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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for ikzf1
Z-value: 1.32
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Transcription factors associated with ikzf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ikzf1 | dr11_v1_chr13_-_15986871_15986871 | 0.19 | 6.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_32817274 Show fit | 22.05 |
ENSDART00000142582
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr5_-_71722257 Show fit | 19.11 |
ENSDART00000013404
|
adenylate kinase 1 |
|
| chr5_+_32222303 Show fit | 17.73 |
ENSDART00000051362
|
myosin heavy chain 4 |
|
| chr25_+_29161609 Show fit | 17.19 |
ENSDART00000180752
|
pyruvate kinase M1/2b |
|
| chr6_-_29195642 Show fit | 13.91 |
ENSDART00000078625
|
dermatopontin |
|
| chr23_-_23256726 Show fit | 13.65 |
ENSDART00000131353
|
si:dkey-98j1.5 |
|
| chr6_-_39764995 Show fit | 12.44 |
ENSDART00000085277
|
phosphofructokinase, muscle b |
|
| chr7_+_39386982 Show fit | 12.36 |
ENSDART00000146702
|
troponin I type 2b (skeletal, fast), tandem duplicate 2 |
|
| chr8_-_18535822 Show fit | 10.53 |
ENSDART00000100558
|
nexilin (F actin binding protein) |
|
| chr22_-_29191152 Show fit | 10.42 |
ENSDART00000132702
|
parvalbumin 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ikzf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 19.1 | GO:0009180 | ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) |
| 0.5 | 14.5 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.3 | 13.2 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.2 | 12.5 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
| 1.1 | 12.4 | GO:0061718 | glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.3 | 11.5 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 1.5 | 10.5 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.2 | 9.8 | GO:0043297 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 2.7 | 8.2 | GO:0003223 | ventricular compact myocardium morphogenesis(GO:0003223) |
| 0.1 | 8.2 | GO:0001708 | cell fate specification(GO:0001708) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 25.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 25.1 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 17.6 | GO:0005829 | cytosol(GO:0005829) |
| 0.4 | 12.9 | GO:0031672 | A band(GO:0031672) |
| 1.1 | 12.4 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.3 | 12.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 8.0 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.2 | 7.2 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 6.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 38.7 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 25.7 | GO:0003774 | motor activity(GO:0003774) |
| 1.5 | 19.1 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 12.8 | GO:0003779 | actin binding(GO:0003779) |
| 1.1 | 12.4 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.3 | 10.4 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 1.4 | 8.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.7 | 7.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.8 | 7.2 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 7.1 | GO:0003823 | antigen binding(GO:0003823) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 5.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 5.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 4.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.3 | 3.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 3.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 3.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 3.4 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 19.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 6.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 6.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 5.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 4.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.7 | 4.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 3.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.3 | 2.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 0.1 | 2.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |