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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for irf1a
Z-value: 1.53
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Transcription factors associated with irf1a
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_13681681 Show fit | 27.66 |
ENSDART00000057825
|
complement factor D (adipsin) |
|
| chr19_-_7115229 Show fit | 27.04 |
ENSDART00000001930
|
proteasome subunit beta 13a |
|
| chr5_+_13373593 Show fit | 24.15 |
ENSDART00000051668
ENSDART00000183883 |
chemokine (C-C motif) ligand 19a, tandem duplicate 2 |
|
| chr19_+_7115223 Show fit | 22.86 |
ENSDART00000001359
|
proteasome subunit beta 12 |
|
| chr20_+_26683933 Show fit | 16.61 |
ENSDART00000139852
ENSDART00000077751 |
forkhead box Q1b |
|
| chr19_+_7124337 Show fit | 14.65 |
ENSDART00000031380
|
transporter associated with antigen processing, subunit type a |
|
| chr8_-_36469117 Show fit | 13.97 |
ENSDART00000111240
|
major histocompatibility complex class II DAB gene |
|
| chr4_-_17669881 Show fit | 13.94 |
ENSDART00000066997
|
DNA-damage regulated autophagy modulator 1 |
|
| chr16_+_29514473 Show fit | 12.79 |
ENSDART00000034102
|
cathepsin S, ortholog 2, tandem duplicate 2 |
|
| chr11_-_20096018 Show fit | 12.26 |
ENSDART00000030420
|
opioid growth factor receptor-like 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of irf1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 60.0 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.0 | 58.0 | GO:0035556 | intracellular signal transduction(GO:0035556) |
| 0.1 | 34.2 | GO:0051603 | proteolysis involved in cellular protein catabolic process(GO:0051603) |
| 1.4 | 30.3 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 9.2 | 27.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.6 | 24.1 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.1 | 22.5 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.8 | 14.7 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 0.1 | 14.3 | GO:0017148 | negative regulation of translation(GO:0017148) |
| 1.0 | 14.0 | GO:0019882 | antigen processing and presentation(GO:0019882) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 60.8 | GO:0005615 | extracellular space(GO:0005615) |
| 2.1 | 60.0 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 27.1 | GO:0005764 | lysosome(GO:0005764) |
| 1.7 | 14.0 | GO:0042611 | MHC protein complex(GO:0042611) |
| 2.2 | 13.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 1.0 | 8.9 | GO:0071797 | LUBAC complex(GO:0071797) |
| 1.5 | 8.8 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 1.9 | 7.7 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 7.7 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 7.4 | GO:0031901 | early endosome membrane(GO:0031901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 51.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 28.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 25.5 | GO:0032182 | ubiquitin-like protein binding(GO:0032182) |
| 0.5 | 24.1 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.4 | 23.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 20.7 | GO:0008270 | zinc ion binding(GO:0008270) |
| 2.2 | 15.4 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.5 | 14.9 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 12.5 | GO:0043492 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492) |
| 0.1 | 10.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 17.3 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.4 | 11.4 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.5 | 8.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 7.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.8 | 6.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.2 | 4.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.2 | 4.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 3.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 27.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.9 | 18.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.6 | 16.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 11.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.3 | 11.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.1 | 10.2 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.2 | 9.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.9 | 8.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.9 | 8.3 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 1.0 | 7.2 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |