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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irx5a+irx5b_irx3a+irx3b

Z-value: 1.36

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Transcription factors associated with irx5a+irx5b_irx3a+irx3b

Gene Symbol Gene ID Gene Info
ENSDARG00000034043 iroquois homeobox 5a
ENSDARG00000074070 iroquois homeobox 5b
ENSDARG00000031138 iroquois homeobox 3b
ENSDARG00000101076 iroquois homeobox 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx3adr11_v1_chr7_+_36041509_36041509-0.471.4e-06Click!
irx5bdr11_v1_chr25_+_36152215_36152215-0.355.0e-04Click!
irx5adr11_v1_chr7_-_35710263_35710263-0.331.0e-03Click!
irx3bdr11_v1_chr25_-_36492779_36492779-0.261.0e-02Click!

Activity profile of irx5a+irx5b_irx3a+irx3b motif

Sorted Z-values of irx5a+irx5b_irx3a+irx3b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_50147948 22.69 ENSDART00000149010
haptoglobin
chr13_+_2908764 13.09 ENSDART00000162362
wu:fj16a03
chr20_+_34029820 12.93 ENSDART00000143901
ENSDART00000134305
proteoglycan 4b
chr24_-_24983047 11.64 ENSDART00000066631
solute carrier family 51, alpha subunit
chr22_-_23781083 11.01 ENSDART00000166563
ENSDART00000170458
ENSDART00000166158
ENSDART00000171246
complement factor H like 3
chr11_+_13224281 9.53 ENSDART00000102557
ENSDART00000178706
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr22_+_6293563 9.44 ENSDART00000063416
ribonuclease like 2
chr23_+_19701587 9.28 ENSDART00000104425
deoxyribonuclease I-like 1
chr7_+_56577522 8.23 ENSDART00000149130
ENSDART00000149624
haptoglobin
chr14_+_21106444 7.84 ENSDART00000075744
ENSDART00000132363
aldolase b, fructose-bisphosphate
chr22_+_37874691 7.78 ENSDART00000028565
alpha-2-HS-glycoprotein 1
chr5_+_45677781 7.76 ENSDART00000163120
ENSDART00000126537
group-specific component (vitamin D binding protein)
chr11_+_40812590 7.65 ENSDART00000186690
ERBB receptor feedback inhibitor 1a
chr7_+_56577906 7.51 ENSDART00000184023
haptoglobin
chr13_-_34683370 7.47 ENSDART00000113661
kinesin family member 16Bb
chr5_+_66170479 7.44 ENSDART00000172117
glycine dehydrogenase (decarboxylating)
chr6_+_41144155 7.05 ENSDART00000191395
ENSDART00000143577
solute carrier family 6 member 22, tandem duplicate 2
chr3_-_50136424 6.74 ENSDART00000188843
bloodthirsty-related gene family, member 2
chr1_-_7951002 6.59 ENSDART00000138187
si:dkey-79f11.8
chr14_-_36799280 6.59 ENSDART00000168615
ring finger protein 130
chr15_-_21132480 6.42 ENSDART00000078734
ENSDART00000157481
alpha-2-macroglobulin-like
chr22_-_23666504 6.41 ENSDART00000158665
complement factor H
chr8_+_19356072 6.39 ENSDART00000063272
macrophage expressed 1, tandem duplicate 2
chr8_+_3405612 6.26 ENSDART00000163437
zgc:112433
chr6_-_20952187 6.23 ENSDART00000074327
insulin-like growth factor binding protein 2a
chr22_+_10781894 6.16 ENSDART00000081183
ectodermal-neural cortex 3
chr8_-_13972626 6.09 ENSDART00000144296
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr15_-_21155641 6.05 ENSDART00000061098
ENSDART00000046443
si:dkey-105h12.2
chr20_+_23440632 5.97 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr11_-_18384534 5.87 ENSDART00000156499
protein kinase C, delta b
chr1_+_31706668 5.86 ENSDART00000057879
arsenite methyltransferase
chr14_+_21107032 5.63 ENSDART00000138319
ENSDART00000139103
ENSDART00000184735
aldolase b, fructose-bisphosphate
chr19_-_11237125 5.59 ENSDART00000163921
signal sequence receptor, beta
chr15_+_21202820 5.13 ENSDART00000154036
si:dkey-52d15.2
chr18_-_49286381 5.08 ENSDART00000174248
ENSDART00000174038
si:zfos-464b6.2
chr3_-_50147160 5.06 ENSDART00000191341
bloodthirsty-related gene family, member 2
chr21_-_588858 5.04 ENSDART00000168983
transmembrane protein 38B
chr1_-_23293261 5.02 ENSDART00000122648
UDP-glucose 6-dehydrogenase
chr18_+_22109379 5.01 ENSDART00000147230
zgc:158868
chr9_+_24088062 5.00 ENSDART00000126198
leucine rich repeat (in FLII) interacting protein 1a
chr21_+_11139175 4.98 ENSDART00000169024
alanine--glyoxylate aminotransferase 2
chr3_-_50146854 4.97 ENSDART00000157047
si:dkey-120c6.5
chr19_-_8748571 4.86 ENSDART00000031173
ribosomal protein S27, isoform 1
chr4_-_17725008 4.70 ENSDART00000016658
choline phosphotransferase 1
chr22_-_22340688 4.68 ENSDART00000105597
si:ch211-129c21.1
chr10_-_6976645 4.65 ENSDART00000123312
SH2 domain containing 4A
chr22_-_24858042 4.63 ENSDART00000137998
ENSDART00000078216
ENSDART00000138378
vitellogenin 7
chr9_+_426392 4.61 ENSDART00000172515
basic leucine zipper and W2 domains 1b
chr1_+_40237276 4.45 ENSDART00000037553
fatty acid amide hydrolase 2a
chr21_-_30658509 4.42 ENSDART00000139764
si:dkey-22f5.9
chr25_-_35963158 4.41 ENSDART00000153612
sorting nexin 20
chr10_+_8656417 4.35 ENSDART00000123131
phorbol-12-myristate-13-acetate-induced protein 1
chr13_-_41908583 4.33 ENSDART00000136515
inositol polyphosphate multikinase a
chr20_-_5267600 4.30 ENSDART00000099258
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4
chr11_+_13223625 4.29 ENSDART00000161275
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr24_-_25244637 4.24 ENSDART00000153798
HERV-H LTR-associating 2b, tandem duplicate 2
chr3_-_18792492 4.24 ENSDART00000134208
ENSDART00000034373
hydroxyacylglutathione hydrolase
chr5_+_29831235 4.22 ENSDART00000109660
F11 receptor, tandem duplicate 1
chr2_-_127945 4.20 ENSDART00000056453
insulin-like growth factor binding protein 1b
chr13_-_41901225 4.12 ENSDART00000167582
inositol polyphosphate multikinase a
chr2_+_17055069 4.11 ENSDART00000115078
thrombopoietin
chr13_-_43149063 4.11 ENSDART00000099601
V-set immunoregulatory receptor
chr16_+_23984179 4.11 ENSDART00000175879
apolipoprotein C-II
chr3_-_32541033 4.02 ENSDART00000151476
ENSDART00000055324
reticulocalbin 3, EF-hand calcium binding domain
chr15_+_19324697 3.95 ENSDART00000022015
VPS26 retromer complex component B
chr2_-_29996036 3.94 ENSDART00000020792
canopy1
chr16_-_42186093 3.94 ENSDART00000076030
fibrillarin
chr10_+_8401929 3.86 ENSDART00000059028
hydrogen voltage-gated channel 1
chr21_+_26991198 3.85 ENSDART00000065397
FK506 binding protein 2
chr20_-_33566640 3.82 ENSDART00000159729
si:dkey-65b13.9
chr3_-_402714 3.80 ENSDART00000134062
ENSDART00000105659
major histocompatibility complex class I ZJA
chr3_+_21200763 3.77 ENSDART00000067841
zgc:112038
chr16_+_29516098 3.76 ENSDART00000174895
cathepsin S, ortholog 2, tandem duplicate 2
chr14_-_46113321 3.73 ENSDART00000169040
ENSDART00000161475
ENSDART00000124925
si:ch211-235e9.8
chr3_+_19336286 3.66 ENSDART00000111528
KRI1 homolog
chr3_+_62161184 3.66 ENSDART00000090370
ENSDART00000192665
NADPH oxidase organizer 1a
chr11_+_42474694 3.64 ENSDART00000056048
ENSDART00000184710
si:ch1073-165f9.2
chr3_-_32925476 3.63 ENSDART00000189673
amine oxidase, copper containing 2
chr25_-_3867990 3.62 ENSDART00000075663
calcium release activated channel regulator 2B
chr12_+_17154655 3.62 ENSDART00000028003
ankyrin repeat domain 22
chr4_-_8795250 3.61 ENSDART00000169823
patatin-like phospholipase domain containing 3
chr15_-_37875601 3.59 ENSDART00000122439
si:dkey-238d18.4
chr15_+_12377887 3.57 ENSDART00000170769
interleukin 10 receptor, alpha
chr20_-_7176809 3.55 ENSDART00000012247
ENSDART00000125019
24-dehydrocholesterol reductase
chr3_-_16784280 3.48 ENSDART00000137108
ENSDART00000137276
si:dkey-30j10.5
chr17_-_4395373 3.40 ENSDART00000015923
kelch-like family member 10a
chr1_-_55116453 3.39 ENSDART00000142348
SERTA domain containing 2a
chr19_+_7115223 3.37 ENSDART00000001359
proteasome subunit beta 12
chr3_+_25999477 3.36 ENSDART00000024316
minichromosome maintenance complex component 5
chr2_-_37537887 3.36 ENSDART00000143496
ENSDART00000025841
rho/rac guanine nucleotide exchange factor (GEF) 18a
chr20_-_25518488 3.33 ENSDART00000186993
cytochrome P450, family 2, subfamily N, polypeptide 13
chr25_-_13728111 3.32 ENSDART00000169865
lecithin-cholesterol acyltransferase
chr18_+_25546227 3.31 ENSDART00000085824
peroxisomal biogenesis factor 11 alpha
chr9_+_29985010 3.30 ENSDART00000020743
cms1 ribosomal small subunit homolog (yeast)
chr23_+_17939611 3.29 ENSDART00000104618
chitinase, acidic.6
chr6_-_7438584 3.28 ENSDART00000053776
FK506 binding protein 11
chr21_+_8533533 3.28 ENSDART00000077924

chr8_+_52515188 3.27 ENSDART00000163668
si:ch1073-392o20.2
chr13_-_337318 3.23 ENSDART00000166175
zgc:171534
chr12_-_33789006 3.20 ENSDART00000034550
lethal giant larvae homolog 2 (Drosophila)
chr7_+_58179513 3.19 ENSDART00000123117
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr3_-_32956808 3.16 ENSDART00000183902
caspase 6, apoptosis-related cysteine peptidase, like 1
chr8_+_14886452 3.13 ENSDART00000146589
sterol O-acyltransferase 1
chr6_+_3710865 3.13 ENSDART00000170781
phosphatase, orphan 2
chr20_-_7072487 3.11 ENSDART00000145954
si:ch211-121a2.2
chr16_-_15263099 3.10 ENSDART00000125691
syntrophin, basic 1
chr4_-_8043839 3.08 ENSDART00000190047
ENSDART00000057567
si:ch211-240l19.5
chr8_-_36475328 3.07 ENSDART00000048448
si:busm1-266f07.2
chr3_+_18795570 3.06 ENSDART00000042368
fumarylacetoacetate hydrolase domain containing 1
chr3_+_3681116 3.05 ENSDART00000109618
ADP-ribosyltransferase 4 (Dombrock blood group)
chr16_-_53259409 3.04 ENSDART00000157080
si:ch211-269k10.4
chr7_-_60831082 3.04 ENSDART00000073654
ENSDART00000136999
pyruvate carboxylase b
chr4_-_12997587 3.04 ENSDART00000140532
si:dkey-6a5.3
chr10_+_28428222 3.01 ENSDART00000135003
si:ch211-222e20.4
chr24_-_25098719 2.98 ENSDART00000193651
pleckstrin homology-like domain, family B, member 2b
chr2_+_36608387 2.97 ENSDART00000159541
p21 protein (Cdc42/Rac)-activated kinase 2a
chr7_+_9922607 2.97 ENSDART00000184532
ENSDART00000113396
ceramide synthase 3a
chr17_-_13072334 2.96 ENSDART00000159598

chr18_-_40773413 2.96 ENSDART00000133797
vasodilator stimulated phosphoprotein b
chr5_-_25620594 2.96 ENSDART00000189346
cytochrome P450, family 1, subfamily D, polypeptide 1
chr22_-_26353916 2.95 ENSDART00000077958
calpain 2, (m/II) large subunit b
chr6_+_612594 2.88 ENSDART00000150903
kynureninase
chr11_+_14284866 2.88 ENSDART00000163729
si:ch211-262i1.3
chr4_-_78020361 2.85 ENSDART00000159559
ENSDART00000162341
pepsinogen 3, group I (pepsinogen A)
chr10_+_27096043 2.83 ENSDART00000064107
ENSDART00000159751
CXADR, Ig-like cell adhesion molecule
chr11_-_42134968 2.80 ENSDART00000187115

chr14_+_10567104 2.80 ENSDART00000160723
G protein-coupled receptor 174
chr4_-_20313810 2.76 ENSDART00000136350
decapping mRNA 1B
chr24_+_32525146 2.75 ENSDART00000132417
ENSDART00000110185
YME1-like 1a
chr19_-_7115229 2.70 ENSDART00000001930
proteasome subunit beta 13a
chr23_+_42813415 2.70 ENSDART00000055577
myosin, light chain 9a, regulatory
chr24_-_32582378 2.67 ENSDART00000066590
retinol dehydrogenase 12, like
chr15_-_16884912 2.67 ENSDART00000062135
zgc:103681
chr11_-_16975190 2.67 ENSDART00000122222
succinate-CoA ligase, GDP-forming, beta subunit
chr13_-_4223955 2.64 ENSDART00000113060
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr7_+_52154215 2.61 ENSDART00000098712
zgc:77041
chr1_-_56032619 2.60 ENSDART00000143793
complement component c3a, duplicate 4
chr4_+_2230701 2.58 ENSDART00000080439
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr5_-_29152457 2.57 ENSDART00000078469
NADPH oxidase activator 1
chr18_+_3572314 2.57 ENSDART00000169814
ENSDART00000157819
stress-associated endoplasmic reticulum protein 1
chr12_-_30549022 2.56 ENSDART00000102474
zgc:158404
chr3_-_32596394 2.56 ENSDART00000103239
tetraspanin 4b
chr20_+_32406011 2.54 ENSDART00000018640
ENSDART00000137910
sorting nexin 3
chr15_-_1745408 2.54 ENSDART00000182311
syntaxin 1A (brain)
chr24_-_33308045 2.54 ENSDART00000149711
solute carrier family 4 (anion exchanger), member 2b
chr2_-_37140423 2.53 ENSDART00000144220
tetraspanin 37
chr15_-_6946286 2.53 ENSDART00000019330
enoyl CoA hydratase 1, peroxisomal
chr23_+_46157638 2.49 ENSDART00000076048
bloodthirsty-related gene family, member 32
chr15_-_29573267 2.48 ENSDART00000099947
SAM domain, SH3 domain and nuclear localisation signals 1a
chr2_-_37532772 2.45 ENSDART00000133951
rho/rac guanine nucleotide exchange factor (GEF) 18a
chr3_+_1030479 2.44 ENSDART00000143449
zgc:172253
chr7_+_48806420 2.43 ENSDART00000083431
carnitine palmitoyltransferase 1Aa (liver)
chr3_+_12764894 2.43 ENSDART00000166071
cytochrome P450, family 2, subfamily K, polypeptide16
chr24_-_26715174 2.42 ENSDART00000079726
phospholipase D1b
chr19_-_12965020 2.42 ENSDART00000128975
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr3_-_45822914 2.41 ENSDART00000155879
si:ch211-66h3.4
chr16_+_42018367 2.41 ENSDART00000058613
Fli-1 proto-oncogene, ETS transcription factor b
chr3_+_29445473 2.40 ENSDART00000020381
GRB2-related adaptor protein 2a
chr14_-_10617127 2.39 ENSDART00000154299
si:dkey-92i17.2
chr9_+_20853894 2.36 ENSDART00000003648
WD repeat domain 3
chr5_+_26686279 2.36 ENSDART00000193543
transport and golgi organization 2 homolog (Drosophila)
chr8_-_23783633 2.33 ENSDART00000132657
si:ch211-163l21.7
chr5_-_48680580 2.33 ENSDART00000031194
LysM, putative peptidoglycan-binding, domain containing 3
chr5_+_4533244 2.33 ENSDART00000158826
Danio rerio thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (LOC561325), mRNA.
chr24_-_11068280 2.32 ENSDART00000190602

chr23_-_31645760 2.31 ENSDART00000035031
serum/glucocorticoid regulated kinase 1
chr8_+_30742898 2.31 ENSDART00000018475
small nuclear ribonucleoprotein D3 polypeptide
chr17_+_24684778 2.30 ENSDART00000146309
ENSDART00000082237
zinc finger protein 593
chr20_+_46216431 2.27 ENSDART00000185384
syntaxin 7-like
chr1_-_58573646 2.25 ENSDART00000167777
adhesion G protein-coupled receptor E5b, duplicate 3
chr1_-_58561963 2.25 ENSDART00000165040
solute carrier family 27 (fatty acid transporter), member 1b
chr9_-_9415000 2.25 ENSDART00000146210
si:ch211-214p13.9
chr5_+_24087035 2.24 ENSDART00000183644
tumor protein p53
chr14_+_12170460 2.24 ENSDART00000146521
ras homolog gene family, member Gd
chr4_+_25607101 2.21 ENSDART00000133929
acyl-CoA thioesterase 14
chr18_-_44847855 2.21 ENSDART00000086823
signal recognition particle receptor (docking protein)
chr15_-_8309207 2.20 ENSDART00000143880
ENSDART00000061351
tumor necrosis factor receptor superfamily, member 19
chr2_-_13333932 2.18 ENSDART00000150238
ENSDART00000168258
si:dkey-185p13.1
vacuolar protein sorting 4b homolog B (S. cerevisiae)
chr4_+_18843015 2.17 ENSDART00000152086
ENSDART00000066977
ENSDART00000132567
BCL2 interacting killer
chr23_-_13875252 2.16 ENSDART00000104834
ENSDART00000193807
glucose-6-phosphate dehydrogenase
chr9_-_28616436 2.16 ENSDART00000136985
si:ch73-7i4.2
chr6_-_43262400 2.14 ENSDART00000156267
FERM domain containing 4Ba
chr3_-_40202607 2.14 ENSDART00000074757
zinc finger protein 598
chr9_-_20853439 2.13 ENSDART00000028247
ENSDART00000133321
ganglioside induced differentiation associated protein 2
chr8_-_24252933 2.11 ENSDART00000057624
zgc:110353
chr8_-_4760723 2.10 ENSDART00000064201
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr16_+_11585576 2.10 ENSDART00000172967
si:dkey-11o1.6
chr6_-_40071899 2.09 ENSDART00000034730
Sec61 translocon alpha 1 subunit
chr9_-_5337923 2.08 ENSDART00000017939
TNF superfamily member 13b
chr17_+_22102791 2.07 ENSDART00000047772
mal, T cell differentiation protein
chr13_+_24671481 2.07 ENSDART00000001678
ADAM metallopeptidase domain 8a
chr13_+_22717366 2.05 ENSDART00000134122
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr18_-_38244871 2.05 ENSDART00000076399
N-acetyltransferase 10
chr3_+_1735214 2.04 ENSDART00000185454

chr19_+_770300 2.04 ENSDART00000062518
glutathione S-transferase rho
chr15_-_33964897 2.04 ENSDART00000172075
ENSDART00000158126
ENSDART00000160456
lipolysis stimulated lipoprotein receptor
chr21_-_20929575 2.03 ENSDART00000163889
complement component 6
chr9_-_41040492 2.02 ENSDART00000163164
adenosine deaminase, tRNA-specific 3
chr14_+_1007169 2.01 ENSDART00000172676
coagulation factor VIII, procoagulant component
chr14_-_33260858 1.99 ENSDART00000186403
ENSDART00000111397
glycerophosphodiester phosphodiesterase domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of irx5a+irx5b_irx3a+irx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 13.8 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
2.0 6.1 GO:2000257 regulation of protein activation cascade(GO:2000257)
2.0 5.9 GO:0018872 arsonoacetate metabolic process(GO:0018872)
1.9 7.4 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
1.4 7.1 GO:0042182 ketone catabolic process(GO:0042182)
1.2 11.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.0 4.8 GO:0010719 photoreceptor cell morphogenesis(GO:0008594) negative regulation of epithelial to mesenchymal transition(GO:0010719)
1.0 7.6 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.9 10.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.9 4.7 GO:0010693 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.9 3.6 GO:0010896 regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.9 2.6 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.9 1.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.8 3.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.7 2.2 GO:1901216 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.7 5.9 GO:0071467 cellular response to pH(GO:0071467)
0.7 2.9 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.7 5.0 GO:0003188 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.7 2.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.7 2.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.6 5.7 GO:0031126 snoRNA 3'-end processing(GO:0031126)
0.6 3.7 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.6 2.4 GO:0032530 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.6 3.3 GO:0016559 peroxisome fission(GO:0016559)
0.5 1.6 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.5 1.6 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.5 2.1 GO:0001782 B cell homeostasis(GO:0001782) positive regulation of B cell proliferation(GO:0030890)
0.5 8.8 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.5 1.5 GO:0019695 choline metabolic process(GO:0019695)
0.5 4.9 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.5 10.6 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.5 2.8 GO:0044209 AMP salvage(GO:0044209)
0.5 4.7 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.5 2.8 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.4 2.2 GO:0031652 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.4 8.9 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.4 2.2 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.4 9.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 1.3 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.4 1.7 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.4 1.6 GO:0097037 heme export(GO:0097037)
0.4 1.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.4 1.2 GO:1904478 regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.4 3.1 GO:0000479 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.4 1.6 GO:0051661 maintenance of centrosome location(GO:0051661)
0.4 4.3 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 4.2 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.4 4.2 GO:0050892 intestinal absorption(GO:0050892)
0.4 4.2 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.4 1.1 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.4 1.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.4 2.8 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.4 1.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.3 3.1 GO:0034435 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.3 7.2 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.3 0.3 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.3 8.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 1.3 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.3 5.5 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.3 2.6 GO:0042554 superoxide anion generation(GO:0042554)
0.3 1.0 GO:0072337 modified amino acid transport(GO:0072337)
0.3 1.6 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.6 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.3 3.3 GO:0006032 chitin catabolic process(GO:0006032)
0.3 2.1 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3 7.8 GO:0051180 vitamin transport(GO:0051180)
0.3 0.9 GO:0001692 histamine metabolic process(GO:0001692)
0.3 1.5 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 1.2 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.3 1.3 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.3 2.7 GO:0045444 fat cell differentiation(GO:0045444)
0.3 2.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.3 1.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.3 1.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.3 1.0 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 1.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 4.7 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.2 1.0 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 1.0 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 0.9 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.2 2.2 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.2 0.8 GO:0008334 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) histone mRNA metabolic process(GO:0008334)
0.2 4.8 GO:0015701 bicarbonate transport(GO:0015701)
0.2 1.2 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.2 3.0 GO:0046686 response to cadmium ion(GO:0046686)
0.2 0.8 GO:0050994 regulation of lipid catabolic process(GO:0050994)
0.2 1.2 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.2 1.0 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.2 1.0 GO:0019079 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.2 4.1 GO:0002574 thrombocyte differentiation(GO:0002574)
0.2 6.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 2.8 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.2 0.6 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 5.8 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.2 1.7 GO:0010888 negative regulation of cholesterol storage(GO:0010887) negative regulation of lipid storage(GO:0010888)
0.2 3.7 GO:0006801 superoxide metabolic process(GO:0006801)
0.2 1.8 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.2 0.5 GO:0048785 hatching gland development(GO:0048785)
0.2 3.6 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.2 0.5 GO:1902626 mature ribosome assembly(GO:0042256) assembly of large subunit precursor of preribosome(GO:1902626)
0.2 1.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 0.8 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.2 0.5 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.2 1.6 GO:0042989 sequestering of actin monomers(GO:0042989)
0.2 0.5 GO:0009258 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 6.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 0.6 GO:0090230 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.1 5.4 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 0.7 GO:0072574 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.1 0.4 GO:0097095 frontonasal suture morphogenesis(GO:0097095)
0.1 1.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.2 GO:0055015 ventricular cardiac muscle cell development(GO:0055015)
0.1 0.6 GO:0006404 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.1 0.7 GO:0031053 primary miRNA processing(GO:0031053)
0.1 0.4 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 1.3 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.4 GO:0009268 response to pH(GO:0009268)
0.1 1.3 GO:0051382 kinetochore assembly(GO:0051382)
0.1 1.0 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 1.4 GO:0050779 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 1.6 GO:0033198 response to ATP(GO:0033198)
0.1 0.5 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.1 1.3 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.1 0.4 GO:0045987 eating behavior(GO:0042755) positive regulation of smooth muscle contraction(GO:0045987)
0.1 0.5 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 1.0 GO:0071357 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 3.4 GO:0019835 cytolysis(GO:0019835)
0.1 1.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 15.4 GO:0042742 defense response to bacterium(GO:0042742)
0.1 2.5 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 1.1 GO:0098787 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.5 GO:0034087 establishment of mitotic sister chromatid cohesion(GO:0034087) establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 6.1 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1 12.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 3.0 GO:0001843 neural tube closure(GO:0001843)
0.1 1.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.1 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 0.3 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 8.0 GO:0007596 blood coagulation(GO:0007596)
0.1 1.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 3.8 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 0.4 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.1 1.7 GO:0014823 response to activity(GO:0014823)
0.1 0.7 GO:0061511 centriole elongation(GO:0061511)
0.1 0.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.6 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 4.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 1.7 GO:0015693 magnesium ion transport(GO:0015693)
0.1 2.7 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 1.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 6.6 GO:0009308 amine metabolic process(GO:0009308)
0.1 1.9 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.1 2.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 2.1 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 0.7 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 1.8 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 9.2 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.9 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.1 3.0 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 0.7 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.0 GO:0050909 sensory perception of taste(GO:0050909)
0.1 0.8 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 2.6 GO:0072376 complement activation(GO:0006956) protein activation cascade(GO:0072376)
0.1 1.6 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 8.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 2.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 1.9 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.6 GO:0009217 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.1 0.6 GO:0070285 pigment cell development(GO:0070285)
0.1 0.6 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.1 3.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 1.9 GO:0006270 DNA replication initiation(GO:0006270)
0.1 2.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.9 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.1 0.5 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.1 6.0 GO:0007030 Golgi organization(GO:0007030)
0.1 0.4 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.1 0.8 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.7 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 1.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 0.4 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 1.3 GO:0051492 regulation of stress fiber assembly(GO:0051492)
0.1 0.5 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 2.4 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 0.8 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.1 0.7 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 0.6 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.1 0.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529)
0.1 3.9 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.1 1.3 GO:0010324 membrane invagination(GO:0010324)
0.1 0.7 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.1 0.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 2.8 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.3 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.1 0.9 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 3.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 4.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.3 GO:0019563 glycerol catabolic process(GO:0019563)
0.1 2.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 0.7 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 0.2 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.1 1.1 GO:0098781 ncRNA transcription(GO:0098781)
0.1 0.6 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.3 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.0 6.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 22.4 GO:0006955 immune response(GO:0006955)
0.0 1.1 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.4 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 1.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 2.0 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043280)
0.0 0.9 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.7 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.2 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 0.7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.4 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.0 0.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.2 GO:0090280 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) positive regulation of calcium ion import(GO:0090280)
0.0 0.4 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0 0.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.9 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.7 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.5 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0030859 polarized epithelial cell differentiation(GO:0030859)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.8 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 4.2 GO:0008033 tRNA processing(GO:0008033)
0.0 1.8 GO:0036303 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 6.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.5 GO:0036065 fucosylation(GO:0036065)
0.0 0.7 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 1.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.5 GO:0031398 positive regulation of protein ubiquitination(GO:0031398) positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.0 0.7 GO:0051923 sulfation(GO:0051923)
0.0 0.2 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.0 1.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 1.4 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 1.2 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 2.7 GO:0008202 steroid metabolic process(GO:0008202)
0.0 2.0 GO:0009617 response to bacterium(GO:0009617)
0.0 0.8 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.3 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.5 GO:0070672 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 29.7 GO:0006508 proteolysis(GO:0006508)
0.0 0.2 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.1 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.4 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 2.8 GO:0016042 lipid catabolic process(GO:0016042)
0.0 0.5 GO:0061138 morphogenesis of a branching epithelium(GO:0061138)
0.0 0.5 GO:0021986 habenula development(GO:0021986)
0.0 0.1 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.1 GO:2001057 reactive nitrogen species metabolic process(GO:2001057)
0.0 0.5 GO:0034728 nucleosome organization(GO:0034728)
0.0 0.5 GO:0006284 base-excision repair(GO:0006284)
0.0 0.2 GO:0072178 pronephric duct morphogenesis(GO:0039023) nephric duct morphogenesis(GO:0072178)
0.0 0.4 GO:0035305 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.4 GO:0006506 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0 1.5 GO:0022618 ribonucleoprotein complex assembly(GO:0022618)
0.0 0.4 GO:0048821 erythrocyte development(GO:0048821)
0.0 0.1 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.2 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0060974 cell migration involved in heart formation(GO:0060974)
0.0 1.1 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.1 GO:0051642 centrosome localization(GO:0051642)
0.0 1.0 GO:0031497 chromatin assembly(GO:0031497)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0005960 glycine cleavage complex(GO:0005960)
0.9 2.7 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.7 2.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.7 2.6 GO:0061702 inflammasome complex(GO:0061702)
0.7 3.9 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 1.8 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.6 6.5 GO:0030904 retromer complex(GO:0030904)
0.6 2.2 GO:0019815 B cell receptor complex(GO:0019815)
0.4 1.8 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.4 3.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.4 4.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.4 2.0 GO:0031298 replication fork protection complex(GO:0031298)
0.3 2.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.3 2.4 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.3 2.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.3 2.1 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.3 1.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 0.3 GO:0015934 large ribosomal subunit(GO:0015934)
0.3 1.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.2 1.0 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.2 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.2 5.6 GO:0030686 90S preribosome(GO:0030686)
0.2 11.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 6.1 GO:0005839 proteasome core complex(GO:0005839)
0.2 0.8 GO:1904423 dehydrodolichyl diphosphate synthase complex(GO:1904423)
0.2 3.2 GO:0005579 membrane attack complex(GO:0005579)
0.2 1.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 0.9 GO:0043034 costamere(GO:0043034)
0.2 3.2 GO:0042555 MCM complex(GO:0042555)
0.2 1.0 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.2 0.3 GO:0000941 condensed nuclear chromosome inner kinetochore(GO:0000941)
0.2 1.5 GO:0071797 LUBAC complex(GO:0071797)
0.2 4.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 0.5 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.2 1.4 GO:0070652 HAUS complex(GO:0070652)
0.2 0.8 GO:0055087 Ski complex(GO:0055087)
0.1 6.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 3.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.7 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 3.0 GO:0045180 basal cortex(GO:0045180)
0.1 1.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.4 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.2 GO:0044218 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 2.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.1 GO:0045095 keratin filament(GO:0045095)
0.1 1.9 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.7 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 2.0 GO:0005844 polysome(GO:0005844)
0.1 1.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 5.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 10.7 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 4.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 3.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.7 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 2.4 GO:0005876 spindle microtubule(GO:0005876)
0.1 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0030914 STAGA complex(GO:0030914)
0.1 1.0 GO:0005581 collagen trimer(GO:0005581)
0.1 3.6 GO:0005811 lipid particle(GO:0005811)
0.1 9.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 79.6 GO:0005615 extracellular space(GO:0005615)
0.1 6.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 8.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 4.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.9 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.1 GO:0031201 SNARE complex(GO:0031201)
0.0 1.0 GO:0000421 autophagosome membrane(GO:0000421)
0.0 5.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 5.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.6 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.3 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0030139 endocytic vesicle(GO:0030139)
0.0 7.3 GO:0005730 nucleolus(GO:0005730)
0.0 26.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 2.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 7.7 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.1 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 2.9 GO:0012506 vesicle membrane(GO:0012506)
0.0 1.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 3.2 GO:0000785 chromatin(GO:0000785)
0.0 0.3 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 13.8 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
2.8 8.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
2.6 7.8 GO:0005499 vitamin D binding(GO:0005499)
2.0 5.9 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
1.8 7.2 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
1.3 10.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.2 5.9 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.0 3.0 GO:0004736 pyruvate carboxylase activity(GO:0004736)
1.0 5.0 GO:0008131 primary amine oxidase activity(GO:0008131)
1.0 3.0 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.9 10.4 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.9 9.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.9 7.2 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.9 2.7 GO:0004776 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.9 2.6 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.8 4.2 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.8 2.4 GO:0008517 folic acid transporter activity(GO:0008517)
0.8 3.1 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.7 4.3 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.7 6.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.7 7.4 GO:0016594 glycine binding(GO:0016594)
0.7 2.0 GO:0052717 tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.7 4.6 GO:0045735 nutrient reservoir activity(GO:0045735)
0.5 3.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.5 6.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.5 1.5 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.4 1.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 2.0 GO:0043295 glutathione binding(GO:0043295)
0.4 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 10.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.4 1.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.4 4.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.4 1.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.4 1.9 GO:0005542 folic acid binding(GO:0005542)
0.4 1.9 GO:0004001 adenosine kinase activity(GO:0004001)
0.4 2.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 1.7 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
0.3 1.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 1.0 GO:0003999 adenine phosphoribosyltransferase activity(GO:0003999)
0.3 2.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 6.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 8.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 2.7 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.3 4.2 GO:0008061 chitin binding(GO:0008061)
0.3 1.2 GO:0034511 U3 snoRNA binding(GO:0034511)
0.3 7.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 4.8 GO:0045159 myosin II binding(GO:0045159)
0.3 0.8 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.3 1.1 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.3 1.1 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.3 1.8 GO:1903924 estradiol binding(GO:1903924)
0.3 2.1 GO:0002020 protease binding(GO:0002020)
0.2 6.0 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.2 1.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.2 1.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2 1.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 1.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 3.9 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.2 2.3 GO:0035198 miRNA binding(GO:0035198)
0.2 9.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 1.6 GO:0042834 peptidoglycan binding(GO:0042834)
0.2 1.8 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.2 1.1 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 1.0 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 1.6 GO:0015232 heme transporter activity(GO:0015232)
0.2 5.4 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.2 2.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 3.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.8 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.2 9.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 43.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 1.0 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.2 0.6 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.2 2.6 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.2 4.0 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 3.4 GO:0008242 omega peptidase activity(GO:0008242)
0.2 5.0 GO:0008483 transaminase activity(GO:0008483)
0.2 1.7 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 1.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 2.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 14.9 GO:0004540 ribonuclease activity(GO:0004540)
0.2 0.5 GO:0030623 U5 snRNA binding(GO:0030623)
0.2 0.8 GO:0070573 metallodipeptidase activity(GO:0070573)
0.2 2.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.2 0.6 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.2 0.5 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.2 5.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 4.8 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 1.6 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 1.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.3 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 1.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.6 GO:0005463 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.1 0.7 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 1.4 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 0.7 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 1.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) excitatory extracellular ligand-gated ion channel activity(GO:0005231) ATP-gated ion channel activity(GO:0035381)
0.1 2.1 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.1 15.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.7 GO:0005537 mannose binding(GO:0005537)
0.1 2.6 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.1 0.6 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.1 2.1 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.5 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 2.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 5.2 GO:0000049 tRNA binding(GO:0000049)
0.1 2.0 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 0.3 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.1 0.5 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 0.5 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309) double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 1.0 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 1.4 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 6.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.3 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 1.4 GO:0030515 snoRNA binding(GO:0030515)
0.1 19.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 1.5 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.1 1.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 3.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.6 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.1 1.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.3 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 3.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.8 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 2.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.2 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 4.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.6 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.6 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.2 GO:0000035 acyl binding(GO:0000035)
0.1 1.3 GO:0008009 chemokine activity(GO:0008009) chemokine receptor binding(GO:0042379)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 4.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 13.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.4 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 1.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.4 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.9 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 1.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 4.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.1 GO:0005507 copper ion binding(GO:0005507)
0.1 0.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 1.4 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 4.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 4.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 2.1 GO:0071949 FAD binding(GO:0071949)
0.0 3.7 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.2 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 1.8 GO:0043022 ribosome binding(GO:0043022)
0.0 1.9 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0008329 lipopolysaccharide receptor activity(GO:0001875) signaling pattern recognition receptor activity(GO:0008329)
0.0 0.8 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 1.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.0 0.5 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.7 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 4.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.2 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 1.7 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 2.5 GO:0004386 helicase activity(GO:0004386)
0.0 2.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 1.0 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.5 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 11.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.8 GO:0031491 nucleosome binding(GO:0031491)
0.0 7.4 GO:0005525 GTP binding(GO:0005525)
0.0 5.1 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.0 1.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.8 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.3 14.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 1.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 4.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 1.5 PID IL27 PATHWAY IL27-mediated signaling events
0.1 1.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.0 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 0.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 2.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 2.9 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 0.8 PID AURORA A PATHWAY Aurora A signaling
0.0 1.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 7.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.6 PID P73PATHWAY p73 transcription factor network
0.0 2.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.8 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID MYC PATHWAY C-MYC pathway
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 2.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.9 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.8 2.5 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.7 6.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.6 7.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.6 13.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.6 5.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.6 9.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.4 5.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 1.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.3 2.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3 7.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 2.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 2.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 5.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 1.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 2.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 3.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 4.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 4.3 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.2 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.0 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.2 2.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.3 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 0.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 17.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 3.6 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 2.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 1.9 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 1.6 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.8 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 0.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 3.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.7 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 2.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.9 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 1.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 1.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 3.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.2 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 3.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation