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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf1a

Z-value: 1.53

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Transcription factors associated with irf1a

Gene Symbol Gene ID Gene Info
ENSDARG00000043492 interferon regulatory factor 1a

Activity profile of irf1a motif

Sorted Z-values of irf1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_13681681 27.66 ENSDART00000057825
complement factor D (adipsin)
chr19_-_7115229 27.04 ENSDART00000001930
proteasome subunit beta 13a
chr5_+_13373593 24.15 ENSDART00000051668
ENSDART00000183883
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr19_+_7115223 22.86 ENSDART00000001359
proteasome subunit beta 12
chr20_+_26683933 16.61 ENSDART00000139852
ENSDART00000077751
forkhead box Q1b
chr19_+_7124337 14.65 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr8_-_36469117 13.97 ENSDART00000111240
major histocompatibility complex class II DAB gene
chr4_-_17669881 13.94 ENSDART00000066997
DNA-damage regulated autophagy modulator 1
chr16_+_29514473 12.79 ENSDART00000034102
cathepsin S, ortholog 2, tandem duplicate 2
chr11_-_20096018 12.26 ENSDART00000030420
opioid growth factor receptor-like 2
chr1_-_52431220 12.11 ENSDART00000111256
zgc:194101
chr22_-_10158038 11.58 ENSDART00000047444
RanBP-type and C3HC4-type zinc finger containing 1
chr9_+_25330905 11.55 ENSDART00000101470
integral membrane protein 2Bb
chr4_-_12795030 11.36 ENSDART00000150427
beta-2-microglobulin
chr21_+_8533533 11.00 ENSDART00000077924

chr5_-_57723929 10.97 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr1_-_25177086 10.75 ENSDART00000144711
ENSDART00000177225
transmembrane protein 154
chr1_-_52447364 10.72 ENSDART00000140740
si:ch211-217k17.10
chr22_-_36926342 10.46 ENSDART00000151804
si:dkey-37m8.11
chr11_+_1575435 10.43 ENSDART00000155713
ENSDART00000156562
si:dkey-40c23.1
chr14_+_36889893 10.31 ENSDART00000124159
si:ch211-132p1.3
chr4_+_5842433 10.22 ENSDART00000124085
ENSDART00000179848
ubiquitin specific peptidase 18
chr19_+_23296616 9.90 ENSDART00000134567
immunity-related GTPase family, f1
chr22_-_10580194 9.71 ENSDART00000105848
si:dkey-42i9.7
chr4_-_76206413 9.17 ENSDART00000170738
si:ch211-106j21.5
chr23_+_642001 9.07 ENSDART00000030643
ENSDART00000124850
interferon regulatory factor 10
chr22_-_18164671 9.02 ENSDART00000014057
regulatory factor X-associated ankyrin-containing protein
chr3_+_29941777 8.95 ENSDART00000113889
interferon-induced protein 35
chr19_-_325584 8.83 ENSDART00000134266
glycerol-3-phosphate dehydrogenase 1c
chr15_-_29162193 8.82 ENSDART00000138449
ENSDART00000099885
XIAP associated factor 1
chr22_-_5553007 8.74 ENSDART00000165269
zgc:171601
chr2_-_42035250 8.66 ENSDART00000056460
ENSDART00000140788
guanylate binding protein 1
chr3_+_1724941 8.55 ENSDART00000193402

chr16_-_51271962 8.53 ENSDART00000164021
ENSDART00000046420
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1
chr6_+_52947699 8.47 ENSDART00000180913
ubiquitin-like modifier activating enzyme 7
chr10_+_5060191 8.36 ENSDART00000145908
ENSDART00000122397
coactivator-associated arginine methyltransferase 1, like
chr7_-_60351876 8.34 ENSDART00000098563
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr22_-_18164835 8.30 ENSDART00000143189
regulatory factor X-associated ankyrin-containing protein
chr22_+_36902352 8.21 ENSDART00000036273
tripartite motif containing 35-20
chr15_-_47929455 8.17 ENSDART00000064462
proteasome subunit alpha 6, like
chr4_-_76370630 7.96 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
chr23_+_642395 7.82 ENSDART00000186995
interferon regulatory factor 10
chr19_+_14115838 7.79 ENSDART00000192057
keratinocyte differentiation factor 1b
chr16_-_50952266 7.74 ENSDART00000165408
si:dkeyp-97a10.3
chr24_+_12945803 7.67 ENSDART00000005105
proteasome activator subunit 1
chr23_+_46183410 7.62 ENSDART00000167596
ENSDART00000151149
ENSDART00000150896
bloodthirsty-related gene family, member 31
chr1_-_7930679 7.50 ENSDART00000146090
si:dkey-79f11.10
chr1_-_58002973 7.28 ENSDART00000140390
si:ch211-114l13.9
chr20_+_51199666 7.10 ENSDART00000169321
heat shock protein 90, alpha (cytosolic), class B member 1
chr5_-_825920 7.01 ENSDART00000126982
zgc:158463
chr21_-_22673758 7.00 ENSDART00000164910
grass carp reovirus (GCRV)-induced gene 2i
chr6_+_52947186 6.92 ENSDART00000155831
ubiquitin-like modifier activating enzyme 7
chr3_-_48980319 6.85 ENSDART00000165319
finTRIM family, member 42
chr13_+_47810211 6.83 ENSDART00000122964
zmp:0000001006
chr3_+_1942219 6.78 ENSDART00000114520
zgc:165583
chr4_+_25558849 6.74 ENSDART00000113663
ENSDART00000100755
ENSDART00000111416
ENSDART00000127840
ENSDART00000168618
ENSDART00000111820
ENSDART00000113866
ENSDART00000110107
ENSDART00000111344
ENSDART00000108548
zgc:195175
chr9_+_42269059 6.54 ENSDART00000113435
si:dkey-10c21.1
chr22_+_29990448 6.32 ENSDART00000165313
si:dkey-286j15.3
chr3_-_4760384 6.20 ENSDART00000108810

chr17_-_23631400 6.16 ENSDART00000079563
Fas cell surface death receptor
chr6_-_1223551 5.97 ENSDART00000182112

chr11_+_1584747 5.92 ENSDART00000154583
si:dkey-40c23.2
chr11_+_37638873 5.77 ENSDART00000186384
ENSDART00000184291
ENSDART00000131782
ENSDART00000140502
SH2 domain containing 5
chr4_-_76129431 5.73 ENSDART00000162809
si:ch211-106j21.2
chr23_+_5736226 5.70 ENSDART00000134527
ENSDART00000112220
finTRIM family, member 57
chr3_-_37148594 5.66 ENSDART00000140855
MLX, MAX dimerization protein
chr5_+_38680061 5.61 ENSDART00000143259
si:dkey-58f10.11
chr4_-_76027176 5.58 ENSDART00000165718
si:dkey-71l4.1
chr22_-_15693085 5.52 ENSDART00000141861
si:ch1073-396h14.1
chr3_-_367283 5.52 ENSDART00000155936
ENSDART00000161964
ENSDART00000158560
ENSDART00000135595
ENSDART00000145890
major histocompatibility complex class I ZAA
chr4_-_76079075 5.50 ENSDART00000158469
si:ch211-232d10.3
chr11_+_37251825 5.40 ENSDART00000169804
interleukin 17 receptor C
chr22_-_6465060 5.34 ENSDART00000081687
zgc:172133
chr18_+_14684115 5.34 ENSDART00000108469
spermatogenesis associated 2-like
chr11_-_30341431 5.30 ENSDART00000078378
CASP8 and FADD-like apoptosis regulator a
chr13_+_27328098 5.26 ENSDART00000037585
Mab-21 domain containing 1
chr3_-_34586403 5.22 ENSDART00000151515
septin 9a
chr18_-_38270077 5.21 ENSDART00000185546
cell cycle associated protein 1b
chr25_+_4979446 5.14 ENSDART00000154131
ENSDART00000155537
si:ch73-265h17.1
chr18_-_38270596 5.07 ENSDART00000098889
cell cycle associated protein 1b
chr4_-_75616197 5.04 ENSDART00000157778
si:dkey-71l4.3
chr1_+_58360935 5.01 ENSDART00000140754
si:dkey-222h21.1
chr25_+_8955530 5.00 ENSDART00000156444
si:ch211-256a21.4
chr5_-_26247973 4.99 ENSDART00000098527
endoplasmic reticulum aminopeptidase 1b
chr5_+_38679623 4.99 ENSDART00000131879
ENSDART00000170010
si:dkey-58f10.11
si:dkey-58f10.10
chr5_-_41841675 4.96 ENSDART00000141683
si:dkey-65b12.6
chr4_-_76239517 4.87 ENSDART00000172599
si:ch211-106j21.6
chr25_-_13553055 4.81 ENSDART00000103831
ENSDART00000139290
anoctamin 10b
chr9_-_18215644 4.74 ENSDART00000145876
epithelial stromal interaction 1
chr5_-_26247671 4.64 ENSDART00000145187
endoplasmic reticulum aminopeptidase 1b
chr19_-_15281996 4.60 ENSDART00000103784
endothelin 2
chr25_-_31629095 4.56 ENSDART00000170673
ENSDART00000166930
laminin, beta 1a
chr17_+_25833947 4.54 ENSDART00000044328
ENSDART00000154604
acyl-CoA synthetase short chain family member 1
chr9_+_23765587 4.50 ENSDART00000145120
si:ch211-219a4.3
chr5_+_38684651 4.46 ENSDART00000137852
si:dkey-58f10.10
chr19_+_4066449 4.42 ENSDART00000162461
bloodthirsty-related gene family, member 26
chr4_+_60482963 4.39 ENSDART00000157679
si:dkey-211i20.2
chr18_-_14901437 4.34 ENSDART00000145842
ENSDART00000008035
TraB domain containing
chr4_-_75511162 4.32 ENSDART00000157651
si:dkey-71l4.5
chr6_-_19271210 4.31 ENSDART00000163628
ENSDART00000159124
zgc:174863
chr20_-_20402500 4.31 ENSDART00000190747
ENSDART00000185065
protein kinase C, eta, b
chr8_-_12867128 4.19 ENSDART00000142201
solute carrier family 2 (facilitated glucose transporter), member 6
chr4_-_60916298 4.18 ENSDART00000142335
si:dkey-196n19.2
chr16_-_40459104 4.16 ENSDART00000032389
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr3_-_7974028 4.10 ENSDART00000144459
tripartite motif containing 35-22
chr23_-_35649000 4.06 ENSDART00000053310
transmembrane protein 18
chr12_-_37299646 4.04 ENSDART00000146142
ENSDART00000085201
peripheral myelin protein 22b
chr3_-_11040575 4.03 ENSDART00000159802

chr23_-_6865946 4.02 ENSDART00000056426
finTRIM family, member 58
chr7_+_26049818 4.00 ENSDART00000173611
si:dkey-6n21.12
chr5_-_26247215 3.99 ENSDART00000136806
endoplasmic reticulum aminopeptidase 1b
chr18_-_38270430 3.97 ENSDART00000139519
cell cycle associated protein 1b
chr15_+_28355023 3.95 ENSDART00000122159
si:dkey-118k5.3
chr3_-_7997887 3.92 ENSDART00000172256
si:ch211-175l6.2
chr3_+_48473346 3.83 ENSDART00000166294
meteorin, glial cell differentiation regulator-like
chr7_-_7984015 3.78 ENSDART00000163203
si:cabz01030277.1
chr3_-_10739625 3.70 ENSDART00000156144
zgc:112965
chr20_-_26936887 3.70 ENSDART00000160827
finTRIM family, member 79
chr3_-_22366032 3.63 ENSDART00000029849
interferon phi 1
chr22_-_17459587 3.54 ENSDART00000142267
si:ch211-197g15.10
chr1_-_8141135 3.36 ENSDART00000152295
si:dkeyp-9d4.4
chr22_-_5958066 3.35 ENSDART00000145821
si:rp71-36a1.3
chr4_+_70911498 3.33 ENSDART00000157674
si:dkey-16p6.1
chr4_-_60790123 3.31 ENSDART00000137702
si:dkey-254e13.6
chr4_-_71177920 3.30 ENSDART00000158287
si:dkey-193i10.1
chr4_+_70317135 3.29 ENSDART00000159286
si:dkey-29j8.1
chr25_-_35960229 3.27 ENSDART00000073434
sorting nexin 20
chr7_-_30492018 3.21 ENSDART00000099639
ENSDART00000162705
ENSDART00000173663
ADAM metallopeptidase domain 10a
chr9_-_23765480 3.17 ENSDART00000027212
si:ch211-219a4.6
chr4_-_25215968 3.17 ENSDART00000066932
ENSDART00000066933
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_71366326 3.08 ENSDART00000170807
si:ch211-76m11.8
chr3_-_1859198 3.03 ENSDART00000121870
MICAL like 1b, duplicate 2
chr8_-_12867434 3.01 ENSDART00000081657
solute carrier family 2 (facilitated glucose transporter), member 6
chr14_-_32893785 2.93 ENSDART00000169380
solute carrier family 25, member 43
chr4_-_75641117 2.92 ENSDART00000182165
si:dkey-71l4.2
chr25_+_245018 2.91 ENSDART00000155344
zgc:92481
chr22_+_9994833 2.78 ENSDART00000172696
ENSDART00000192101

chr1_-_8966046 2.77 ENSDART00000136198
suppressor of cytokine signaling 1b
chr13_-_7387390 2.71 ENSDART00000088322
si:dkey-45k15.1
chr11_-_19775182 2.67 ENSDART00000037894
nicotinamide phosphoribosyltransferase b
chr3_+_36127287 2.67 ENSDART00000058605
ENSDART00000182500
serine carboxypeptidase 1
chr4_-_75615597 2.67 ENSDART00000187794
si:dkey-71l4.3
chr12_-_13549538 2.66 ENSDART00000133895
GH3 domain containing
chr4_+_59841099 2.62 ENSDART00000144806
si:dkey-196n19.2
chr2_-_707152 2.60 ENSDART00000082304
finTRIM family, member 93
chr22_-_5518117 2.52 ENSDART00000164613

chr4_+_70782916 2.51 ENSDART00000187960
si:dkey-16p6.1
chr9_-_14084044 2.43 ENSDART00000141571
fer-1-like family member 6
chr4_-_70057031 2.41 ENSDART00000158207
ENSDART00000184786
ENSDART00000182391
ENSDART00000167979
si:ch211-171l17.14
chr6_+_42338309 2.29 ENSDART00000015277
glutathione peroxidase 1b
chr1_-_8000428 2.26 ENSDART00000133098
si:dkey-79f11.5
chr4_-_71533509 2.24 ENSDART00000122012
ENSDART00000168597
si:dkey-16p6.1
chr1_-_47161996 2.22 ENSDART00000053153
major histocompatibility complex class I ZBA
chr5_+_38685089 2.21 ENSDART00000139743
si:dkey-58f10.10
chr2_-_43745146 2.20 ENSDART00000056164
ENSDART00000098052
finTRIM family, member 96
chr21_-_11632403 2.17 ENSDART00000171708
ENSDART00000138619
ENSDART00000136308
ENSDART00000144770
calpastatin
chr4_+_70967639 2.14 ENSDART00000159230
si:dkeyp-80d11.12
chr23_+_36063599 2.12 ENSDART00000103147
homeobox C12a
chr9_-_9960940 2.10 ENSDART00000092164
protein arginine methyltransferase 2
chr4_-_40008099 2.04 ENSDART00000165574
ENSDART00000171888
si:ch211-215p11.1
chr14_-_48786708 2.00 ENSDART00000169730
si:ch211-199b20.3
chr15_-_41749364 1.98 ENSDART00000155464
finTRIM family, member 73
chr4_-_46948863 1.98 ENSDART00000168835
si:dkey-16p6.1
chr3_-_7961226 1.94 ENSDART00000159801
tripartite motif containing 35-23
chr24_+_24809877 1.93 ENSDART00000185117
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr4_-_50933168 1.93 ENSDART00000150296
si:ch211-208f21.3
chr13_-_47810394 1.91 ENSDART00000105025
zmp:0000001138
chr18_+_8812549 1.90 ENSDART00000017619
IMP (inosine 5'-monophosphate) dehydrogenase 1a
chr16_-_46587938 1.88 ENSDART00000181433

chr18_+_50525109 1.86 ENSDART00000098390
ubiquitin-like 7b (bone marrow stromal cell-derived)
chr5_-_38248347 1.86 ENSDART00000084917
ENSDART00000139479
solute carrier family 12, member 9
chr1_-_38361496 1.85 ENSDART00000015323
F-box protein 8
chr4_+_8016457 1.84 ENSDART00000014036
optineurin
chr19_-_11248982 1.75 ENSDART00000091237
immunity-related GTPase family, f3
chr10_+_40623414 1.71 ENSDART00000187616
zgc:172131
chr7_+_66884570 1.70 ENSDART00000082664
SET binding factor 2
chr22_-_866196 1.66 ENSDART00000146619
DNA-damage regulated autophagy modulator 2b
chr1_+_31706668 1.58 ENSDART00000057879
arsenite methyltransferase
chr22_-_8594846 1.55 ENSDART00000081690
ENSDART00000192241
si:ch73-27e22.1
chr2_-_48539673 1.52 ENSDART00000168202

chr4_-_31699842 1.51 ENSDART00000166400
si:dkey-265e15.5
chr6_+_31684 1.49 ENSDART00000188853
ENSDART00000184553

chr14_+_22397251 1.49 ENSDART00000185239
ENSDART00000124072
ENSDART00000054977
ATPase copper transporting alpha
chr16_+_48678655 1.49 ENSDART00000150156
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr13_-_1151410 1.46 ENSDART00000007231
proteasome subunit beta 1
chr22_-_11520405 1.45 ENSDART00000063157
solute carrier family 26 (anion exchanger), member 11
chr4_+_43522945 1.44 ENSDART00000183921
ENSDART00000181832
si:dkeyp-53e4.4
chr15_-_21702317 1.42 ENSDART00000155824
si:dkey-40g16.6
chr22_+_11520249 1.40 ENSDART00000063147
N-sulfoglucosamine sulfohydrolase (sulfamidase)
chr4_+_29702703 1.35 ENSDART00000167771
si:ch211-214c20.1
chr4_+_29703166 1.33 ENSDART00000132876
si:ch211-214c20.1
chr10_+_2899108 1.33 ENSDART00000147031
endoplasmic reticulum aminopeptidase 1a
chr18_-_12858016 1.32 ENSDART00000130343
poly (ADP-ribose) polymerase family, member 12a
chr3_+_19336286 1.29 ENSDART00000111528
KRI1 homolog
chr2_+_49667767 1.27 ENSDART00000191013
ENSDART00000193757
ENSDART00000187134
ENSDART00000189100

chr4_-_45028479 1.27 ENSDART00000143150
ENSDART00000076870
si:dkey-51d8.1
chr7_+_19600262 1.27 ENSDART00000007310
zgc:171731
chr22_+_10158502 1.26 ENSDART00000005869
ribonuclease P/MRP 14 subunit
chr4_-_42398699 1.24 ENSDART00000164183
si:ch211-59d8.2
chr5_-_38179220 1.21 ENSDART00000147701
si:ch211-284e13.11

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 27.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
2.9 11.6 GO:1903019 negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019)
2.4 7.1 GO:0036363 transforming growth factor beta activation(GO:0036363) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
2.3 11.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
2.2 8.8 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
1.9 60.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
1.6 7.8 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
1.5 6.2 GO:0070227 lymphocyte apoptotic process(GO:0070227)
1.4 30.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.1 4.6 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
1.0 14.0 GO:0019882 antigen processing and presentation(GO:0019882)
0.8 14.7 GO:0046686 response to cadmium ion(GO:0046686)
0.8 4.6 GO:0055016 hypochord development(GO:0055016)
0.8 4.5 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.7 4.0 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.6 10.5 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.6 24.1 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.5 1.6 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.5 8.3 GO:0090279 regulation of calcium ion import(GO:0090279)
0.5 5.3 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.5 2.8 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.5 1.8 GO:0090161 Golgi ribbon formation(GO:0090161)
0.5 3.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.4 2.3 GO:0010269 response to selenium ion(GO:0010269)
0.3 3.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.3 2.2 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.3 8.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.3 1.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.3 2.7 GO:0051601 exocyst localization(GO:0051601)
0.3 7.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.3 0.8 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.2 1.3 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.2 1.9 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.2 1.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.2 3.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.2 1.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 7.7 GO:0010952 positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952)
0.1 8.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 14.3 GO:0017148 negative regulation of translation(GO:0017148)
0.1 6.7 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 1.2 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.1 0.7 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 10.2 GO:0010506 regulation of autophagy(GO:0010506)
0.1 1.9 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 0.9 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.1 3.0 GO:0032456 endocytic recycling(GO:0032456)
0.1 34.2 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.1 1.5 GO:0008272 sulfate transport(GO:0008272)
0.1 5.2 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.1 22.5 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.7 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.0 1.2 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.6 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 58.0 GO:0035556 intracellular signal transduction(GO:0035556)
0.0 2.9 GO:0048738 cardiac muscle tissue development(GO:0048738)
0.0 10.3 GO:0006915 apoptotic process(GO:0006915)
0.0 2.5 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 0.4 GO:0006289 nucleotide-excision repair(GO:0006289)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.3 GO:0042612 MHC class I protein complex(GO:0042612)
2.1 60.0 GO:0005839 proteasome core complex(GO:0005839)
1.9 7.7 GO:0008537 proteasome activator complex(GO:0008537)
1.7 14.0 GO:0042611 MHC protein complex(GO:0042611)
1.5 8.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.0 8.9 GO:0071797 LUBAC complex(GO:0071797)
0.5 7.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.4 2.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.2 4.6 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 5.2 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 7.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 27.1 GO:0005764 lysosome(GO:0005764)
0.1 2.7 GO:0000145 exocyst(GO:0000145)
0.1 6.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 60.8 GO:0005615 extracellular space(GO:0005615)
0.0 1.3 GO:0030686 90S preribosome(GO:0030686)
0.0 5.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 7.7 GO:0030424 axon(GO:0030424)
0.0 0.2 GO:0030428 cell septum(GO:0030428)
0.0 1.8 GO:0055037 recycling endosome(GO:0055037)
0.0 1.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.0 1.1 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 51.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
2.2 8.8 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
2.2 15.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
1.3 7.7 GO:0061133 endopeptidase activator activity(GO:0061133)
1.2 6.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
1.2 3.6 GO:0005132 type I interferon receptor binding(GO:0005132)
1.2 8.4 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
1.1 4.6 GO:0031708 endothelin B receptor binding(GO:0031708)
1.1 3.2 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
1.0 7.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.8 4.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.7 2.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.5 24.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.5 2.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.5 1.6 GO:0030791 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.5 14.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.5 5.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 23.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 2.1 GO:0015440 peptide antigen-transporting ATPase activity(GO:0015433) peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977)
0.4 5.3 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 1.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 2.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.3 1.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.3 0.8 GO:0009041 uridylate kinase activity(GO:0009041)
0.3 25.5 GO:0032182 ubiquitin-like protein binding(GO:0032182)
0.2 7.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 8.3 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.2 2.1 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.2 0.5 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
0.2 0.8 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 3.6 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 28.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 2.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 2.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 8.3 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 12.5 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 0.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 1.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.9 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 10.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 10.2 GO:0004175 endopeptidase activity(GO:0004175)
0.1 2.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 4.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.0 4.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 7.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.4 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 3.8 GO:0060090 binding, bridging(GO:0060090)
0.0 20.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 4.2 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 2.7 GO:0000149 SNARE binding(GO:0000149)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5 17.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.5 8.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.4 11.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 4.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 4.6 PID ENDOTHELIN PATHWAY Endothelins
0.2 7.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.9 PID ARF6 PATHWAY Arf6 signaling events
0.1 0.9 PID IL23 PATHWAY IL23-mediated signaling events
0.0 3.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.1 27.7 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
1.4 7.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.1 10.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
1.0 7.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.9 8.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.9 18.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.9 4.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.9 8.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.8 6.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.6 16.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 9.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 1.5 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 0.9 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 11.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 5.7 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.1 4.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease