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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf10+irf8+irf9

Z-value: 2.37

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Transcription factors associated with irf10+irf8+irf9

Gene Symbol Gene ID Gene Info
ENSDARG00000016457 interferon regulatory factor 9
ENSDARG00000027658 interferon regulatory factor 10
ENSDARG00000056407 interferon regulatory factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf10dr11_v1_chr23_+_642001_6420520.741.1e-17Click!
irf9dr11_v1_chr12_+_13282797_132828070.511.1e-07Click!
irf8dr11_v1_chr18_+_30567945_305679450.431.2e-05Click!

Activity profile of irf10+irf8+irf9 motif

Sorted Z-values of irf10+irf8+irf9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_17776981 31.11 ENSDART00000141693
chemokine (C-C motif) ligand 19b
chr7_+_25033924 27.02 ENSDART00000170873
sb:cb1058
chr19_-_7115229 26.43 ENSDART00000001930
proteasome subunit beta 13a
chr1_-_7951002 23.10 ENSDART00000138187
si:dkey-79f11.8
chr15_+_13984879 22.49 ENSDART00000159438
zgc:162730
chr5_+_13373593 21.58 ENSDART00000051668
ENSDART00000183883
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr19_+_7115223 21.39 ENSDART00000001359
proteasome subunit beta 12
chr19_-_325584 21.34 ENSDART00000134266
glycerol-3-phosphate dehydrogenase 1c
chr2_+_20539402 21.17 ENSDART00000129585
si:ch73-14h1.2
chr16_+_29514473 19.63 ENSDART00000034102
cathepsin S, ortholog 2, tandem duplicate 2
chr4_-_17669881 19.58 ENSDART00000066997
DNA-damage regulated autophagy modulator 1
chr13_+_22675802 19.46 ENSDART00000145538
ENSDART00000143312
zgc:193505
chr20_-_16223245 18.73 ENSDART00000014721
enoyl CoA hydratase domain containing 2
chr1_-_52443379 18.37 ENSDART00000144676
si:ch211-217k17.11
chr3_+_29941777 18.03 ENSDART00000113889
interferon-induced protein 35
chr11_-_20096018 18.02 ENSDART00000030420
opioid growth factor receptor-like 2
chr1_-_25177086 17.77 ENSDART00000144711
ENSDART00000177225
transmembrane protein 154
chr16_+_29509133 17.74 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr16_+_29492937 17.28 ENSDART00000011497
cathepsin K
chr15_-_43625549 17.20 ENSDART00000168589
cathepsin C
chr8_-_27656765 16.72 ENSDART00000078491
Moloney leukemia virus 10b, tandem duplicate 2
chr4_-_26095755 16.43 ENSDART00000100611
ENSDART00000191266
si:ch211-244b2.3
chr4_-_76383223 16.18 ENSDART00000161866
ENSDART00000168456
ENSDART00000174287
ENSDART00000174048
zgc:123107
chr22_-_10580194 16.17 ENSDART00000105848
si:dkey-42i9.7
chr4_-_26108053 16.17 ENSDART00000066951
si:ch211-244b2.4
chr7_-_52417060 15.83 ENSDART00000148579
myocardial zonula adherens protein
chr19_-_7110617 15.66 ENSDART00000104838
proteasome subunit beta 8A
chr4_+_5842433 15.52 ENSDART00000124085
ENSDART00000179848
ubiquitin specific peptidase 18
chr23_+_642001 15.47 ENSDART00000030643
ENSDART00000124850
interferon regulatory factor 10
chr23_-_37536127 15.03 ENSDART00000078253
torsin family 1 like 1
chr6_+_52947699 14.99 ENSDART00000180913
ubiquitin-like modifier activating enzyme 7
chr9_+_23765587 14.95 ENSDART00000145120
si:ch211-219a4.3
chr12_-_30583668 14.77 ENSDART00000153406
caspase 7, apoptosis-related cysteine peptidase
chr19_-_15281996 14.75 ENSDART00000103784
endothelin 2
chr15_+_24588963 14.68 ENSDART00000155075
zgc:198241
chr21_-_22673758 14.60 ENSDART00000164910
grass carp reovirus (GCRV)-induced gene 2i
chr3_-_29941357 14.05 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
granulin a
chr19_+_23296616 13.95 ENSDART00000134567
immunity-related GTPase family, f1
chr16_-_31686602 13.52 ENSDART00000170357
complement component 1, s subcomponent
chr4_-_26107841 13.51 ENSDART00000172012
si:ch211-244b2.4
chr16_-_9802449 13.49 ENSDART00000081208
TAP binding protein (tapasin)-like
chr11_+_1584747 13.43 ENSDART00000154583
si:dkey-40c23.2
chr19_+_7124337 13.41 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr23_+_642395 13.32 ENSDART00000186995
interferon regulatory factor 10
chr22_+_34616151 13.20 ENSDART00000155399
ENSDART00000104705
si:ch1073-214b20.2
chr22_+_19405517 13.12 ENSDART00000138245
ENSDART00000155144
si:dkey-78l4.2
chr3_+_24603923 13.05 ENSDART00000172589
si:dkey-68o6.6
chr1_+_58332000 13.04 ENSDART00000145234
gamma-glutamyltransferase 1 like 2.1
chr6_+_52947186 13.00 ENSDART00000155831
ubiquitin-like modifier activating enzyme 7
chr1_-_7930679 12.96 ENSDART00000146090
si:dkey-79f11.10
chr3_+_1942219 12.79 ENSDART00000114520
zgc:165583
chr3_+_1724941 12.70 ENSDART00000193402

chr12_-_23658888 12.61 ENSDART00000088319
mitogen-activated protein kinase kinase kinase 8
chr4_-_12795030 12.58 ENSDART00000150427
beta-2-microglobulin
chr7_-_66877058 12.41 ENSDART00000155954
adrenomedullin a
chr2_-_37744951 12.40 ENSDART00000144807
myosin IXb
chr17_+_45395846 12.04 ENSDART00000058793
neudesin neurotrophic factor
chr15_+_24572926 11.78 ENSDART00000155636
ENSDART00000187800
dehydrogenase/reductase (SDR family) member 13b
chr25_+_35942867 11.42 ENSDART00000066985
hydroxysteroid (17-beta) dehydrogenase 2
chr18_+_13248956 11.02 ENSDART00000080709
phospholipase C, gamma 2
chr18_-_38270596 10.94 ENSDART00000098889
cell cycle associated protein 1b
chr11_+_11974708 10.90 ENSDART00000125060
zgc:64002
chr17_-_23631400 10.75 ENSDART00000079563
Fas cell surface death receptor
chr18_-_38270077 10.57 ENSDART00000185546
cell cycle associated protein 1b
chr3_+_52092599 10.39 ENSDART00000104648
zgc:165582
chr15_-_47929455 10.37 ENSDART00000064462
proteasome subunit alpha 6, like
chr22_+_36902352 10.29 ENSDART00000036273
tripartite motif containing 35-20
chr15_-_29162193 10.23 ENSDART00000138449
ENSDART00000099885
XIAP associated factor 1
chr13_+_27232848 10.15 ENSDART00000138043
Ras and Rab interactor 2
chr23_+_2666944 10.15 ENSDART00000192861

chr4_+_7822773 10.11 ENSDART00000171391
si:ch1073-67j19.2
chr5_+_38684651 10.04 ENSDART00000137852
si:dkey-58f10.10
chr3_+_6291635 9.94 ENSDART00000185055
ENSDART00000157707
si:ch211-12p12.2
chr10_+_5060191 9.80 ENSDART00000145908
ENSDART00000122397
coactivator-associated arginine methyltransferase 1, like
chr21_-_22676323 9.78 ENSDART00000167392
grass carp reovirus (GCRV)-induced gene 2h
chr9_+_42269059 9.73 ENSDART00000113435
si:dkey-10c21.1
chr10_+_31809226 9.57 ENSDART00000087898
forkhead box O1 b
chr14_-_16810401 9.52 ENSDART00000158396
ENSDART00000170758
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr18_+_26422124 9.50 ENSDART00000060245
cathepsin H
chr16_+_25285998 9.37 ENSDART00000154112
si:dkey-29h14.10
chr6_-_19271210 9.33 ENSDART00000163628
ENSDART00000159124
zgc:174863
chr6_+_29217392 9.28 ENSDART00000006386
ATPase Na+/K+ transporting subunit beta 1a
chr23_-_37575030 9.26 ENSDART00000031875
torsin family 1 like 3
chr3_-_49925313 9.25 ENSDART00000164361
glucagon receptor a
chr16_+_11834516 9.23 ENSDART00000146611
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr24_-_28419444 9.21 ENSDART00000105749
negative regulator of reactive oxygen species
chr5_+_27421639 9.14 ENSDART00000146285
cytochrome b561 family, member A3a
chr4_-_76206413 9.06 ENSDART00000170738
si:ch211-106j21.5
chr25_-_35960229 9.05 ENSDART00000073434
sorting nexin 20
chr2_-_43135700 9.01 ENSDART00000098284
finTRIM family, member 14
chr18_-_38270430 8.80 ENSDART00000139519
cell cycle associated protein 1b
chr5_-_30382925 8.74 ENSDART00000125381
grass carp reovirus (GCRV)-induced gene 2o
chr11_-_19775182 8.67 ENSDART00000037894
nicotinamide phosphoribosyltransferase b
chr6_+_59029485 8.54 ENSDART00000050140

chr3_-_22366032 8.44 ENSDART00000029849
interferon phi 1
chr3_-_1906976 8.39 ENSDART00000180953
zgc:101806
chr7_-_19614916 8.37 ENSDART00000169029
zgc:194655
chr15_-_17071328 8.24 ENSDART00000122617
si:ch211-24o10.6
chr13_-_45155792 8.21 ENSDART00000163556
runt-related transcription factor 3
chr2_+_45479841 8.18 ENSDART00000151856
si:ch211-66k16.28
chr22_-_6941098 8.12 ENSDART00000105864
zgc:171500
chr3_-_45361573 8.12 ENSDART00000154796
interleukin 21 receptor, tandem duplicate 1
chr6_+_41096058 7.94 ENSDART00000028373
FK506 binding protein 5
chr5_-_57723929 7.91 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr1_-_8966046 7.88 ENSDART00000136198
suppressor of cytokine signaling 1b
chr7_+_17908235 7.88 ENSDART00000077113
metastasis associated 1 family, member 2
chr9_-_23765480 7.87 ENSDART00000027212
si:ch211-219a4.6
chr12_-_44018667 7.82 ENSDART00000170692
si:dkey-201i2.4
chr2_-_42035250 7.76 ENSDART00000056460
ENSDART00000140788
guanylate binding protein 1
chr22_-_17474583 7.75 ENSDART00000148027
si:ch211-197g15.8
chr16_+_48678655 7.74 ENSDART00000150156
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_30510839 7.74 ENSDART00000168189
ENSDART00000174868
insulin-like growth factor 2 mRNA binding protein 2b
chr25_-_25550938 7.70 ENSDART00000150412
ENSDART00000103622
interferon regulatory factor 7
chr7_+_25053331 7.69 ENSDART00000173998
si:dkey-23i12.7
chr22_-_17474781 7.65 ENSDART00000186817
si:ch211-197g15.8
chr13_+_27232694 7.55 ENSDART00000131128
Ras and Rab interactor 2
chr5_+_38619813 7.55 ENSDART00000133314
si:ch211-271e10.3
chr3_-_32079916 7.40 ENSDART00000040900
BCL2 associated X, apoptosis regulator b
chr10_+_26645953 7.37 ENSDART00000131482
adhesion G protein-coupled receptor G4b
chr19_+_4066449 7.27 ENSDART00000162461
bloodthirsty-related gene family, member 26
chr12_-_35936329 7.25 ENSDART00000166634
ring finger protein 213b
chr1_-_44928987 7.25 ENSDART00000134635
si:dkey-9i23.15
chr15_+_32268790 7.24 ENSDART00000154457
FH2 domain containing 4
chr22_-_30678518 7.22 ENSDART00000138282
si:dkey-42l16.1
chr19_-_24745317 7.17 ENSDART00000142774
si:dkeyp-92c9.3
chr2_-_24554416 7.15 ENSDART00000052061
calponin 2
chr23_-_4409668 7.14 ENSDART00000081823
si:ch73-142c19.1
chr24_+_12945803 7.08 ENSDART00000005105
proteasome activator subunit 1
chr7_+_3442834 6.99 ENSDART00000138247
si:ch211-285c6.2
chr19_-_7690975 6.97 ENSDART00000151384
si:dkey-204a24.10
chr10_+_26646104 6.97 ENSDART00000187685
adhesion G protein-coupled receptor G4b
chr12_+_38556462 6.80 ENSDART00000021069
ENSDART00000145377
ribosomal protein L38
chr3_+_36127287 6.68 ENSDART00000058605
ENSDART00000182500
serine carboxypeptidase 1
chr15_-_31067589 6.62 ENSDART00000060157
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3
chr6_+_46309795 6.61 ENSDART00000154817
si:dkeyp-67f1.1
chr7_+_19615056 6.58 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
chr25_+_32390794 6.58 ENSDART00000012600
galactokinase 2
chr6_+_32834007 6.56 ENSDART00000157353
cylindromatosis (turban tumor syndrome), like
chr3_-_22366562 6.55 ENSDART00000129447
interferon phi 1
chr4_-_76027176 6.49 ENSDART00000165718
si:dkey-71l4.1
chr20_+_37393134 6.43 ENSDART00000128321
adhesion G protein-coupled receptor G6
chr8_+_22277198 6.39 ENSDART00000005989
DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
chr22_-_17459587 6.38 ENSDART00000142267
si:ch211-197g15.10
chr13_-_37631092 6.11 ENSDART00000108855
si:dkey-188i13.7
chr4_-_58945951 6.11 ENSDART00000159145
si:dkey-28i19.4
chr15_+_28355023 6.01 ENSDART00000122159
si:dkey-118k5.3
chr22_-_5958066 6.00 ENSDART00000145821
si:rp71-36a1.3
chr9_-_18215644 5.99 ENSDART00000145876
epithelial stromal interaction 1
chr2_+_42005475 5.99 ENSDART00000056461
guanylate binding protein 2
chr4_-_76079075 5.97 ENSDART00000158469
si:ch211-232d10.3
chr4_-_56673431 5.95 ENSDART00000161464
ENSDART00000191926
si:ch211-227p7.5
chr16_+_40508882 5.95 ENSDART00000126129
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr5_+_38631119 5.89 ENSDART00000131832
ENSDART00000162215
si:ch211-271e10.6
chr1_+_58360935 5.82 ENSDART00000140754
si:dkey-222h21.1
chr4_-_76129431 5.60 ENSDART00000162809
si:ch211-106j21.2
chr6_-_49983329 5.56 ENSDART00000113083
agouti signaling protein 1
chr6_+_32834760 5.49 ENSDART00000121562
cylindromatosis (turban tumor syndrome), like
chr11_-_31276064 5.38 ENSDART00000141062
ENSDART00000004780
mannosidase, alpha, class 2B, member 1
chr15_-_36369743 5.38 ENSDART00000155942
si:dkey-23k10.3
chr15_-_21702317 5.30 ENSDART00000155824
si:dkey-40g16.6
chr4_-_75616197 5.24 ENSDART00000157778
si:dkey-71l4.3
chr3_-_7997887 5.23 ENSDART00000172256
si:ch211-175l6.2
chr8_+_47188154 5.20 ENSDART00000137319
si:dkeyp-100a1.6
chr7_-_37563883 5.03 ENSDART00000148805
nucleotide-binding oligomerization domain containing 2
chr15_-_5624361 4.97 ENSDART00000176446
ENSDART00000114410
WD repeat domain 62
chr4_+_68939595 4.89 ENSDART00000168331
ENSDART00000193212
si:dkey-264f17.2
chr25_+_4979446 4.88 ENSDART00000154131
ENSDART00000155537
si:ch73-265h17.1
chr4_-_40008579 4.83 ENSDART00000167236
si:ch211-215p11.1
chr13_-_37642890 4.81 ENSDART00000146483
ENSDART00000136071
ENSDART00000111786
si:dkey-188i13.9
chr17_+_35362851 4.80 ENSDART00000137659
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr15_-_37867995 4.72 ENSDART00000192698
si:dkey-238d18.4
chr4_+_35198656 4.71 ENSDART00000187990
si:dkey-269p2.1
chr4_-_76239517 4.68 ENSDART00000172599
si:ch211-106j21.6
chr5_-_26247215 4.65 ENSDART00000136806
endoplasmic reticulum aminopeptidase 1b
chr14_+_35024521 4.58 ENSDART00000158634
ENSDART00000170631
early B cell factor 3a
chr22_-_8174244 4.58 ENSDART00000156571
si:ch73-44m9.3
chr2_-_707152 4.56 ENSDART00000082304
finTRIM family, member 93
chr4_-_75511162 4.54 ENSDART00000157651
si:dkey-71l4.5
chr4_-_60916298 4.44 ENSDART00000142335
si:dkey-196n19.2
chr3_-_1938588 4.43 ENSDART00000013001
ENSDART00000186405
zgc:152753
chr12_-_3053873 4.40 ENSDART00000023796
ENSDART00000137148
dicarbonyl/L-xylulose reductase
chr4_+_76906112 4.32 ENSDART00000180696
si:dkey-240n22.6
chr19_-_10971230 4.24 ENSDART00000166196

chr1_-_8000428 4.24 ENSDART00000133098
si:dkey-79f11.5
chr4_-_1757460 4.05 ENSDART00000144074
transmembrane 7 superfamily member 3
chr10_-_4375190 4.01 ENSDART00000016102

chr5_+_38743644 3.95 ENSDART00000137658
si:dkey-58f10.6
chr4_-_71177920 3.92 ENSDART00000158287
si:dkey-193i10.1
chr22_-_10570749 3.92 ENSDART00000140736
si:dkey-42i9.6
chr22_-_6465060 3.81 ENSDART00000081687
zgc:172133
chr15_-_31043183 3.80 ENSDART00000100145
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1
chr16_+_25806400 3.79 ENSDART00000154652
immunity-related GTPase family, q1
chr12_-_18578432 3.78 ENSDART00000122858
zinc finger, DHHC-type containing 4
chr5_+_8919698 3.70 ENSDART00000046440
1-acylglycerol-3-phosphate O-acyltransferase 9, like
chr13_-_14908664 3.66 ENSDART00000138867
adaptor-related protein complex 5, sigma 1 subunit
chr4_+_70911498 3.64 ENSDART00000157674
si:dkey-16p6.1
chr11_-_23458792 3.61 ENSDART00000032844
pleckstrin homology domain containing, family A member 6
chr5_+_38662125 3.56 ENSDART00000136949
si:dkey-58f10.13
chr20_-_20402500 3.54 ENSDART00000190747
ENSDART00000185065
protein kinase C, eta, b
chr4_+_60482963 3.47 ENSDART00000157679
si:dkey-211i20.2

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf8+irf9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 21.3 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
4.9 24.3 GO:0071763 nuclear membrane organization(GO:0071763)
3.7 14.7 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
3.3 16.7 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
3.1 9.2 GO:0036363 transforming growth factor beta activation(GO:0036363)
2.7 16.2 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
2.7 10.7 GO:0070227 lymphocyte apoptotic process(GO:0070227)
2.6 7.7 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
2.3 6.9 GO:0005997 xylulose metabolic process(GO:0005997)
2.1 6.4 GO:0060879 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
2.1 10.4 GO:2000562 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
2.1 16.4 GO:0031179 peptide modification(GO:0031179)
1.9 7.7 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
1.9 60.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
1.9 15.0 GO:0046685 response to arsenic-containing substance(GO:0046685)
1.9 5.6 GO:0043455 regulation of secondary metabolic process(GO:0043455)
1.8 12.9 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
1.8 14.0 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
1.6 4.8 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
1.5 25.7 GO:0048002 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) antigen processing and presentation of peptide antigen(GO:0048002)
1.4 7.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.4 7.2 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
1.3 9.3 GO:0098773 skin epidermis development(GO:0098773)
1.3 52.7 GO:0071346 cellular response to interferon-gamma(GO:0071346)
1.3 6.4 GO:0006309 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.9 6.6 GO:0006012 galactose metabolic process(GO:0006012)
0.9 5.4 GO:0006013 mannose metabolic process(GO:0006013)
0.8 3.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.8 13.4 GO:0046686 response to cadmium ion(GO:0046686)
0.7 7.4 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.7 11.7 GO:0036065 fucosylation(GO:0036065)
0.7 9.5 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.7 2.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.7 11.3 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.6 2.6 GO:0014005 microglia development(GO:0014005)
0.5 18.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 12.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.4 10.3 GO:0097194 execution phase of apoptosis(GO:0097194)
0.4 3.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.4 2.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.3 7.1 GO:0010950 positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952)
0.3 1.8 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.3 1.7 GO:0032648 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.3 29.8 GO:0017148 negative regulation of translation(GO:0017148)
0.3 5.7 GO:0006825 copper ion transport(GO:0006825)
0.3 10.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 11.0 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 13.5 GO:0031638 zymogen activation(GO:0031638)
0.2 1.2 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.2 20.7 GO:0009612 response to mechanical stimulus(GO:0009612)
0.2 2.3 GO:0060337 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 9.2 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.2 6.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 108.5 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.2 19.6 GO:0010506 regulation of autophagy(GO:0010506)
0.2 9.3 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.2 12.4 GO:0030048 actin filament-based movement(GO:0030048)
0.1 1.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 7.9 GO:0016575 histone deacetylation(GO:0016575)
0.1 9.5 GO:0001945 lymph vessel development(GO:0001945)
0.1 1.0 GO:0071451 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 2.9 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 9.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 6.1 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 1.9 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.1 5.9 GO:0009306 protein secretion(GO:0009306)
0.1 0.9 GO:0006999 nuclear pore organization(GO:0006999)
0.1 2.9 GO:0032456 endocytic recycling(GO:0032456)
0.1 14.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 1.3 GO:0042574 retinal metabolic process(GO:0042574)
0.1 4.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.4 GO:0030825 regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284) inflammatory response to wounding(GO:0090594)
0.1 7.8 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 1.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 10.7 GO:0060047 heart contraction(GO:0060047)
0.0 2.0 GO:0039021 pronephric glomerulus development(GO:0039021)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 2.5 GO:0051607 defense response to virus(GO:0051607)
0.0 3.7 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 19.4 GO:0006915 apoptotic process(GO:0006915)
0.0 0.8 GO:0007632 visual behavior(GO:0007632)
0.0 61.3 GO:0035556 intracellular signal transduction(GO:0035556)
0.0 9.8 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.8 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 2.6 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centriole replication(GO:0046600) negative regulation of centrosome cycle(GO:0046606) negative regulation of organelle assembly(GO:1902116)
0.0 3.6 GO:0032259 methylation(GO:0032259)
0.0 0.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 5.5 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 0.8 GO:0006936 muscle contraction(GO:0006936)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 21.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
2.2 60.4 GO:0005839 proteasome core complex(GO:0005839)
2.1 12.6 GO:0042612 MHC class I protein complex(GO:0042612)
2.0 16.2 GO:0042611 MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)
1.8 7.1 GO:0008537 proteasome activator complex(GO:0008537)
1.7 8.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
1.0 9.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.9 9.3 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.5 16.7 GO:0043186 P granule(GO:0043186)
0.4 7.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 23.7 GO:0030426 growth cone(GO:0030426)
0.3 92.7 GO:0005764 lysosome(GO:0005764)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 11.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 8.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 9.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 7.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 10.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.8 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 6.8 GO:0022626 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.1 0.6 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 12.4 GO:0016459 myosin complex(GO:0016459)
0.1 101.8 GO:0005615 extracellular space(GO:0005615)
0.1 1.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 12.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 3.3 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 56.7 GO:0005829 cytosol(GO:0005829)
0.0 1.0 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0032797 SMN complex(GO:0032797)
0.0 4.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.7 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
5.3 21.3 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
5.0 15.0 GO:0005132 type I interferon receptor binding(GO:0005132)
4.0 28.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
3.7 14.7 GO:0031708 endothelin B receptor binding(GO:0031708)
2.9 11.4 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
2.8 52.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
2.3 18.7 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
2.1 10.7 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
2.0 7.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.8 9.2 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
1.8 16.4 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
1.7 8.4 GO:0015440 peptide antigen-transporting ATPase activity(GO:0015433) peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977)
1.6 4.8 GO:0009041 uridylate kinase activity(GO:0009041)
1.4 9.8 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
1.4 5.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.3 6.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
1.2 7.1 GO:0061133 endopeptidase activator activity(GO:0061133)
1.2 52.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.1 24.3 GO:0019894 kinesin binding(GO:0019894)
1.0 10.4 GO:0016936 galactoside binding(GO:0016936)
1.0 14.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
1.0 11.7 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.9 45.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.8 5.6 GO:0031779 melanocortin receptor binding(GO:0031779)
0.7 1.5 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.7 2.1 GO:0004904 interferon receptor activity(GO:0004904)
0.7 97.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.6 9.5 GO:0051117 ATPase binding(GO:0051117)
0.6 5.0 GO:0050700 CARD domain binding(GO:0050700)
0.5 12.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.5 8.4 GO:0031386 protein tag(GO:0031386)
0.5 9.3 GO:0001671 ATPase activator activity(GO:0001671)
0.5 3.7 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.5 1.8 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.4 2.7 GO:0003777 microtubule motor activity(GO:0003777)
0.4 5.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 6.4 GO:0043236 laminin binding(GO:0043236)
0.3 5.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.3 1.3 GO:0005461 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.3 11.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.3 7.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 7.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 9.2 GO:0019957 chemokine binding(GO:0019956) C-C chemokine binding(GO:0019957)
0.2 12.4 GO:0000146 microfilament motor activity(GO:0000146)
0.2 1.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 8.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 2.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 5.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 1.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 6.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 6.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 3.5 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 4.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 26.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 9.2 GO:0019838 growth factor binding(GO:0019838)
0.1 13.4 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 10.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 6.4 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.1 12.4 GO:0005179 hormone activity(GO:0005179)
0.1 1.6 GO:0070411 I-SMAD binding(GO:0070411)
0.1 12.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 7.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 39.0 GO:0005525 GTP binding(GO:0005525)
0.1 6.9 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.1 0.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 8.7 GO:0004175 endopeptidase activity(GO:0004175)
0.0 16.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 9.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 9.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 24.6 GO:0008270 zinc ion binding(GO:0008270)
0.0 4.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 7.2 GO:0016887 ATPase activity(GO:0016887)
0.0 1.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 25.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 31.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
1.6 12.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.7 11.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.5 14.7 PID ENDOTHELIN PATHWAY Endothelins
0.4 17.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 12.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.3 7.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.3 12.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.3 44.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 15.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 9.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 7.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 2.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 3.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 7.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.0 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.1 60.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.8 10.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
1.6 14.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.4 17.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.3 6.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.2 13.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.1 30.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.8 7.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.6 11.0 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.6 12.6 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.5 7.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.5 26.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.4 2.9 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.3 5.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.2 2.0 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 1.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 14.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 3.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 6.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.5 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm