ISMARA results: hoxa1a+hoxb1b-1+hoxc1a

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxa1a+hoxb1b-1+hoxc1a

Z-value: 1.86

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Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a

Gene Symbol	Gene ID	Gene Info
hoxb1b-1 NCBI UniProt	ENSDARG00000054033	homeobox B1b
hoxc1a NCBI UniProt	ENSDARG00000070337	homeobox C1a
hoxa1a NCBI UniProt	ENSDARG00000104307	homeobox A1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxc1a	dr11_v1_chr23_+_36178104_36178104	0.63	7.4e-12	Click!
hoxa1a	dr11_v1_chr19_+_19786117_19786213	-0.34	7.9e-04	Click!
hoxb1b	dr11_v1_chr12_+_27141140_27141140	0.13	2.1e-01	Click!

Activity profile of hoxa1a+hoxb1b-1+hoxc1a motif

Sorted Z-values of hoxa1a+hoxb1b-1+hoxc1a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_25916530 Show fit	48.51	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr20_-_9462433 Show fit	36.56	ENSDART00000152674 ENSDART00000040557	zgc:101840 NCBI UniProt Show fit	zgc:101840
chr25_+_7461624 Show fit	32.02	ENSDART00000170569	syt12 NCBI UniProt Show fit	synaptotagmin XII
chr9_-_51370293 Show fit	26.26	ENSDART00000084806	slc4a10b NCBI UniProt Show fit	solute carrier family 4, sodium bicarbonate transporter, member 10b
chr23_-_11870962 Show fit	25.45	ENSDART00000143481	si:dkey-178k16.1 NCBI UniProt Show fit	si:dkey-178k16.1
chr1_-_14258409 Show fit	23.60	ENSDART00000079359	pde5aa NCBI UniProt Show fit	phosphodiesterase 5A, cGMP-specific, a
chr11_-_1131569 Show fit	22.89	ENSDART00000173228	slc6a11b NCBI UniProt Show fit	solute carrier family 6 (neurotransmitter transporter), member 11b
chr9_+_34425736 Show fit	21.33	ENSDART00000135147	si:ch211-218d20.15 NCBI UniProt Show fit	si:ch211-218d20.15
chr15_-_27972474 Show fit	19.96	ENSDART00000162753	CR391930.1 NCBI UniProt Show fit
chr10_+_466926 Show fit	18.97	ENSDART00000145220	arvcfa NCBI UniProt Show fit	ARVCF, delta catenin family member a

Showing 1 to 10 of 177 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	65.7	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
1.9	48.5	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.3	43.3	GO:0035725	sodium ion transmembrane transport(GO:0035725)
1.2	32.0	GO:0060291	long-term synaptic potentiation(GO:0060291)
1.6	27.5	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
5.4	26.9	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
1.1	26.3	GO:0015701	bicarbonate transport(GO:0015701)
1.2	26.2	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	21.8	GO:0007186	G-protein coupled receptor signaling pathway(GO:0007186)
0.5	19.0	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Showing 1 to 10 of 72 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	49.3	GO:0043679	axon terminus(GO:0043679)
0.7	36.1	GO:0098839	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
1.4	34.5	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.2	32.0	GO:0070382	exocytic vesicle(GO:0070382)
0.3	26.3	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	22.0	GO:0043005	neuron projection(GO:0043005)
3.0	17.9	GO:0005955	calcineurin complex(GO:0005955)
0.2	17.3	GO:0005871	kinesin complex(GO:0005871)
3.3	16.6	GO:0042584	chromaffin granule membrane(GO:0042584)
0.2	16.0	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	48.6	GO:0001786	phosphatidylserine binding(GO:0001786)
16.2	48.5	GO:1903136	cuprous ion binding(GO:1903136)
0.1	39.8	GO:0003779	actin binding(GO:0003779)
0.5	39.6	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
1.8	34.5	GO:0015026	coreceptor activity(GO:0015026)
0.0	26.8	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.9	26.3	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
1.8	23.6	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	23.4	GO:0003723	RNA binding(GO:0003723)
1.8	22.9	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	36.2	PID BMP PATHWAY	BMP receptor signaling
1.5	19.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
2.7	16.0	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.4	13.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.7	9.7	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	3.4	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	3.1	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.7	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.3	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	34.5	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
1.1	17.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.8	16.0	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	13.9	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.9	9.7	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.3	8.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	8.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	5.1	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.4	4.7	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	3.4	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression

Showing 1 to 10 of 16 entries

Results for hoxa1a+hoxb1b-1+hoxc1a

Z-value: 1.86

Motif logo

Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a

Activity-expression correlation:

Activity profile of hoxa1a+hoxb1b-1+hoxc1a motif

Sorted Z-values of hoxa1a+hoxb1b-1+hoxc1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: