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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxa9a+hoxa9b

Z-value: 1.39

Motif logo

Transcription factors associated with hoxa9a+hoxa9b

Gene Symbol Gene ID Gene Info
ENSDARG00000056819 homeobox A9b
ENSDARG00000105013 homeobox A9a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxa9bdr11_v1_chr16_+_20915319_209153190.462.6e-06Click!
hoxa9adr11_v1_chr19_+_19750101_197502230.312.7e-03Click!

Activity profile of hoxa9a+hoxa9b motif

Sorted Z-values of hoxa9a+hoxa9b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_+_38301080 38.21 ENSDART00000105672
myosin binding protein C, fast type b
chr7_+_39386982 22.52 ENSDART00000146702
troponin I type 2b (skeletal, fast), tandem duplicate 2
chr3_+_32526263 21.54 ENSDART00000150897
si:ch73-367p23.2
chr5_-_32274383 19.41 ENSDART00000122889
myosin, heavy polypeptide 1.3, skeletal muscle
chr8_+_6576940 16.80 ENSDART00000138135
V-set and immunoglobulin domain containing 8b
chr6_-_46875310 16.64 ENSDART00000154442
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr6_+_55032439 16.52 ENSDART00000164232
ENSDART00000158845
ENSDART00000157584
ENSDART00000026359
ENSDART00000122794
ENSDART00000183742
myosin binding protein Hb
chr3_+_33300522 15.83 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr19_-_10425140 15.10 ENSDART00000145319
si:ch211-171h4.3
chr5_+_32206378 14.77 ENSDART00000126873
ENSDART00000051361
myosin, heavy polypeptide 2, fast muscle specific
chr1_+_7546259 13.74 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr7_+_69841017 13.55 ENSDART00000169107

chr11_-_6048490 12.59 ENSDART00000066164
plasmalemma vesicle associated protein b
chr15_+_32711172 11.29 ENSDART00000163936
ENSDART00000168135
periostin, osteoblast specific factor b
chr8_-_2616326 10.98 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr21_+_11969603 10.69 ENSDART00000142247
ENSDART00000140652
motilin-like
chr5_+_2815021 10.69 ENSDART00000020472
4-hydroxyphenylpyruvate dioxygenase a
chr1_-_681116 10.29 ENSDART00000165894
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr16_+_34111919 9.86 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
transcription elongation factor A (SII), 3
chr7_+_31879649 9.74 ENSDART00000099789
myosin binding protein C, cardiac
chr1_-_33647138 9.33 ENSDART00000142111
ENSDART00000015547
claudin g
chr3_+_46425262 9.25 ENSDART00000153690
sc:d0202
chr17_+_1323699 9.14 ENSDART00000172540
adenylosuccinate synthase like 1
chr7_+_31879986 8.99 ENSDART00000138491
myosin binding protein C, cardiac
chr20_+_6142433 8.58 ENSDART00000054084
ENSDART00000136986
transthyretin (prealbumin, amyloidosis type I)
chr7_-_69853453 8.38 ENSDART00000049928
myozenin 2a
chr16_-_13516745 8.16 ENSDART00000145410
si:dkeyp-69b9.3
chr12_-_6172154 7.80 ENSDART00000185434
apobec1 complementation factor
chr4_-_16354292 7.78 ENSDART00000139919
lumican
chr25_-_3830272 7.75 ENSDART00000055843
CD151 molecule
chr9_-_9992697 7.75 ENSDART00000123415
UDP glucuronosyltransferase 1 family a, b
chr19_+_17385561 7.74 ENSDART00000141397
ENSDART00000143913
ENSDART00000133626
ribosomal protein L15
chr11_+_36243774 7.57 ENSDART00000023323
zgc:172270
chr8_-_23599096 7.30 ENSDART00000183096
solute carrier family 38, member 5b
chr13_+_13681681 7.30 ENSDART00000057825
complement factor D (adipsin)
chr16_+_12836143 7.28 ENSDART00000067741
calcium channel, voltage-dependent, gamma subunit 6b
chr7_-_4461104 7.23 ENSDART00000023090
ENSDART00000140770
solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 1
chr20_-_33959815 7.22 ENSDART00000133081
selectin P
chr2_-_48196092 7.20 ENSDART00000139944
secondary ossification center associated regulator of chondrocyte maturation
chr3_-_3209432 7.18 ENSDART00000140635
si:ch211-229i14.2
chr12_-_26406323 7.10 ENSDART00000131896
myozenin 1b
chr5_-_16351306 7.05 ENSDART00000168643

chr22_+_28446365 6.98 ENSDART00000189359
ABI family, member 3 (NESH) binding protein b
chr24_-_12938922 6.95 ENSDART00000024084
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr9_-_6380653 6.80 ENSDART00000078523
esophageal cancer related gene 4a
chr22_+_28446557 6.76 ENSDART00000089546
ABI family, member 3 (NESH) binding protein b
chr15_+_21202820 6.72 ENSDART00000154036
si:dkey-52d15.2
chr7_+_26545911 6.60 ENSDART00000135313
tyrosine kinase, non-receptor, 1
chr4_-_16353733 6.58 ENSDART00000186785
lumican
chr7_+_35268880 6.51 ENSDART00000182231
dipeptidase 2
chr7_+_26545502 6.32 ENSDART00000140528
tyrosine kinase, non-receptor, 1
chr16_+_1254390 6.32 ENSDART00000092627
ADAMTS like 4
chr18_-_46010 6.29 ENSDART00000052641
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr9_-_23807032 6.15 ENSDART00000027443
extended synaptotagmin-like protein 3
chr8_+_3405612 6.14 ENSDART00000163437
zgc:112433
chr21_+_18997511 6.11 ENSDART00000145591
ribosomal protein L17
chr6_+_50451337 6.10 ENSDART00000155051
myelocytomatosis oncogene homolog
chr20_-_463786 6.08 ENSDART00000032212
fyn-related Src family tyrosine kinase
chr19_-_31042570 5.99 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
basic leucine zipper and W2 domains 2
chr19_-_27550768 5.99 ENSDART00000142313
si:dkeyp-46h3.8
chr10_-_8053753 5.94 ENSDART00000162289
si:ch211-251f6.7
chr23_-_31506854 5.89 ENSDART00000131352
ENSDART00000138625
ENSDART00000133002
EYA transcriptional coactivator and phosphatase 4
chr19_+_19775757 5.81 ENSDART00000164677
homeobox A3a
chr20_-_38758797 5.79 ENSDART00000061394
tripartite motif containing 54
chr14_-_36799280 5.74 ENSDART00000168615
ring finger protein 130
chr25_+_16214854 5.68 ENSDART00000109672
ENSDART00000190093
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr23_+_18722715 5.67 ENSDART00000137438
myosin, heavy chain 7B, cardiac muscle, beta b
chr1_+_45056371 5.57 ENSDART00000073689
ENSDART00000167309
bloodthirsty-related gene family, member 1
chr17_-_2595736 5.56 ENSDART00000128797
zona pellucida glycoprotein 3, tandem duplicate 2
chr7_-_41851605 5.52 ENSDART00000142981
myosin light chain kinase 3
chr21_+_11749097 5.51 ENSDART00000102408
ENSDART00000102404
elongation factor, RNA polymerase II, 2
chr13_-_36582341 5.49 ENSDART00000137335
lectin, galactoside binding soluble 3a
chr16_+_29509133 5.46 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr7_+_27317174 5.42 ENSDART00000193058
SRY (sex determining region Y)-box 6
chr2_-_3437862 5.41 ENSDART00000053012
cytochrome P450, family 8, subfamily B, polypeptide 1
chr21_-_20840714 5.40 ENSDART00000144861
ENSDART00000139430
complement component 6
chr9_-_12575776 5.35 ENSDART00000128931
ENSDART00000182695
insulin-like growth factor 2 mRNA binding protein 2a
chr12_-_4540564 5.26 ENSDART00000106566

chr11_-_25213651 5.21 ENSDART00000097316
ENSDART00000152186
myosin, heavy chain 7B, cardiac muscle, beta a
chr10_-_1961930 5.14 ENSDART00000122446
teratocarcinoma-derived growth factor 1
chr3_+_23743139 5.13 ENSDART00000187409
homeobox B3a
chr7_+_48761875 5.13 ENSDART00000003690
aggrecan a
chr11_-_40457325 5.04 ENSDART00000128442
tumor necrosis factor receptor superfamily, member 1B
chr23_-_24263474 5.03 ENSDART00000160312
heat shock protein family, member 7 (cardiovascular)
chr9_+_48007081 5.02 ENSDART00000060593
ENSDART00000099835
zgc:92380
chr7_+_1473929 5.00 ENSDART00000050687
lysophosphatidylcholine acyltransferase 4
chr8_-_39739627 4.99 ENSDART00000135422
ENSDART00000067844
si:ch211-170d8.5
chr10_-_8053385 4.96 ENSDART00000142714
si:ch211-251f6.7
chr23_-_21215520 4.95 ENSDART00000143206
multiple EGF-like-domains 6a
chr3_+_21189766 4.92 ENSDART00000078807
zgc:123295
chr22_-_5323482 4.88 ENSDART00000145785
sphingosine-1-phosphate receptor 4
chr3_+_2669813 4.86 ENSDART00000014205

chr10_-_8046764 4.82 ENSDART00000099031
zgc:136254
chr11_-_37997419 4.80 ENSDART00000102870
solute carrier family 41 (magnesium transporter), member 1
chr22_-_20695237 4.79 ENSDART00000112722
oogenesis-related gene
chr23_-_21215311 4.76 ENSDART00000112424
multiple EGF-like-domains 6a
chr13_+_30228077 4.72 ENSDART00000100813
ENSDART00000147729
ENSDART00000133404
ribosomal protein S24
chr10_+_10788811 4.70 ENSDART00000101077
ENSDART00000139143
prostaglandin D2 synthase a
chr22_+_15624371 4.67 ENSDART00000124868
lipoprotein lipase
chr1_+_57145072 4.67 ENSDART00000152776
si:ch73-94k4.4
chr7_-_24047316 4.66 ENSDART00000184799
dehydrogenase/reductase (SDR family) member 4
chr4_+_7841627 4.65 ENSDART00000037997
upper zone of growth plate and cartilage matrix associated a
chr3_+_23742868 4.57 ENSDART00000153512
homeobox B3a
chr17_+_50701748 4.52 ENSDART00000191938
ENSDART00000183220
ENSDART00000049464
fermitin family member 2
chr6_+_27338512 4.51 ENSDART00000155004
kelch-like family member 30
chr1_-_11642432 4.50 ENSDART00000139755
ENSDART00000115316
si:dkey-26i13.4
chr7_+_48761646 4.48 ENSDART00000017467
aggrecan a
chr8_-_38159805 4.46 ENSDART00000112331
ENSDART00000180006
adhesion G protein-coupled receptor A2
chr20_+_29634653 4.45 ENSDART00000101556
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2b
chr16_-_16761164 4.41 ENSDART00000135872
si:dkey-27n14.1
chr7_-_24046999 4.40 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dehydrogenase/reductase (SDR family) member 4
chr7_-_20453661 4.40 ENSDART00000174001
netrin 5
chr2_+_29884363 4.39 ENSDART00000139247
si:ch211-207d6.2
chr5_+_28830643 4.37 ENSDART00000051448
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr19_+_19761966 4.37 ENSDART00000163697
homeobox A3a
chr11_-_141592 4.35 ENSDART00000092787
cyclin-dependent kinase 4
chr7_+_13988075 4.34 ENSDART00000186812
furin (paired basic amino acid cleaving enzyme) a
chr23_+_19790962 4.33 ENSDART00000142228
filamin A, alpha (actin binding protein 280)
chr8_-_38201415 4.32 ENSDART00000155189
PDZ and LIM domain 2 (mystique)
chr14_+_41345175 4.24 ENSDART00000086104
NADPH oxidase 1
chr19_-_15229421 4.23 ENSDART00000055619
phosphatase and actin regulator 4a
chr7_+_30626378 4.20 ENSDART00000173533
ENSDART00000052541
cyclin B2
chr12_-_4346085 4.17 ENSDART00000112433
carbonic anhydrase XV c
chr9_-_9415000 4.14 ENSDART00000146210
si:ch211-214p13.9
chr1_+_57187794 4.11 ENSDART00000152485
si:dkey-27j5.9
chr17_-_2590222 4.10 ENSDART00000185711

chr1_+_1805294 4.08 ENSDART00000103850
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr20_+_38458084 4.06 ENSDART00000020153
ENSDART00000135912
coenzyme Q8A
chr5_-_38197080 4.05 ENSDART00000140708
si:ch211-284e13.9
chr17_-_30652738 4.05 ENSDART00000154960
SH3 and SYLF domain containing 1
chr17_+_15788100 4.04 ENSDART00000027667
ras-related GTP binding D
chr4_-_1147655 3.95 ENSDART00000171561
si:ch211-117i20.2
chr15_-_452347 3.95 ENSDART00000115233
V-set and transmembrane domain containing 5
chr14_+_23520986 3.92 ENSDART00000170473
ENSDART00000175970
si:ch211-221f10.2
chr7_-_37919475 3.90 ENSDART00000052368
HEAT repeat containing 3
chr23_+_5631381 3.89 ENSDART00000149143
plakophilin 1a
chr19_-_3777217 3.86 ENSDART00000160510
si:dkey-206d17.15
chr10_+_41199660 3.85 ENSDART00000125314
adrenoceptor beta 3b
chr7_-_16598212 3.85 ENSDART00000128488
E2F transcription factor 8
chr6_+_52927651 3.84 ENSDART00000141094
si:dkeyp-3f10.11
chr23_-_3758637 3.84 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
high mobility group AT-hook 1a
chr12_-_36268723 3.83 ENSDART00000113740
potassium inwardly-rectifying channel, subfamily J, member 16
chr18_+_808911 3.82 ENSDART00000172518
cytochrome c oxidase subunit Vab
chr16_-_22192006 3.80 ENSDART00000163338
interleukin 6 receptor
chr8_-_32803227 3.77 ENSDART00000110079
zgc:194839
chr8_-_36399884 3.76 ENSDART00000108538
si:zfos-2070c2.3
chr1_-_58664854 3.71 ENSDART00000109528
adhesion G protein-coupled receptor E5b, duplicate 3
chr8_+_6954984 3.69 ENSDART00000145610
si:ch211-255g12.6
chr20_-_29418620 3.68 ENSDART00000172634
ryanodine receptor 3
chr16_+_54248706 3.62 ENSDART00000156915
dopamine receptor D2 like
chr16_-_45152169 3.61 ENSDART00000171452
si:ch73-343g19.4
chr21_-_13690712 3.61 ENSDART00000065817
POU domain, class 5, transcription factor 3
chr5_-_44286987 3.59 ENSDART00000184112
si:ch73-337l15.2
chr17_+_25833947 3.58 ENSDART00000044328
ENSDART00000154604
acyl-CoA synthetase short chain family member 1
chr2_-_20599315 3.53 ENSDART00000114199
si:ch211-267e7.3
chr16_+_3982590 3.51 ENSDART00000149295
zinc finger CCCH-type containing 12A
chr4_+_22480169 3.50 ENSDART00000146272
ENSDART00000066904
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2
chr14_+_22022441 3.46 ENSDART00000149121
cardiotrophin-like cytokine factor 1
chr3_+_5087787 3.46 ENSDART00000162787
si:ch73-338o16.4
chr8_+_32402441 3.45 ENSDART00000191451
epithelial mitogen homolog (mouse)
chr11_+_19159083 3.43 ENSDART00000138964
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr13_+_40501455 3.42 ENSDART00000114985
heparanase 2
chr11_+_24703108 3.42 ENSDART00000159173
G protein-coupled receptor 25
chr23_+_9560797 3.41 ENSDART00000180014
adhesion regulating molecule 1
chr11_+_36675599 3.40 ENSDART00000170464
si:ch211-11c3.11
chr15_-_32383340 3.39 ENSDART00000185632
complement component 4
chr5_+_9408901 3.39 ENSDART00000193364

chr13_-_22961605 3.38 ENSDART00000143112
ENSDART00000057641
tetraspanin 15
chr4_-_64703 3.38 ENSDART00000167851

chr12_-_11258404 3.35 ENSDART00000149229
si:ch73-30l9.1
chr18_+_39649825 3.34 ENSDART00000087960
gliomedin
chr17_-_114121 3.33 ENSDART00000172408
ENSDART00000157784
Rho GTPase activating protein 11A
chr12_-_32421046 3.30 ENSDART00000075567
ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1
chr16_-_35952789 3.30 ENSDART00000180118
eva-1 homolog Ba (C. elegans)
chr9_-_51563575 3.27 ENSDART00000167034
ENSDART00000148918
TRAF family member-associated NFKB activator
chr4_+_37936839 3.26 ENSDART00000164505
si:dkeyp-82b4.2
chr5_+_9377005 3.26 ENSDART00000124924
UDP glucuronosyltransferase 2 family, polypeptide A7
chr18_+_39649660 3.26 ENSDART00000149859
gliomedin
chr5_-_34921046 3.25 ENSDART00000180245
Rho guanine nucleotide exchange factor (GEF) 28
chr5_-_71838520 3.24 ENSDART00000174396

chr1_+_524388 3.23 ENSDART00000020327
mitochondrial ribosomal protein L16
chr13_+_21870269 3.22 ENSDART00000144612
zinc finger, SWIM-type containing 8
chr13_-_290377 3.22 ENSDART00000134963
chitin synthase 1
chr7_+_49681040 3.20 ENSDART00000176372
ENSDART00000192172
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr3_+_21200763 3.18 ENSDART00000067841
zgc:112038
chr20_-_25533739 3.17 ENSDART00000063064
cytochrome P450, family 2, subfamily AD, polypeptide 6
chr4_+_72797711 3.17 ENSDART00000190934
ENSDART00000163236
myelin regulatory factor-like
chr21_-_21828261 3.16 ENSDART00000151181
defensin, beta-like 2
chr1_+_524717 3.12 ENSDART00000102421
ENSDART00000184473
mitochondrial ribosomal protein L16
chr19_+_19756425 3.11 ENSDART00000167606
homeobox A3a
chr14_+_16151636 3.10 ENSDART00000159352
polymerase (RNA) I polypeptide A
chr10_+_31953502 3.10 ENSDART00000185634
LHFPL tetraspan subfamily member 6
chr4_+_16715267 3.08 ENSDART00000143849
plakophilin 2
chr15_+_37986069 3.07 ENSDART00000156984
si:dkey-238d18.8
chr18_+_3004572 3.06 ENSDART00000190328

chr8_-_38355555 3.05 ENSDART00000134283
ENSDART00000132077
ENSDART00000146378
sorbin and SH3 domain containing 3
chr1_+_12177195 3.04 ENSDART00000146842
ENSDART00000142081
STRA6-like
chr23_-_45897900 3.03 ENSDART00000149263
finTRIM family, member 92
chr23_+_39963599 3.03 ENSDART00000166539
FYVE and coiled-coil domain containing 1a
chr3_+_57820913 2.99 ENSDART00000168101

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa9a+hoxa9b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 18.7 GO:0003210 cardiac atrium formation(GO:0003210)
2.7 8.0 GO:0090008 hypoblast development(GO:0090008)
2.4 7.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
2.3 16.1 GO:0060017 parathyroid gland development(GO:0060017)
2.3 6.8 GO:0070314 G1 to G0 transition(GO:0070314)
2.1 6.3 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
1.9 9.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.8 7.3 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
1.8 10.7 GO:0006572 tyrosine catabolic process(GO:0006572)
1.7 7.0 GO:0019626 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
1.6 8.2 GO:0051145 smooth muscle cell differentiation(GO:0051145)
1.6 9.6 GO:0003151 outflow tract morphogenesis(GO:0003151)
1.5 4.5 GO:0022009 central nervous system vasculogenesis(GO:0022009)
1.5 7.3 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
1.4 5.6 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
1.2 7.2 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
1.1 5.5 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
1.0 7.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.0 2.9 GO:0043654 recognition of apoptotic cell(GO:0043654)
1.0 3.8 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.9 5.7 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.9 5.5 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.9 2.7 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.9 3.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.9 4.3 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.9 8.6 GO:0072337 modified amino acid transport(GO:0072337)
0.8 2.5 GO:0036076 ligamentous ossification(GO:0036076)
0.8 5.0 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.8 2.4 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.8 3.8 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.8 2.3 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.8 7.6 GO:0044857 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.7 12.6 GO:0043114 regulation of vascular permeability(GO:0043114)
0.7 14.8 GO:0014823 response to activity(GO:0014823)
0.7 2.7 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.7 2.0 GO:0015882 L-ascorbic acid transport(GO:0015882)
0.7 5.9 GO:2001240 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.6 3.2 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.6 11.3 GO:0016203 muscle attachment(GO:0016203)
0.6 3.0 GO:0035461 vitamin transmembrane transport(GO:0035461) vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.6 3.0 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.6 4.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.6 1.8 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.6 3.6 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.6 2.3 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.6 2.8 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.6 7.8 GO:0016556 mRNA modification(GO:0016556)
0.6 2.2 GO:0032965 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.5 3.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.5 5.4 GO:0060612 adipose tissue development(GO:0060612)
0.5 4.2 GO:0042554 superoxide anion generation(GO:0042554)
0.5 2.1 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.5 2.0 GO:0015677 copper ion import(GO:0015677)
0.5 3.5 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.5 2.9 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.5 2.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.5 6.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.5 3.6 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.5 22.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.4 1.8 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.4 4.8 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.4 4.3 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.4 2.5 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.4 1.2 GO:0071435 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.4 2.4 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.4 4.6 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.4 5.8 GO:0043248 proteasome assembly(GO:0043248)
0.4 3.4 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.4 2.3 GO:1901655 cellular response to ketone(GO:1901655)
0.4 14.4 GO:0030199 collagen fibril organization(GO:0030199)
0.3 2.4 GO:0030194 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.3 1.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.3 5.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.3 3.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 5.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.3 5.0 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.3 15.1 GO:0000187 activation of MAPK activity(GO:0000187)
0.3 1.8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.3 1.8 GO:0005513 detection of calcium ion(GO:0005513)
0.3 1.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.3 3.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 2.5 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.3 7.2 GO:0006884 cell volume homeostasis(GO:0006884)
0.3 1.0 GO:1903798 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.2 2.7 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.2 1.7 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.2 3.1 GO:0009303 rRNA transcription(GO:0009303)
0.2 1.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 2.2 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 1.0 GO:2000562 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2 1.4 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.2 3.0 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 1.5 GO:0035777 pronephric distal tubule development(GO:0035777)
0.2 4.1 GO:0030183 B cell differentiation(GO:0030183)
0.2 2.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.2 6.4 GO:0032543 mitochondrial translation(GO:0032543)
0.2 9.8 GO:0007602 phototransduction(GO:0007602)
0.2 4.5 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.2 1.1 GO:0006415 translational termination(GO:0006415)
0.2 9.9 GO:0006414 translational elongation(GO:0006414)
0.2 1.6 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.2 4.0 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.2 1.5 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 1.2 GO:0035912 establishment of cell polarity involved in ameboidal cell migration(GO:0003365) aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.1 2.8 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 3.4 GO:1990798 pancreas regeneration(GO:1990798)
0.1 7.8 GO:0006354 DNA-templated transcription, elongation(GO:0006354)
0.1 39.2 GO:0060537 muscle tissue development(GO:0060537)
0.1 2.9 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 10.7 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 6.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 2.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 1.8 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 11.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.6 GO:0010888 negative regulation of cholesterol storage(GO:0010887) negative regulation of lipid storage(GO:0010888)
0.1 0.8 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 0.7 GO:0007343 egg activation(GO:0007343)
0.1 1.1 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.1 0.7 GO:0044319 wound healing, spreading of cells(GO:0044319) epiboly involved in wound healing(GO:0090505) skeletal muscle satellite cell migration(GO:1902766)
0.1 5.1 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 0.4 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.1 1.7 GO:0002574 thrombocyte differentiation(GO:0002574)
0.1 1.2 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 2.0 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.1 2.3 GO:0019835 cytolysis(GO:0019835)
0.1 1.9 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 4.9 GO:0051028 mRNA transport(GO:0051028)
0.1 8.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 2.0 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 17.2 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.1 7.2 GO:0051216 cartilage development(GO:0051216)
0.1 6.1 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.1 0.5 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.1 0.9 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 0.6 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.1 1.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.3 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 4.7 GO:0060215 primitive hemopoiesis(GO:0060215)
0.1 3.2 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1 1.3 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.2 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 13.5 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 2.9 GO:2000027 regulation of organ morphogenesis(GO:2000027)
0.1 0.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 1.4 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.7 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 2.0 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 1.2 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 17.3 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.0 0.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 1.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 1.2 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 2.9 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 2.9 GO:0001666 response to hypoxia(GO:0001666) response to decreased oxygen levels(GO:0036293)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.6 GO:0032456 endocytic recycling(GO:0032456)
0.0 12.5 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 2.1 GO:0031101 fin regeneration(GO:0031101)
0.0 2.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 1.1 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 1.1 GO:0031076 embryonic camera-type eye development(GO:0031076)
0.0 2.4 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 1.7 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 2.7 GO:0016358 dendrite development(GO:0016358)
0.0 3.4 GO:0051604 protein maturation(GO:0051604)
0.0 0.4 GO:0042574 retinal metabolic process(GO:0042574)
0.0 1.4 GO:0051607 defense response to virus(GO:0051607)
0.0 2.2 GO:0055001 muscle cell development(GO:0055001)
0.0 1.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 1.1 GO:0006910 phagocytosis, recognition(GO:0006910) regulation of B cell activation(GO:0050864) positive regulation of B cell activation(GO:0050871)
0.0 0.1 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.0 1.4 GO:0009755 hormone-mediated signaling pathway(GO:0009755)
0.0 1.1 GO:0006936 muscle contraction(GO:0006936)
0.0 0.1 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 8.8 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.0 3.0 GO:0006644 phospholipid metabolic process(GO:0006644)
0.0 5.8 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.9 GO:0008203 cholesterol metabolic process(GO:0008203) secondary alcohol metabolic process(GO:1902652)
0.0 1.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.5 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 1.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 1.0 GO:0042157 lipoprotein metabolic process(GO:0042157)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:1990909 Wnt signalosome(GO:1990909)
1.0 7.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.0 4.1 GO:0019815 B cell receptor complex(GO:0019815)
0.8 4.0 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.7 5.5 GO:0001772 immunological synapse(GO:0001772)
0.6 1.8 GO:0097189 apoptotic body(GO:0097189)
0.6 7.6 GO:0014704 intercalated disc(GO:0014704)
0.6 2.3 GO:0044609 DBIRD complex(GO:0044609)
0.5 4.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 5.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.5 3.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.5 22.5 GO:0005861 troponin complex(GO:0005861)
0.4 15.7 GO:0000421 autophagosome membrane(GO:0000421)
0.4 3.2 GO:0030428 cell septum(GO:0030428)
0.4 4.7 GO:0042627 chylomicron(GO:0042627)
0.4 45.1 GO:0016459 myosin complex(GO:0016459)
0.3 1.4 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 0.9 GO:0097541 axonemal basal plate(GO:0097541)
0.3 1.8 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 2.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.3 3.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 2.1 GO:0005614 interstitial matrix(GO:0005614)
0.3 3.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 3.9 GO:0030057 desmosome(GO:0030057)
0.2 13.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 2.4 GO:0034451 centriolar satellite(GO:0034451)
0.2 3.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 2.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 8.9 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.2 2.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 17.6 GO:0030018 Z disc(GO:0030018)
0.2 23.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 2.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 60.0 GO:0031012 extracellular matrix(GO:0031012)
0.1 1.6 GO:0045095 keratin filament(GO:0045095)
0.1 2.3 GO:0005579 membrane attack complex(GO:0005579)
0.1 6.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.8 GO:0000801 central element(GO:0000801)
0.1 2.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 5.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.9 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 3.0 GO:0005776 autophagosome(GO:0005776)
0.1 14.0 GO:0016324 apical plasma membrane(GO:0016324)
0.1 4.0 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.4 GO:0035339 SPOTS complex(GO:0035339)
0.1 2.0 GO:0032039 integrator complex(GO:0032039)
0.1 5.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 3.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 24.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 5.9 GO:0005882 intermediate filament(GO:0005882)
0.1 2.7 GO:0005811 lipid particle(GO:0005811)
0.1 1.4 GO:0098798 mitochondrial protein complex(GO:0098798)
0.0 1.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 4.0 GO:0000786 nucleosome(GO:0000786)
0.0 4.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.5 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 3.6 GO:0005840 ribosome(GO:0005840)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.5 GO:0005911 cell-cell junction(GO:0005911)
0.0 6.5 GO:0005764 lysosome(GO:0005764)
0.0 3.5 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 1.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 4.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.6 GO:0000785 chromatin(GO:0000785)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.4 GO:0005769 early endosome(GO:0005769)
0.0 14.4 GO:0005615 extracellular space(GO:0005615)
0.0 2.1 GO:0009986 cell surface(GO:0009986)
0.0 7.0 GO:0005576 extracellular region(GO:0005576)
0.0 0.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
2.1 8.6 GO:0070324 thyroid hormone binding(GO:0070324)
1.8 5.4 GO:0008397 sterol 12-alpha-hydroxylase activity(GO:0008397)
1.7 18.7 GO:0032036 myosin heavy chain binding(GO:0032036)
1.6 4.7 GO:0034185 apolipoprotein binding(GO:0034185)
1.5 15.5 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
1.3 6.5 GO:0070573 metallodipeptidase activity(GO:0070573)
1.1 5.5 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
1.0 5.8 GO:0061133 endopeptidase activator activity(GO:0061133)
1.0 3.8 GO:0051380 norepinephrine binding(GO:0051380)
0.9 5.7 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.8 7.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.8 2.4 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.7 3.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.7 15.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.7 3.4 GO:0060182 apelin receptor activity(GO:0060182)
0.7 2.7 GO:0008887 glycerate kinase activity(GO:0008887)
0.7 4.6 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.6 8.0 GO:0070697 activin receptor binding(GO:0070697)
0.6 4.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 4.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.6 3.6 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.6 2.9 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.6 2.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.6 6.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.5 3.8 GO:0005549 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.5 2.7 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.5 7.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.5 3.1 GO:0019215 intermediate filament binding(GO:0019215)
0.5 2.0 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.5 5.6 GO:0035804 structural constituent of egg coat(GO:0035804)
0.5 15.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.5 3.8 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.5 4.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.4 3.0 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.4 5.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.4 3.2 GO:0004100 chitin synthase activity(GO:0004100)
0.4 1.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.4 3.0 GO:0015157 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.3 11.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 1.6 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.3 4.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 1.9 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.3 4.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 2.4 GO:0015057 thrombin receptor activity(GO:0015057)
0.3 2.8 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.3 7.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 2.7 GO:0005522 profilin binding(GO:0005522)
0.3 2.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 13.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.3 1.8 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.2 14.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 1.7 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 6.3 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 3.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 4.1 GO:0030552 cAMP binding(GO:0030552)
0.2 4.2 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.2 9.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 4.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.2 17.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 2.8 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.2 9.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.2 7.0 GO:0030145 manganese ion binding(GO:0030145)
0.2 0.6 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.2 4.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 0.9 GO:0035197 siRNA binding(GO:0035197)
0.2 2.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 0.9 GO:0016415 octanoyltransferase activity(GO:0016415)
0.2 1.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2 3.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 24.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 3.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 10.0 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.4 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.1 1.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 3.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 3.5 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 1.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.7 GO:0050699 WW domain binding(GO:0050699)
0.1 6.4 GO:0019843 rRNA binding(GO:0019843)
0.1 0.4 GO:0004771 sterol esterase activity(GO:0004771)
0.1 1.0 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 2.9 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 8.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 2.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.0 GO:0016936 galactoside binding(GO:0016936)
0.1 1.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 2.9 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 8.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 16.3 GO:0005179 hormone activity(GO:0005179)
0.1 17.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 2.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1 1.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.5 GO:0048495 Roundabout binding(GO:0048495)
0.1 2.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 19.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 8.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.6 GO:0034452 dynactin binding(GO:0034452)
0.1 4.5 GO:0005178 integrin binding(GO:0005178)
0.1 1.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 3.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.1 6.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.8 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 14.3 GO:0003774 motor activity(GO:0003774)
0.1 0.2 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 2.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 8.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 5.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.4 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 3.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 15.8 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.8 GO:0005109 frizzled binding(GO:0005109)
0.0 6.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 1.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.8 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 12.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 1.2 GO:0044325 ion channel binding(GO:0044325)
0.0 1.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.3 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 18.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 3.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 14.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 4.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 7.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.3 8.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.3 4.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 11.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 5.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 8.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 30.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 7.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 2.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 1.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 1.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 4.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 3.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.4 PID CD40 PATHWAY CD40/CD40L signaling
0.1 4.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 7.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 6.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 14.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
1.1 5.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.0 5.0 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.8 8.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.7 3.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.7 9.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.6 7.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.5 11.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.5 4.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 5.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.4 5.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.4 2.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 3.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 4.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 2.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 7.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 5.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 4.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 3.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 2.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 4.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 2.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.2 3.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 3.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 18.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 4.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.7 REACTOME OPSINS Genes involved in Opsins
0.1 7.3 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 3.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.6 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 3.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 6.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.0 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 2.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.2 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.9 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 1.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events