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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for irx5a+irx5b_irx3a+irx3b
Z-value: 1.36
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Transcription factors associated with irx5a+irx5b_irx3a+irx3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| irx3a | dr11_v1_chr7_+_36041509_36041509 | -0.47 | 1.4e-06 | Click! |
| irx5b | dr11_v1_chr25_+_36152215_36152215 | -0.35 | 5.0e-04 | Click! |
| irx5a | dr11_v1_chr7_-_35710263_35710263 | -0.33 | 1.0e-03 | Click! |
| irx3b | dr11_v1_chr25_-_36492779_36492779 | -0.26 | 1.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_50147948 Show fit | 22.69 |
ENSDART00000149010
|
haptoglobin |
|
| chr13_+_2908764 Show fit | 13.09 |
ENSDART00000162362
|
wu:fj16a03 |
|
| chr20_+_34029820 Show fit | 12.93 |
ENSDART00000143901
ENSDART00000134305 |
proteoglycan 4b |
|
| chr24_-_24983047 Show fit | 11.64 |
ENSDART00000066631
|
solute carrier family 51, alpha subunit |
|
| chr22_-_23781083 Show fit | 11.01 |
ENSDART00000166563
ENSDART00000170458 ENSDART00000166158 ENSDART00000171246 |
complement factor H like 3 |
|
| chr11_+_13224281 Show fit | 9.53 |
ENSDART00000102557
ENSDART00000178706 |
ATP-binding cassette, sub-family B (MDR/TAP), member 11b |
|
| chr22_+_6293563 Show fit | 9.44 |
ENSDART00000063416
|
ribonuclease like 2 |
|
| chr23_+_19701587 Show fit | 9.28 |
ENSDART00000104425
|
deoxyribonuclease I-like 1 |
|
| chr7_+_56577522 Show fit | 8.23 |
ENSDART00000149130
ENSDART00000149624 |
haptoglobin |
|
| chr14_+_21106444 Show fit | 7.84 |
ENSDART00000075744
ENSDART00000132363 |
aldolase b, fructose-bisphosphate |
Network of associatons between targets according to the STRING database.
First level regulatory network of irx5a+irx5b_irx3a+irx3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.7 | GO:0006508 | proteolysis(GO:0006508) |
| 0.0 | 22.4 | GO:0006955 | immune response(GO:0006955) |
| 0.1 | 15.4 | GO:0042742 | defense response to bacterium(GO:0042742) |
| 3.5 | 13.8 | GO:0015722 | canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782) |
| 0.1 | 12.6 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 1.2 | 11.7 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.5 | 10.6 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.9 | 10.4 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.4 | 9.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 9.2 | GO:0006637 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 79.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 26.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 11.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 10.7 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 9.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 8.4 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 7.7 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 2.5 | 7.4 | GO:0005960 | glycine cleavage complex(GO:0005960) |
| 0.0 | 7.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.6 | 6.5 | GO:0030904 | retromer complex(GO:0030904) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 43.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 19.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 15.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 14.9 | GO:0004540 | ribonuclease activity(GO:0004540) |
| 3.5 | 13.8 | GO:0015432 | canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432) |
| 0.1 | 13.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 11.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.3 | 10.7 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.4 | 10.6 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.9 | 10.4 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 7.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.6 | 3.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.1 | 2.9 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 2.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.6 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.6 | 13.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.6 | 9.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.3 | 7.8 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.6 | 7.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.7 | 6.6 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 1.6 | 6.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.4 | 5.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.6 | 5.0 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 5.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |