.94	ENSDART00000187406 ENSDART00000123505 ENSDART00000151775	rab11fip4a NCBI UniProt Show fit	RAB11 family interacting protein 4 (class II) a
chr16_-_43026273 Show fit	26.09	ENSDART00000156820 ENSDART00000189080	si:dkey-7j14.5 NCBI UniProt Show fit	si:dkey-7j14.5
chr1_-_22861348 Show fit	25.78	ENSDART00000139412	SMIM18 NCBI UniProt Show fit	si:dkey-92j12.6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of junba+junbb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	84.5	GO:0007019	microtubule depolymerization(GO:0007019)
4.9	68.8	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.2	49.6	GO:0006470	protein dephosphorylation(GO:0006470)
0.2	48.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.3	43.0	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
1.6	39.7	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
1.4	39.2	GO:0016082	synaptic vesicle priming(GO:0016082)
1.4	36.2	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.2	36.2	GO:0030705	cytoskeleton-dependent intracellular transport(GO:0030705)
0.3	35.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)

Showing 1 to 10 of 236 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	112.4	GO:0043025	neuronal cell body(GO:0043025)
17.0	102.2	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2	68.1	GO:0043005	neuron projection(GO:0043005)
0.6	50.4	GO:0005871	kinesin complex(GO:0005871)
3.9	46.9	GO:0044295	axonal growth cone(GO:0044295)
0.3	41.3	GO:0030425	dendrite(GO:0030425)
0.8	28.9	GO:0055038	recycling endosome membrane(GO:0055038)
0.6	27.3	GO:0030125	clathrin vesicle coat(GO:0030125)
0.3	26.2	GO:0043197	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1	25.2	GO:0045202	synapse(GO:0045202)

Showing 1 to 10 of 109 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	95.9	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	56.3	GO:0015631	tubulin binding(GO:0015631)
0.4	42.1	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
1.5	41.1	GO:0017080	sodium channel regulator activity(GO:0017080)
1.2	40.4	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2	38.4	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.6	34.2	GO:0005178	integrin binding(GO:0005178)
0.5	33.2	GO:0051427	hormone receptor binding(GO:0051427)
2.5	32.1	GO:0031628	opioid receptor binding(GO:0031628)
2.2	31.3	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)

Showing 1 to 10 of 154 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	23.3	PID REELIN PATHWAY	Reelin signaling pathway
1.6	20.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.8	17.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.7	15.1	PID RHOA PATHWAY	RhoA signaling pathway
0.5	15.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.7	14.5	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	12.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.4	9.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.5	8.8	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.6	6.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	39.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
2.2	36.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.7	34.1	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.5	16.3	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.9	15.0	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
1.1	14.5	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.4	14.1	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
2.3	11.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.7	10.5	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2	9.7	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)

Showing 1 to 10 of 56 entries

Results for junba+junbb

Z-value: 2.39

Motif logo

Transcription factors associated with junba+junbb

Activity-expression correlation:

Activity profile of junba+junbb motif

Sorted Z-values of junba+junbb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of junba+junbb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: