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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for hoxb1a+hoxb1b-2
Z-value: 1.30
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Transcription factors associated with hoxb1a+hoxb1b-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxb1a | dr11_v1_chr3_+_23768898_23768898 | 0.15 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_36378494 Show fit | 33.28 |
ENSDART00000058503
|
glycoprotein M6Aa |
|
| chr7_-_13381129 Show fit | 31.31 |
ENSDART00000164326
|
si:ch73-119p20.1 |
|
| chr12_-_25916530 Show fit | 25.27 |
ENSDART00000186386
|
synuclein, gamma b (breast cancer-specific protein 1) |
|
| chr25_+_7461624 Show fit | 23.82 |
ENSDART00000170569
|
synaptotagmin XII |
|
| chr1_-_38709551 Show fit | 23.23 |
ENSDART00000128794
|
glycoprotein M6Ab |
|
| chr4_+_21129752 Show fit | 22.43 |
ENSDART00000169764
|
synaptotagmin Ia |
|
| chr3_+_29714775 Show fit | 21.88 |
ENSDART00000041388
|
calcium channel, voltage-dependent, gamma subunit 2a |
|
| chr1_-_20911297 Show fit | 19.33 |
ENSDART00000078271
|
carboxypeptidase E |
|
| chr25_-_13842618 Show fit | 18.38 |
ENSDART00000160258
|
mitogen-activated protein kinase 8 interacting protein 1a |
|
| chr4_+_26496489 Show fit | 18.16 |
ENSDART00000160652
|
IQ motif and Sec7 domain 3a |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxb1a+hoxb1b-2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 40.2 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 40.2 | GO:0031175 | neuron projection development(GO:0031175) |
| 0.4 | 32.4 | GO:0021549 | cerebellum development(GO:0021549) |
| 1.1 | 26.8 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.6 | 23.8 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.3 | 23.8 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 1.3 | 23.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 1.0 | 23.2 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 1.0 | 22.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 19.3 | GO:0016485 | protein processing(GO:0016485) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 56.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.6 | 25.3 | GO:0043679 | axon terminus(GO:0043679) |
| 0.4 | 24.8 | GO:0016342 | catenin complex(GO:0016342) |
| 0.2 | 23.8 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.6 | 23.7 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 4.5 | 22.4 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.1 | 20.9 | GO:0036477 | dendrite(GO:0030425) somatodendritic compartment(GO:0036477) |
| 0.8 | 19.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 17.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 2.9 | 17.6 | GO:0005955 | calcineurin complex(GO:0005955) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 46.2 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.4 | 40.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 8.4 | 25.3 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.4 | 21.9 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 1.0 | 19.5 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.7 | 19.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 2.9 | 17.6 | GO:0033192 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 17.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.0 | 14.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 1.2 | 14.1 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 19.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.5 | 19.3 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 1.4 | 17.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 5.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 3.2 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 2.5 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 2.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 19.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.9 | 19.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 1.0 | 17.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 9.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.4 | 5.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 3.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 3.1 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 2.9 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.0 | 1.4 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |