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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for hoxa11b
Z-value: 1.18
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Transcription factors associated with hoxa11b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxa11b | dr11_v1_chr16_+_20904754_20904754 | -0.38 | 2.0e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_36585399 Show fit | 8.58 |
ENSDART00000030211
|
glia maturation factor, beta |
|
| chr11_-_3343463 Show fit | 6.38 |
ENSDART00000066177
|
tubulin, alpha 2 |
|
| chr8_-_44904723 Show fit | 6.15 |
ENSDART00000040804
|
PRA1 domain family, member 2 |
|
| chr10_-_24371312 Show fit | 5.88 |
ENSDART00000149362
|
phosphatidylinositol transfer protein, alpha b |
|
| chr3_+_46763745 Show fit | 5.68 |
ENSDART00000185437
|
protein kinase C substrate 80K-H |
|
| chr24_-_6158933 Show fit | 5.51 |
ENSDART00000021609
|
glutamate decarboxylase 2 |
|
| chr20_+_29565906 Show fit | 5.42 |
ENSDART00000062383
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a |
|
| chr10_+_7029664 Show fit | 5.15 |
ENSDART00000166206
|
pleckstrin and Sec7 domain containing 3, like |
|
| chr6_+_40661703 Show fit | 5.11 |
ENSDART00000142492
|
enolase 1b, (alpha) |
|
| chr5_+_24245682 Show fit | 4.97 |
ENSDART00000049003
|
ATPase H+ transporting V1 subunit Aa |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxa11b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.2 | GO:0015031 | protein transport(GO:0015031) |
| 0.2 | 14.7 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.5 | 11.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 10.3 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.2 | 9.8 | GO:0032012 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 9.5 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.3 | 7.5 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.6 | 6.7 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.1 | 6.7 | GO:0048278 | vesicle docking(GO:0048278) |
| 0.1 | 6.3 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 2.6 | 10.3 | GO:0017177 | glucosidase II complex(GO:0017177) |
| 0.1 | 7.8 | GO:0005769 | early endosome(GO:0005769) |
| 0.5 | 7.7 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.2 | 7.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 7.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 7.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 6.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 6.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 6.1 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 12.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 8.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 8.6 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 0.1 | 7.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.7 | 7.7 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.8 | 7.5 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 7.3 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.0 | 7.2 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 7.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 6.4 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 5.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 3.3 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.2 | 3.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.4 | 3.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 3.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 10.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.7 | 9.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 7.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.5 | 7.2 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 7.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 6.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 5.6 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.2 | 5.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.4 | 5.0 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.3 | 4.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |